Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

u6 snrna-associated sm-like protein lsm3

Species:

Leishmania braziliensis

UniProt:

A4H4A0_LEIBR

TriTrypDb:

LbrM.05.0550 , LBRM2903_050010600

Length:

191

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005688	U6 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H4A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H4A0

Function

Biological processes
Term	Name	Level	Count
GO:0000365	mRNA trans splicing, via spliceosome	9	1
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045291	mRNA trans splicing, SL addition	10	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0017069	snRNA binding	5	1
GO:0017070	U6 snRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.434
CLV_NRD_NRD_1	157	159	PF00675	0.756
CLV_PCSK_KEX2_1	159	161	PF00082	0.763
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.713
DEG_APCC_DBOX_1	115	123	PF00400	0.483
DEG_APCC_DBOX_1	159	167	PF00400	0.533
DEG_Nend_Nbox_1	1	3	PF02207	0.411
DEG_SPOP_SBC_1	33	37	PF00917	0.464
DEG_SPOP_SBC_1	76	80	PF00917	0.659
DOC_MAPK_gen_1	176	186	PF00069	0.481
DOC_MAPK_MEF2A_6	179	188	PF00069	0.476
DOC_MAPK_MEF2A_6	38	46	PF00069	0.476
DOC_USP7_MATH_1	33	37	PF00917	0.531
DOC_USP7_MATH_1	66	70	PF00917	0.624
DOC_USP7_MATH_1	76	80	PF00917	0.551
DOC_WW_Pin1_4	5	10	PF00397	0.439
LIG_14-3-3_CanoR_1	11	16	PF00244	0.604
LIG_14-3-3_CanoR_1	34	42	PF00244	0.470
LIG_AP2alpha_2	86	88	PF02296	0.523
LIG_Clathr_ClatBox_1	119	123	PF01394	0.476
LIG_FHA_1	22	28	PF00498	0.513
LIG_Integrin_isoDGR_2	147	149	PF01839	0.738
LIG_LIR_Gen_1	85	95	PF02991	0.345
LIG_LIR_Nem_3	85	91	PF02991	0.519
LIG_SH2_STAT3	90	93	PF00017	0.325
LIG_SH2_STAT5	15	18	PF00017	0.496
LIG_SH2_STAT5	90	93	PF00017	0.488
LIG_SH3_2	6	11	PF14604	0.458
LIG_SH3_3	3	9	PF00018	0.425
LIG_SH3_3	81	87	PF00018	0.664
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.492
LIG_SUMO_SIM_par_1	118	124	PF11976	0.487
LIG_SUMO_SIM_par_1	182	187	PF11976	0.465
LIG_UBA3_1	12	18	PF00899	0.491
LIG_UBA3_1	42	50	PF00899	0.477
MOD_CDC14_SPxK_1	8	11	PF00782	0.463
MOD_CDK_SPxK_1	5	11	PF00069	0.446
MOD_CK1_1	23	29	PF00069	0.547
MOD_CK1_1	4	10	PF00069	0.449
MOD_CK1_1	53	59	PF00069	0.551
MOD_CK1_1	79	85	PF00069	0.624
MOD_GlcNHglycan	142	146	PF01048	0.550
MOD_GlcNHglycan	166	169	PF01048	0.505
MOD_GlcNHglycan	55	59	PF01048	0.772
MOD_GlcNHglycan	81	84	PF01048	0.671
MOD_GSK3_1	1	8	PF00069	0.437
MOD_GSK3_1	184	191	PF00069	0.388
MOD_GSK3_1	19	26	PF00069	0.601
MOD_GSK3_1	28	35	PF00069	0.513
MOD_GSK3_1	50	57	PF00069	0.585
MOD_GSK3_1	75	82	PF00069	0.684
MOD_LATS_1	48	54	PF00433	0.485
MOD_NEK2_1	1	6	PF00069	0.481
MOD_NEK2_1	141	146	PF00069	0.710
MOD_NEK2_1	54	59	PF00069	0.720
MOD_PIKK_1	28	34	PF00454	0.501
MOD_PKA_2	115	121	PF00069	0.496
MOD_PKA_2	33	39	PF00069	0.468
MOD_Plk_1	171	177	PF00069	0.564
MOD_Plk_4	11	17	PF00069	0.490
MOD_Plk_4	115	121	PF00069	0.484
MOD_ProDKin_1	5	11	PF00069	0.446
TRG_DiLeu_BaEn_1	173	178	PF01217	0.522
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.518
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.567
TRG_DiLeu_LyEn_5	173	178	PF01217	0.522
TRG_ER_diArg_1	157	160	PF00400	0.761
TRG_NLS_MonoExtC_3	157	162	PF00514	0.707
TRG_NLS_MonoExtN_4	157	163	PF00514	0.706

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WP36	Leishmania donovani	81%	100%
A4HSH6	Leishmania infantum	81%	100%
E9AKG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QJE8	Leishmania major	80%	99%