BTAD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H487_LEIBR

TriTrypDb:

LbrM.05.0420 , LBRM2903_050009300

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000152	nuclear ubiquitin ligase complex	3	1
GO:0005680	anaphase-promoting complex	4	1
GO:0005737	cytoplasm	2	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4H487

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H487

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0007088	regulation of mitotic nuclear division	6	1
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	5	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010638	positive regulation of organelle organization	6	1
GO:0010965	regulation of mitotic sister chromatid separation	6	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0022402	cell cycle process	2	1
GO:0030071	regulation of mitotic metaphase/anaphase transition	7	1
GO:0030163	protein catabolic process	4	1
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0033043	regulation of organelle organization	5	1
GO:0033044	regulation of chromosome organization	6	1
GO:0033045	regulation of sister chromatid segregation	5	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0044784	metaphase/anaphase transition of cell cycle	4	1
GO:0045787	positive regulation of cell cycle	5	1
GO:0045840	positive regulation of mitotic nuclear division	7	1
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	8	1
GO:0045931	positive regulation of mitotic cell cycle	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051130	positive regulation of cellular component organization	5	1
GO:0051301	cell division	2	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051726	regulation of cell cycle	4	1
GO:0051783	regulation of nuclear division	6	1
GO:0051785	positive regulation of nuclear division	7	1
GO:0051983	regulation of chromosome segregation	4	1
GO:0065007	biological regulation	1	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090068	positive regulation of cell cycle process	6	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901970	positive regulation of mitotic sister chromatid separation	7	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901989	positive regulation of cell cycle phase transition	7	1
GO:1901990	regulation of mitotic cell cycle phase transition	6	1
GO:1901992	positive regulation of mitotic cell cycle phase transition	7	1
GO:1902099	regulation of metaphase/anaphase transition of cell cycle	6	1
GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	7	1
GO:1903047	mitotic cell cycle process	3	1
