MSP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H4A2_LEIBR

TriTrypDb:

LbrM.05.0570 , LBRM2903_050010800

Length:

408

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H4A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.672
CLV_C14_Caspase3-7	221	225	PF00656	0.430
CLV_C14_Caspase3-7	26	30	PF00656	0.622
CLV_C14_Caspase3-7	327	331	PF00656	0.407
CLV_NRD_NRD_1	229	231	PF00675	0.689
CLV_NRD_NRD_1	259	261	PF00675	0.755
CLV_NRD_NRD_1	277	279	PF00675	0.749
CLV_NRD_NRD_1	376	378	PF00675	0.455
CLV_PCSK_KEX2_1	229	231	PF00082	0.689
CLV_PCSK_KEX2_1	259	261	PF00082	0.740
CLV_PCSK_KEX2_1	277	279	PF00082	0.640
CLV_PCSK_KEX2_1	376	378	PF00082	0.455
CLV_PCSK_SKI1_1	377	381	PF00082	0.532
DOC_MAPK_MEF2A_6	353	360	PF00069	0.410
DOC_MAPK_NFAT4_5	357	365	PF00069	0.485
DOC_PP2B_LxvP_1	209	212	PF13499	0.494
DOC_PP4_FxxP_1	318	321	PF00568	0.415
DOC_SPAK_OSR1_1	119	123	PF12202	0.577
DOC_USP7_MATH_1	212	216	PF00917	0.526
DOC_USP7_MATH_1	225	229	PF00917	0.500
DOC_USP7_MATH_1	324	328	PF00917	0.546
DOC_USP7_MATH_1	34	38	PF00917	0.536
DOC_USP7_MATH_1	382	386	PF00917	0.594
DOC_USP7_MATH_1	397	401	PF00917	0.650
DOC_USP7_MATH_1	65	69	PF00917	0.686
DOC_WW_Pin1_4	107	112	PF00397	0.742
DOC_WW_Pin1_4	233	238	PF00397	0.596
DOC_WW_Pin1_4	293	298	PF00397	0.556
DOC_WW_Pin1_4	91	96	PF00397	0.788
LIG_14-3-3_CanoR_1	105	114	PF00244	0.698
LIG_14-3-3_CanoR_1	146	154	PF00244	0.549
LIG_14-3-3_CanoR_1	229	237	PF00244	0.539
LIG_14-3-3_CanoR_1	24	32	PF00244	0.515
LIG_APCC_ABBA_1	176	181	PF00400	0.392
LIG_BIR_II_1	1	5	PF00653	0.527
LIG_BRCT_BRCA1_1	36	40	PF00533	0.530
LIG_BRCT_BRCA1_1	370	374	PF00533	0.293
LIG_EH1_1	358	366	PF00400	0.420
LIG_eIF4E_1	359	365	PF01652	0.420
LIG_FHA_1	146	152	PF00498	0.617
LIG_FHA_1	197	203	PF00498	0.521
LIG_FHA_1	252	258	PF00498	0.610
LIG_FHA_1	34	40	PF00498	0.553
LIG_FHA_1	378	384	PF00498	0.568
LIG_FHA_1	73	79	PF00498	0.585
LIG_IRF3_LxIS_1	364	371	PF10401	0.233
LIG_LIR_Apic_2	316	321	PF02991	0.416
LIG_LIR_Gen_1	123	132	PF02991	0.559
LIG_LIR_LC3C_4	206	211	PF02991	0.457
LIG_LIR_Nem_3	123	127	PF02991	0.534
LIG_LIR_Nem_3	363	369	PF02991	0.340
LIG_SH2_CRK	359	363	PF00017	0.388
LIG_SH2_CRK	56	60	PF00017	0.509
LIG_SH2_PTP2	124	127	PF00017	0.580
LIG_SH2_PTP2	369	372	PF00017	0.466
LIG_SH2_STAT5	11	14	PF00017	0.570
LIG_SH2_STAT5	124	127	PF00017	0.511
LIG_SH2_STAT5	369	372	PF00017	0.354
LIG_SH3_3	10	16	PF00018	0.588
LIG_SH3_3	108	114	PF00018	0.755
LIG_SH3_3	198	204	PF00018	0.468
LIG_SH3_3	28	34	PF00018	0.649
LIG_SH3_3	402	408	PF00018	0.774
LIG_TRAF2_1	115	118	PF00917	0.650
LIG_TYR_ITIM	122	127	PF00017	0.555
