Glutaredoxin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

monothiol glutaredoxin, putative

Species:

Leishmania braziliensis

UniProt:

A4H476_LEIBR

TriTrypDb:

LbrM.05.0310 , LBRM2903_050008200

Length:

180

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005759	mitochondrial matrix	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H476

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H476

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0042592	homeostatic process	3	1
GO:0045454	cell redox homeostasis	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	8
GO:0015035	protein-disulfide reductase activity	3	9
GO:0015036	disulfide oxidoreductase activity	4	9
GO:0016491	oxidoreductase activity	2	9
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	9
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0051536	iron-sulfur cluster binding	3	8
GO:0051540	metal cluster binding	2	8
GO:0097573	obsolete glutathione oxidoreductase activity	4	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.655
CLV_PCSK_KEX2_1	6	8	PF00082	0.655
CLV_PCSK_PC7_1	2	8	PF00082	0.429
CLV_PCSK_SKI1_1	163	167	PF00082	0.298
DEG_Nend_UBRbox_1	1	4	PF02207	0.693
DOC_CYCLIN_RxL_1	2	11	PF00134	0.598
DOC_PP1_RVXF_1	88	95	PF00149	0.331
DOC_PP2B_LxvP_1	46	49	PF13499	0.400
DOC_USP7_MATH_1	25	29	PF00917	0.542
DOC_USP7_MATH_1	42	46	PF00917	0.675
DOC_WW_Pin1_4	62	67	PF00397	0.446
DOC_WW_Pin1_4	95	100	PF00397	0.288
LIG_14-3-3_CanoR_1	103	113	PF00244	0.281
LIG_14-3-3_CanoR_1	56	62	PF00244	0.590
LIG_14-3-3_CanoR_1	7	16	PF00244	0.635
LIG_BRCT_BRCA1_1	57	61	PF00533	0.574
LIG_eIF4E_1	149	155	PF01652	0.281
LIG_FHA_1	105	111	PF00498	0.379
LIG_FHA_1	169	175	PF00498	0.345
LIG_FHA_1	36	42	PF00498	0.392
LIG_FHA_1	62	68	PF00498	0.593
LIG_GBD_Chelix_1	74	82	PF00786	0.309
LIG_LIR_Gen_1	112	121	PF02991	0.314
LIG_LIR_Gen_1	122	132	PF02991	0.284
LIG_LIR_LC3C_4	89	93	PF02991	0.422
LIG_LIR_Nem_3	112	117	PF02991	0.314
LIG_LIR_Nem_3	122	126	PF02991	0.284
LIG_LIR_Nem_3	140	145	PF02991	0.281
LIG_LYPXL_yS_3	145	148	PF13949	0.281
LIG_SH2_SRC	149	152	PF00017	0.281
LIG_SH2_STAT5	121	124	PF00017	0.235
LIG_SH2_STAT5	149	152	PF00017	0.281
LIG_SH3_3	140	146	PF00018	0.281
LIG_SH3_3	96	102	PF00018	0.281
LIG_UBA3_1	113	120	PF00899	0.252
LIG_WRC_WIRS_1	48	53	PF05994	0.394
MOD_CDK_SPxxK_3	62	69	PF00069	0.408
MOD_CK1_1	36	42	PF00069	0.433
MOD_CK1_1	44	50	PF00069	0.564
MOD_GlcNHglycan	10	13	PF01048	0.694
MOD_GlcNHglycan	27	30	PF01048	0.494
MOD_GlcNHglycan	38	41	PF01048	0.596
MOD_GlcNHglycan	57	60	PF01048	0.589
MOD_GSK3_1	137	144	PF00069	0.283
MOD_GSK3_1	31	38	PF00069	0.624
MOD_NEK2_1	166	171	PF00069	0.402
MOD_NEK2_1	31	36	PF00069	0.668
MOD_NEK2_1	61	66	PF00069	0.463
MOD_PKA_2	104	110	PF00069	0.316
MOD_PKA_2	55	61	PF00069	0.556
MOD_Plk_4	119	125	PF00069	0.295
MOD_Plk_4	169	175	PF00069	0.414
MOD_ProDKin_1	62	68	PF00069	0.447
MOD_ProDKin_1	95	101	PF00069	0.288
TRG_ENDOCYTIC_2	121	124	PF00928	0.299
TRG_ENDOCYTIC_2	145	148	PF00928	0.281
TRG_ER_diArg_1	102	105	PF00400	0.316
TRG_ER_diArg_1	6	8	PF00400	0.632
TRG_ER_diLys_1	175	180	PF00400	0.374

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0B8	Leptomonas seymouri	69%	100%
A0A1X0P212	Trypanosomatidae	62%	100%
A0A3S7WP17	Leishmania donovani	76%	100%
A4HSF1	Leishmania infantum	76%	100%
D0A4I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AKD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QJH1	Leishmania major	75%	100%
Q6YFE4	Lachancea kluyveri	33%	100%