LeishMANIAdb
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Phosphate carrier protein, mitochondrial-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphate carrier protein, mitochondrial-like protein
Gene product:
phosphate carrier protein, mitochondrial precursor-like protein
Species:
Leishmania braziliensis
UniProt:
A4H474_LEIBR
TriTrypDb:
LbrM.05.0290 , LBRM2903_050008000 *
Length:
498

Annotations

LeishMANIAdb annotations

Forms a well-defined channel with 6 helices. Some paralogs tend to have an additional hydrophobic segment that might be a transit or signal peptide. It is unclear if the N-peptide is a signal or transit peptide. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005743 mitochondrial inner membrane 5 8
GO:0016020 membrane 2 8
GO:0019866 organelle inner membrane 4 8
GO:0031090 organelle membrane 3 8
GO:0031966 mitochondrial membrane 4 8
GO:0110165 cellular anatomical entity 1 9
GO:0005737 cytoplasm 2 1

Expansion

Sequence features

A4H474
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H474

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 9
GO:0006811 monoatomic ion transport 4 9
GO:0006817 phosphate ion transport 7 9
GO:0006820 monoatomic anion transport 5 9
GO:0009987 cellular process 1 9
GO:0015698 inorganic anion transport 6 9
GO:0034220 monoatomic ion transmembrane transport 3 9
GO:0035435 phosphate ion transmembrane transport 6 9
GO:0051179 localization 1 9
GO:0051234 establishment of localization 2 9
GO:0055085 transmembrane transport 2 9
GO:0098656 monoatomic anion transmembrane transport 4 9
GO:0098660 inorganic ion transmembrane transport 4 9
GO:0098661 inorganic anion transmembrane transport 5 9
GO:1990542 mitochondrial transmembrane transport 3 9
GO:1990547 mitochondrial phosphate ion transmembrane transport 4 9
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 9
GO:0005315 inorganic phosphate transmembrane transporter activity 4 9
GO:0015291 secondary active transmembrane transporter activity 4 9
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 9
GO:0022804 active transmembrane transporter activity 3 9
GO:0022857 transmembrane transporter activity 2 9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 185 189 PF00656 0.523
CLV_NRD_NRD_1 17 19 PF00675 0.436
CLV_PCSK_KEX2_1 17 19 PF00082 0.436
CLV_PCSK_PC1ET2_1 17 19 PF00082 0.436
CLV_PCSK_SKI1_1 310 314 PF00082 0.346
CLV_Separin_Metazoa 449 453 PF03568 0.425
DEG_APCC_DBOX_1 210 218 PF00400 0.578
DEG_APCC_DBOX_1 309 317 PF00400 0.578
DEG_MDM2_SWIB_1 349 357 PF02201 0.306
DEG_SPOP_SBC_1 263 267 PF00917 0.503
DOC_AGCK_PIF_2 228 233 PF00069 0.397
DOC_AGCK_PIF_2 344 349 PF00069 0.472
DOC_CDC14_PxL_1 203 211 PF14671 0.397
DOC_CYCLIN_yCln2_LP_2 79 82 PF00134 0.785
DOC_MAPK_MEF2A_6 461 469 PF00069 0.539
DOC_PP1_RVXF_1 101 107 PF00149 0.631
DOC_PP1_RVXF_1 450 457 PF00149 0.442
DOC_PP1_SILK_1 200 205 PF00149 0.397
DOC_PP2B_LxvP_1 79 82 PF13499 0.785
DOC_USP7_MATH_1 13 17 PF00917 0.712
DOC_USP7_MATH_1 198 202 PF00917 0.505
DOC_USP7_MATH_1 20 24 PF00917 0.725
DOC_USP7_MATH_1 258 262 PF00917 0.705
DOC_USP7_MATH_1 263 267 PF00917 0.678
DOC_USP7_MATH_1 426 430 PF00917 0.479
DOC_USP7_MATH_1 439 443 PF00917 0.410
DOC_USP7_MATH_1 75 79 PF00917 0.610
DOC_WW_Pin1_4 253 258 PF00397 0.629
DOC_WW_Pin1_4 299 304 PF00397 0.578
DOC_WW_Pin1_4 412 417 PF00397 0.546
DOC_WW_Pin1_4 92 97 PF00397 0.750
LIG_14-3-3_CanoR_1 129 138 PF00244 0.367
LIG_14-3-3_CanoR_1 144 149 PF00244 0.367
LIG_14-3-3_CanoR_1 18 23 PF00244 0.641
LIG_14-3-3_CanoR_1 298 303 PF00244 0.506
LIG_14-3-3_CanoR_1 307 317 PF00244 0.502
LIG_14-3-3_CanoR_1 406 414 PF00244 0.578
LIG_14-3-3_CanoR_1 434 444 PF00244 0.397
LIG_Actin_RPEL_3 450 469 PF02755 0.397
LIG_AP2alpha_1 186 190 PF02296 0.508
LIG_BRCT_BRCA1_1 22 26 PF00533 0.625
LIG_BRCT_BRCA1_1 224 228 PF00533 0.539
LIG_BRCT_BRCA1_1 301 305 PF00533 0.517
LIG_BRCT_BRCA1_1 345 349 PF00533 0.472
LIG_FHA_1 117 123 PF00498 0.418
LIG_FHA_1 138 144 PF00498 0.424
LIG_FHA_1 370 376 PF00498 0.349
