Monocarboxylate transporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

monocarboxylate transporter-like protein

Species:

Leishmania braziliensis

UniProt:

A4H494_LEIBR

TriTrypDb:

LbrM.05.0490 , LBRM2903_050010000

Length:

542

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H494

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H494

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.385
CLV_NRD_NRD_1	150	152	PF00675	0.315
CLV_NRD_NRD_1	206	208	PF00675	0.276
CLV_NRD_NRD_1	232	234	PF00675	0.332
CLV_NRD_NRD_1	321	323	PF00675	0.319
CLV_PCSK_KEX2_1	149	151	PF00082	0.292
CLV_PCSK_KEX2_1	206	208	PF00082	0.262
CLV_PCSK_KEX2_1	232	234	PF00082	0.301
CLV_PCSK_KEX2_1	321	323	PF00082	0.311
CLV_PCSK_KEX2_1	536	538	PF00082	0.380
CLV_PCSK_KEX2_1	8	10	PF00082	0.318
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.380
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.318
CLV_PCSK_SKI1_1	12	16	PF00082	0.454
CLV_PCSK_SKI1_1	301	305	PF00082	0.185
CLV_PCSK_SKI1_1	321	325	PF00082	0.346
CLV_PCSK_SKI1_1	330	334	PF00082	0.289
CLV_PCSK_SKI1_1	336	340	PF00082	0.244
CLV_PCSK_SKI1_1	533	537	PF00082	0.443
DEG_Nend_UBRbox_1	1	4	PF02207	0.530
DEG_SPOP_SBC_1	377	381	PF00917	0.414
DOC_MAPK_HePTP_8	323	335	PF00069	0.385
DOC_MAPK_HePTP_8	458	470	PF00069	0.562
DOC_MAPK_MEF2A_6	326	335	PF00069	0.543
DOC_MAPK_MEF2A_6	461	470	PF00069	0.530
DOC_MAPK_MEF2A_6	90	97	PF00069	0.492
DOC_MAPK_NFAT4_5	330	338	PF00069	0.385
DOC_PP1_RVXF_1	319	326	PF00149	0.542
DOC_PP4_FxxP_1	463	466	PF00568	0.607
DOC_PP4_FxxP_1	484	487	PF00568	0.315
DOC_USP7_MATH_1	143	147	PF00917	0.464
DOC_USP7_MATH_1	192	196	PF00917	0.329
DOC_USP7_MATH_1	227	231	PF00917	0.469
DOC_USP7_MATH_1	360	364	PF00917	0.276
DOC_USP7_UBL2_3	536	540	PF12436	0.663
DOC_WW_Pin1_4	115	120	PF00397	0.185
DOC_WW_Pin1_4	135	140	PF00397	0.282
DOC_WW_Pin1_4	74	79	PF00397	0.315
LIG_14-3-3_CanoR_1	12	19	PF00244	0.493
LIG_14-3-3_CanoR_1	184	188	PF00244	0.276
LIG_14-3-3_CanoR_1	321	326	PF00244	0.491
LIG_14-3-3_CanoR_1	330	336	PF00244	0.486
LIG_Actin_WH2_2	527	542	PF00022	0.508
LIG_BRCT_BRCA1_1	110	114	PF00533	0.334
LIG_BRCT_BRCA1_1	131	135	PF00533	0.269
LIG_BRCT_BRCA1_1	333	337	PF00533	0.471
LIG_BRCT_BRCA1_1	383	387	PF00533	0.276
LIG_BRCT_BRCA1_1	76	80	PF00533	0.315
LIG_BRCT_BRCA1_2	110	116	PF00533	0.459
LIG_FHA_1	184	190	PF00498	0.276
LIG_FHA_1	260	266	PF00498	0.537
LIG_FHA_1	423	429	PF00498	0.427
LIG_FHA_1	446	452	PF00498	0.427
LIG_FHA_1	97	103	PF00498	0.324
LIG_FHA_2	322	328	PF00498	0.492
LIG_FHA_2	368	374	PF00498	0.185
