Nucleolar GTP-binding protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GTPase, putative

Species:

Leishmania braziliensis

UniProt:

A4H492_LEIBR

TriTrypDb:

LbrM.05.0470 , LBRM2903_050009800

Length:

640

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0005739	mitochondrion	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4H492

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H492

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016787	hydrolase activity	2	5
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	522	526	PF00656	0.693
CLV_NRD_NRD_1	129	131	PF00675	0.371
CLV_NRD_NRD_1	144	146	PF00675	0.272
CLV_NRD_NRD_1	20	22	PF00675	0.542
CLV_NRD_NRD_1	242	244	PF00675	0.419
CLV_NRD_NRD_1	339	341	PF00675	0.232
CLV_NRD_NRD_1	596	598	PF00675	0.492
CLV_NRD_NRD_1	605	607	PF00675	0.433
CLV_NRD_NRD_1	76	78	PF00675	0.272
CLV_PCSK_KEX2_1	146	148	PF00082	0.273
CLV_PCSK_KEX2_1	20	22	PF00082	0.524
CLV_PCSK_KEX2_1	242	244	PF00082	0.508
CLV_PCSK_KEX2_1	313	315	PF00082	0.544
CLV_PCSK_KEX2_1	339	341	PF00082	0.232
CLV_PCSK_KEX2_1	36	38	PF00082	0.431
CLV_PCSK_KEX2_1	46	48	PF00082	0.259
CLV_PCSK_KEX2_1	604	606	PF00082	0.536
CLV_PCSK_KEX2_1	76	78	PF00082	0.271
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.273
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.544
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.431
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.259
CLV_PCSK_PC1ET2_1	604	606	PF00082	0.558
CLV_PCSK_SKI1_1	10	14	PF00082	0.590
CLV_PCSK_SKI1_1	233	237	PF00082	0.501
CLV_PCSK_SKI1_1	33	37	PF00082	0.446
CLV_PCSK_SKI1_1	363	367	PF00082	0.222
CLV_PCSK_SKI1_1	410	414	PF00082	0.385
CLV_PCSK_SKI1_1	435	439	PF00082	0.367
CLV_PCSK_SKI1_1	456	460	PF00082	0.386
CLV_PCSK_SKI1_1	482	486	PF00082	0.442
CLV_PCSK_SKI1_1	491	495	PF00082	0.436
CLV_PCSK_SKI1_1	551	555	PF00082	0.652
CLV_PCSK_SKI1_1	597	601	PF00082	0.485
DEG_APCC_DBOX_1	146	154	PF00400	0.284
DOC_ANK_TNKS_1	572	579	PF00023	0.491
DOC_CKS1_1	12	17	PF01111	0.410
DOC_CYCLIN_RxL_1	6	16	PF00134	0.613
DOC_MAPK_gen_1	100	109	PF00069	0.284
DOC_MAPK_gen_1	110	118	PF00069	0.284
DOC_MAPK_gen_1	142	150	PF00069	0.284
DOC_MAPK_gen_1	242	253	PF00069	0.352
DOC_MAPK_gen_1	313	323	PF00069	0.398
DOC_MAPK_gen_1	424	432	PF00069	0.513
DOC_MAPK_gen_1	567	577	PF00069	0.500
DOC_MAPK_MEF2A_6	110	118	PF00069	0.284
DOC_MAPK_MEF2A_6	274	281	PF00069	0.321
DOC_MAPK_MEF2A_6	314	323	PF00069	0.385
DOC_PP4_FxxP_1	470	473	PF00568	0.392
DOC_USP7_MATH_1	474	478	PF00917	0.436
DOC_USP7_UBL2_3	142	146	PF12436	0.284
DOC_USP7_UBL2_3	182	186	PF12436	0.671
DOC_USP7_UBL2_3	3	7	PF12436	0.592
DOC_USP7_UBL2_3	42	46	PF12436	0.405
DOC_USP7_UBL2_3	438	442	PF12436	0.396
DOC_USP7_UBL2_3	563	567	PF12436	0.575
DOC_USP7_UBL2_3	600	604	PF12436	0.509
DOC_WW_Pin1_4	11	16	PF00397	0.428
DOC_WW_Pin1_4	314	319	PF00397	0.439
LIG_14-3-3_CanoR_1	20	24	PF00244	0.640
LIG_14-3-3_CanoR_1	339	344	PF00244	0.473
