Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H493_LEIBR

TriTrypDb:

LbrM.05.0480 , LBRM2903_050009900

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H493

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H493

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.429
CLV_C14_Caspase3-7	42	46	PF00656	0.512
CLV_NRD_NRD_1	110	112	PF00675	0.549
CLV_NRD_NRD_1	165	167	PF00675	0.594
CLV_NRD_NRD_1	184	186	PF00675	0.490
CLV_NRD_NRD_1	98	100	PF00675	0.535
CLV_PCSK_FUR_1	182	186	PF00082	0.485
CLV_PCSK_KEX2_1	110	112	PF00082	0.623
CLV_PCSK_KEX2_1	165	167	PF00082	0.594
CLV_PCSK_KEX2_1	184	186	PF00082	0.490
CLV_PCSK_KEX2_1	97	99	PF00082	0.730
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.730
CLV_PCSK_SKI1_1	105	109	PF00082	0.673
CLV_PCSK_SKI1_1	117	121	PF00082	0.561
CLV_PCSK_SKI1_1	146	150	PF00082	0.447
CLV_Separin_Metazoa	169	173	PF03568	0.516
DEG_APCC_DBOX_1	145	153	PF00400	0.443
DEG_SCF_FBW7_1	74	80	PF00400	0.505
DOC_CKS1_1	106	111	PF01111	0.631
DOC_CKS1_1	74	79	PF01111	0.504
DOC_MAPK_gen_1	144	151	PF00069	0.503
DOC_USP7_MATH_1	132	136	PF00917	0.492
DOC_USP7_MATH_1	178	182	PF00917	0.425
DOC_USP7_MATH_1	189	193	PF00917	0.411
DOC_USP7_MATH_1	84	88	PF00917	0.618
DOC_WW_Pin1_4	105	110	PF00397	0.802
DOC_WW_Pin1_4	73	78	PF00397	0.547
LIG_14-3-3_CanoR_1	28	35	PF00244	0.374
LIG_14-3-3_CanoR_1	98	106	PF00244	0.732
LIG_BIR_II_1	1	5	PF00653	0.475
LIG_BRCT_BRCA1_1	39	43	PF00533	0.565
LIG_FHA_1	29	35	PF00498	0.373
LIG_FHA_1	74	80	PF00498	0.607
LIG_GBD_Chelix_1	12	20	PF00786	0.473
LIG_PROFILIN_1	89	95	PF00235	0.498
LIG_PTB_Apo_2	60	67	PF02174	0.513
LIG_PTB_Phospho_1	60	66	PF10480	0.513
LIG_SH2_CRK	30	34	PF00017	0.509
LIG_SH2_GRB2like	159	162	PF00017	0.440
LIG_SH2_STAP1	30	34	PF00017	0.509
LIG_SH2_STAT5	159	162	PF00017	0.440
LIG_SH2_STAT5	30	33	PF00017	0.453
LIG_SH2_STAT5	66	69	PF00017	0.507
LIG_SH3_2	106	111	PF14604	0.533
LIG_SH3_2	92	97	PF14604	0.566
LIG_SH3_3	103	109	PF00018	0.512
LIG_SH3_3	128	134	PF00018	0.639
LIG_SH3_3	71	77	PF00018	0.562
LIG_SH3_3	86	92	PF00018	0.649
MOD_CDK_SPK_2	105	110	PF00069	0.652
MOD_CDK_SPxK_1	105	111	PF00069	0.541
MOD_CDK_SPxxK_3	105	112	PF00069	0.559
MOD_CK1_1	2	8	PF00069	0.596
MOD_CK1_1	49	55	PF00069	0.507
MOD_GlcNHglycan	117	120	PF01048	0.544
MOD_GlcNHglycan	48	51	PF01048	0.612
MOD_GSK3_1	189	196	PF00069	0.452
MOD_GSK3_1	44	51	PF00069	0.544
MOD_GSK3_1	73	80	PF00069	0.763
MOD_N-GLC_1	2	7	PF02516	0.597
MOD_PIKK_1	28	34	PF00454	0.374
MOD_PIKK_1	77	83	PF00454	0.519
MOD_PKA_2	100	106	PF00069	0.581
MOD_Plk_1	2	8	PF00069	0.596
MOD_Plk_4	56	62	PF00069	0.588
MOD_ProDKin_1	105	111	PF00069	0.805
MOD_ProDKin_1	73	79	PF00069	0.550
MOD_SUMO_for_1	69	72	PF00179	0.604
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.365
TRG_ENDOCYTIC_2	30	33	PF00928	0.510
TRG_ER_diArg_1	109	111	PF00400	0.548
TRG_ER_diArg_1	144	147	PF00400	0.460
TRG_ER_diArg_1	182	185	PF00400	0.493
TRG_ER_diArg_1	98	101	PF00400	0.540
TRG_NLS_MonoExtC_3	96	101	PF00514	0.535
TRG_NLS_MonoExtN_4	94	101	PF00514	0.525
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZW8	Leptomonas seymouri	35%	81%
A0A3S5H5I0	Leishmania donovani	60%	81%
A4HSG9	Leishmania infantum	61%	81%
E9AKF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	81%