LIG_HP1_1	93	97	PF01393	0.542
LIG_Integrin_RGD_1	233	235	PF01839	0.185
LIG_LIR_Apic_2	462	466	PF02991	0.603
LIG_LIR_Gen_1	122	131	PF02991	0.315
LIG_LIR_Gen_1	191	199	PF02991	0.315
LIG_LIR_Gen_1	370	378	PF02991	0.312
LIG_LIR_Gen_1	42	52	PF02991	0.262
LIG_LIR_Gen_1	433	441	PF02991	0.298
LIG_LIR_Nem_3	122	128	PF02991	0.315
LIG_LIR_Nem_3	191	196	PF02991	0.315
LIG_LIR_Nem_3	20	25	PF02991	0.535
LIG_LIR_Nem_3	324	328	PF02991	0.425
LIG_LIR_Nem_3	339	344	PF02991	0.385
LIG_LIR_Nem_3	370	375	PF02991	0.197
LIG_LIR_Nem_3	388	393	PF02991	0.209
LIG_LIR_Nem_3	42	48	PF02991	0.262
LIG_LIR_Nem_3	433	437	PF02991	0.305
LIG_LIR_Nem_3	5	10	PF02991	0.686
LIG_LIR_Nem_3	502	506	PF02991	0.277
LIG_LIR_Nem_3	77	83	PF02991	0.311
LIG_NRBOX	517	523	PF00104	0.459
LIG_PCNA_yPIPBox_3	274	287	PF02747	0.385
LIG_PCNA_yPIPBox_3	527	535	PF02747	0.674
LIG_Pex14_1	183	187	PF04695	0.279
LIG_Pex14_2	105	109	PF04695	0.315
LIG_Pex14_2	337	341	PF04695	0.337
LIG_Pex14_2	389	393	PF04695	0.315
LIG_SH2_CRK	352	356	PF00017	0.358
LIG_SH2_CRK	503	507	PF00017	0.340
LIG_SH2_GRB2like	372	375	PF00017	0.185
LIG_SH2_NCK_1	372	376	PF00017	0.329
LIG_SH2_SRC	372	375	PF00017	0.296
LIG_SH2_STAP1	414	418	PF00017	0.427
LIG_SH2_STAP1	434	438	PF00017	0.163
LIG_SH2_STAT5	25	28	PF00017	0.388
LIG_SH2_STAT5	361	364	PF00017	0.262
LIG_SH2_STAT5	414	417	PF00017	0.334
LIG_SH2_STAT5	520	523	PF00017	0.418
LIG_SUMO_SIM_par_1	244	249	PF11976	0.491
LIG_SUMO_SIM_par_1	25	30	PF11976	0.334
LIG_TRFH_1	135	139	PF08558	0.329
LIG_TYR_ITIM	354	359	PF00017	0.315
LIG_TYR_ITIM	518	523	PF00017	0.388
LIG_TYR_ITSM	368	375	PF00017	0.358
LIG_UBA3_1	454	461	PF00899	0.506
LIG_WRC_WIRS_1	386	391	PF05994	0.334
LIG_WRC_WIRS_1	404	409	PF05994	0.432
LIG_WW_3	91	95	PF00397	0.334
MOD_CK1_1	130	136	PF00069	0.350
MOD_CK1_1	258	264	PF00069	0.443
MOD_CK1_1	364	370	PF00069	0.470
MOD_CK1_1	381	387	PF00069	0.352
MOD_CK1_1	46	52	PF00069	0.315
MOD_CK1_1	62	68	PF00069	0.292
MOD_CK2_1	114	120	PF00069	0.459
MOD_CK2_1	219	225	PF00069	0.333
MOD_CK2_1	321	327	PF00069	0.382
MOD_CK2_1	367	373	PF00069	0.207
MOD_GlcNHglycan	132	135	PF01048	0.267
MOD_GlcNHglycan	160	163	PF01048	0.308
MOD_GlcNHglycan	166	169	PF01048	0.319
MOD_GlcNHglycan	190	193	PF01048	0.327
MOD_GlcNHglycan	29	32	PF01048	0.334
MOD_GlcNHglycan	366	369	PF01048	0.459
MOD_GlcNHglycan	484	487	PF01048	0.334
MOD_GlcNHglycan	61	64	PF01048	0.427
MOD_GSK3_1	110	117	PF00069	0.360
MOD_GSK3_1	119	126	PF00069	0.358
MOD_GSK3_1	188	195	PF00069	0.329
MOD_GSK3_1	254	261	PF00069	0.280
MOD_GSK3_1	360	367	PF00069	0.427