GO:1905818	regulation of chromosome separation	5	1
GO:1905820	positive regulation of chromosome separation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.429
CLV_C14_Caspase3-7	539	543	PF00656	0.443
CLV_NRD_NRD_1	134	136	PF00675	0.555
CLV_NRD_NRD_1	232	234	PF00675	0.473
CLV_NRD_NRD_1	300	302	PF00675	0.467
CLV_NRD_NRD_1	361	363	PF00675	0.640
CLV_NRD_NRD_1	424	426	PF00675	0.559
CLV_NRD_NRD_1	733	735	PF00675	0.304
CLV_NRD_NRD_1	778	780	PF00675	0.477
CLV_NRD_NRD_1	796	798	PF00675	0.330
CLV_PCSK_KEX2_1	134	136	PF00082	0.555
CLV_PCSK_KEX2_1	231	233	PF00082	0.486
CLV_PCSK_KEX2_1	300	302	PF00082	0.467
CLV_PCSK_KEX2_1	361	363	PF00082	0.640
CLV_PCSK_KEX2_1	424	426	PF00082	0.559
CLV_PCSK_KEX2_1	615	617	PF00082	0.371
CLV_PCSK_KEX2_1	733	735	PF00082	0.304
CLV_PCSK_KEX2_1	778	780	PF00082	0.304
CLV_PCSK_KEX2_1	796	798	PF00082	0.433
CLV_PCSK_PC1ET2_1	615	617	PF00082	0.371
CLV_PCSK_PC7_1	357	363	PF00082	0.644
CLV_PCSK_SKI1_1	432	436	PF00082	0.518
CLV_PCSK_SKI1_1	608	612	PF00082	0.373
CLV_PCSK_SKI1_1	649	653	PF00082	0.317
CLV_PCSK_SKI1_1	697	701	PF00082	0.371
CLV_PCSK_SKI1_1	713	717	PF00082	0.304
CLV_PCSK_SKI1_1	747	751	PF00082	0.281
CLV_PCSK_SKI1_1	754	758	PF00082	0.333
DEG_APCC_DBOX_1	607	615	PF00400	0.369
DEG_SPOP_SBC_1	492	496	PF00917	0.561
DOC_CYCLIN_yCln2_LP_2	481	487	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	555	561	PF00134	0.419
DOC_MAPK_DCC_7	406	414	PF00069	0.557
DOC_MAPK_gen_1	605	614	PF00069	0.374
DOC_MAPK_gen_1	704	714	PF00069	0.227
DOC_MAPK_gen_1	733	743	PF00069	0.304
DOC_MAPK_MEF2A_6	707	716	PF00069	0.227
DOC_MAPK_MEF2A_6	734	743	PF00069	0.304
DOC_MAPK_RevD_3	764	779	PF00069	0.304
DOC_MIT_MIM_1	59	67	PF04212	0.443
DOC_PP2B_LxvP_1	414	417	PF13499	0.609
DOC_PP2B_LxvP_1	419	422	PF13499	0.544
DOC_PP4_FxxP_1	100	103	PF00568	0.443
DOC_USP7_MATH_1	111	115	PF00917	0.664
DOC_USP7_MATH_1	273	277	PF00917	0.407
DOC_USP7_MATH_1	320	324	PF00917	0.540
DOC_USP7_MATH_1	393	397	PF00917	0.824
DOC_USP7_MATH_1	472	476	PF00917	0.632
DOC_USP7_MATH_1	492	496	PF00917	0.589
DOC_USP7_MATH_1	514	518	PF00917	0.726
DOC_USP7_MATH_1	575	579	PF00917	0.371
DOC_USP7_UBL2_3	683	687	PF12436	0.304
DOC_WW_Pin1_4	348	353	PF00397	0.570
DOC_WW_Pin1_4	4	9	PF00397	0.691
DOC_WW_Pin1_4	407	412	PF00397	0.807
DOC_WW_Pin1_4	517	522	PF00397	0.415
DOC_WW_Pin1_4	554	559	PF00397	0.353
DOC_WW_Pin1_4	688	693	PF00397	0.379
LIG_14-3-3_CanoR_1	107	115	PF00244	0.518
LIG_14-3-3_CanoR_1	134	138	PF00244	0.554
LIG_14-3-3_CanoR_1	258	264	PF00244	0.471
LIG_14-3-3_CanoR_1	274	282	PF00244	0.348
LIG_14-3-3_CanoR_1	383	392	PF00244	0.685
LIG_14-3-3_CanoR_1	418	422	PF00244	0.478
