Putative DNA replication licensing factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM8, putative

Species:

Leishmania braziliensis

UniProt:

A4H477_LEIBR

TriTrypDb:

LbrM.05.0320 , LBRM2903_050008300

Length:

996

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032991	protein-containing complex	1	1
GO:0042555	MCM complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H477

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H477

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0032392	DNA geometric change	7	7
GO:0032508	DNA duplex unwinding	8	7
GO:0051276	chromosome organization	5	7
GO:0071103	DNA conformation change	6	7
GO:0071840	cellular component organization or biogenesis	2	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003697	single-stranded DNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	450	454	PF00656	0.510
CLV_C14_Caspase3-7	512	516	PF00656	0.425
CLV_C14_Caspase3-7	751	755	PF00656	0.517
CLV_NRD_NRD_1	110	112	PF00675	0.515
CLV_NRD_NRD_1	207	209	PF00675	0.432
CLV_NRD_NRD_1	378	380	PF00675	0.434
CLV_NRD_NRD_1	744	746	PF00675	0.579
CLV_PCSK_KEX2_1	110	112	PF00082	0.515
CLV_PCSK_KEX2_1	207	209	PF00082	0.432
CLV_PCSK_KEX2_1	378	380	PF00082	0.434
CLV_PCSK_KEX2_1	4	6	PF00082	0.637
CLV_PCSK_KEX2_1	744	746	PF00082	0.579
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.536
CLV_PCSK_SKI1_1	140	144	PF00082	0.406
CLV_PCSK_SKI1_1	218	222	PF00082	0.598
CLV_PCSK_SKI1_1	233	237	PF00082	0.199
CLV_PCSK_SKI1_1	553	557	PF00082	0.308
CLV_PCSK_SKI1_1	601	605	PF00082	0.244
CLV_PCSK_SKI1_1	656	660	PF00082	0.251
CLV_PCSK_SKI1_1	779	783	PF00082	0.356
CLV_PCSK_SKI1_1	925	929	PF00082	0.497
CLV_PCSK_SKI1_1	968	972	PF00082	0.385
DEG_APCC_DBOX_1	937	945	PF00400	0.468
DEG_Nend_UBRbox_3	1	3	PF02207	0.541
DEG_SPOP_SBC_1	190	194	PF00917	0.493
DEG_SPOP_SBC_1	607	611	PF00917	0.508
DOC_CKS1_1	846	851	PF01111	0.478
DOC_CYCLIN_RxL_1	776	786	PF00134	0.355
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.498
DOC_MAPK_DCC_7	68	76	PF00069	0.432
DOC_MAPK_gen_1	422	429	PF00069	0.510
DOC_MAPK_gen_1	924	931	PF00069	0.419
DOC_MAPK_MEF2A_6	553	560	PF00069	0.451
DOC_MAPK_MEF2A_6	573	580	PF00069	0.358
DOC_MAPK_NFAT4_5	553	561	PF00069	0.508
DOC_PP1_RVXF_1	777	784	PF00149	0.346
DOC_PP2B_LxvP_1	355	358	PF13499	0.358
DOC_PP2B_LxvP_1	74	77	PF13499	0.461
DOC_PP2B_LxvP_1	772	775	PF13499	0.472
DOC_PP2B_LxvP_1	903	906	PF13499	0.445
DOC_PP4_FxxP_1	676	679	PF00568	0.451
DOC_PP4_FxxP_1	846	849	PF00568	0.477
DOC_SPAK_OSR1_1	714	718	PF12202	0.429
DOC_USP7_MATH_1	190	194	PF00917	0.507
DOC_USP7_MATH_1	198	202	PF00917	0.564
DOC_USP7_MATH_1	211	215	PF00917	0.391
DOC_USP7_MATH_1	279	283	PF00917	0.508
DOC_USP7_MATH_1	493	497	PF00917	0.623
DOC_USP7_MATH_1	505	509	PF00917	0.554
DOC_USP7_MATH_1	607	611	PF00917	0.502
DOC_USP7_MATH_1	914	918	PF00917	0.571
DOC_USP7_UBL2_3	924	928	PF12436	0.460
DOC_USP7_UBL2_3	986	990	PF12436	0.453
DOC_WW_Pin1_4	14	19	PF00397	0.526
DOC_WW_Pin1_4	218	223	PF00397	0.583
DOC_WW_Pin1_4	242	247	PF00397	0.451
DOC_WW_Pin1_4	319	324	PF00397	0.565
DOC_WW_Pin1_4	39	44	PF00397	0.518
DOC_WW_Pin1_4	705	710	PF00397	0.451
DOC_WW_Pin1_4	845	850	PF00397	0.580
DOC_WW_Pin1_4	855	860	PF00397	0.444
LIG_14-3-3_CanoR_1	180	190	PF00244	0.531
LIG_14-3-3_CanoR_1	208	214	PF00244	0.357
LIG_14-3-3_CanoR_1	248	256	PF00244	0.534
LIG_14-3-3_CanoR_1	394	399	PF00244	0.449
LIG_14-3-3_CanoR_1	49	55	PF00244	0.511
LIG_14-3-3_CanoR_1	506	514	PF00244	0.651
LIG_14-3-3_CanoR_1	537	543	PF00244	0.456
LIG_14-3-3_CanoR_1	835	842	PF00244	0.495
LIG_14-3-3_CanoR_1	968	977	PF00244	0.370
LIG_APCC_ABBA_1	950	955	PF00400	0.359
LIG_BRCT_BRCA1_1	842	846	PF00533	0.479
LIG_CtBP_PxDLS_1	548	553	PF00389	0.451
LIG_deltaCOP1_diTrp_1	56	62	PF00928	0.415
LIG_EH1_1	96	104	PF00400	0.481
LIG_FHA_1	139	145	PF00498	0.491
LIG_FHA_1	49	55	PF00498	0.501
LIG_FHA_1	493	499	PF00498	0.514
LIG_FHA_1	537	543	PF00498	0.465
LIG_FHA_1	614	620	PF00498	0.465
LIG_FHA_1	664	670	PF00498	0.545
LIG_FHA_1	680	686	PF00498	0.391
LIG_FHA_1	734	740	PF00498	0.451
LIG_FHA_1	817	823	PF00498	0.634
LIG_FHA_1	89	95	PF00498	0.499
LIG_FHA_1	969	975	PF00498	0.360
LIG_FHA_2	15	21	PF00498	0.532
LIG_FHA_2	219	225	PF00498	0.406
LIG_FHA_2	266	272	PF00498	0.441
LIG_FHA_2	310	316	PF00498	0.631
LIG_FHA_2	362	368	PF00498	0.359
LIG_FHA_2	448	454	PF00498	0.498
LIG_FHA_2	55	61	PF00498	0.616
LIG_FHA_2	626	632	PF00498	0.451
LIG_FHA_2	641	647	PF00498	0.451
LIG_FHA_2	880	886	PF00498	0.451
LIG_LIR_Apic_2	275	279	PF02991	0.508
LIG_LIR_Apic_2	843	849	PF02991	0.476
LIG_LIR_Gen_1	155	163	PF02991	0.349
LIG_LIR_Gen_1	221	231	PF02991	0.396
LIG_LIR_Gen_1	56	66	PF02991	0.432
LIG_LIR_Gen_1	713	721	PF02991	0.451
LIG_LIR_Gen_1	95	105	PF02991	0.470
LIG_LIR_Nem_3	128	134	PF02991	0.478
LIG_LIR_Nem_3	155	160	PF02991	0.339
LIG_LIR_Nem_3	221	226	PF02991	0.395
LIG_LIR_Nem_3	311	316	PF02991	0.408
LIG_LIR_Nem_3	56	62	PF02991	0.445
LIG_LIR_Nem_3	713	718	PF02991	0.451
LIG_LIR_Nem_3	899	903	PF02991	0.443
LIG_LIR_Nem_3	95	100	PF02991	0.445
LIG_LIR_Nem_3	979	983	PF02991	0.301
LIG_PALB2_WD40_1	530	538	PF16756	0.451
LIG_Pex14_2	157	161	PF04695	0.362
LIG_SH2_CRK	210	214	PF00017	0.408
LIG_SH2_CRK	980	984	PF00017	0.292
LIG_SH2_NCK_1	210	214	PF00017	0.408
LIG_SH2_STAP1	50	54	PF00017	0.582
LIG_SH2_STAP1	888	892	PF00017	0.451
LIG_SH2_STAT3	804	807	PF00017	0.385
LIG_SH2_STAT3	888	891	PF00017	0.451
LIG_SH2_STAT5	50	53	PF00017	0.506
LIG_SH2_STAT5	804	807	PF00017	0.385
LIG_SH2_STAT5	861	864	PF00017	0.451
LIG_SH2_STAT5	991	994	PF00017	0.351
LIG_SH3_1	436	442	PF00018	0.512
LIG_SH3_2	105	110	PF14604	0.638
LIG_SH3_3	102	108	PF00018	0.616
LIG_SH3_3	131	137	PF00018	0.428
LIG_SH3_3	15	21	PF00018	0.520
LIG_SH3_3	436	442	PF00018	0.512
LIG_SH3_3	578	584	PF00018	0.470
LIG_SH3_3	58	64	PF00018	0.429
LIG_SUMO_SIM_par_1	149	155	PF11976	0.360
LIG_SUMO_SIM_par_1	349	354	PF11976	0.388
LIG_SUMO_SIM_par_1	577	583	PF11976	0.451
LIG_SUMO_SIM_par_1	657	663	PF11976	0.451
LIG_SUMO_SIM_par_1	72	78	PF11976	0.712
LIG_SUMO_SIM_par_1	90	96	PF11976	0.390
LIG_SUMO_SIM_par_1	957	964	PF11976	0.442
LIG_TRAF2_1	518	521	PF00917	0.435
LIG_UBA3_1	546	553	PF00899	0.451
LIG_WRC_WIRS_1	897	902	PF05994	0.416
MOD_CDC14_SPxK_1	245	248	PF00782	0.451
MOD_CDK_SPK_2	855	860	PF00069	0.451
MOD_CDK_SPxK_1	242	248	PF00069	0.451
MOD_CK1_1	10	16	PF00069	0.630
MOD_CK1_1	318	324	PF00069	0.625
MOD_CK1_1	327	333	PF00069	0.599
MOD_CK1_1	397	403	PF00069	0.462
MOD_CK1_1	408	414	PF00069	0.489
MOD_CK1_1	508	514	PF00069	0.545
MOD_CK1_1	625	631	PF00069	0.451
MOD_CK1_1	724	730	PF00069	0.391
MOD_CK1_1	845	851	PF00069	0.497
MOD_CK2_1	14	20	PF00069	0.536
MOD_CK2_1	50	56	PF00069	0.519
MOD_CK2_1	515	521	PF00069	0.449
MOD_CK2_1	625	631	PF00069	0.451
MOD_CK2_1	927	933	PF00069	0.364
MOD_Cter_Amidation	108	111	PF01082	0.502
MOD_Cter_Amidation	2	5	PF01082	0.630
MOD_Cter_Amidation	922	925	PF01082	0.633
MOD_GlcNHglycan	193	196	PF01048	0.616
MOD_GlcNHglycan	213	216	PF01048	0.337
MOD_GlcNHglycan	281	284	PF01048	0.308
MOD_GlcNHglycan	323	326	PF01048	0.630
MOD_GlcNHglycan	384	387	PF01048	0.463
MOD_GlcNHglycan	495	498	PF01048	0.739
MOD_GlcNHglycan	502	505	PF01048	0.610
MOD_GlcNHglycan	507	510	PF01048	0.554
MOD_GlcNHglycan	511	514	PF01048	0.489
MOD_GlcNHglycan	517	520	PF01048	0.446
MOD_GlcNHglycan	601	604	PF01048	0.244
MOD_GlcNHglycan	624	627	PF01048	0.251
MOD_GlcNHglycan	765	768	PF01048	0.479
MOD_GlcNHglycan	8	12	PF01048	0.622
MOD_GlcNHglycan	842	845	PF01048	0.548
MOD_GlcNHglycan	907	910	PF01048	0.543
MOD_GlcNHglycan	916	919	PF01048	0.558
MOD_GlcNHglycan	968	971	PF01048	0.402
MOD_GSK3_1	181	188	PF00069	0.536
MOD_GSK3_1	233	240	PF00069	0.451
MOD_GSK3_1	314	321	PF00069	0.578
MOD_GSK3_1	403	410	PF00069	0.579
MOD_GSK3_1	493	500	PF00069	0.571
MOD_GSK3_1	50	57	PF00069	0.417
MOD_GSK3_1	505	512	PF00069	0.592
MOD_GSK3_1	538	545	PF00069	0.451
MOD_GSK3_1	609	616	PF00069	0.469
MOD_GSK3_1	622	629	PF00069	0.527
MOD_GSK3_1	7	14	PF00069	0.647
MOD_GSK3_1	816	823	PF00069	0.555
MOD_GSK3_1	834	841	PF00069	0.567
MOD_GSK3_1	84	91	PF00069	0.570
MOD_GSK3_1	892	899	PF00069	0.451
MOD_N-GLC_1	336	341	PF02516	0.519
MOD_N-GLC_1	705	710	PF02516	0.251
MOD_NEK2_1	170	175	PF00069	0.547
MOD_NEK2_1	314	319	PF00069	0.572
MOD_NEK2_1	407	412	PF00069	0.446
MOD_NEK2_1	429	434	PF00069	0.684
MOD_NEK2_1	538	543	PF00069	0.462
MOD_NEK2_1	556	561	PF00069	0.451
MOD_NEK2_1	586	591	PF00069	0.451
MOD_NEK2_1	615	620	PF00069	0.500
MOD_NEK2_1	674	679	PF00069	0.451
MOD_NEK2_1	695	700	PF00069	0.441
MOD_NEK2_1	721	726	PF00069	0.399
MOD_NEK2_1	763	768	PF00069	0.466
MOD_NEK2_1	783	788	PF00069	0.360
MOD_NEK2_1	853	858	PF00069	0.288
MOD_NEK2_1	892	897	PF00069	0.451
MOD_NEK2_2	927	932	PF00069	0.375
MOD_OFUCOSY	606	613	PF10250	0.251
MOD_PIKK_1	327	333	PF00454	0.660
MOD_PIKK_1	336	342	PF00454	0.475
MOD_PIKK_1	400	406	PF00454	0.554
MOD_PIKK_1	586	592	PF00454	0.472
MOD_PIKK_1	783	789	PF00454	0.360
MOD_PK_1	394	400	PF00069	0.307
MOD_PKA_2	11	17	PF00069	0.605
MOD_PKA_2	247	253	PF00069	0.441
MOD_PKA_2	48	54	PF00069	0.513
MOD_PKA_2	484	490	PF00069	0.557
MOD_PKA_2	505	511	PF00069	0.671
MOD_PKA_2	536	542	PF00069	0.456
MOD_PKA_2	572	578	PF00069	0.456
MOD_PKA_2	680	686	PF00069	0.534
MOD_PKA_2	721	727	PF00069	0.391
MOD_PKA_2	834	840	PF00069	0.488
MOD_Plk_1	308	314	PF00069	0.451
MOD_Plk_1	626	632	PF00069	0.451
MOD_Plk_1	853	859	PF00069	0.368
MOD_Plk_2-3	266	272	PF00069	0.387
MOD_Plk_2-3	309	315	PF00069	0.623
MOD_Plk_2-3	361	367	PF00069	0.369
MOD_Plk_4	237	243	PF00069	0.451
MOD_Plk_4	309	315	PF00069	0.623
MOD_Plk_4	484	490	PF00069	0.496
MOD_Plk_4	497	503	PF00069	0.455
MOD_Plk_4	50	56	PF00069	0.538
MOD_Plk_4	542	548	PF00069	0.451
MOD_Plk_4	556	562	PF00069	0.451
MOD_Plk_4	680	686	PF00069	0.456
MOD_ProDKin_1	14	20	PF00069	0.524
MOD_ProDKin_1	218	224	PF00069	0.586
MOD_ProDKin_1	242	248	PF00069	0.451
MOD_ProDKin_1	319	325	PF00069	0.570
MOD_ProDKin_1	39	45	PF00069	0.532
MOD_ProDKin_1	705	711	PF00069	0.451
MOD_ProDKin_1	845	851	PF00069	0.580
MOD_ProDKin_1	855	861	PF00069	0.444
MOD_SUMO_for_1	873	876	PF00179	0.451
MOD_SUMO_rev_2	376	385	PF00179	0.382
MOD_SUMO_rev_2	649	658	PF00179	0.451
TRG_DiLeu_BaEn_1	300	305	PF01217	0.508
TRG_DiLeu_BaEn_1	654	659	PF01217	0.451
TRG_DiLeu_BaEn_1	979	984	PF01217	0.385
TRG_DiLeu_BaEn_4	300	306	PF01217	0.508
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.432
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.541
TRG_ENDOCYTIC_2	210	213	PF00928	0.407
TRG_ENDOCYTIC_2	980	983	PF00928	0.295
TRG_ER_diArg_1	206	208	PF00400	0.450
TRG_ER_diArg_1	393	396	PF00400	0.373
TRG_ER_diArg_1	483	486	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	399	404	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.251
TRG_Pf-PMV_PEXEL_1	975	979	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM6	Leptomonas seymouri	64%	99%
A0A3S5H5H2	Leishmania donovani	80%	100%
A4HSF2	Leishmania infantum	79%	100%
E9AKD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
F4KAB8	Arabidopsis thaliana	26%	100%
Q4QJG9	Leishmania major	80%	99%
Q86B14	Dictyostelium discoideum	25%	100%