Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H489_LEIBR

TriTrypDb:

LbrM.05.0440 , LBRM2903_050009500

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H489

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H489

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.444
CLV_C14_Caspase3-7	503	507	PF00656	0.374
CLV_C14_Caspase3-7	602	606	PF00656	0.465
CLV_NRD_NRD_1	10	12	PF00675	0.326
CLV_NRD_NRD_1	156	158	PF00675	0.489
CLV_NRD_NRD_1	283	285	PF00675	0.369
CLV_NRD_NRD_1	524	526	PF00675	0.429
CLV_NRD_NRD_1	619	621	PF00675	0.498
CLV_PCSK_FUR_1	8	12	PF00082	0.429
CLV_PCSK_KEX2_1	10	12	PF00082	0.327
CLV_PCSK_KEX2_1	155	157	PF00082	0.487
CLV_PCSK_KEX2_1	283	285	PF00082	0.402
CLV_PCSK_KEX2_1	524	526	PF00082	0.518
CLV_PCSK_KEX2_1	619	621	PF00082	0.498
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.487
CLV_PCSK_SKI1_1	221	225	PF00082	0.539
CLV_PCSK_SKI1_1	631	635	PF00082	0.460
CLV_PCSK_SKI1_1	649	653	PF00082	0.491
CLV_Separin_Metazoa	216	220	PF03568	0.299
DEG_APCC_DBOX_1	283	291	PF00400	0.401
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DEG_SPOP_SBC_1	241	245	PF00917	0.669
DEG_SPOP_SBC_1	599	603	PF00917	0.607
DOC_ANK_TNKS_1	581	588	PF00023	0.432
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.595
DOC_MAPK_gen_1	155	164	PF00069	0.481
DOC_MAPK_gen_1	524	532	PF00069	0.499
DOC_MAPK_MEF2A_6	157	166	PF00069	0.473
DOC_MAPK_MEF2A_6	344	352	PF00069	0.403
DOC_MAPK_MEF2A_6	525	534	PF00069	0.363
DOC_PP1_RVXF_1	120	126	PF00149	0.471
DOC_PP1_RVXF_1	31	38	PF00149	0.326
DOC_PP2B_LxvP_1	199	202	PF13499	0.508
DOC_PP2B_LxvP_1	74	77	PF13499	0.482
DOC_PP4_FxxP_1	446	449	PF00568	0.398
DOC_PP4_FxxP_1	534	537	PF00568	0.424
DOC_USP7_MATH_1	210	214	PF00917	0.585
DOC_USP7_MATH_1	241	245	PF00917	0.624
DOC_USP7_MATH_1	250	254	PF00917	0.466
DOC_USP7_MATH_1	401	405	PF00917	0.703
DOC_USP7_MATH_1	42	46	PF00917	0.709
DOC_USP7_MATH_1	49	53	PF00917	0.572
DOC_USP7_MATH_1	507	511	PF00917	0.332
DOC_USP7_MATH_1	547	551	PF00917	0.676
DOC_USP7_MATH_1	554	558	PF00917	0.596
DOC_USP7_MATH_1	598	602	PF00917	0.606
DOC_USP7_MATH_1	645	649	PF00917	0.525
DOC_USP7_MATH_1	68	72	PF00917	0.555
DOC_USP7_MATH_1	75	79	PF00917	0.686
DOC_USP7_UBL2_3	675	679	PF12436	0.738
DOC_WW_Pin1_4	185	190	PF00397	0.427
DOC_WW_Pin1_4	197	202	PF00397	0.537
DOC_WW_Pin1_4	489	494	PF00397	0.382
DOC_WW_Pin1_4	552	557	PF00397	0.476
DOC_WW_Pin1_4	565	570	PF00397	0.376
LIG_14-3-3_CanoR_1	10	15	PF00244	0.340
LIG_14-3-3_CanoR_1	3	7	PF00244	0.511
LIG_14-3-3_CanoR_1	631	638	PF00244	0.419
LIG_14-3-3_CanoR_1	649	654	PF00244	0.493
LIG_14-3-3_CanoR_1	660	666	PF00244	0.646
LIG_APCC_ABBA_1	572	577	PF00400	0.477
LIG_BRCT_BRCA1_1	128	132	PF00533	0.248