LIG_14-3-3_CanoR_1	465	471	PF00244	0.517
LIG_14-3-3_CanoR_1	582	589	PF00244	0.419
LIG_14-3-3_CanoR_1	697	703	PF00244	0.370
LIG_14-3-3_CanoR_1	704	710	PF00244	0.304
LIG_APCC_ABBA_1	371	376	PF00400	0.545
LIG_APCC_ABBA_1	716	721	PF00400	0.304
LIG_BIR_III_2	585	589	PF00653	0.414
LIG_BRCT_BRCA1_1	159	163	PF00533	0.549
LIG_Clathr_ClatBox_1	64	68	PF01394	0.391
LIG_Clathr_ClatBox_1	740	744	PF01394	0.304
LIG_CtBP_PxDLS_1	151	155	PF00389	0.525
LIG_eIF4E_1	71	77	PF01652	0.416
LIG_FHA_1	141	147	PF00498	0.560
LIG_FHA_1	181	187	PF00498	0.492
LIG_FHA_1	273	279	PF00498	0.465
LIG_FHA_1	5	11	PF00498	0.721
LIG_FHA_1	510	516	PF00498	0.687
LIG_FHA_1	591	597	PF00498	0.357
LIG_FHA_1	689	695	PF00498	0.369
LIG_FHA_1	718	724	PF00498	0.455
LIG_FHA_2	224	230	PF00498	0.389
LIG_FHA_2	242	248	PF00498	0.675
LIG_FHA_2	306	312	PF00498	0.418
LIG_FHA_2	330	336	PF00498	0.437
LIG_FHA_2	342	348	PF00498	0.529
LIG_FHA_2	367	373	PF00498	0.688
LIG_FHA_2	400	406	PF00498	0.568
LIG_FHA_2	582	588	PF00498	0.402
LIG_FHA_2	767	773	PF00498	0.304
LIG_KLC1_Yacidic_2	372	376	PF13176	0.545
LIG_LIR_Apic_2	372	377	PF02991	0.538
LIG_LIR_Apic_2	443	447	PF02991	0.451
LIG_LIR_Gen_1	178	186	PF02991	0.512
LIG_LIR_Gen_1	315	322	PF02991	0.478
LIG_LIR_Gen_1	542	552	PF02991	0.376
LIG_LIR_Gen_1	68	78	PF02991	0.441
LIG_LIR_Nem_3	178	184	PF02991	0.540
LIG_LIR_Nem_3	311	316	PF02991	0.487
LIG_LIR_Nem_3	542	547	PF02991	0.385
LIG_LIR_Nem_3	657	662	PF02991	0.304
LIG_LIR_Nem_3	68	74	PF02991	0.431
LIG_LIR_Nem_3	89	94	PF02991	0.354
LIG_LYPXL_yS_3	98	101	PF13949	0.535
LIG_MYND_1	99	103	PF01753	0.437
LIG_NRBOX	212	218	PF00104	0.415
LIG_NRBOX	452	458	PF00104	0.424
LIG_NRBOX	752	758	PF00104	0.304
LIG_PCNA_PIPBox_1	46	55	PF02747	0.483
LIG_PCNA_yPIPBox_3	796	809	PF02747	0.397
LIG_Pex14_1	137	141	PF04695	0.637
LIG_Pex14_1	190	194	PF04695	0.370
LIG_RPA_C_Fungi	729	741	PF08784	0.369
LIG_SH2_CRK	601	605	PF00017	0.385
LIG_SH2_CRK	662	666	PF00017	0.304
LIG_SH2_CRK	91	95	PF00017	0.361
LIG_SH2_NCK_1	181	185	PF00017	0.503
LIG_SH2_PTP2	316	319	PF00017	0.478
LIG_SH2_PTP2	374	377	PF00017	0.536
LIG_SH2_PTP2	767	770	PF00017	0.369
LIG_SH2_SRC	206	209	PF00017	0.384
LIG_SH2_SRC	374	377	PF00017	0.536
LIG_SH2_SRC	52	55	PF00017	0.364
LIG_SH2_SRC	626	629	PF00017	0.331
LIG_SH2_STAP1	436	440	PF00017	0.352
LIG_SH2_STAP1	54	58	PF00017	0.460
LIG_SH2_STAP1	563	567	PF00017	0.323
LIG_SH2_STAP1	626	630	PF00017	0.333
LIG_SH2_STAP1	719	723	PF00017	0.304
LIG_SH2_STAT3	201	204	PF00017	0.397
LIG_SH2_STAT3	702	705	PF00017	0.392
LIG_SH2_STAT5	194	197	PF00017	0.384
LIG_SH2_STAT5	218	221	PF00017	0.470
