LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
protein kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4H485_LEIBR
TriTrypDb:
LbrM.05.0400 , LBRM2903_050009000 *
Length:
730

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H485
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H485

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 14
GO:0006793 phosphorus metabolic process 3 14
GO:0006796 phosphate-containing compound metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 14
GO:0009987 cellular process 1 14
GO:0016310 phosphorylation 5 14
GO:0019538 protein metabolic process 3 14
GO:0036211 protein modification process 4 14
GO:0043170 macromolecule metabolic process 3 14
GO:0043412 macromolecule modification 4 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0071704 organic substance metabolic process 2 14
GO:1901564 organonitrogen compound metabolic process 3 14
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 14
GO:0003824 catalytic activity 1 14
GO:0004672 protein kinase activity 3 14
GO:0005488 binding 1 14
GO:0005524 ATP binding 5 14
GO:0016301 kinase activity 4 14
GO:0016740 transferase activity 2 14
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 14
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 14
GO:0017076 purine nucleotide binding 4 14
GO:0030554 adenyl nucleotide binding 5 14
GO:0032553 ribonucleotide binding 3 14
GO:0032555 purine ribonucleotide binding 4 14
GO:0032559 adenyl ribonucleotide binding 5 14
GO:0035639 purine ribonucleoside triphosphate binding 4 14
GO:0036094 small molecule binding 2 14
GO:0043167 ion binding 2 14
GO:0043168 anion binding 3 14
GO:0097159 organic cyclic compound binding 2 14
GO:0097367 carbohydrate derivative binding 2 14
GO:0140096 catalytic activity, acting on a protein 2 14
GO:1901265 nucleoside phosphate binding 3 14
GO:1901363 heterocyclic compound binding 2 14
GO:0004674 protein serine/threonine kinase activity 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 152 156 PF00656 0.241
CLV_C14_Caspase3-7 165 169 PF00656 0.292
CLV_C14_Caspase3-7 186 190 PF00656 0.464
CLV_C14_Caspase3-7 257 261 PF00656 0.410
CLV_C14_Caspase3-7 318 322 PF00656 0.460
CLV_C14_Caspase3-7 335 339 PF00656 0.582
CLV_C14_Caspase3-7 360 364 PF00656 0.550
CLV_C14_Caspase3-7 91 95 PF00656 0.632
CLV_NRD_NRD_1 350 352 PF00675 0.488
CLV_NRD_NRD_1 355 357 PF00675 0.455
CLV_NRD_NRD_1 379 381 PF00675 0.652
CLV_PCSK_KEX2_1 350 352 PF00082 0.488
CLV_PCSK_KEX2_1 379 381 PF00082 0.610
CLV_PCSK_KEX2_1 503 505 PF00082 0.296
CLV_PCSK_KEX2_1 63 65 PF00082 0.637
CLV_PCSK_PC1ET2_1 503 505 PF00082 0.186
CLV_PCSK_PC1ET2_1 63 65 PF00082 0.637
CLV_PCSK_SKI1_1 188 192 PF00082 0.319
CLV_PCSK_SKI1_1 350 354 PF00082 0.489
CLV_PCSK_SKI1_1 574 578 PF00082 0.288
DOC_CKS1_1 614 619 PF01111 0.264
DOC_CYCLIN_yCln2_LP_2 232 238 PF00134 0.413
DOC_CYCLIN_yCln2_LP_2 708 714 PF00134 0.321
DOC_MAPK_gen_1 494 501 PF00069 0.264
DOC_MAPK_gen_1 520 527 PF00069 0.245
DOC_MAPK_gen_1 574 583 PF00069 0.301
DOC_MAPK_HePTP_8 517 529 PF00069 0.356
DOC_MAPK_MEF2A_6 520 529 PF00069 0.310
DOC_MAPK_MEF2A_6 577 585 PF00069 0.301
DOC_PP2B_LxvP_1 436 439 PF13499 0.690
DOC_PP2B_LxvP_1 74 77 PF13499 0.515
DOC_USP7_MATH_1 15 19 PF00917 0.739
DOC_USP7_MATH_1 352 356 PF00917 0.625
DOC_USP7_MATH_1 77 81 PF00917 0.722
DOC_USP7_UBL2_3 292 296 PF12436 0.296
DOC_USP7_UBL2_3 455 459 PF12436 0.266
DOC_WW_Pin1_4 427 432 PF00397 0.521
DOC_WW_Pin1_4 449 454 PF00397 0.550
DOC_WW_Pin1_4 47 52 PF00397 0.530
DOC_WW_Pin1_4 613 618 PF00397 0.264
DOC_WW_Pin1_4 719 724 PF00397 0.529
DOC_WW_Pin1_4 75 80 PF00397 0.617
LIG_14-3-3_CanoR_1 356 362 PF00244 0.541
LIG_14-3-3_CanoR_1 43 47 PF00244 0.792
LIG_14-3-3_CanoR_1 471 477 PF00244 0.402
LIG_14-3-3_CanoR_1 520 526 PF00244 0.229
LIG_Actin_WH2_2 458 473 PF00022 0.410
LIG_APCC_ABBA_1 288 293 PF00400 0.410
LIG_APCC_ABBA_1 525 530 PF00400 0.264
LIG_BIR_II_1 1 5 PF00653 0.492
LIG_BIR_III_4 189 193 PF00653 0.321
LIG_Clathr_ClatBox_1 582 586 PF01394 0.264
LIG_deltaCOP1_diTrp_1 302 309 PF00928 0.266
LIG_eIF4E_1 106 112 PF01652 0.531
LIG_FHA_1 323 329 PF00498 0.526
LIG_FHA_1 418 424 PF00498 0.579
LIG_FHA_1 465 471 PF00498 0.420
LIG_FHA_1 522 528 PF00498 0.264
LIG_FHA_1 536 542 PF00498 0.264
LIG_FHA_1 715 721 PF00498 0.481
LIG_FHA_1 99 105 PF00498 0.417
LIG_FHA_2 126 132 PF00498 0.314
LIG_FHA_2 163 169 PF00498 0.283
LIG_FHA_2 255 261 PF00498 0.290
LIG_FHA_2 642 648 PF00498 0.258
LIG_FHA_2 701 707 PF00498 0.385
LIG_Integrin_isoDGR_2 274 276 PF01839 0.410
LIG_Integrin_isoDGR_2 472 474 PF01839 0.356
LIG_LIR_Apic_2 616 622 PF02991 0.310
LIG_LIR_Gen_1 660 669 PF02991 0.264
LIG_LIR_Nem_3 105 109 PF02991 0.517
LIG_LIR_Nem_3 411 417 PF02991 0.678
LIG_LIR_Nem_3 449 454 PF02991 0.379
LIG_LIR_Nem_3 461 465 PF02991 0.294
LIG_LIR_Nem_3 660 665 PF02991 0.253
LIG_MYND_1 698 702 PF01753 0.410
LIG_NRBOX 685 691 PF00104 0.410
LIG_Pex14_1 662 666 PF04695 0.264
LIG_Pex14_2 540 544 PF04695 0.264
LIG_SH2_CRK 106 110 PF00017 0.538
LIG_SH2_CRK 466 470 PF00017 0.375
LIG_SH2_CRK 557 561 PF00017 0.321
LIG_SH2_STAP1 466 470 PF00017 0.264
LIG_SH2_STAT5 106 109 PF00017 0.484
LIG_SH2_STAT5 125 128 PF00017 0.162
LIG_SH2_STAT5 164 167 PF00017 0.365
LIG_SH2_STAT5 176 179 PF00017 0.264
LIG_SH2_STAT5 194 197 PF00017 0.192
LIG_SH2_STAT5 279 282 PF00017 0.278
LIG_SH2_STAT5 287 290 PF00017 0.278
LIG_SH2_STAT5 466 469 PF00017 0.431
LIG_SH2_STAT5 531 534 PF00017 0.443
LIG_SH2_STAT5 565 568 PF00017 0.335
LIG_SH3_3 17 23 PF00018 0.781
LIG_SH3_3 366 372 PF00018 0.637
LIG_SH3_3 382 388 PF00018 0.731
LIG_SH3_3 425 431 PF00018 0.455
LIG_SH3_3 611 617 PF00018 0.255
LIG_SH3_3 650 656 PF00018 0.263
LIG_SH3_3 717 723 PF00018 0.640
LIG_SH3_3 73 79 PF00018 0.750
LIG_SUMO_SIM_anti_2 498 503 PF11976 0.310
LIG_SUMO_SIM_par_1 479 485 PF11976 0.268
LIG_SUMO_SIM_par_1 581 586 PF11976 0.278
LIG_TRAF2_1 488 491 PF00917 0.410
LIG_TRAF2_1 88 91 PF00917 0.648
LIG_TYR_ITIM 104 109 PF00017 0.555
LIG_UBA3_1 686 692 PF00899 0.378
LIG_WRC_WIRS_1 537 542 PF05994 0.302
MOD_CDK_SPxK_1 449 455 PF00069 0.529
MOD_CDK_SPxxK_3 427 434 PF00069 0.490
MOD_CK1_1 145 151 PF00069 0.322
MOD_CK1_1 2 8 PF00069 0.725
MOD_CK1_1 322 328 PF00069 0.505
MOD_CK1_1 362 368 PF00069 0.674
MOD_CK1_1 391 397 PF00069 0.491
MOD_CK1_1 406 412 PF00069 0.630
MOD_CK1_1 430 436 PF00069 0.456
MOD_CK1_1 45 51 PF00069 0.711
MOD_CK1_1 485 491 PF00069 0.229
MOD_CK1_1 533 539 PF00069 0.272
MOD_CK1_1 80 86 PF00069 0.826
MOD_CK2_1 125 131 PF00069 0.277
MOD_CK2_1 443 449 PF00069 0.537
MOD_CK2_1 46 52 PF00069 0.556
MOD_CK2_1 485 491 PF00069 0.277
MOD_CK2_1 641 647 PF00069 0.258
MOD_CK2_1 700 706 PF00069 0.268
MOD_CK2_1 719 725 PF00069 0.717
MOD_GlcNHglycan 144 147 PF01048 0.296
MOD_GlcNHglycan 17 20 PF01048 0.718
MOD_GlcNHglycan 182 186 PF01048 0.323
MOD_GlcNHglycan 38 41 PF01048 0.779
MOD_GlcNHglycan 532 535 PF01048 0.264
MOD_GlcNHglycan 604 607 PF01048 0.410
MOD_GSK3_1 11 18 PF00069 0.651
MOD_GSK3_1 188 195 PF00069 0.299
MOD_GSK3_1 327 334 PF00069 0.694
MOD_GSK3_1 357 364 PF00069 0.650
MOD_GSK3_1 388 395 PF00069 0.586
MOD_GSK3_1 405 412 PF00069 0.561
MOD_GSK3_1 42 49 PF00069 0.700
MOD_GSK3_1 426 433 PF00069 0.493
MOD_GSK3_1 449 456 PF00069 0.499
MOD_GSK3_1 604 611 PF00069 0.366
MOD_GSK3_1 633 640 PF00069 0.292
MOD_GSK3_1 669 676 PF00069 0.299
MOD_GSK3_1 714 721 PF00069 0.610
MOD_N-GLC_1 3 8 PF02516 0.727
MOD_N-GLC_1 357 362 PF02516 0.469
MOD_N-GLC_1 392 397 PF02516 0.604
MOD_N-GLC_1 417 422 PF02516 0.633
MOD_N-GLC_1 46 51 PF02516 0.700
MOD_N-GLC_1 56 61 PF02516 0.763
MOD_N-GLC_1 669 674 PF02516 0.356
MOD_N-GLC_2 9 11 PF02516 0.471
MOD_NEK2_1 3 8 PF00069 0.662
MOD_NEK2_1 361 366 PF00069 0.648
MOD_NEK2_1 594 599 PF00069 0.297
MOD_NEK2_2 548 553 PF00069 0.410
MOD_PIKK_1 67 73 PF00454 0.513
MOD_PK_1 543 549 PF00069 0.410
MOD_PKA_2 275 281 PF00069 0.380
MOD_PKA_2 42 48 PF00069 0.704
MOD_PKA_2 521 527 PF00069 0.406
MOD_PKA_2 700 706 PF00069 0.264
MOD_Plk_1 357 363 PF00069 0.618
MOD_Plk_1 392 398 PF00069 0.583
MOD_Plk_2-3 482 488 PF00069 0.310
MOD_Plk_4 275 281 PF00069 0.344
MOD_Plk_4 327 333 PF00069 0.699
MOD_Plk_4 393 399 PF00069 0.601
MOD_Plk_4 419 425 PF00069 0.606
MOD_Plk_4 536 542 PF00069 0.324
MOD_Plk_4 609 615 PF00069 0.304
MOD_Plk_4 641 647 PF00069 0.264
MOD_Plk_4 657 663 PF00069 0.264
MOD_Plk_4 77 83 PF00069 0.579
MOD_ProDKin_1 427 433 PF00069 0.520
MOD_ProDKin_1 449 455 PF00069 0.553
MOD_ProDKin_1 47 53 PF00069 0.530
MOD_ProDKin_1 613 619 PF00069 0.264
MOD_ProDKin_1 719 725 PF00069 0.534
MOD_ProDKin_1 75 81 PF00069 0.618
MOD_SUMO_for_1 625 628 PF00179 0.278
MOD_SUMO_rev_2 182 190 PF00179 0.410
TRG_DiLeu_BaEn_1 685 690 PF01217 0.385
TRG_DiLeu_BaEn_4 490 496 PF01217 0.321
TRG_ENDOCYTIC_2 106 109 PF00928 0.513
TRG_ENDOCYTIC_2 287 290 PF00928 0.375
TRG_ENDOCYTIC_2 414 417 PF00928 0.681
TRG_ENDOCYTIC_2 466 469 PF00928 0.275
TRG_ENDOCYTIC_2 514 517 PF00928 0.420
TRG_ENDOCYTIC_2 557 560 PF00928 0.317
TRG_ER_diArg_1 177 180 PF00400 0.360
TRG_ER_diArg_1 378 380 PF00400 0.646
TRG_Pf-PMV_PEXEL_1 379 383 PF00026 0.541
TRG_Pf-PMV_PEXEL_1 400 404 PF00026 0.481
TRG_Pf-PMV_PEXEL_1 564 568 PF00026 0.292

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZR8 Leptomonas seymouri 72% 91%
A0A0S4J7Q1 Bodo saltans 54% 100%
A0A1X0P0R3 Trypanosomatidae 63% 100%
A0A3S7WP16 Leishmania donovani 84% 93%
A0A422N0Q9 Trypanosoma rangeli 61% 100%
A4HJS4 Leishmania braziliensis 24% 100%
A4HSG1 Leishmania infantum 84% 93%
D0A4H1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E9AKE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
Q4QJG3 Leishmania major 83% 100%
V5D179 Trypanosoma cruzi 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS