Dual specificity phosphatase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual specificity phosphatase-like protein

Species:

Leishmania braziliensis

UniProt:

A4H479_LEIBR

TriTrypDb:

LbrM.05.0340 , LBRM2903_050007100

Length:

873

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H479

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H479

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016311	dephosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0009966	regulation of signal transduction	4	1
GO:0009968	negative regulation of signal transduction	5	1
GO:0010646	regulation of cell communication	4	1
GO:0010648	negative regulation of cell communication	5	1
GO:0023051	regulation of signaling	3	1
GO:0023057	negative regulation of signaling	4	1
GO:0043408	regulation of MAPK cascade	6	1
GO:0043409	negative regulation of MAPK cascade	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0048583	regulation of response to stimulus	3	1
GO:0048585	negative regulation of response to stimulus	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:1902531	regulation of intracellular signal transduction	5	1
GO:1902532	negative regulation of intracellular signal transduction	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0004721	phosphoprotein phosphatase activity	3	6
GO:0004725	protein tyrosine phosphatase activity	4	6
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6
GO:0140096	catalytic activity, acting on a protein	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.561
CLV_C14_Caspase3-7	272	276	PF00656	0.526
CLV_C14_Caspase3-7	35	39	PF00656	0.592
CLV_NRD_NRD_1	224	226	PF00675	0.630
CLV_NRD_NRD_1	353	355	PF00675	0.532
CLV_NRD_NRD_1	385	387	PF00675	0.464
CLV_NRD_NRD_1	503	505	PF00675	0.612
CLV_NRD_NRD_1	511	513	PF00675	0.581
CLV_NRD_NRD_1	552	554	PF00675	0.825
CLV_NRD_NRD_1	558	560	PF00675	0.733
CLV_NRD_NRD_1	621	623	PF00675	0.806
CLV_NRD_NRD_1	786	788	PF00675	0.623
CLV_PCSK_FUR_1	509	513	PF00082	0.621
CLV_PCSK_KEX2_1	223	225	PF00082	0.716
CLV_PCSK_KEX2_1	353	355	PF00082	0.516
CLV_PCSK_KEX2_1	385	387	PF00082	0.475
CLV_PCSK_KEX2_1	509	511	PF00082	0.623
CLV_PCSK_KEX2_1	552	554	PF00082	0.825
CLV_PCSK_KEX2_1	621	623	PF00082	0.806
CLV_PCSK_KEX2_1	786	788	PF00082	0.623
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.766
CLV_PCSK_SKI1_1	244	248	PF00082	0.462
CLV_PCSK_SKI1_1	288	292	PF00082	0.526
CLV_PCSK_SKI1_1	380	384	PF00082	0.388
DEG_APCC_DBOX_1	509	517	PF00400	0.610
DEG_APCC_DBOX_1	620	628	PF00400	0.812
DEG_Nend_UBRbox_3	1	3	PF02207	0.587
DEG_SCF_FBW7_2	54	60	PF00400	0.625