LIG_14-3-3_CanoR_1	570	576	PF00244	0.661
LIG_CaM_NSCaTE_8	631	638	PF13499	0.487
LIG_deltaCOP1_diTrp_1	132	139	PF00928	0.289
LIG_deltaCOP1_diTrp_1	425	432	PF00928	0.376
LIG_deltaCOP1_diTrp_1	461	469	PF00928	0.363
LIG_deltaCOP1_diTrp_1	627	634	PF00928	0.499
LIG_eIF4E_1	247	253	PF01652	0.449
LIG_FHA_1	360	366	PF00498	0.432
LIG_FHA_1	400	406	PF00498	0.432
LIG_FHA_1	418	424	PF00498	0.365
LIG_FHA_1	559	565	PF00498	0.752
LIG_FHA_1	80	86	PF00498	0.284
LIG_FHA_2	136	142	PF00498	0.307
LIG_FHA_2	532	538	PF00498	0.702
LIG_FHA_2	58	64	PF00498	0.179
LIG_LIR_Gen_1	103	109	PF02991	0.284
LIG_LIR_Gen_1	265	276	PF02991	0.328
LIG_LIR_Gen_1	353	361	PF02991	0.432
LIG_LIR_Gen_1	497	505	PF02991	0.443
LIG_LIR_Gen_1	628	638	PF02991	0.490
LIG_LIR_Nem_3	103	108	PF02991	0.284
LIG_LIR_Nem_3	209	214	PF02991	0.322
LIG_LIR_Nem_3	244	250	PF02991	0.345
LIG_LIR_Nem_3	265	271	PF02991	0.318
LIG_LIR_Nem_3	273	279	PF02991	0.335
LIG_LIR_Nem_3	353	359	PF02991	0.432
LIG_LIR_Nem_3	425	429	PF02991	0.399
LIG_LIR_Nem_3	497	502	PF02991	0.419
LIG_LIR_Nem_3	628	634	PF02991	0.484
LIG_LYPXL_yS_3	276	279	PF13949	0.318
LIG_LYPXL_yS_3	326	329	PF13949	0.432
LIG_PCNA_PIPBox_1	492	501	PF02747	0.383
LIG_PCNA_PIPBox_1	582	591	PF02747	0.403
LIG_PCNA_yPIPBox_3	377	391	PF02747	0.432
LIG_PCNA_yPIPBox_3	605	619	PF02747	0.469
LIG_Pex14_1	135	139	PF04695	0.284
LIG_Pex14_1	207	211	PF04695	0.343
LIG_Pex14_2	236	240	PF04695	0.492
LIG_SH2_CRK	105	109	PF00017	0.284
LIG_SH2_PTP2	358	361	PF00017	0.432
LIG_SH2_STAP1	105	109	PF00017	0.284
LIG_SH2_STAT3	460	463	PF00017	0.329
LIG_SH2_STAT5	222	225	PF00017	0.309
LIG_SH2_STAT5	358	361	PF00017	0.432
LIG_SH2_STAT5	588	591	PF00017	0.589
LIG_SH3_2	15	20	PF14604	0.631
LIG_SH3_3	12	18	PF00018	0.633
LIG_SH3_3	282	288	PF00018	0.388
LIG_SH3_4	3	10	PF00018	0.594
LIG_SUMO_SIM_par_1	114	121	PF11976	0.284
LIG_TRAF2_1	526	529	PF00917	0.750
LIG_TRAF2_1	608	611	PF00917	0.375
LIG_TYR_ITIM	324	329	PF00017	0.432
LIG_WRC_WIRS_1	499	504	PF05994	0.450
MOD_CK1_1	527	533	PF00069	0.646
MOD_CK1_1	57	63	PF00069	0.179
MOD_CK2_1	114	120	PF00069	0.282
MOD_CK2_1	419	425	PF00069	0.426
MOD_CK2_1	523	529	PF00069	0.656
MOD_CK2_1	541	547	PF00069	0.751
MOD_Cter_Amidation	4	7	PF01082	0.590
MOD_GlcNHglycan	154	158	PF01048	0.285
MOD_GlcNHglycan	233	236	PF01048	0.470
MOD_GSK3_1	153	160	PF00069	0.371
MOD_GSK3_1	196	203	PF00069	0.504
MOD_GSK3_1	330	337	PF00069	0.432
MOD_GSK3_1	519	526	PF00069	0.556
MOD_GSK3_1	527	534	PF00069	0.455
MOD_GSK3_1	558	565	PF00069	0.717
MOD_LATS_1	480	486	PF00433	0.351
MOD_N-GLC_1	24	29	PF02516	0.621
MOD_N-GLC_1	305	310	PF02516	0.439
MOD_N-GLC_1	531	536	PF02516	0.751
MOD_N-GLC_1	558	563	PF02516	0.498
MOD_N-GLC_2	255	257	PF02516	0.313
MOD_NEK2_1	262	267	PF00069	0.318
MOD_NEK2_1	281	286	PF00069	0.360
MOD_NEK2_1	334	339	PF00069	0.443
MOD_NEK2_1	361	366	PF00069	0.443
MOD_NEK2_1	40	45	PF00069	0.272
MOD_NEK2_1	79	84	PF00069	0.284