LIG_BRCT_BRCA1_1	566	570	PF00533	0.463
LIG_BRCT_BRCA1_1	77	81	PF00533	0.728
LIG_deltaCOP1_diTrp_1	411	419	PF00928	0.243
LIG_deltaCOP1_diTrp_1	639	643	PF00928	0.310
LIG_FHA_1	213	219	PF00498	0.576
LIG_FHA_1	258	264	PF00498	0.331
LIG_FHA_1	405	411	PF00498	0.418
LIG_FHA_1	490	496	PF00498	0.385
LIG_FHA_2	14	20	PF00498	0.301
LIG_FHA_2	144	150	PF00498	0.367
LIG_FHA_2	306	312	PF00498	0.521
LIG_FHA_2	501	507	PF00498	0.524
LIG_FHA_2	566	572	PF00498	0.489
LIG_FHA_2	632	638	PF00498	0.388
LIG_FHA_2	660	666	PF00498	0.575
LIG_FHA_2	98	104	PF00498	0.448
LIG_LIR_Apic_2	531	537	PF02991	0.399
LIG_LIR_Gen_1	109	118	PF02991	0.538
LIG_LIR_Gen_1	19	30	PF02991	0.403
LIG_LIR_Gen_1	586	596	PF02991	0.528
LIG_LIR_Nem_3	109	115	PF02991	0.571
LIG_LIR_Nem_3	144	150	PF02991	0.347
LIG_LIR_Nem_3	19	25	PF02991	0.335
LIG_LIR_Nem_3	571	575	PF02991	0.463
LIG_LIR_Nem_3	586	592	PF02991	0.446
LIG_LYPXL_S_1	176	180	PF13949	0.496
LIG_LYPXL_S_1	442	446	PF13949	0.491
LIG_LYPXL_yS_3	177	180	PF13949	0.501
LIG_MYND_3	370	374	PF01753	0.422
LIG_Pex14_1	268	272	PF04695	0.387
LIG_Pex14_2	154	158	PF04695	0.474
LIG_Pex14_2	518	522	PF04695	0.491
LIG_SH2_CRK	9	13	PF00017	0.396
LIG_SH2_NCK_1	315	319	PF00017	0.383
LIG_SH2_PTP2	441	444	PF00017	0.474
LIG_SH2_SRC	108	111	PF00017	0.469
LIG_SH2_SRC	340	343	PF00017	0.345
LIG_SH2_SRC	441	444	PF00017	0.426
LIG_SH2_STAT3	378	381	PF00017	0.528
LIG_SH2_STAT3	473	476	PF00017	0.394
LIG_SH2_STAT5	112	115	PF00017	0.439
LIG_SH2_STAT5	14	17	PF00017	0.330
LIG_SH2_STAT5	24	27	PF00017	0.256
LIG_SH2_STAT5	342	345	PF00017	0.297
LIG_SH2_STAT5	441	444	PF00017	0.404
LIG_SH2_STAT5	473	476	PF00017	0.359
LIG_SH2_STAT5	511	514	PF00017	0.390
LIG_SH2_STAT5	583	586	PF00017	0.399
LIG_SH2_STAT5	661	664	PF00017	0.602
LIG_SH3_3	300	306	PF00018	0.405
LIG_SH3_3	387	393	PF00018	0.515
LIG_SH3_3	457	463	PF00018	0.413
LIG_SH3_3	493	499	PF00018	0.276
LIG_SH3_3	587	593	PF00018	0.493
LIG_SUMO_SIM_par_1	114	119	PF11976	0.483
LIG_TRAF2_1	393	396	PF00917	0.569
LIG_TRAF2_1	662	665	PF00917	0.541
LIG_TRFH_1	197	201	PF08558	0.586
LIG_TYR_ITIM	338	343	PF00017	0.279
LIG_WW_3	47	51	PF00397	0.589
MOD_CDK_SPxxK_3	197	204	PF00069	0.357
MOD_CK1_1	13	19	PF00069	0.470
MOD_CK1_1	143	149	PF00069	0.361
MOD_CK1_1	203	209	PF00069	0.588
MOD_CK1_1	254	260	PF00069	0.438
MOD_CK1_1	404	410	PF00069	0.576
MOD_CK1_1	425	431	PF00069	0.361
MOD_CK1_1	601	607	PF00069	0.764
MOD_CK2_1	13	19	PF00069	0.299
MOD_CK2_1	143	149	PF00069	0.349
MOD_CK2_1	210	216	PF00069	0.599
MOD_CK2_1	305	311	PF00069	0.557
MOD_CK2_1	374	380	PF00069	0.442
MOD_CK2_1	396	402	PF00069	0.451
MOD_CK2_1	565	571	PF00069	0.364
MOD_CK2_1	603	609	PF00069	0.527
MOD_CK2_1	631	637	PF00069	0.415
MOD_CK2_1	659	665	PF00069	0.493