DEG_SIAH_1	713	721	PF03145	0.597
DEG_SPOP_SBC_1	429	433	PF00917	0.616
DEG_SPOP_SBC_1	476	480	PF00917	0.765
DEG_SPOP_SBC_1	525	529	PF00917	0.602
DEG_SPOP_SBC_1	530	534	PF00917	0.568
DEG_SPOP_SBC_1	656	660	PF00917	0.730
DEG_SPOP_SBC_1	661	665	PF00917	0.677
DOC_AGCK_PIF_1	159	164	PF00069	0.576
DOC_CKS1_1	54	59	PF01111	0.621
DOC_CKS1_1	564	569	PF01111	0.581
DOC_CYCLIN_RxL_1	114	123	PF00134	0.592
DOC_MAPK_gen_1	283	293	PF00069	0.293
DOC_MAPK_gen_1	340	348	PF00069	0.293
DOC_MAPK_gen_1	385	393	PF00069	0.526
DOC_MAPK_gen_1	621	629	PF00069	0.579
DOC_MAPK_MEF2A_6	180	187	PF00069	0.581
DOC_MAPK_MEF2A_6	342	350	PF00069	0.293
DOC_MAPK_MEF2A_6	385	393	PF00069	0.526
DOC_MAPK_MEF2A_6	621	629	PF00069	0.579
DOC_PP2B_LxvP_1	207	210	PF13499	0.595
DOC_PP2B_PxIxI_1	613	619	PF00149	0.601
DOC_PP4_FxxP_1	497	500	PF00568	0.591
DOC_USP7_MATH_1	201	205	PF00917	0.696
DOC_USP7_MATH_1	255	259	PF00917	0.529
DOC_USP7_MATH_1	269	273	PF00917	0.401
DOC_USP7_MATH_1	427	431	PF00917	0.799
DOC_USP7_MATH_1	445	449	PF00917	0.558
DOC_USP7_MATH_1	493	497	PF00917	0.770
DOC_USP7_MATH_1	612	616	PF00917	0.616
DOC_USP7_MATH_1	684	688	PF00917	0.632
DOC_USP7_MATH_1	69	73	PF00917	0.615
DOC_USP7_MATH_1	714	718	PF00917	0.684
DOC_USP7_MATH_1	723	727	PF00917	0.617
DOC_USP7_MATH_1	763	767	PF00917	0.559
DOC_USP7_MATH_1	815	819	PF00917	0.571
DOC_USP7_MATH_1	867	871	PF00917	0.579
DOC_USP7_UBL2_3	672	676	PF12436	0.595
DOC_WW_Pin1_4	133	138	PF00397	0.569
DOC_WW_Pin1_4	139	144	PF00397	0.552
DOC_WW_Pin1_4	195	200	PF00397	0.657
DOC_WW_Pin1_4	228	233	PF00397	0.513
DOC_WW_Pin1_4	410	415	PF00397	0.575
DOC_WW_Pin1_4	422	427	PF00397	0.742
DOC_WW_Pin1_4	441	446	PF00397	0.515
DOC_WW_Pin1_4	53	58	PF00397	0.621
DOC_WW_Pin1_4	563	568	PF00397	0.775
DOC_WW_Pin1_4	577	582	PF00397	0.713
DOC_WW_Pin1_4	61	66	PF00397	0.589
DOC_WW_Pin1_4	675	680	PF00397	0.592
DOC_WW_Pin1_4	710	715	PF00397	0.818
DOC_WW_Pin1_4	754	759	PF00397	0.636
DOC_WW_Pin1_4	848	853	PF00397	0.818
DOC_WW_Pin1_4	863	868	PF00397	0.579
DOC_WW_Pin1_4	97	102	PF00397	0.571
LIG_14-3-3_CanoR_1	340	349	PF00244	0.399
LIG_14-3-3_CanoR_1	380	389	PF00244	0.411
LIG_14-3-3_CanoR_1	398	404	PF00244	0.349
LIG_14-3-3_CanoR_1	46	54	PF00244	0.613
LIG_14-3-3_CanoR_1	484	492	PF00244	0.772
LIG_14-3-3_CanoR_1	552	558	PF00244	0.616
LIG_14-3-3_CanoR_1	573	581	PF00244	0.812
LIG_14-3-3_CanoR_1	626	630	PF00244	0.610
LIG_14-3-3_CanoR_1	68	77	PF00244	0.616
LIG_14-3-3_CanoR_1	715	719	PF00244	0.603
LIG_Actin_WH2_2	222	239	PF00022	0.736
LIG_BRCT_BRCA1_1	135	139	PF00533	0.576
LIG_BRCT_BRCA1_1	230	234	PF00533	0.513
LIG_BRCT_BRCA1_1	404	408	PF00533	0.678
