Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H490_LEIBR

TriTrypDb:

LbrM.05.0450 , LBRM2903_050009600

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H490

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H490

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	442	446	PF00656	0.804
CLV_C14_Caspase3-7	580	584	PF00656	0.614
CLV_C14_Caspase3-7	587	591	PF00656	0.594
CLV_C14_Caspase3-7	652	656	PF00656	0.640
CLV_NRD_NRD_1	109	111	PF00675	0.725
CLV_NRD_NRD_1	257	259	PF00675	0.551
CLV_NRD_NRD_1	26	28	PF00675	0.359
CLV_NRD_NRD_1	328	330	PF00675	0.579
CLV_NRD_NRD_1	621	623	PF00675	0.506
CLV_NRD_NRD_1	744	746	PF00675	0.602
CLV_PCSK_FUR_1	741	745	PF00082	0.567
CLV_PCSK_KEX2_1	14	16	PF00082	0.475
CLV_PCSK_KEX2_1	257	259	PF00082	0.540
CLV_PCSK_KEX2_1	26	28	PF00082	0.314
CLV_PCSK_KEX2_1	316	318	PF00082	0.488
CLV_PCSK_KEX2_1	328	330	PF00082	0.588
CLV_PCSK_KEX2_1	400	402	PF00082	0.513
CLV_PCSK_KEX2_1	449	451	PF00082	0.680
CLV_PCSK_KEX2_1	621	623	PF00082	0.506
CLV_PCSK_KEX2_1	741	743	PF00082	0.546
CLV_PCSK_KEX2_1	744	746	PF00082	0.598
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.468
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.450
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.479
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.680
CLV_PCSK_PC7_1	10	16	PF00082	0.454
CLV_PCSK_SKI1_1	27	31	PF00082	0.400
CLV_PCSK_SKI1_1	289	293	PF00082	0.476
DEG_APCC_DBOX_1	671	679	PF00400	0.623
DEG_APCC_KENBOX_2	762	766	PF00400	0.677
DEG_SCF_FBW7_2	747	753	PF00400	0.677
DEG_SPOP_SBC_1	209	213	PF00917	0.714
DEG_SPOP_SBC_1	332	336	PF00917	0.438
DOC_ANK_TNKS_1	774	781	PF00023	0.470
DOC_CKS1_1	747	752	PF01111	0.693
DOC_CYCLIN_RxL_1	24	32	PF00134	0.361
DOC_CYCLIN_RxL_1	672	682	PF00134	0.599
DOC_MAPK_gen_1	475	485	PF00069	0.597
DOC_MAPK_gen_1	621	629	PF00069	0.604
DOC_MAPK_gen_1	797	805	PF00069	0.343
DOC_PP1_RVXF_1	315	322	PF00149	0.425
DOC_PP1_RVXF_1	597	604	PF00149	0.511
DOC_PP4_FxxP_1	542	545	PF00568	0.538
DOC_USP7_MATH_1	167	171	PF00917	0.519
DOC_USP7_MATH_1	209	213	PF00917	0.714
DOC_USP7_MATH_1	281	285	PF00917	0.455
DOC_USP7_MATH_1	338	342	PF00917	0.488
DOC_USP7_MATH_1	554	558	PF00917	0.457
DOC_USP7_MATH_1	635	639	PF00917	0.631
DOC_USP7_MATH_1	649	653	PF00917	0.408
DOC_USP7_MATH_1	684	688	PF00917	0.467
DOC_USP7_MATH_1	823	827	PF00917	0.522
DOC_USP7_MATH_1	93	97	PF00917	0.684
DOC_USP7_UBL2_3	111	115	PF12436	0.680