MOD_GlcNHglycan	237	240	PF01048	0.457
MOD_GlcNHglycan	316	319	PF01048	0.522
MOD_GlcNHglycan	398	401	PF01048	0.452
MOD_GlcNHglycan	404	407	PF01048	0.574
MOD_GlcNHglycan	476	479	PF01048	0.353
MOD_GlcNHglycan	483	486	PF01048	0.328
MOD_GlcNHglycan	51	54	PF01048	0.553
MOD_GlcNHglycan	549	552	PF01048	0.632
MOD_GlcNHglycan	605	608	PF01048	0.711
MOD_GlcNHglycan	70	73	PF01048	0.611
MOD_GSK3_1	250	257	PF00069	0.660
MOD_GSK3_1	369	376	PF00069	0.510
MOD_GSK3_1	401	408	PF00069	0.483
MOD_GSK3_1	425	432	PF00069	0.483
MOD_GSK3_1	474	481	PF00069	0.404
MOD_GSK3_1	49	56	PF00069	0.559
MOD_GSK3_1	552	559	PF00069	0.480
MOD_GSK3_1	594	601	PF00069	0.649
MOD_GSK3_1	627	634	PF00069	0.507
MOD_GSK3_1	645	652	PF00069	0.399
MOD_GSK3_1	89	96	PF00069	0.765
MOD_N-GLC_1	428	433	PF02516	0.282
MOD_NEK2_1	2	7	PF00069	0.483
MOD_NEK2_1	373	378	PF00069	0.536
MOD_NEK2_1	474	479	PF00069	0.345
MOD_NEK2_1	93	98	PF00069	0.618
MOD_NEK2_2	556	561	PF00069	0.395
MOD_PIKK_1	517	523	PF00454	0.348
MOD_PKA_1	10	16	PF00069	0.382
MOD_PKA_2	10	16	PF00069	0.328
MOD_PKA_2	2	8	PF00069	0.488
MOD_PKA_2	313	319	PF00069	0.388
MOD_PKA_2	49	55	PF00069	0.520
MOD_PKA_2	618	624	PF00069	0.487
MOD_PKA_2	659	665	PF00069	0.569
MOD_PKB_1	8	16	PF00069	0.394
MOD_Plk_1	116	122	PF00069	0.438
MOD_Plk_1	143	149	PF00069	0.371
MOD_Plk_1	373	379	PF00069	0.544
MOD_Plk_1	507	513	PF00069	0.368
MOD_Plk_1	627	633	PF00069	0.590
MOD_Plk_2-3	374	380	PF00069	0.544
MOD_Plk_4	325	331	PF00069	0.378
MOD_Plk_4	346	352	PF00069	0.370
MOD_Plk_4	453	459	PF00069	0.364
MOD_Plk_4	637	643	PF00069	0.281
MOD_ProDKin_1	185	191	PF00069	0.428
MOD_ProDKin_1	197	203	PF00069	0.538
MOD_ProDKin_1	489	495	PF00069	0.379
MOD_ProDKin_1	552	558	PF00069	0.460
MOD_ProDKin_1	565	571	PF00069	0.376
TRG_ENDOCYTIC_2	112	115	PF00928	0.529
TRG_ENDOCYTIC_2	177	180	PF00928	0.501
TRG_ENDOCYTIC_2	220	223	PF00928	0.465
TRG_ENDOCYTIC_2	340	343	PF00928	0.280
TRG_ENDOCYTIC_2	443	446	PF00928	0.441
TRG_ENDOCYTIC_2	9	12	PF00928	0.553
TRG_ER_diArg_1	156	158	PF00400	0.489
TRG_ER_diArg_1	618	620	PF00400	0.460
TRG_ER_diArg_1	9	11	PF00400	0.360
TRG_ER_diLys_1	677	681	PF00400	0.716
TRG_NES_CRM1_1	341	353	PF08389	0.451
TRG_NLS_MonoExtC_3	154	159	PF00514	0.481
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P332	Leptomonas seymouri	54%	99%
A0A0S4IZM9	Bodo saltans	27%	100%
A0A0S4J2Q8	Bodo saltans	28%	100%
A0A1X0P0G0	Trypanosomatidae	34%	100%
A0A3S5H5H7	Leishmania donovani	79%	100%
A0A422N0S3	Trypanosoma rangeli	35%	100%
A4HSG5	Leishmania infantum	79%	100%
D0A4G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AKE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4QJF9	Leishmania major	78%	99%
V5B0Z2	Trypanosoma cruzi	34%	100%