LIG_BRCT_BRCA1_1	493	497	PF00533	0.586
LIG_BRCT_BRCA1_1	720	724	PF00533	0.595
LIG_deltaCOP1_diTrp_1	799	804	PF00928	0.588
LIG_FHA_1	136	142	PF00498	0.576
LIG_FHA_1	144	150	PF00498	0.556
LIG_FHA_1	2	8	PF00498	0.604
LIG_FHA_1	263	269	PF00498	0.598
LIG_FHA_1	578	584	PF00498	0.671
LIG_FHA_1	662	668	PF00498	0.820
LIG_FHA_1	72	78	PF00498	0.606
LIG_FHA_1	826	832	PF00498	0.562
LIG_FHA_1	856	862	PF00498	0.588
LIG_FHA_2	298	304	PF00498	0.293
LIG_FHA_2	531	537	PF00498	0.821
LIG_LIR_Apic_2	494	500	PF02991	0.592
LIG_LIR_Gen_1	158	164	PF02991	0.573
LIG_LIR_Gen_1	169	178	PF02991	0.518
LIG_LIR_Gen_1	721	729	PF02991	0.601
LIG_LIR_Gen_1	798	806	PF02991	0.581
LIG_LIR_Gen_1	818	826	PF02991	0.475
LIG_LIR_Nem_3	158	162	PF02991	0.572
LIG_LIR_Nem_3	169	174	PF02991	0.517
LIG_LIR_Nem_3	407	412	PF02991	0.480
LIG_LIR_Nem_3	721	727	PF02991	0.601
LIG_LIR_Nem_3	798	804	PF02991	0.587
LIG_LIR_Nem_3	811	816	PF02991	0.500
LIG_PCNA_yPIPBox_3	304	317	PF02747	0.526
LIG_Pex14_2	135	139	PF04695	0.576
LIG_RPA_C_Fungi	349	361	PF08784	0.526
LIG_SH2_CRK	813	817	PF00017	0.568
LIG_SH2_NCK_1	813	817	PF00017	0.568
LIG_SH2_SRC	375	378	PF00017	0.526
LIG_SH2_STAP1	375	379	PF00017	0.501
LIG_SH2_STAT5	289	292	PF00017	0.526
LIG_SH2_STAT5	366	369	PF00017	0.412
LIG_SH2_STAT5	813	816	PF00017	0.566
LIG_SH2_STAT5	94	97	PF00017	0.540
LIG_SH2_STAT5	99	102	PF00017	0.559
LIG_SH3_2	500	505	PF14604	0.609
LIG_SH3_3	207	213	PF00018	0.670
LIG_SH3_3	439	445	PF00018	0.592
LIG_SH3_3	497	503	PF00018	0.598
LIG_SH3_3	51	57	PF00018	0.620
LIG_SH3_3	59	65	PF00018	0.591
LIG_SH3_3	606	612	PF00018	0.827
LIG_SH3_3	73	79	PF00018	0.538
LIG_SH3_3	737	743	PF00018	0.596
LIG_SH3_3	846	852	PF00018	0.774
LIG_SH3_3	861	867	PF00018	0.572
LIG_SH3_CIN85_PxpxPR_1	499	504	PF14604	0.598
LIG_SUMO_SIM_par_1	144	151	PF11976	0.592
LIG_SUMO_SIM_par_1	265	272	PF11976	0.589
LIG_SUMO_SIM_par_1	560	566	PF11976	0.591
LIG_TRAF2_1	238	241	PF00917	0.679
LIG_TRAF2_1	24	27	PF00917	0.591
LIG_TRAF2_1	299	302	PF00917	0.532
LIG_TRAF2_1	517	520	PF00917	0.587
LIG_TRAF2_1	585	588	PF00917	0.601
LIG_TRAF2_1	686	689	PF00917	0.795
LIG_TRFH_1	139	143	PF08558	0.579
LIG_WRC_WIRS_1	161	166	PF05994	0.572
LIG_WRC_WIRS_1	468	473	PF05994	0.599
MOD_CDK_SPK_2	61	66	PF00069	0.627
MOD_CDK_SPK_2	710	715	PF00069	0.849
MOD_CDK_SPxxK_3	61	68	PF00069	0.630
MOD_CK1_1	133	139	PF00069	0.572
MOD_CK1_1	142	148	PF00069	0.542
MOD_CK1_1	160	166	PF00069	0.489
MOD_CK1_1	19	25	PF00069	0.604
MOD_CK1_1	217	223	PF00069	0.717
MOD_CK1_1	387	393	PF00069	0.526
MOD_CK1_1	425	431	PF00069	0.713
MOD_CK1_1	448	454	PF00069	0.658
MOD_CK1_1	470	476	PF00069	0.741
MOD_CK1_1	477	483	PF00069	0.707