DOC_USP7_UBL2_3	492	496	PF12436	0.402
DOC_WW_Pin1_4	134	139	PF00397	0.713
DOC_WW_Pin1_4	182	187	PF00397	0.506
DOC_WW_Pin1_4	189	194	PF00397	0.540
DOC_WW_Pin1_4	743	748	PF00397	0.641
DOC_WW_Pin1_4	95	100	PF00397	0.691
LIG_14-3-3_CanoR_1	110	115	PF00244	0.651
LIG_14-3-3_CanoR_1	133	138	PF00244	0.583
LIG_14-3-3_CanoR_1	15	24	PF00244	0.609
LIG_14-3-3_CanoR_1	306	315	PF00244	0.520
LIG_14-3-3_CanoR_1	329	339	PF00244	0.439
LIG_14-3-3_CanoR_1	350	360	PF00244	0.649
LIG_14-3-3_CanoR_1	410	415	PF00244	0.342
LIG_14-3-3_CanoR_1	458	466	PF00244	0.624
LIG_14-3-3_CanoR_1	482	486	PF00244	0.618
LIG_14-3-3_CanoR_1	58	62	PF00244	0.608
LIG_14-3-3_CanoR_1	669	678	PF00244	0.598
LIG_14-3-3_CanoR_1	797	803	PF00244	0.462
LIG_14-3-3_CanoR_1	804	810	PF00244	0.431
LIG_Actin_WH2_2	47	65	PF00022	0.379
LIG_APCC_ABBAyCdc20_2	26	32	PF00400	0.350
LIG_APCC_ABBAyCdc20_2	704	710	PF00400	0.630
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BIR_III_2	269	273	PF00653	0.635
LIG_BIR_III_2	312	316	PF00653	0.487
LIG_BIR_III_4	374	378	PF00653	0.591
LIG_Clathr_ClatBox_1	197	201	PF01394	0.515
LIG_deltaCOP1_diTrp_1	259	265	PF00928	0.499
LIG_deltaCOP1_diTrp_1	419	428	PF00928	0.554
LIG_eIF4E_1	515	521	PF01652	0.403
LIG_FHA_1	334	340	PF00498	0.471
LIG_FHA_1	563	569	PF00498	0.339
LIG_FHA_1	624	630	PF00498	0.494
LIG_FHA_1	768	774	PF00498	0.518
LIG_FHA_2	338	344	PF00498	0.487
LIG_FHA_2	64	70	PF00498	0.538
LIG_FHA_2	672	678	PF00498	0.516
LIG_FHA_2	747	753	PF00498	0.690
LIG_LIR_Apic_2	638	643	PF02991	0.343
LIG_LIR_Gen_1	282	292	PF02991	0.374
LIG_LIR_Gen_1	361	369	PF02991	0.504
LIG_LIR_Gen_1	419	429	PF02991	0.553
LIG_LIR_Gen_1	534	543	PF02991	0.578
LIG_LIR_Gen_1	56	64	PF02991	0.517
LIG_LIR_Gen_1	608	619	PF02991	0.322
LIG_LIR_Gen_1	706	716	PF02991	0.490
LIG_LIR_Nem_3	244	249	PF02991	0.527
LIG_LIR_Nem_3	282	288	PF02991	0.382
LIG_LIR_Nem_3	361	366	PF02991	0.501
LIG_LIR_Nem_3	419	425	PF02991	0.548
LIG_LIR_Nem_3	534	539	PF02991	0.461
LIG_LIR_Nem_3	56	62	PF02991	0.460
LIG_LIR_Nem_3	615	620	PF02991	0.319
LIG_LIR_Nem_3	706	711	PF02991	0.506
LIG_NRBOX	152	158	PF00104	0.597
LIG_PCNA_PIPBox_1	726	735	PF02747	0.331
LIG_PCNA_TLS_4	357	364	PF02747	0.502
LIG_PCNA_yPIPBox_3	717	730	PF02747	0.491
LIG_Pex14_2	688	692	PF04695	0.661
LIG_SH2_CRK	179	183	PF00017	0.484
LIG_SH2_CRK	522	526	PF00017	0.494
LIG_SH2_NCK_1	81	85	PF00017	0.602
LIG_SH2_PTP2	90	93	PF00017	0.490