MOD_PIKK_1	568	574	PF00454	0.769
MOD_PK_1	339	345	PF00069	0.473
MOD_PKA_1	339	345	PF00069	0.473
MOD_PKA_2	19	25	PF00069	0.625
MOD_PKA_2	338	344	PF00069	0.473
MOD_PKA_2	376	382	PF00069	0.443
MOD_PKA_2	541	547	PF00069	0.704
MOD_Plk_1	135	141	PF00069	0.295
MOD_Plk_1	153	159	PF00069	0.405
MOD_Plk_1	24	30	PF00069	0.614
MOD_Plk_1	505	511	PF00069	0.640
MOD_Plk_1	519	525	PF00069	0.570
MOD_Plk_1	527	533	PF00069	0.767
MOD_Plk_2-3	519	525	PF00069	0.569
MOD_Plk_2-3	623	629	PF00069	0.626
MOD_Plk_4	103	109	PF00069	0.284
MOD_Plk_4	114	120	PF00069	0.284
MOD_Plk_4	330	336	PF00069	0.430
MOD_Plk_4	404	410	PF00069	0.432
MOD_Plk_4	519	525	PF00069	0.651
MOD_Plk_4	54	60	PF00069	0.280
MOD_Plk_4	584	590	PF00069	0.556
MOD_ProDKin_1	11	17	PF00069	0.418
MOD_ProDKin_1	314	320	PF00069	0.428
MOD_SUMO_rev_2	117	125	PF00179	0.370
MOD_SUMO_rev_2	543	553	PF00179	0.692
TRG_ENDOCYTIC_2	105	108	PF00928	0.284
TRG_ENDOCYTIC_2	211	214	PF00928	0.325
TRG_ENDOCYTIC_2	247	250	PF00928	0.347
TRG_ENDOCYTIC_2	276	279	PF00928	0.318
TRG_ENDOCYTIC_2	326	329	PF00928	0.432
TRG_ENDOCYTIC_2	358	361	PF00928	0.432
TRG_ENDOCYTIC_2	499	502	PF00928	0.411
TRG_ER_diArg_1	145	148	PF00400	0.284
TRG_ER_diArg_1	241	243	PF00400	0.498
TRG_ER_diArg_1	338	340	PF00400	0.432
TRG_ER_diArg_1	464	467	PF00400	0.375
TRG_ER_diArg_1	76	78	PF00400	0.271
TRG_NLS_Bipartite_1	130	150	PF00514	0.405
TRG_NLS_Bipartite_1	20	40	PF00514	0.499
TRG_NLS_MonoExtC_3	144	149	PF00514	0.284
TRG_NLS_MonoExtN_4	142	149	PF00514	0.284
TRG_NLS_MonoExtN_4	310	317	PF00514	0.511
TRG_NLS_MonoExtN_4	33	40	PF00514	0.449
TRG_NLS_MonoExtN_4	595	601	PF00514	0.495
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P303	Leptomonas seymouri	83%	100%
A0A0S4JVL9	Bodo saltans	65%	100%
A0A1X0NJV6	Trypanosomatidae	69%	100%
A0A3S5H5H9	Leishmania donovani	87%	100%
A0A422N2R2	Trypanosoma rangeli	69%	100%
A2XGQ1	Oryza sativa subsp. indica	51%	100%
A4HSG8	Leishmania infantum	87%	100%
C9ZUE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AKF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
J9VQ03	Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487)	46%	89%
O14236	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	100%
P0CS94	Cryptococcus neoformans var. grubii	46%	92%
P53742	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
Q10LF7	Oryza sativa subsp. japonica	51%	100%
Q13823	Homo sapiens	48%	88%
Q4QJF6	Leishmania major	87%	100%
Q6C036	Yarrowia lipolytica (strain CLIB 122 / E 150)	45%	100%
Q6CSP9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	46%	100%
Q6FWS1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	44%	100%
Q6TGJ8	Cryptococcus gattii	45%	88%
Q75DA4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	47%	100%
Q7SHR8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	44%	100%
Q99LH1	Mus musculus	52%	88%
Q9C3Z4	Pneumocystis carinii	45%	100%
Q9C923	Arabidopsis thaliana	50%	100%
V5BAQ6	Trypanosoma cruzi	67%	100%