Putative microtubule-associated protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

microtubule-associated protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H483_LEIBR

TriTrypDb:

LbrM.05.0380 , LBRM2903_050008800 , LBRM2903_050008900

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H483

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H483

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0005515	protein binding	2	3
GO:0008017	microtubule binding	5	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.576
CLV_C14_Caspase3-7	170	174	PF00656	0.590
CLV_C14_Caspase3-7	207	211	PF00656	0.594
CLV_C14_Caspase3-7	244	248	PF00656	0.588
CLV_C14_Caspase3-7	281	285	PF00656	0.598
CLV_C14_Caspase3-7	318	322	PF00656	0.597
CLV_C14_Caspase3-7	355	359	PF00656	0.581
CLV_C14_Caspase3-7	392	396	PF00656	0.597
CLV_C14_Caspase3-7	429	433	PF00656	0.591
CLV_C14_Caspase3-7	466	470	PF00656	0.592
CLV_C14_Caspase3-7	503	507	PF00656	0.588
CLV_C14_Caspase3-7	59	63	PF00656	0.552
CLV_C14_Caspase3-7	611	615	PF00656	0.538
CLV_C14_Caspase3-7	96	100	PF00656	0.571
CLV_NRD_NRD_1	626	628	PF00675	0.561
CLV_NRD_NRD_1	735	737	PF00675	0.803
CLV_PCSK_KEX2_1	110	112	PF00082	0.593
CLV_PCSK_KEX2_1	147	149	PF00082	0.593
CLV_PCSK_KEX2_1	184	186	PF00082	0.587
CLV_PCSK_KEX2_1	221	223	PF00082	0.598
CLV_PCSK_KEX2_1	258	260	PF00082	0.595
CLV_PCSK_KEX2_1	295	297	PF00082	0.604
CLV_PCSK_KEX2_1	332	334	PF00082	0.602
CLV_PCSK_KEX2_1	369	371	PF00082	0.594
CLV_PCSK_KEX2_1	406	408	PF00082	0.600
CLV_PCSK_KEX2_1	443	445	PF00082	0.597
CLV_PCSK_KEX2_1	480	482	PF00082	0.590
CLV_PCSK_KEX2_1	517	519	PF00082	0.604
CLV_PCSK_KEX2_1	626	628	PF00082	0.561
CLV_PCSK_KEX2_1	73	75	PF00082	0.594
CLV_PCSK_KEX2_1	735	737	PF00082	0.803
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.546
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.546
CLV_PCSK_PC1ET2_1	184	186	PF00082	0.540
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.552
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.548
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.558
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.556
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.547
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.553
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.551
CLV_PCSK_PC1ET2_1	480	482	PF00082	0.544
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.557
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.547
CLV_PCSK_SKI1_1	793	797	PF00082	0.521
CLV_PCSK_SKI1_1	828	832	PF00082	0.520
DEG_SCF_FBW7_1	755	760	PF00400	0.544
DEG_SPOP_SBC_1	750	754	PF00917	0.658