MOD_CK1_1	514	520	PF00069	0.792
MOD_CK1_1	55	61	PF00069	0.630
MOD_CK1_1	551	557	PF00069	0.629
MOD_CK1_1	565	571	PF00069	0.676
MOD_CK1_1	598	604	PF00069	0.854
MOD_CK1_1	632	638	PF00069	0.792
MOD_CK1_1	700	706	PF00069	0.815
MOD_CK1_1	765	771	PF00069	0.745
MOD_CK1_1	795	801	PF00069	0.644
MOD_CK1_1	811	817	PF00069	0.520
MOD_CK1_1	818	824	PF00069	0.607
MOD_CK1_1	851	857	PF00069	0.674
MOD_CK1_1	859	865	PF00069	0.714
MOD_CK1_1	866	872	PF00069	0.709
MOD_CK2_1	100	106	PF00069	0.599
MOD_CK2_1	297	303	PF00069	0.293
MOD_CK2_1	514	520	PF00069	0.640
MOD_CK2_1	530	536	PF00069	0.746
MOD_CK2_1	582	588	PF00069	0.605
MOD_CK2_1	647	653	PF00069	0.786
MOD_CK2_1	723	729	PF00069	0.780
MOD_CK2_1	838	844	PF00069	0.577
MOD_CK2_1	867	873	PF00069	0.582
MOD_Cter_Amidation	619	622	PF01082	0.819
MOD_GlcNHglycan	102	105	PF01048	0.604
MOD_GlcNHglycan	110	113	PF01048	0.575
MOD_GlcNHglycan	358	361	PF01048	0.526
MOD_GlcNHglycan	4	7	PF01048	0.606
MOD_GlcNHglycan	404	407	PF01048	0.449
MOD_GlcNHglycan	427	430	PF01048	0.766
MOD_GlcNHglycan	447	450	PF01048	0.571
MOD_GlcNHglycan	486	489	PF01048	0.766
MOD_GlcNHglycan	570	573	PF01048	0.649
MOD_GlcNHglycan	575	578	PF01048	0.759
MOD_GlcNHglycan	600	603	PF01048	0.666
MOD_GlcNHglycan	635	638	PF01048	0.813
MOD_GlcNHglycan	699	702	PF01048	0.803
MOD_GlcNHglycan	721	724	PF01048	0.833
MOD_GlcNHglycan	781	784	PF01048	0.631
MOD_GlcNHglycan	80	83	PF01048	0.552
MOD_GlcNHglycan	858	861	PF01048	0.610
MOD_GSK3_1	135	142	PF00069	0.577
MOD_GSK3_1	15	22	PF00069	0.607
MOD_GSK3_1	160	167	PF00069	0.572
MOD_GSK3_1	170	177	PF00069	0.527
MOD_GSK3_1	189	196	PF00069	0.498
MOD_GSK3_1	213	220	PF00069	0.568
MOD_GSK3_1	255	262	PF00069	0.666
MOD_GSK3_1	317	324	PF00069	0.517
MOD_GSK3_1	367	374	PF00069	0.526
MOD_GSK3_1	380	387	PF00069	0.314
MOD_GSK3_1	425	432	PF00069	0.737
MOD_GSK3_1	441	448	PF00069	0.562
MOD_GSK3_1	470	477	PF00069	0.805
MOD_GSK3_1	479	486	PF00069	0.681
MOD_GSK3_1	48	55	PF00069	0.617
MOD_GSK3_1	514	521	PF00069	0.713
MOD_GSK3_1	525	532	PF00069	0.650
MOD_GSK3_1	56	63	PF00069	0.591
MOD_GSK3_1	573	580	PF00069	0.699
MOD_GSK3_1	625	632	PF00069	0.719
MOD_GSK3_1	656	663	PF00069	0.793
MOD_GSK3_1	710	717	PF00069	0.682
MOD_GSK3_1	719	726	PF00069	0.617
MOD_GSK3_1	775	782	PF00069	0.666
MOD_GSK3_1	788	795	PF00069	0.599
MOD_GSK3_1	804	811	PF00069	0.632
MOD_GSK3_1	817	824	PF00069	0.649
MOD_GSK3_1	825	832	PF00069	0.572
MOD_GSK3_1	851	858	PF00069	0.582
MOD_GSK3_1	859	866	PF00069	0.725
MOD_N-GLC_1	1	6	PF02516	0.605
MOD_N-GLC_1	189	194	PF02516	0.588
MOD_N-GLC_1	227	232	PF02516	0.511
MOD_N-GLC_1	262	267	PF02516	0.394
MOD_N-GLC_1	371	376	PF02516	0.293