MOD_GSK3_1	373	380	PF00069	0.362
MOD_GSK3_1	381	388	PF00069	0.384
MOD_GSK3_1	506	513	PF00069	0.334
MOD_GSK3_1	64	71	PF00069	0.315
MOD_LATS_1	319	325	PF00433	0.459
MOD_N-GLC_1	10	15	PF02516	0.362
MOD_N-GLC_1	158	163	PF02516	0.269
MOD_N-GLC_1	235	240	PF02516	0.207
MOD_N-GLC_1	281	286	PF02516	0.207
MOD_N-GLC_1	373	378	PF02516	0.317
MOD_N-GLC_1	499	504	PF02516	0.392
MOD_NEK2_1	108	113	PF00069	0.304
MOD_NEK2_1	114	119	PF00069	0.280
MOD_NEK2_1	127	132	PF00069	0.196
MOD_NEK2_1	198	203	PF00069	0.427
MOD_NEK2_1	412	417	PF00069	0.350
MOD_NEK2_1	430	435	PF00069	0.265
MOD_NEK2_1	471	476	PF00069	0.406
MOD_NEK2_1	48	53	PF00069	0.427
MOD_NEK2_1	68	73	PF00069	0.129
MOD_NEK2_1	96	101	PF00069	0.319
MOD_NEK2_2	183	188	PF00069	0.334
MOD_OFUCOSY	505	510	PF10250	0.427
MOD_PIKK_1	256	262	PF00454	0.343
MOD_PKA_1	321	327	PF00069	0.459
MOD_PKA_2	183	189	PF00069	0.334
MOD_PKA_2	321	327	PF00069	0.433
MOD_Plk_1	10	16	PF00069	0.383
MOD_Plk_1	373	379	PF00069	0.317
MOD_Plk_1	41	47	PF00069	0.315
MOD_Plk_1	499	505	PF00069	0.408
MOD_Plk_2-3	235	241	PF00069	0.207
MOD_Plk_4	143	149	PF00069	0.309
MOD_Plk_4	173	179	PF00069	0.416
MOD_Plk_4	198	204	PF00069	0.324
MOD_Plk_4	367	373	PF00069	0.373
MOD_Plk_4	382	388	PF00069	0.315
MOD_Plk_4	395	401	PF00069	0.315
MOD_Plk_4	423	429	PF00069	0.459
MOD_Plk_4	439	445	PF00069	0.416
MOD_Plk_4	471	477	PF00069	0.317
MOD_Plk_4	98	104	PF00069	0.358
MOD_ProDKin_1	115	121	PF00069	0.207
MOD_ProDKin_1	135	141	PF00069	0.282
MOD_ProDKin_1	74	80	PF00069	0.315
MOD_SUMO_rev_2	251	257	PF00179	0.209
TRG_DiLeu_BaEn_3	239	245	PF01217	0.421
TRG_ENDOCYTIC_2	352	355	PF00928	0.322
TRG_ENDOCYTIC_2	356	359	PF00928	0.307
TRG_ENDOCYTIC_2	372	375	PF00928	0.129
TRG_ENDOCYTIC_2	434	437	PF00928	0.370
TRG_ENDOCYTIC_2	503	506	PF00928	0.340
TRG_ENDOCYTIC_2	520	523	PF00928	0.388
TRG_ER_diArg_1	148	151	PF00400	0.388
TRG_ER_diArg_1	320	322	PF00400	0.409
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2L5	Leptomonas seymouri	70%	100%
A0A1X0NKM3	Trypanosomatidae	51%	100%
A0A3S5IQJ1	Trypanosoma rangeli	52%	100%
A0A3S7WP49	Leishmania donovani	76%	94%
A4HSH0	Leishmania infantum	76%	94%
C9ZND1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	99%
D4A734	Rattus norvegicus	21%	100%
E9AKF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	95%
Q4QJF4	Leishmania major	75%	100%
Q57VW6	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	47%	99%
Q7RTX9	Homo sapiens	20%	100%
Q8BGC3	Mus musculus	21%	100%
Q8K1C7	Mus musculus	21%	100%
V5ARW7	Trypanosoma cruzi	51%	100%