PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4A3_LEIBR

TriTrypDb:

LbrM.05.0580 , LBRM2903_250009200

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0008180	COP9 signalosome	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H4A3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4A3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.532
CLV_PCSK_SKI1_1	170	174	PF00082	0.719
CLV_PCSK_SKI1_1	87	91	PF00082	0.556
DOC_CKS1_1	113	118	PF01111	0.519
DOC_CYCLIN_RxL_1	66	77	PF00134	0.574
DOC_CYCLIN_RxL_1	93	104	PF00134	0.547
DOC_MAPK_gen_1	98	105	PF00069	0.456
DOC_PP1_RVXF_1	67	74	PF00149	0.577
DOC_USP7_MATH_1	25	29	PF00917	0.645
DOC_USP7_MATH_1	31	35	PF00917	0.676
DOC_USP7_MATH_1	59	63	PF00917	0.594
DOC_USP7_MATH_1	80	84	PF00917	0.403
DOC_WW_Pin1_4	112	117	PF00397	0.614
DOC_WW_Pin1_4	170	175	PF00397	0.562
LIG_14-3-3_CanoR_1	163	168	PF00244	0.635
LIG_BRCT_BRCA1_1	33	37	PF00533	0.599
LIG_FHA_1	133	139	PF00498	0.744
LIG_FHA_1	62	68	PF00498	0.694
LIG_FHA_2	16	22	PF00498	0.649
LIG_FHA_2	171	177	PF00498	0.546
LIG_FHA_2	73	79	PF00498	0.584
LIG_LIR_Gen_1	104	113	PF02991	0.668
LIG_LIR_Nem_3	104	108	PF02991	0.595
LIG_LIR_Nem_3	122	126	PF02991	0.597
LIG_MLH1_MIPbox_1	33	37	PF16413	0.599
LIG_NRBOX	66	72	PF00104	0.573
LIG_SH2_CRK	38	42	PF00017	0.538
LIG_SH2_NCK_1	175	179	PF00017	0.402
LIG_SH2_SRC	175	178	PF00017	0.428
LIG_SH2_SRC	190	193	PF00017	0.455
LIG_SH2_STAT5	9	12	PF00017	0.564
LIG_SH3_3	110	116	PF00018	0.589
LIG_SUMO_SIM_anti_2	60	69	PF11976	0.543
LIG_TYR_ITIM	121	126	PF00017	0.552
LIG_WRC_WIRS_1	102	107	PF05994	0.583
MOD_CK1_1	104	110	PF00069	0.554
MOD_CK1_1	166	172	PF00069	0.676
MOD_CK2_1	40	46	PF00069	0.500
MOD_GlcNHglycan	27	30	PF01048	0.655
MOD_GlcNHglycan	42	45	PF01048	0.388
MOD_GSK3_1	166	173	PF00069	0.721
MOD_N-GLC_1	170	175	PF02516	0.562
MOD_NEK2_1	30	35	PF00069	0.547
MOD_NEK2_2	31	36	PF00069	0.593
MOD_NEK2_2	82	87	PF00069	0.397
MOD_NMyristoyl	1	7	PF02799	0.507
MOD_PIKK_1	107	113	PF00454	0.550
MOD_PIKK_1	88	94	PF00454	0.676
MOD_Plk_1	31	37	PF00069	0.594
MOD_Plk_4	101	107	PF00069	0.524
MOD_Plk_4	31	37	PF00069	0.621
MOD_Plk_4	5	11	PF00069	0.478
MOD_ProDKin_1	112	118	PF00069	0.615
MOD_ProDKin_1	170	176	PF00069	0.556
TRG_ENDOCYTIC_2	123	126	PF00928	0.593
TRG_ENDOCYTIC_2	38	41	PF00928	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8M2	Leptomonas seymouri	45%	85%
A0A3Q8IF59	Leishmania donovani	82%	100%
A0A3R7KB37	Trypanosoma rangeli	21%	96%
A4I182	Leishmania infantum	82%	100%
D0A5G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	99%
E9AXB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QA56	Leishmania major	82%	100%