LIG_SH2_STAT5	303	306	PF00017	0.525
LIG_SH2_STAT5	316	319	PF00017	0.641
LIG_SH2_STAT5	374	377	PF00017	0.536
LIG_SH2_STAT5	52	55	PF00017	0.428
LIG_SH2_STAT5	659	662	PF00017	0.304
LIG_SH2_STAT5	719	722	PF00017	0.369
LIG_SH2_STAT5	767	770	PF00017	0.369
LIG_SH2_STAT5	800	803	PF00017	0.388
LIG_SH3_2	352	357	PF14604	0.571
LIG_SH3_3	102	108	PF00018	0.562
LIG_SH3_3	301	307	PF00018	0.534
LIG_SH3_3	349	355	PF00018	0.620
LIG_SH3_3	409	415	PF00018	0.769
LIG_SH3_3	465	471	PF00018	0.468
LIG_SH3_3	486	492	PF00018	0.554
LIG_SUMO_SIM_par_1	182	188	PF11976	0.505
LIG_SUMO_SIM_par_1	329	335	PF11976	0.506
LIG_TRAF2_1	244	247	PF00917	0.626
LIG_TRAF2_1	312	315	PF00917	0.453
LIG_TRAF2_1	44	47	PF00917	0.488
LIG_TRAF2_1	749	752	PF00917	0.304
LIG_TYR_ITIM	179	184	PF00017	0.535
LIG_TYR_ITIM	660	665	PF00017	0.304
LIG_TYR_ITIM	765	770	PF00017	0.369
LIG_UBA3_1	330	334	PF00899	0.417
LIG_UBA3_1	740	747	PF00899	0.222
MOD_CK1_1	140	146	PF00069	0.662
MOD_CK1_1	153	159	PF00069	0.621
MOD_CK1_1	20	26	PF00069	0.649
MOD_CK1_1	239	245	PF00069	0.540
MOD_CK1_1	31	37	PF00069	0.482
MOD_CK1_1	329	335	PF00069	0.446
MOD_CK1_1	398	404	PF00069	0.664
MOD_CK1_1	40	46	PF00069	0.367
MOD_CK1_1	473	479	PF00069	0.641
MOD_CK1_1	493	499	PF00069	0.680
MOD_CK1_1	509	515	PF00069	0.616
MOD_CK1_1	517	523	PF00069	0.406
MOD_CK1_1	590	596	PF00069	0.388
MOD_CK1_1	728	734	PF00069	0.227
MOD_CK1_1	84	90	PF00069	0.381
MOD_CK2_1	223	229	PF00069	0.392
MOD_CK2_1	241	247	PF00069	0.532
MOD_CK2_1	329	335	PF00069	0.508
MOD_CK2_1	399	405	PF00069	0.564
MOD_CK2_1	41	47	PF00069	0.482
MOD_CK2_1	581	587	PF00069	0.404
MOD_CK2_1	766	772	PF00069	0.304
MOD_GlcNHglycan	115	118	PF01048	0.661
MOD_GlcNHglycan	159	162	PF01048	0.601
MOD_GlcNHglycan	165	168	PF01048	0.544
MOD_GlcNHglycan	23	26	PF01048	0.627
MOD_GlcNHglycan	241	244	PF01048	0.512
MOD_GlcNHglycan	386	389	PF01048	0.690
MOD_GlcNHglycan	395	398	PF01048	0.585
MOD_GlcNHglycan	472	475	PF01048	0.636
MOD_GlcNHglycan	508	511	PF01048	0.562
MOD_GlcNHglycan	516	519	PF01048	0.381
MOD_GlcNHglycan	539	542	PF01048	0.383
MOD_GlcNHglycan	573	576	PF01048	0.443
MOD_GlcNHglycan	589	592	PF01048	0.583
MOD_GlcNHglycan	83	86	PF01048	0.406
MOD_GSK3_1	103	110	PF00069	0.572
MOD_GSK3_1	133	140	PF00069	0.563
MOD_GSK3_1	150	157	PF00069	0.600
MOD_GSK3_1	17	24	PF00069	0.625
MOD_GSK3_1	217	224	PF00069	0.498
MOD_GSK3_1	268	275	PF00069	0.512
MOD_GSK3_1	28	35	PF00069	0.490
MOD_GSK3_1	37	44	PF00069	0.302
MOD_GSK3_1	395	402	PF00069	0.712
MOD_GSK3_1	466	473	PF00069	0.549
MOD_GSK3_1	490	497	PF00069	0.630
MOD_GSK3_1	571	578	PF00069	0.452
MOD_GSK3_1	650	657	PF00069	0.312