DOC_CKS1_1	758	763	PF01111	0.553
DOC_PP2B_LxvP_1	662	665	PF13499	0.545
DOC_PP2B_LxvP_1	729	732	PF13499	0.646
DOC_PP4_FxxP_1	796	799	PF00568	0.528
DOC_PP4_FxxP_1	831	834	PF00568	0.522
DOC_USP7_MATH_1	612	616	PF00917	0.539
DOC_USP7_MATH_1	630	634	PF00917	0.475
DOC_USP7_MATH_1	645	649	PF00917	0.532
DOC_USP7_MATH_1	654	658	PF00917	0.726
DOC_USP7_MATH_1	690	694	PF00917	0.598
DOC_USP7_MATH_1	750	754	PF00917	0.670
DOC_USP7_MATH_1	791	795	PF00917	0.513
DOC_USP7_MATH_1	826	830	PF00917	0.520
DOC_WW_Pin1_4	613	618	PF00397	0.540
DOC_WW_Pin1_4	751	756	PF00397	0.541
DOC_WW_Pin1_4	757	762	PF00397	0.533
LIG_14-3-3_CanoR_1	678	682	PF00244	0.566
LIG_14-3-3_CanoR_1	707	715	PF00244	0.561
LIG_14-3-3_CanoR_1	749	755	PF00244	0.655
LIG_14-3-3_CanoR_1	762	768	PF00244	0.513
LIG_14-3-3_CanoR_1	851	855	PF00244	0.499
LIG_ActinCP_TwfCPI_2	796	804	PF01115	0.523
LIG_ActinCP_TwfCPI_2	831	839	PF01115	0.511
LIG_FHA_1	648	654	PF00498	0.629
LIG_FHA_2	131	137	PF00498	0.579
LIG_FHA_2	168	174	PF00498	0.593
LIG_FHA_2	205	211	PF00498	0.593
LIG_FHA_2	242	248	PF00498	0.593
LIG_FHA_2	279	285	PF00498	0.601
LIG_FHA_2	316	322	PF00498	0.598
LIG_FHA_2	353	359	PF00498	0.585
LIG_FHA_2	38	44	PF00498	0.574
LIG_FHA_2	390	396	PF00498	0.601
LIG_FHA_2	427	433	PF00498	0.594
LIG_FHA_2	464	470	PF00498	0.594
LIG_FHA_2	501	507	PF00498	0.590
LIG_FHA_2	57	63	PF00498	0.465
LIG_FHA_2	609	615	PF00498	0.532
LIG_FHA_2	94	100	PF00498	0.575
LIG_LIR_Apic_2	698	703	PF02991	0.644
LIG_LIR_Apic_2	782	787	PF02991	0.499
LIG_LIR_Apic_2	794	799	PF02991	0.495
LIG_LIR_Apic_2	817	822	PF02991	0.516
LIG_LIR_Apic_2	829	834	PF02991	0.492
LIG_LIR_Nem_3	136	141	PF02991	0.537
LIG_LIR_Nem_3	173	178	PF02991	0.546
LIG_LIR_Nem_3	210	215	PF02991	0.538
LIG_LIR_Nem_3	247	252	PF02991	0.549
LIG_LIR_Nem_3	284	289	PF02991	0.555
LIG_LIR_Nem_3	321	326	PF02991	0.550
LIG_LIR_Nem_3	358	363	PF02991	0.541
LIG_LIR_Nem_3	395	400	PF02991	0.557
LIG_LIR_Nem_3	43	49	PF02991	0.534
LIG_LIR_Nem_3	432	437	PF02991	0.544
LIG_LIR_Nem_3	469	474	PF02991	0.544
LIG_LIR_Nem_3	506	511	PF02991	0.550
LIG_LIR_Nem_3	62	67	PF02991	0.477
LIG_LIR_Nem_3	99	104	PF02991	0.539
LIG_LYPXL_yS_3	46	49	PF13949	0.535
LIG_PDZ_Class_1	850	855	PF00595	0.496
LIG_SH2_CRK	700	704	PF00017	0.717
LIG_SH2_CRK	784	788	PF00017	0.497
LIG_SH2_CRK	819	823	PF00017	0.513
LIG_SH2_NCK_1	784	788	PF00017	0.502
LIG_SH2_NCK_1	819	823	PF00017	0.518
LIG_SH2_SRC	24	27	PF00017	0.512
LIG_SH2_STAP1	635	639	PF00017	0.706
LIG_SH2_STAP1	740	744	PF00017	0.522
LIG_SH2_STAT5	130	133	PF00017	0.540
LIG_SH2_STAT5	204	207	PF00017	0.548
LIG_SH2_STAT5	776	779	PF00017	0.498
LIG_SH2_STAT5	811	814	PF00017	0.516
LIG_SH2_STAT5	846	849	PF00017	0.484
LIG_SH3_1	31	37	PF00018	0.560
LIG_SH3_1	717	723	PF00018	0.553
LIG_SH3_2	788	793	PF14604	0.504
LIG_SH3_2	823	828	PF14604	0.517
LIG_SH3_3	121	127	PF00018	0.597
LIG_SH3_3	158	164	PF00018	0.592
LIG_SH3_3	195	201	PF00018	0.594
LIG_SH3_3	232	238	PF00018	0.606
LIG_SH3_3	269	275	PF00018	0.608
LIG_SH3_3	306	312	PF00018	0.605
LIG_SH3_3	31	37	PF00018	0.560
LIG_SH3_3	343	349	PF00018	0.607
LIG_SH3_3	380	386	PF00018	0.607
LIG_SH3_3	417	423	PF00018	0.604
LIG_SH3_3	454	460	PF00018	0.597
LIG_SH3_3	491	497	PF00018	0.593
LIG_SH3_3	678	684	PF00018	0.572
LIG_SH3_3	717	723	PF00018	0.651
LIG_SH3_3	785	791	PF00018	0.697
LIG_SH3_3	820	826	PF00018	0.514
LIG_SH3_3	84	90	PF00018	0.599
LIG_SUMO_SIM_par_1	660	666	PF11976	0.538
LIG_TRAF2_1	115	118	PF00917	0.561
LIG_TRAF2_1	152	155	PF00917	0.553
LIG_TRAF2_1	709	712	PF00917	0.570
MOD_CDK_SPK_2	757	762	PF00069	0.547
MOD_CDK_SPxK_1	613	619	PF00069	0.544
MOD_CK1_1	128	134	PF00069	0.535
MOD_CK1_1	202	208	PF00069	0.547
MOD_CK1_1	595	601	PF00069	0.534
MOD_CK1_1	663	669	PF00069	0.558
MOD_CK1_1	705	711	PF00069	0.563
MOD_CK1_1	739	745	PF00069	0.521
MOD_CK1_1	753	759	PF00069	0.510
MOD_CK1_1	794	800	PF00069	0.569
MOD_CK2_1	549	555	PF00069	0.540
MOD_CK2_1	630	636	PF00069	0.595
MOD_CK2_1	705	711	PF00069	0.563
MOD_GlcNHglycan	2	5	PF01048	0.591
MOD_GlcNHglycan	538	541	PF01048	0.622
MOD_GlcNHglycan	551	554	PF01048	0.510
MOD_GlcNHglycan	599	603	PF01048	0.534
MOD_GlcNHglycan	642	646	PF01048	0.619
MOD_GlcNHglycan	656	659	PF01048	0.668
MOD_GlcNHglycan	669	672	PF01048	0.571
MOD_GlcNHglycan	692	695	PF01048	0.545
MOD_GlcNHglycan	708	711	PF01048	0.546
MOD_GlcNHglycan	781	784	PF01048	0.709
MOD_GlcNHglycan	793	796	PF01048	0.553
MOD_GlcNHglycan	816	819	PF01048	0.524
MOD_GlcNHglycan	828	831	PF01048	0.492
MOD_GSK3_1	125	132	PF00069	0.541
MOD_GSK3_1	162	169	PF00069	0.552
MOD_GSK3_1	199	206	PF00069	0.545
MOD_GSK3_1	236	243	PF00069	0.556
MOD_GSK3_1	273	280	PF00069	0.557
MOD_GSK3_1	310	317	PF00069	0.555
MOD_GSK3_1	347	354	PF00069	0.549
MOD_GSK3_1	384	391	PF00069	0.560
MOD_GSK3_1	421	428	PF00069	0.554
MOD_GSK3_1	458	465	PF00069	0.554
MOD_GSK3_1	495	502	PF00069	0.546
MOD_GSK3_1	51	58	PF00069	0.511
MOD_GSK3_1	608	615	PF00069	0.535
MOD_GSK3_1	630	637	PF00069	0.527
MOD_GSK3_1	641	648	PF00069	0.560
MOD_GSK3_1	663	670	PF00069	0.665
MOD_GSK3_1	673	680	PF00069	0.551
MOD_GSK3_1	702	709	PF00069	0.593
MOD_GSK3_1	749	756	PF00069	0.662
MOD_GSK3_1	757	764	PF00069	0.747
MOD_GSK3_1	775	782	PF00069	0.500
MOD_GSK3_1	8	15	PF00069	0.546
MOD_GSK3_1	810	817	PF00069	0.508
MOD_GSK3_1	841	848	PF00069	0.518
MOD_GSK3_1	88	95	PF00069	0.539