LIG_FHA_1 413 419 PF00498 0.397
LIG_FHA_1 74 80 PF00498 0.762
LIG_FHA_1 83 89 PF00498 0.764
LIG_FHA_2 490 496 PF00498 0.451
LIG_FHA_2 64 70 PF00498 0.753
LIG_GBD_Chelix_1 376 384 PF00786 0.360
LIG_IRF3_LxIS_1 234 241 PF10401 0.397
LIG_LIR_Apic_2 7 13 PF02991 0.646
LIG_LIR_Gen_1 147 156 PF02991 0.265
LIG_LIR_Gen_1 188 198 PF02991 0.522
LIG_LIR_Gen_1 229 239 PF02991 0.539
LIG_LIR_Gen_1 266 276 PF02991 0.597
LIG_LIR_Gen_1 345 354 PF02991 0.322
LIG_LIR_Gen_1 356 366 PF02991 0.321
LIG_LIR_LC3C_4 372 377 PF02991 0.197
LIG_LIR_Nem_3 147 153 PF02991 0.265
LIG_LIR_Nem_3 182 186 PF02991 0.477
LIG_LIR_Nem_3 188 193 PF02991 0.457
LIG_LIR_Nem_3 225 231 PF02991 0.499
LIG_LIR_Nem_3 232 236 PF02991 0.495
LIG_LIR_Nem_3 266 272 PF02991 0.610
LIG_LIR_Nem_3 345 350 PF02991 0.319
LIG_LIR_Nem_3 356 361 PF02991 0.311
LIG_LIR_Nem_3 480 484 PF02991 0.378
LIG_NBox_RRM_1 440 450 PF00076 0.397
LIG_NRBOX 383 389 PF00104 0.433
LIG_NRBOX 51 57 PF00104 0.605
LIG_Pex14_2 151 155 PF04695 0.370
LIG_Pex14_2 186 190 PF04695 0.548
LIG_Pex14_2 272 276 PF04695 0.578
LIG_Pex14_2 349 353 PF04695 0.306
LIG_SH2_CRK 153 157 PF00017 0.418
LIG_SH2_CRK 236 240 PF00017 0.477
LIG_SH2_CRK 326 330 PF00017 0.496
LIG_SH2_CRK 339 343 PF00017 0.285
LIG_SH2_STAT3 220 223 PF00017 0.505
LIG_SH2_STAT5 126 129 PF00017 0.417
LIG_SH2_STAT5 150 153 PF00017 0.311
LIG_SH2_STAT5 194 197 PF00017 0.459
LIG_SH2_STAT5 339 342 PF00017 0.319
LIG_SH3_3 164 170 PF00018 0.336
LIG_SH3_3 240 246 PF00018 0.665
LIG_SH3_3 300 306 PF00018 0.576
LIG_SH3_3 389 395 PF00018 0.337
LIG_SH3_3 415 421 PF00018 0.397
LIG_SUMO_SIM_par_1 466 472 PF11976 0.418
LIG_TYR_ITIM 234 239 PF00017 0.546
LIG_TYR_ITIM 337 342 PF00017 0.249
LIG_WRC_WIRS_1 106 111 PF05994 0.502
LIG_WRC_WIRS_1 145 150 PF05994 0.298
LIG_WRC_WIRS_1 183 188 PF05994 0.578
LIG_WRC_WIRS_1 344 349 PF05994 0.337
MOD_CK1_1 108 114 PF00069 0.326
MOD_CK1_1 35 41 PF00069 0.805
MOD_CK1_1 408 414 PF00069 0.568
MOD_CK1_1 63 69 PF00069 0.778
MOD_CK1_1 92 98 PF00069 0.720
MOD_CK2_1 226 232 PF00069 0.565
MOD_CK2_1 342 348 PF00069 0.418
MOD_CK2_1 96 102 PF00069 0.586
MOD_GlcNHglycan 131 134 PF01048 0.635
MOD_GlcNHglycan 22 25 PF01048 0.492
MOD_GlcNHglycan 260 263 PF01048 0.471
MOD_GlcNHglycan 407 410 PF01048 0.378
MOD_GlcNHglycan 441 444 PF01048 0.305
MOD_GlcNHglycan 492 495 PF01048 0.590
MOD_GlcNHglycan 85 88 PF01048 0.452
MOD_GSK3_1 105 112 PF00069 0.439
MOD_GSK3_1 127 134 PF00069 0.289
MOD_GSK3_1 222 229 PF00069 0.578
MOD_GSK3_1 253 260 PF00069 0.653
MOD_GSK3_1 408 415 PF00069 0.505
MOD_GSK3_1 435 442 PF00069 0.401
MOD_GSK3_1 70 77 PF00069 0.781
MOD_GSK3_1 88 95 PF00069 0.581
MOD_N-GLC_1 35 40 PF02516 0.609
MOD_N-GLC_1 71 76 PF02516 0.535
MOD_NEK2_1 109 114 PF00069 0.365
MOD_NEK2_1 122 127 PF00069 0.376
MOD_NEK2_1 238 243 PF00069 0.481
MOD_NEK2_1 274 279 PF00069 0.477
MOD_NEK2_1 375 380 PF00069 0.323
MOD_NEK2_1 450 455 PF00069 0.475
MOD_NEK2_1 469 474 PF00069 0.376
MOD_NEK2_2 139 144 PF00069 0.283
MOD_NEK2_2 353 358 PF00069 0.530
MOD_PKA_1 18 24 PF00069 0.631
MOD_PKA_2 128 134 PF00069 0.341
MOD_PKA_2 405 411 PF00069 0.578
MOD_Plk_2-3 182 188 PF00069 0.578
MOD_Plk_4 105 111 PF00069 0.457
MOD_Plk_4 122 128 PF00069 0.401
MOD_Plk_4 198 204 PF00069 0.511
MOD_Plk_4 264 270 PF00069 0.486
MOD_Plk_4 337 343 PF00069 0.331
MOD_Plk_4 353 359 PF00069 0.316
MOD_Plk_4 375 381 PF00069 0.369
MOD_Plk_4 395 401 PF00069 0.374
MOD_Plk_4 51 57 PF00069 0.742
MOD_Plk_4 75 81 PF00069 0.788
MOD_ProDKin_1 253 259 PF00069 0.628
MOD_ProDKin_1 299 305 PF00069 0.578
MOD_ProDKin_1 412 418 PF00069 0.546
MOD_ProDKin_1 92 98 PF00069 0.738
TRG_DiLeu_BaEn_2 181 187 PF01217 0.397
TRG_DiLeu_BaLyEn_6 204 209 PF01217 0.459
TRG_DiLeu_BaLyEn_6 463 468 PF01217 0.418
TRG_ENDOCYTIC_2 153 156 PF00928 0.346
TRG_ENDOCYTIC_2 183 186 PF00928 0.505
TRG_ENDOCYTIC_2 231 234 PF00928 0.463
TRG_ENDOCYTIC_2 236 239 PF00928 0.463
TRG_ENDOCYTIC_2 269 272 PF00928 0.619
TRG_ENDOCYTIC_2 326 329 PF00928 0.493
TRG_ENDOCYTIC_2 339 342 PF00928 0.283
TRG_ENDOCYTIC_2 481 484 PF00928 0.281