LIG_UBA3_1	39	43	PF00899	0.513
MOD_CDK_SPK_2	235	240	PF00069	0.608
MOD_CDK_SPxxK_3	233	240	PF00069	0.429
MOD_CK1_1	104	110	PF00069	0.673
MOD_CK1_1	228	234	PF00069	0.469
MOD_CK1_1	298	304	PF00069	0.583
MOD_CK1_1	68	74	PF00069	0.655
MOD_CK1_1	96	102	PF00069	0.752
MOD_GlcNHglycan	107	110	PF01048	0.530
MOD_GlcNHglycan	159	162	PF01048	0.431
MOD_GlcNHglycan	218	221	PF01048	0.694
MOD_GlcNHglycan	242	245	PF01048	0.772
MOD_GlcNHglycan	25	28	PF01048	0.484
MOD_GlcNHglycan	284	287	PF01048	0.749
MOD_GlcNHglycan	297	300	PF01048	0.669
MOD_GlcNHglycan	311	314	PF01048	0.671
MOD_GlcNHglycan	318	321	PF01048	0.620
MOD_GlcNHglycan	384	387	PF01048	0.543
MOD_GlcNHglycan	95	98	PF01048	0.530
MOD_GSK3_1	101	108	PF00069	0.750
MOD_GSK3_1	153	160	PF00069	0.518
MOD_GSK3_1	19	26	PF00069	0.606
MOD_GSK3_1	212	219	PF00069	0.467
MOD_GSK3_1	231	238	PF00069	0.387
MOD_GSK3_1	287	294	PF00069	0.509
MOD_GSK3_1	61	68	PF00069	0.643
MOD_GSK3_1	69	76	PF00069	0.614
MOD_N-GLC_1	34	39	PF02516	0.393
MOD_N-GLC_1	72	77	PF02516	0.442
MOD_N-GLC_2	399	401	PF02516	0.398
MOD_NEK2_1	1	6	PF00069	0.580
MOD_NEK2_1	157	162	PF00069	0.403
MOD_NEK2_1	360	365	PF00069	0.345
MOD_NEK2_1	368	373	PF00069	0.332
MOD_NEK2_1	403	408	PF00069	0.666
MOD_NEK2_1	61	66	PF00069	0.571
MOD_PIKK_1	228	234	PF00454	0.467
MOD_PIKK_1	279	285	PF00454	0.424
MOD_PIKK_1	301	307	PF00454	0.601
MOD_PKA_1	260	266	PF00069	0.556
MOD_PKA_2	145	151	PF00069	0.555
MOD_PKA_2	216	222	PF00069	0.410
MOD_PKA_2	228	234	PF00069	0.444
MOD_PKA_2	23	29	PF00069	0.512
MOD_PKA_2	99	105	PF00069	0.739
MOD_Plk_1	251	257	PF00069	0.533
MOD_Plk_1	34	40	PF00069	0.569
MOD_Plk_4	252	258	PF00069	0.592
MOD_Plk_4	287	293	PF00069	0.559
MOD_Plk_4	34	40	PF00069	0.538
MOD_Plk_4	360	366	PF00069	0.333
MOD_ProDKin_1	107	113	PF00069	0.736
MOD_ProDKin_1	233	239	PF00069	0.593
MOD_ProDKin_1	293	299	PF00069	0.554
MOD_ProDKin_1	91	97	PF00069	0.789
MOD_SUMO_for_1	127	130	PF00179	0.586
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.520
TRG_ENDOCYTIC_2	124	127	PF00928	0.517
TRG_ENDOCYTIC_2	359	362	PF00928	0.444
TRG_ENDOCYTIC_2	369	372	PF00928	0.444
TRG_ENDOCYTIC_2	56	59	PF00928	0.510
TRG_ER_diArg_1	276	278	PF00400	0.495
TRG_ER_diArg_1	375	377	PF00400	0.649
TRG_Pf-PMV_PEXEL_1	267	271	PF00026	0.708

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2J2	Leptomonas seymouri	52%	100%
A0A1X0NKC1	Trypanosomatidae	33%	100%
A0A3S5H5I5	Leishmania donovani	71%	97%
A0A422ND80	Trypanosoma rangeli	33%	100%
A4HSH8	Leishmania infantum	71%	97%
E9AKG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	97%
Q4QJE6	Leishmania major	70%	100%
V5BAR1	Trypanosoma cruzi	28%	100%