MOD_LATS_1	569	575	PF00433	0.453
MOD_N-GLC_1	41	46	PF02516	0.437
MOD_N-GLC_1	728	733	PF02516	0.304
MOD_NEK2_1	152	157	PF00069	0.625
MOD_NEK2_1	163	168	PF00069	0.580
MOD_NEK2_1	217	222	PF00069	0.382
MOD_NEK2_1	223	228	PF00069	0.379
MOD_NEK2_1	41	46	PF00069	0.420
MOD_NEK2_1	440	445	PF00069	0.475
MOD_NEK2_1	477	482	PF00069	0.670
MOD_NEK2_1	562	567	PF00069	0.296
MOD_NEK2_1	589	594	PF00069	0.426
MOD_NEK2_1	67	72	PF00069	0.403
MOD_NEK2_1	698	703	PF00069	0.362
MOD_PIKK_1	185	191	PF00454	0.527
MOD_PIKK_1	200	206	PF00454	0.306
MOD_PIKK_1	211	217	PF00454	0.408
MOD_PIKK_1	273	279	PF00454	0.400
MOD_PIKK_1	341	347	PF00454	0.646
MOD_PIKK_1	399	405	PF00454	0.706
MOD_PKA_1	796	802	PF00069	0.415
MOD_PKA_2	133	139	PF00069	0.558
MOD_PKA_2	257	263	PF00069	0.587
MOD_PKA_2	273	279	PF00069	0.388
MOD_PKA_2	417	423	PF00069	0.552
MOD_PKA_2	581	587	PF00069	0.416
MOD_PKA_2	796	802	PF00069	0.429
MOD_Plk_1	41	47	PF00069	0.443
MOD_Plk_1	67	73	PF00069	0.397
MOD_Plk_4	28	34	PF00069	0.612
MOD_Plk_4	326	332	PF00069	0.534
MOD_Plk_4	473	479	PF00069	0.546
MOD_Plk_4	496	502	PF00069	0.534
MOD_Plk_4	599	605	PF00069	0.402
MOD_Plk_4	654	660	PF00069	0.333
MOD_Plk_4	796	802	PF00069	0.415
MOD_ProDKin_1	348	354	PF00069	0.569
MOD_ProDKin_1	4	10	PF00069	0.690
MOD_ProDKin_1	407	413	PF00069	0.805
MOD_ProDKin_1	517	523	PF00069	0.406
MOD_ProDKin_1	554	560	PF00069	0.347
MOD_ProDKin_1	688	694	PF00069	0.376
MOD_SUMO_for_1	570	573	PF00179	0.389
MOD_SUMO_rev_2	634	642	PF00179	0.369
MOD_SUMO_rev_2	708	715	PF00179	0.304
MOD_SUMO_rev_2	751	756	PF00179	0.329
TRG_DiLeu_BaEn_1	752	757	PF01217	0.304
TRG_DiLeu_BaLyEn_6	333	338	PF01217	0.474
TRG_DiLeu_BaLyEn_6	543	548	PF01217	0.294
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.356
TRG_ENDOCYTIC_2	181	184	PF00928	0.527
TRG_ENDOCYTIC_2	316	319	PF00928	0.512
TRG_ENDOCYTIC_2	436	439	PF00928	0.355
TRG_ENDOCYTIC_2	601	604	PF00928	0.374
TRG_ENDOCYTIC_2	633	636	PF00928	0.318
TRG_ENDOCYTIC_2	662	665	PF00928	0.304
TRG_ENDOCYTIC_2	71	74	PF00928	0.419
TRG_ENDOCYTIC_2	767	770	PF00928	0.304
TRG_ENDOCYTIC_2	91	94	PF00928	0.229
TRG_ENDOCYTIC_2	97	100	PF00928	0.451
TRG_ER_diArg_1	230	233	PF00400	0.478
TRG_ER_diArg_1	299	301	PF00400	0.524
TRG_ER_diArg_1	361	364	PF00400	0.647
TRG_ER_diArg_1	733	736	PF00400	0.304
TRG_ER_diArg_1	777	779	PF00400	0.477
TRG_ER_diArg_1	795	797	PF00400	0.333
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU62	Leptomonas seymouri	59%	88%
A0A3S5H5H6	Leishmania donovani	79%	88%
A4HSG3	Leishmania infantum	79%	88%
E9AKE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	89%
Q4QJG1	Leishmania major	81%	100%