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3H8 Leptomonas seymouri 48% 100%
A0A0S4JBC4 Bodo saltans 40% 100%
A0A0S4JNX4 Bodo saltans 31% 100%
A0A1D6N272 Zea mays 24% 100%
A0A3S7WP13 Leishmania donovani 73% 100%
A4HSE9 Leishmania infantum 73% 100%
A4RPU0 Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) 22% 100%
B4FIJ0 Zea mays 24% 100%
D0A4I3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 100%
E9AFR9 Leishmania major 31% 85%
E9AKD5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 70% 100%
O04619 Arabidopsis thaliana 25% 100%
O61703 Choristoneura fumiferana 34% 100%
O75746 Homo sapiens 23% 73%
P12234 Bos taurus 35% 100%
P16036 Rattus norvegicus 34% 100%
P40614 Caenorhabditis elegans 37% 100%
Q00325 Homo sapiens 34% 100%
Q287T7 Danio rerio 24% 100%
Q2H608 Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) 24% 100%
Q4QJH3 Leishmania major 72% 100%
Q54VX4 Dictyostelium discoideum 22% 100%
Q5R7W2 Pongo abelii 34% 100%
Q5RBC8 Pongo abelii 23% 73%
Q628Z2 Caenorhabditis briggsae 21% 94%
Q66H23 Rattus norvegicus 23% 100%
Q6DHC3 Danio rerio 20% 100%
Q6P316 Xenopus tropicalis 21% 100%
Q7T292 Danio rerio 25% 100%
Q8R0Z5 Mus musculus 25% 100%
Q8RXZ9 Arabidopsis thaliana 21% 100%
Q8VEM8 Mus musculus 35% 100%
Q920G8 Mus musculus 24% 100%
Q96A46 Homo sapiens 25% 100%
Q96U08 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 22% 100%
Q9FI73 Arabidopsis thaliana 24% 100%
Q9FLS8 Arabidopsis thaliana 23% 100%
Q9FMU6 Arabidopsis thaliana 34% 100%
Q9M2Z8 Arabidopsis thaliana 34% 100%
Q9NYZ2 Homo sapiens 24% 100%
Q9VAY3 Drosophila melanogaster 21% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS