Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H475_LEIBR

TriTrypDb:

LbrM.05.0300 , LBRM2903_050008100

Length:

677

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H475

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H475

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	101	103	PF00675	0.578
CLV_NRD_NRD_1	278	280	PF00675	0.674
CLV_NRD_NRD_1	329	331	PF00675	0.576
CLV_NRD_NRD_1	339	341	PF00675	0.606
CLV_NRD_NRD_1	385	387	PF00675	0.517
CLV_NRD_NRD_1	475	477	PF00675	0.728
CLV_NRD_NRD_1	565	567	PF00675	0.639
CLV_PCSK_FUR_1	472	476	PF00082	0.612
CLV_PCSK_KEX2_1	101	103	PF00082	0.578
CLV_PCSK_KEX2_1	216	218	PF00082	0.513
CLV_PCSK_KEX2_1	278	280	PF00082	0.674
CLV_PCSK_KEX2_1	329	331	PF00082	0.565
CLV_PCSK_KEX2_1	338	340	PF00082	0.575
CLV_PCSK_KEX2_1	385	387	PF00082	0.517
CLV_PCSK_KEX2_1	474	476	PF00082	0.722
CLV_PCSK_KEX2_1	565	567	PF00082	0.640
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.513
CLV_PCSK_PC7_1	325	331	PF00082	0.653
CLV_PCSK_SKI1_1	111	115	PF00082	0.573
DEG_APCC_DBOX_1	337	345	PF00400	0.503
DEG_Kelch_Keap1_1	67	72	PF01344	0.538
DEG_Nend_UBRbox_2	1	3	PF02207	0.603
DEG_SPOP_SBC_1	577	581	PF00917	0.529
DEG_SPOP_SBC_1	65	69	PF00917	0.546
DOC_ANK_TNKS_1	641	648	PF00023	0.519
DOC_CYCLIN_RxL_1	6	16	PF00134	0.537
DOC_MAPK_gen_1	278	286	PF00069	0.625
DOC_PP2B_LxvP_1	104	107	PF13499	0.536
DOC_PP2B_LxvP_1	12	15	PF13499	0.638
DOC_PP2B_LxvP_1	299	302	PF13499	0.554
DOC_PP2B_LxvP_1	529	532	PF13499	0.697
DOC_PP2B_LxvP_1	635	638	PF13499	0.553
DOC_PP2B_LxvP_1	641	644	PF13499	0.595
DOC_PP4_FxxP_1	402	405	PF00568	0.498
DOC_USP7_MATH_1	133	137	PF00917	0.653
DOC_USP7_MATH_1	21	25	PF00917	0.726
DOC_USP7_MATH_1	218	222	PF00917	0.658
DOC_USP7_MATH_1	273	277	PF00917	0.543
DOC_USP7_MATH_1	317	321	PF00917	0.706
DOC_USP7_MATH_1	349	353	PF00917	0.577
DOC_USP7_MATH_1	421	425	PF00917	0.608
DOC_USP7_MATH_1	50	54	PF00917	0.616
DOC_USP7_MATH_1	577	581	PF00917	0.712
DOC_USP7_MATH_1	65	69	PF00917	0.615
DOC_WW_Pin1_4	13	18	PF00397	0.563
DOC_WW_Pin1_4	157	162	PF00397	0.664
DOC_WW_Pin1_4	164	169	PF00397	0.629
DOC_WW_Pin1_4	191	196	PF00397	0.598
DOC_WW_Pin1_4	29	34	PF00397	0.659
DOC_WW_Pin1_4	328	333	PF00397	0.722
DOC_WW_Pin1_4	394	399	PF00397	0.665
DOC_WW_Pin1_4	419	424	PF00397	0.610
DOC_WW_Pin1_4	442	447	PF00397	0.524
DOC_WW_Pin1_4	450	455	PF00397	0.500
DOC_WW_Pin1_4	552	557	PF00397	0.790
DOC_WW_Pin1_4	564	569	PF00397	0.581
DOC_WW_Pin1_4	626	631	PF00397	0.680
DOC_WW_Pin1_4	633	638	PF00397	0.599
LIG_14-3-3_CanoR_1	193	199	PF00244	0.527
LIG_14-3-3_CanoR_1	217	223	PF00244	0.507
LIG_14-3-3_CanoR_1	25	30	PF00244	0.677
LIG_14-3-3_CanoR_1	278	286	PF00244	0.487
LIG_14-3-3_CanoR_1	35	39	PF00244	0.518
LIG_14-3-3_CanoR_1	367	376	PF00244	0.544
LIG_14-3-3_CanoR_1	475	483	PF00244	0.571
LIG_14-3-3_CanoR_1	489	494	PF00244	0.514
LIG_BRCT_BRCA1_1	119	123	PF00533	0.489
LIG_BRCT_BRCA1_1	177	181	PF00533	0.442
LIG_FHA_1	177	183	PF00498	0.648
LIG_FHA_1	306	312	PF00498	0.531
LIG_FHA_1	329	335	PF00498	0.610
LIG_FHA_1	395	401	PF00498	0.603
LIG_FHA_1	407	413	PF00498	0.577
LIG_FHA_1	431	437	PF00498	0.483
LIG_FHA_1	450	456	PF00498	0.610
LIG_FHA_1	546	552	PF00498	0.629
LIG_FHA_1	651	657	PF00498	0.498
LIG_FHA_2	123	129	PF00498	0.687
LIG_FHA_2	132	138	PF00498	0.586
LIG_FHA_2	577	583	PF00498	0.715
LIG_LIR_Apic_2	292	298	PF02991	0.525
LIG_LIR_Apic_2	399	405	PF02991	0.610
LIG_LIR_Gen_1	120	130	PF02991	0.517
LIG_LIR_Gen_1	24	33	PF02991	0.619
LIG_LIR_Gen_1	459	468	PF02991	0.503
LIG_LIR_LC3C_4	526	531	PF02991	0.495
LIG_LIR_Nem_3	120	126	PF02991	0.511
LIG_LIR_Nem_3	138	144	PF02991	0.420
LIG_LIR_Nem_3	221	225	PF02991	0.513
LIG_LIR_Nem_3	24	29	PF02991	0.627
LIG_LIR_Nem_3	399	404	PF02991	0.656
LIG_LIR_Nem_3	459	464	PF02991	0.514
LIG_LIR_Nem_3	572	576	PF02991	0.700
LIG_LIR_Nem_3	625	631	PF02991	0.696
LIG_MYND_1	17	21	PF01753	0.613
LIG_PDZ_Class_2	672	677	PF00595	0.447
LIG_Pex14_1	509	513	PF04695	0.473
LIG_Pex14_2	380	384	PF04695	0.575
LIG_SH2_CRK	222	226	PF00017	0.503
LIG_SH2_CRK	461	465	PF00017	0.496
LIG_SH2_NCK_1	391	395	PF00017	0.612
LIG_SH2_PTP2	573	576	PF00017	0.622
LIG_SH2_SRC	242	245	PF00017	0.689
LIG_SH2_SRC	664	667	PF00017	0.467
LIG_SH2_STAP1	461	465	PF00017	0.496
LIG_SH2_STAP1	671	675	PF00017	0.434
LIG_SH2_STAT5	255	258	PF00017	0.443
LIG_SH2_STAT5	265	268	PF00017	0.542
LIG_SH2_STAT5	391	394	PF00017	0.606
LIG_SH2_STAT5	463	466	PF00017	0.490
LIG_SH2_STAT5	573	576	PF00017	0.592
LIG_SH3_1	223	229	PF00018	0.684
LIG_SH3_3	223	229	PF00018	0.684
LIG_SH3_3	241	247	PF00018	0.470
LIG_SH3_3	354	360	PF00018	0.682
LIG_SH3_3	400	406	PF00018	0.453
LIG_SH3_3	515	521	PF00018	0.482
LIG_SH3_3	527	533	PF00018	0.597
LIG_SH3_3	624	630	PF00018	0.731
LIG_SH3_3	643	649	PF00018	0.482
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.508
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.523
LIG_SUMO_SIM_par_1	47	53	PF11976	0.669
LIG_TRAF2_1	524	527	PF00917	0.625
LIG_TRAF2_1	70	73	PF00917	0.538
LIG_TRFH_1	402	406	PF08558	0.425
LIG_TRFH_1	633	637	PF08558	0.573
LIG_WRC_WIRS_1	51	56	PF05994	0.684
LIG_WW_3	404	408	PF00397	0.437
LIG_WW_3	636	640	PF00397	0.661
MOD_CDC14_SPxK_1	32	35	PF00782	0.597
MOD_CDC14_SPxK_1	636	639	PF00782	0.588
MOD_CDK_SPK_2	328	333	PF00069	0.649
MOD_CDK_SPxK_1	29	35	PF00069	0.602
MOD_CDK_SPxK_1	633	639	PF00069	0.605
MOD_CK1_1	122	128	PF00069	0.537
MOD_CK1_1	152	158	PF00069	0.508
MOD_CK1_1	160	166	PF00069	0.595
MOD_CK1_1	245	251	PF00069	0.689
MOD_CK1_1	370	376	PF00069	0.563
MOD_CK1_1	459	465	PF00069	0.610
MOD_CK1_1	492	498	PF00069	0.797
MOD_CK1_1	499	505	PF00069	0.613
MOD_CK1_1	560	566	PF00069	0.705
MOD_CK1_1	585	591	PF00069	0.523
MOD_CK1_1	67	73	PF00069	0.652
MOD_CK2_1	317	323	PF00069	0.705
MOD_CK2_1	345	351	PF00069	0.560
MOD_CK2_1	366	372	PF00069	0.568
MOD_CK2_1	431	437	PF00069	0.483
MOD_CK2_1	66	72	PF00069	0.717
MOD_CK2_1	91	97	PF00069	0.542
MOD_Cter_Amidation	99	102	PF01082	0.544
MOD_GlcNHglycan	119	122	PF01048	0.659
MOD_GlcNHglycan	2	5	PF01048	0.615
MOD_GlcNHglycan	247	250	PF01048	0.585
MOD_GlcNHglycan	267	270	PF01048	0.630
MOD_GlcNHglycan	275	278	PF01048	0.672
MOD_GlcNHglycan	292	295	PF01048	0.546
MOD_GlcNHglycan	347	350	PF01048	0.591
MOD_GlcNHglycan	369	372	PF01048	0.678
MOD_GlcNHglycan	392	395	PF01048	0.467
MOD_GlcNHglycan	458	461	PF01048	0.702
MOD_GlcNHglycan	552	555	PF01048	0.619
MOD_GlcNHglycan	582	587	PF01048	0.796
MOD_GlcNHglycan	590	593	PF01048	0.537
MOD_GlcNHglycan	69	72	PF01048	0.544
MOD_GlcNHglycan	93	96	PF01048	0.689
MOD_GSK3_1	113	120	PF00069	0.564
MOD_GSK3_1	157	164	PF00069	0.554
MOD_GSK3_1	2	9	PF00069	0.562
MOD_GSK3_1	21	28	PF00069	0.622
MOD_GSK3_1	238	245	PF00069	0.586
MOD_GSK3_1	345	352	PF00069	0.571
MOD_GSK3_1	366	373	PF00069	0.695
MOD_GSK3_1	390	397	PF00069	0.660
MOD_GSK3_1	413	420	PF00069	0.656
MOD_GSK3_1	421	428	PF00069	0.691
MOD_GSK3_1	459	466	PF00069	0.536
MOD_GSK3_1	470	477	PF00069	0.558
MOD_GSK3_1	492	499	PF00069	0.765
MOD_GSK3_1	560	567	PF00069	0.632
MOD_GSK3_1	578	585	PF00069	0.660
MOD_GSK3_1	622	629	PF00069	0.584
MOD_GSK3_1	633	640	PF00069	0.689
MOD_LATS_1	365	371	PF00433	0.574
MOD_N-GLC_1	499	504	PF02516	0.671
MOD_N-GLC_2	429	431	PF02516	0.410
MOD_NEK2_1	113	118	PF00069	0.560
MOD_NEK2_1	176	181	PF00069	0.724
MOD_NEK2_1	390	395	PF00069	0.431
MOD_NEK2_1	49	54	PF00069	0.678
MOD_NEK2_1	569	574	PF00069	0.538
MOD_NEK2_1	576	581	PF00069	0.717
MOD_NEK2_1	64	69	PF00069	0.551
MOD_PIKK_1	421	427	PF00454	0.587
MOD_PIKK_1	82	88	PF00454	0.550
MOD_PK_1	25	31	PF00069	0.720
MOD_PKA_1	474	480	PF00069	0.632
MOD_PKA_2	21	27	PF00069	0.699
MOD_PKA_2	290	296	PF00069	0.591
MOD_PKA_2	34	40	PF00069	0.527
MOD_PKA_2	366	372	PF00069	0.713
MOD_PKA_2	406	412	PF00069	0.474
MOD_PKA_2	474	480	PF00069	0.650
MOD_PKA_2	65	71	PF00069	0.656
MOD_PKB_1	472	480	PF00069	0.559
MOD_Plk_1	131	137	PF00069	0.746
MOD_Plk_1	305	311	PF00069	0.529
MOD_Plk_1	436	442	PF00069	0.433
MOD_Plk_1	582	588	PF00069	0.529
MOD_Plk_1	622	628	PF00069	0.518
MOD_Plk_2-3	131	137	PF00069	0.535
MOD_Plk_4	149	155	PF00069	0.530
MOD_Plk_4	176	182	PF00069	0.524
MOD_Plk_4	34	40	PF00069	0.574
MOD_Plk_4	396	402	PF00069	0.623
MOD_Plk_4	431	437	PF00069	0.483
MOD_Plk_4	459	465	PF00069	0.610
MOD_Plk_4	569	575	PF00069	0.603
MOD_ProDKin_1	13	19	PF00069	0.564
MOD_ProDKin_1	157	163	PF00069	0.664
MOD_ProDKin_1	164	170	PF00069	0.627
MOD_ProDKin_1	191	197	PF00069	0.598
MOD_ProDKin_1	29	35	PF00069	0.663
MOD_ProDKin_1	328	334	PF00069	0.718
MOD_ProDKin_1	394	400	PF00069	0.657
MOD_ProDKin_1	419	425	PF00069	0.606
MOD_ProDKin_1	442	448	PF00069	0.529
MOD_ProDKin_1	450	456	PF00069	0.497
MOD_ProDKin_1	552	558	PF00069	0.791
MOD_ProDKin_1	564	570	PF00069	0.581
MOD_ProDKin_1	626	632	PF00069	0.680
MOD_ProDKin_1	633	639	PF00069	0.598
MOD_SUMO_for_1	484	487	PF00179	0.549
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.619
TRG_ENDOCYTIC_2	222	225	PF00928	0.502
TRG_ENDOCYTIC_2	461	464	PF00928	0.502
TRG_ENDOCYTIC_2	573	576	PF00928	0.695
TRG_ER_diArg_1	278	280	PF00400	0.572
TRG_ER_diArg_1	328	330	PF00400	0.670
TRG_ER_diArg_1	337	340	PF00400	0.546
TRG_ER_diArg_1	384	386	PF00400	0.616
TRG_ER_diArg_1	40	43	PF00400	0.484
TRG_ER_diArg_1	472	475	PF00400	0.676
TRG_ER_diArg_1	564	566	PF00400	0.655
TRG_ER_diArg_1	657	660	PF00400	0.704
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ8	Leptomonas seymouri	33%	100%
A0A3S7WP11	Leishmania donovani	70%	72%
A4HSF0	Leishmania infantum	70%	88%
E9AKD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	91%
Q4QJH2	Leishmania major	68%	100%