MOD_N-GLC_1	167	172	PF02516	0.597
MOD_N-GLC_1	241	246	PF02516	0.599
MOD_N-GLC_1	278	283	PF02516	0.606
MOD_N-GLC_1	315	320	PF02516	0.602
MOD_N-GLC_1	352	357	PF02516	0.593
MOD_N-GLC_1	389	394	PF02516	0.605
MOD_N-GLC_1	426	431	PF02516	0.600
MOD_N-GLC_1	463	468	PF02516	0.601
MOD_N-GLC_1	500	505	PF02516	0.595
MOD_N-GLC_1	56	61	PF02516	0.557
MOD_N-GLC_1	93	98	PF02516	0.583
MOD_NEK2_1	129	134	PF00069	0.583
MOD_NEK2_1	166	171	PF00069	0.600
MOD_NEK2_1	203	208	PF00069	0.593
MOD_NEK2_1	240	245	PF00069	0.600
MOD_NEK2_1	277	282	PF00069	0.607
MOD_NEK2_1	314	319	PF00069	0.603
MOD_NEK2_1	351	356	PF00069	0.592
MOD_NEK2_1	388	393	PF00069	0.604
MOD_NEK2_1	425	430	PF00069	0.598
MOD_NEK2_1	462	467	PF00069	0.601
MOD_NEK2_1	499	504	PF00069	0.593
MOD_NEK2_1	535	540	PF00069	0.574
MOD_NEK2_1	55	60	PF00069	0.556
MOD_NEK2_1	643	648	PF00069	0.684
MOD_NEK2_1	775	780	PF00069	0.616
MOD_NEK2_1	810	815	PF00069	0.552
MOD_NEK2_1	845	850	PF00069	0.480
MOD_NEK2_1	92	97	PF00069	0.580
MOD_NEK2_2	677	682	PF00069	0.565
MOD_PIKK_1	541	547	PF00454	0.536
MOD_PIKK_1	685	691	PF00454	0.546
MOD_PIKK_1	702	708	PF00454	0.517
MOD_PIKK_1	761	767	PF00454	0.548
MOD_PIKK_1	8	14	PF00454	0.546
MOD_PKA_1	673	679	PF00069	0.560
MOD_PKA_1	736	742	PF00069	0.537
MOD_PKA_2	667	673	PF00069	0.562
MOD_PKA_2	677	683	PF00069	0.539
MOD_PKA_2	706	712	PF00069	0.600
MOD_PKA_2	761	767	PF00069	0.548
MOD_Plk_1	635	641	PF00069	0.517
MOD_Plk_4	125	131	PF00069	0.540
MOD_Plk_4	162	168	PF00069	0.552
MOD_Plk_4	199	205	PF00069	0.545
MOD_Plk_4	236	242	PF00069	0.555
MOD_Plk_4	273	279	PF00069	0.557
MOD_Plk_4	310	316	PF00069	0.555
MOD_Plk_4	347	353	PF00069	0.548
MOD_Plk_4	384	390	PF00069	0.559
MOD_Plk_4	421	427	PF00069	0.552
MOD_Plk_4	458	464	PF00069	0.554
MOD_Plk_4	495	501	PF00069	0.544
MOD_Plk_4	51	57	PF00069	0.510
MOD_Plk_4	592	598	PF00069	0.531
MOD_Plk_4	630	636	PF00069	0.520
MOD_Plk_4	841	847	PF00069	0.473
MOD_Plk_4	88	94	PF00069	0.538
MOD_ProDKin_1	613	619	PF00069	0.544
MOD_ProDKin_1	751	757	PF00069	0.539
MOD_SUMO_rev_2	116	124	PF00179	0.559
MOD_SUMO_rev_2	153	161	PF00179	0.547
MOD_SUMO_rev_2	190	198	PF00179	0.552
MOD_SUMO_rev_2	227	235	PF00179	0.565
MOD_SUMO_rev_2	264	272	PF00179	0.563
MOD_SUMO_rev_2	301	309	PF00179	0.561
MOD_SUMO_rev_2	338	346	PF00179	0.562
MOD_SUMO_rev_2	375	383	PF00179	0.560
MOD_SUMO_rev_2	412	420	PF00179	0.562
MOD_SUMO_rev_2	449	457	PF00179	0.550
MOD_SUMO_rev_2	486	494	PF00179	0.551
MOD_SUMO_rev_2	79	87	PF00179	0.556
TRG_ENDOCYTIC_2	46	49	PF00928	0.535
TRG_ER_diArg_1	734	736	PF00400	0.798
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AKE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%