LIG_SH2_SRC	640	643	PF00017	0.330
LIG_SH2_STAP1	515	519	PF00017	0.341
LIG_SH2_STAP1	736	740	PF00017	0.584
LIG_SH2_STAT5	363	366	PF00017	0.447
LIG_SH2_STAT5	515	518	PF00017	0.422
LIG_SH2_STAT5	533	536	PF00017	0.422
LIG_SH2_STAT5	90	93	PF00017	0.490
LIG_SH3_1	744	750	PF00018	0.590
LIG_SH3_3	190	196	PF00018	0.523
LIG_SH3_3	594	600	PF00018	0.760
LIG_SH3_3	687	693	PF00018	0.573
LIG_SH3_3	744	750	PF00018	0.590
LIG_SH3_3	773	779	PF00018	0.437
LIG_Sin3_3	50	57	PF02671	0.361
LIG_SUMO_SIM_anti_2	49	56	PF11976	0.401
LIG_SUMO_SIM_par_1	194	202	PF11976	0.512
LIG_SUMO_SIM_par_1	642	648	PF11976	0.575
LIG_SxIP_EBH_1	168	178	PF03271	0.519
LIG_TRAF2_1	749	752	PF00917	0.453
LIG_TYR_ITIM	520	525	PF00017	0.337
LIG_WRC_WIRS_1	685	690	PF05994	0.603
MOD_CK1_1	128	134	PF00069	0.782
MOD_CK1_1	136	142	PF00069	0.715
MOD_CK1_1	148	154	PF00069	0.432
MOD_CK1_1	208	214	PF00069	0.682
MOD_CK1_1	333	339	PF00069	0.459
MOD_CK1_1	439	445	PF00069	0.655
MOD_CK1_1	453	459	PF00069	0.637
MOD_CK1_1	462	468	PF00069	0.543
MOD_CK1_1	679	685	PF00069	0.508
MOD_CK1_1	788	794	PF00069	0.629
MOD_CK1_1	82	88	PF00069	0.413
MOD_CK2_1	101	107	PF00069	0.564
MOD_CK2_1	337	343	PF00069	0.490
MOD_CK2_1	671	677	PF00069	0.537
MOD_CK2_1	746	752	PF00069	0.441
MOD_CK2_1	805	811	PF00069	0.541
MOD_Cter_Amidation	398	401	PF01082	0.531
MOD_GlcNHglycan	174	177	PF01048	0.623
MOD_GlcNHglycan	19	22	PF01048	0.654
MOD_GlcNHglycan	207	210	PF01048	0.563
MOD_GlcNHglycan	241	246	PF01048	0.477
MOD_GlcNHglycan	309	312	PF01048	0.682
MOD_GlcNHglycan	340	343	PF01048	0.570
MOD_GlcNHglycan	351	354	PF01048	0.691
MOD_GlcNHglycan	386	389	PF01048	0.577
MOD_GlcNHglycan	439	442	PF01048	0.587
MOD_GlcNHglycan	552	555	PF01048	0.665
MOD_GlcNHglycan	606	610	PF01048	0.394
MOD_GlcNHglycan	647	650	PF01048	0.588
MOD_GlcNHglycan	658	661	PF01048	0.446
MOD_GlcNHglycan	789	793	PF01048	0.689
MOD_GlcNHglycan	815	818	PF01048	0.543
MOD_GSK3_1	110	117	PF00069	0.504
MOD_GSK3_1	124	131	PF00069	0.730
MOD_GSK3_1	13	20	PF00069	0.504
MOD_GSK3_1	132	139	PF00069	0.650
MOD_GSK3_1	201	208	PF00069	0.614
MOD_GSK3_1	333	340	PF00069	0.467
MOD_GSK3_1	437	444	PF00069	0.705
MOD_GSK3_1	509	516	PF00069	0.601
MOD_GSK3_1	550	557	PF00069	0.622
MOD_GSK3_1	601	608	PF00069	0.553
MOD_GSK3_1	645	652	PF00069	0.558
MOD_GSK3_1	784	791	PF00069	0.641
MOD_GSK3_1	91	98	PF00069	0.722
MOD_N-GLC_1	124	129	PF02516	0.621
MOD_N-GLC_1	16	21	PF02516	0.679
MOD_N-GLC_1	453	458	PF02516	0.530
MOD_NEK2_1	1	6	PF00069	0.612
MOD_NEK2_1	114	119	PF00069	0.652
MOD_NEK2_1	187	192	PF00069	0.622
MOD_NEK2_1	330	335	PF00069	0.448
MOD_NEK2_1	509	514	PF00069	0.466
MOD_NEK2_1	521	526	PF00069	0.488
MOD_NEK2_2	671	676	PF00069	0.648
MOD_NEK2_2	684	689	PF00069	0.375
MOD_NEK2_2	736	741	PF00069	0.590
MOD_PIKK_1	201	207	PF00454	0.484
MOD_PIKK_1	229	235	PF00454	0.354
MOD_PIKK_1	719	725	PF00454	0.618
MOD_PIKK_1	79	85	PF00454	0.386
MOD_PKA_1	110	116	PF00069	0.682
MOD_PKA_2	125	131	PF00069	0.577
MOD_PKA_2	132	138	PF00069	0.551
MOD_PKA_2	349	355	PF00069	0.684
MOD_PKA_2	459	465	PF00069	0.448
MOD_PKA_2	481	487	PF00069	0.631
MOD_PKA_2	543	549	PF00069	0.509
MOD_PKA_2	555	561	PF00069	0.506
MOD_PKA_2	57	63	PF00069	0.615
MOD_PKA_2	671	677	PF00069	0.537
MOD_Plk_1	148	154	PF00069	0.634
MOD_Plk_1	462	468	PF00069	0.603
MOD_Plk_1	676	682	PF00069	0.581
MOD_Plk_1	734	740	PF00069	0.334
MOD_Plk_2-3	623	629	PF00069	0.600
MOD_Plk_4	1	7	PF00069	0.613
MOD_Plk_4	148	154	PF00069	0.483
MOD_Plk_4	19	25	PF00069	0.571
MOD_Plk_4	359	365	PF00069	0.572
MOD_Plk_4	410	416	PF00069	0.565
MOD_Plk_4	486	492	PF00069	0.602
MOD_Plk_4	612	618	PF00069	0.547
MOD_Plk_4	684	690	PF00069	0.598
MOD_ProDKin_1	134	140	PF00069	0.709
MOD_ProDKin_1	182	188	PF00069	0.503
MOD_ProDKin_1	189	195	PF00069	0.533
MOD_ProDKin_1	743	749	PF00069	0.643
MOD_ProDKin_1	95	101	PF00069	0.692
TRG_DiLeu_BaEn_1	194	199	PF01217	0.508
TRG_DiLeu_BaEn_2	727	733	PF01217	0.332
TRG_DiLeu_BaEn_4	752	758	PF01217	0.422
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.508
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.521
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.641
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.630
TRG_ENDOCYTIC_2	363	366	PF00928	0.499
TRG_ENDOCYTIC_2	522	525	PF00928	0.431
TRG_ER_diArg_1	256	258	PF00400	0.556
TRG_ER_diArg_1	297	300	PF00400	0.552
TRG_ER_diArg_1	327	329	PF00400	0.619
TRG_ER_diArg_1	620	622	PF00400	0.507
TRG_ER_diArg_1	740	743	PF00400	0.529
TRG_ER_diArg_1	775	778	PF00400	0.486
TRG_NES_CRM1_1	149	159	PF08389	0.609
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.671
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I264	Leptomonas seymouri	44%	95%
A0A3S7WP37	Leishmania donovani	79%	99%
A4HSG6	Leishmania infantum	80%	98%
E9AKF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	98%
Q4QJF8	Leishmania major	78%	100%