Transcription factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H478_LEIBR

TriTrypDb:

LbrM.05.0330 , LBRM2903_050008400

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	11

Expansion

Sequence features

A4H478

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H478

PDB structure(s): 7ane_f

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	12
GO:0006518	peptide metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	12
GO:0043043	peptide biosynthetic process	5	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043603	amide metabolic process	3	12
GO:0043604	amide biosynthetic process	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	12
GO:0005198	structural molecule activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	49	53	PF00656	0.575
CLV_NRD_NRD_1	10	12	PF00675	0.538
CLV_NRD_NRD_1	142	144	PF00675	0.432
CLV_NRD_NRD_1	239	241	PF00675	0.400
CLV_NRD_NRD_1	26	28	PF00675	0.482
CLV_PCSK_KEX2_1	10	12	PF00082	0.538
CLV_PCSK_KEX2_1	142	144	PF00082	0.421
CLV_PCSK_KEX2_1	238	240	PF00082	0.412
CLV_PCSK_KEX2_1	252	254	PF00082	0.430
CLV_PCSK_KEX2_1	26	28	PF00082	0.497
CLV_PCSK_PC1ET2_1	252	254	PF00082	0.446
CLV_PCSK_SKI1_1	252	256	PF00082	0.424
CLV_PCSK_SKI1_1	263	267	PF00082	0.468
CLV_PCSK_SKI1_1	360	364	PF00082	0.503
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SPOP_SBC_1	161	165	PF00917	0.754
DOC_CDC14_PxL_1	25	33	PF14671	0.497
DOC_MAPK_gen_1	225	235	PF00069	0.352
DOC_MAPK_gen_1	309	319	PF00069	0.405
DOC_MAPK_MEF2A_6	228	235	PF00069	0.432
DOC_MAPK_MEF2A_6	309	317	PF00069	0.413
DOC_USP7_MATH_1	153	157	PF00917	0.747
DOC_USP7_MATH_1	159	163	PF00917	0.709
DOC_USP7_MATH_1	202	206	PF00917	0.700
DOC_WW_Pin1_4	346	351	PF00397	0.437
LIG_14-3-3_CanoR_1	238	244	PF00244	0.388
LIG_14-3-3_CanoR_1	336	344	PF00244	0.482
LIG_APCC_ABBAyCdc20_2	17	23	PF00400	0.517
LIG_BRCT_BRCA1_1	226	230	PF00533	0.546
LIG_BRCT_BRCA1_1	336	340	PF00533	0.534
LIG_CaM_IQ_9	109	124	PF13499	0.612
LIG_eIF4E_1	249	255	PF01652	0.549
LIG_eIF4E_1	41	47	PF01652	0.513
LIG_FHA_1	107	113	PF00498	0.358
LIG_FHA_1	240	246	PF00498	0.361
LIG_FHA_2	170	176	PF00498	0.583
LIG_Integrin_isoDGR_2	324	326	PF01839	0.401
LIG_Integrin_RGD_1	273	275	PF01839	0.601
LIG_LIR_Gen_1	213	221	PF02991	0.356
LIG_LIR_Gen_1	227	236	PF02991	0.389
LIG_LIR_LC3C_4	314	317	PF02991	0.383
LIG_LIR_Nem_3	213	217	PF02991	0.358
LIG_LIR_Nem_3	227	233	PF02991	0.386
LIG_LIR_Nem_3	23	28	PF02991	0.474
LIG_PCNA_yPIPBox_3	106	120	PF02747	0.399
LIG_PCNA_yPIPBox_3	94	104	PF02747	0.608
LIG_Pex14_2	188	192	PF04695	0.452
LIG_SH2_CRK	194	198	PF00017	0.474