MOD_N-GLC_1	480	485	PF02516	0.612
MOD_N-GLC_1	730	735	PF02516	0.702
MOD_N-GLC_1	792	797	PF02516	0.751
MOD_N-GLC_1	809	814	PF02516	0.538
MOD_NEK2_1	1	6	PF00069	0.605
MOD_NEK2_1	162	167	PF00069	0.572
MOD_NEK2_1	174	179	PF00069	0.520
MOD_NEK2_1	319	324	PF00069	0.526
MOD_NEK2_1	629	634	PF00069	0.593
MOD_NEK2_1	662	667	PF00069	0.740
MOD_NEK2_1	831	836	PF00069	0.669
MOD_PIKK_1	19	25	PF00454	0.604
MOD_PIKK_1	321	327	PF00454	0.526
MOD_PIKK_1	491	497	PF00454	0.823
MOD_PIKK_1	565	571	PF00454	0.582
MOD_PIKK_1	638	644	PF00454	0.602
MOD_PIKK_1	775	781	PF00454	0.585
MOD_PIKK_1	835	841	PF00454	0.804
MOD_PK_1	157	163	PF00069	0.571
MOD_PKA_1	511	517	PF00069	0.606
MOD_PKA_2	217	223	PF00069	0.717
MOD_PKA_2	384	390	PF00069	0.454
MOD_PKA_2	397	403	PF00069	0.314
MOD_PKA_2	483	489	PF00069	0.765
MOD_PKA_2	511	517	PF00069	0.725
MOD_PKA_2	551	557	PF00069	0.817
MOD_PKA_2	625	631	PF00069	0.751
MOD_PKA_2	714	720	PF00069	0.595
MOD_PKB_1	509	517	PF00069	0.610
MOD_Plk_1	157	163	PF00069	0.571
MOD_Plk_1	248	254	PF00069	0.707
MOD_Plk_1	262	268	PF00069	0.572
MOD_Plk_1	371	377	PF00069	0.293
MOD_Plk_1	588	594	PF00069	0.608
MOD_Plk_1	809	815	PF00069	0.555
MOD_Plk_2-3	371	377	PF00069	0.526
MOD_Plk_4	130	136	PF00069	0.564
MOD_Plk_4	263	269	PF00069	0.460
MOD_Plk_4	518	524	PF00069	0.646
MOD_Plk_4	612	618	PF00069	0.599
MOD_Plk_4	625	631	PF00069	0.523
MOD_Plk_4	635	641	PF00069	0.542
MOD_ProDKin_1	133	139	PF00069	0.572
MOD_ProDKin_1	195	201	PF00069	0.657
MOD_ProDKin_1	228	234	PF00069	0.513
MOD_ProDKin_1	410	416	PF00069	0.574
MOD_ProDKin_1	422	428	PF00069	0.742
MOD_ProDKin_1	441	447	PF00069	0.518
MOD_ProDKin_1	53	59	PF00069	0.623
MOD_ProDKin_1	563	569	PF00069	0.776
MOD_ProDKin_1	577	583	PF00069	0.714
MOD_ProDKin_1	61	67	PF00069	0.591
MOD_ProDKin_1	675	681	PF00069	0.594
MOD_ProDKin_1	710	716	PF00069	0.816
MOD_ProDKin_1	754	760	PF00069	0.640
MOD_ProDKin_1	848	854	PF00069	0.821
MOD_ProDKin_1	863	869	PF00069	0.577
MOD_ProDKin_1	97	103	PF00069	0.576
MOD_SUMO_rev_2	231	239	PF00179	0.481
MOD_SUMO_rev_2	296	306	PF00179	0.526
TRG_ENDOCYTIC_2	131	134	PF00928	0.562
TRG_ENDOCYTIC_2	813	816	PF00928	0.566
TRG_ER_diArg_1	224	226	PF00400	0.654
TRG_ER_diArg_1	508	511	PF00400	0.625
TRG_ER_diArg_1	544	547	PF00400	0.627
TRG_ER_diArg_1	552	555	PF00400	0.593
TRG_ER_diArg_1	621	623	PF00400	0.573
TRG_ER_diArg_1	65	68	PF00400	0.633
TRG_NLS_MonoExtN_4	221	227	PF00514	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5G7	Leishmania donovani	59%	100%
A4HSF4	Leishmania infantum	59%	100%
E9AKC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4QJI1	Leishmania major	57%	94%