LIG_SH2_CRK	25	29	PF00017	0.496
LIG_SH2_GRB2like	288	291	PF00017	0.418
LIG_SH2_GRB2like	41	44	PF00017	0.579
LIG_SH2_NCK_1	243	247	PF00017	0.391
LIG_SH2_NCK_1	66	70	PF00017	0.489
LIG_SH2_STAP1	226	230	PF00017	0.433
LIG_SH2_STAP1	243	247	PF00017	0.376
LIG_SH2_STAT5	187	190	PF00017	0.441
LIG_SH2_STAT5	234	237	PF00017	0.358
LIG_SH2_STAT5	258	261	PF00017	0.443
LIG_SH2_STAT5	288	291	PF00017	0.389
LIG_SH2_STAT5	344	347	PF00017	0.431
LIG_SH2_STAT5	41	44	PF00017	0.516
LIG_SH3_3	353	359	PF00018	0.490
LIG_SH3_3	90	96	PF00018	0.622
LIG_SUMO_SIM_anti_2	311	317	PF11976	0.388
LIG_TRAF2_1	172	175	PF00917	0.661
MOD_CK1_1	162	168	PF00069	0.771
MOD_CK2_1	161	167	PF00069	0.691
MOD_CK2_1	169	175	PF00069	0.710
MOD_Cter_Amidation	250	253	PF01082	0.445
MOD_GlcNHglycan	302	305	PF01048	0.606
MOD_GlcNHglycan	4	7	PF01048	0.556
MOD_GlcNHglycan	48	51	PF01048	0.559
MOD_GlcNHglycan	76	79	PF01048	0.754
MOD_GSK3_1	104	111	PF00069	0.500
MOD_GSK3_1	153	160	PF00069	0.732
MOD_N-GLC_1	148	153	PF02516	0.496
MOD_NEK2_1	104	109	PF00069	0.599
MOD_NEK2_1	192	197	PF00069	0.460
MOD_NEK2_1	2	7	PF00069	0.569
MOD_NEK2_1	46	51	PF00069	0.485
MOD_PIKK_1	124	130	PF00454	0.554
MOD_PIKK_1	212	218	PF00454	0.473
MOD_PKA_1	239	245	PF00069	0.383
MOD_PKA_2	239	245	PF00069	0.383
MOD_PKA_2	335	341	PF00069	0.326
MOD_PKB_1	106	114	PF00069	0.574
MOD_Plk_1	86	92	PF00069	0.703
MOD_Plk_4	192	198	PF00069	0.472
MOD_Plk_4	283	289	PF00069	0.416
MOD_ProDKin_1	346	352	PF00069	0.444
MOD_SUMO_rev_2	110	119	PF00179	0.608
MOD_SUMO_rev_2	248	254	PF00179	0.579
TRG_AP2beta_CARGO_1	229	239	PF09066	0.388
TRG_DiLeu_BaEn_1	115	120	PF01217	0.514
TRG_DiLeu_BaEn_1	311	316	PF01217	0.407
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.548
TRG_ENDOCYTIC_2	194	197	PF00928	0.467
TRG_ENDOCYTIC_2	214	217	PF00928	0.286
TRG_ENDOCYTIC_2	25	28	PF00928	0.497
TRG_ER_diArg_1	14	17	PF00400	0.510
TRG_ER_diArg_1	142	145	PF00400	0.437
TRG_ER_diArg_1	238	240	PF00400	0.412
TRG_ER_diArg_1	25	27	PF00400	0.506
TRG_ER_diArg_1	340	343	PF00400	0.544
TRG_ER_diArg_1	9	11	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	176	180	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUU3	Leptomonas seymouri	68%	96%
A0A0S4J6I9	Bodo saltans	51%	100%
A0A1X0P0T0	Trypanosomatidae	61%	100%
A0A3S5H5H3	Leishmania donovani	82%	98%
A0A422NDL4	Trypanosoma rangeli	60%	100%
A4HSF3	Leishmania infantum	82%	98%
D0A4H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AKE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
Q4QJG8	Leishmania major	80%	100%
V5AZT2	Trypanosoma cruzi	61%	100%