Putative ARP2/3 complex 16kDa subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Download

Quick info

Protein:

Gene product:

ARP2/3 complex 16kDa subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4H473_LEIBR

TriTrypDb:

LbrM.05.0280 , LBRM2903_050007800

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005885	Arp2/3 protein complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H473

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H473

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	2
GO:0008064	regulation of actin polymerization or depolymerization	6	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0030832	regulation of actin filament length	5	2
GO:0030833	regulation of actin filament polymerization	7	2
GO:0032271	regulation of protein polymerization	6	2
GO:0032535	regulation of cellular component size	4	2
GO:0032956	regulation of actin cytoskeleton organization	5	2
GO:0032970	regulation of actin filament-based process	4	2
GO:0033043	regulation of organelle organization	5	2
GO:0034314	Arp2/3 complex-mediated actin nucleation	7	2
GO:0043254	regulation of protein-containing complex assembly	5	2
GO:0044087	regulation of cellular component biogenesis	4	2
GO:0045010	actin nucleation	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051128	regulation of cellular component organization	4	2
GO:0051493	regulation of cytoskeleton organization	6	2
GO:0065007	biological regulation	1	2
GO:0065008	regulation of biological quality	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090066	regulation of anatomical structure size	3	2
GO:0097435	supramolecular fiber organization	4	2
GO:0110053	regulation of actin filament organization	6	2
GO:1902903	regulation of supramolecular fiber organization	5	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.608
CLV_NRD_NRD_1	143	145	PF00675	0.610
CLV_PCSK_KEX2_1	143	145	PF00082	0.610
CLV_PCSK_KEX2_1	90	92	PF00082	0.828
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.828
CLV_PCSK_SKI1_1	143	147	PF00082	0.611
CLV_PCSK_SKI1_1	198	202	PF00082	0.590
CLV_PCSK_SKI1_1	46	50	PF00082	0.721
DEG_APCC_DBOX_1	142	150	PF00400	0.599
DEG_Nend_UBRbox_1	1	4	PF02207	0.839
DOC_CYCLIN_RxL_1	141	151	PF00134	0.603
DOC_CYCLIN_RxL_1	43	50	PF00134	0.716
DOC_PP1_RVXF_1	44	50	PF00149	0.718
DOC_PP2B_LxvP_1	205	208	PF13499	0.650
DOC_USP7_MATH_1	167	171	PF00917	0.779
DOC_USP7_MATH_1	186	190	PF00917	0.414
DOC_USP7_MATH_1	277	281	PF00917	0.650
DOC_WW_Pin1_4	107	112	PF00397	0.469
DOC_WW_Pin1_4	248	253	PF00397	0.650
DOC_WW_Pin1_4	3	8	PF00397	0.835
DOC_WW_Pin1_4	36	41	PF00397	0.749
DOC_WW_Pin1_4	91	96	PF00397	0.804
LIG_14-3-3_CanoR_1	46	52	PF00244	0.717
LIG_14-3-3_CanoR_1	91	95	PF00244	0.807
LIG_14-3-3_CterR_2	276	281	PF00244	0.650
LIG_BIR_III_4	267	271	PF00653	0.650
LIG_BRCT_BRCA1_1	40	44	PF00533	0.725
LIG_BRCT_BRCA1_1	93	97	PF00533	0.795
LIG_FHA_1	129	135	PF00498	0.636
LIG_GBD_Chelix_1	118	126	PF00786	0.602
LIG_LIR_Apic_2	89	95	PF02991	0.813
LIG_LIR_Nem_3	232	236	PF02991	0.650
LIG_LIR_Nem_3	41	47	PF02991	0.724
LIG_LIR_Nem_3	94	100	PF02991	0.792
LIG_Pex14_2	45	49	PF04695	0.718
LIG_Pex14_2	97	101	PF04695	0.789
LIG_REV1ctd_RIR_1	42	50	PF16727	0.719
LIG_SH2_CRK	92	96	PF00017	0.801
LIG_SH2_NCK_1	92	96	PF00017	0.801
LIG_SH2_STAP1	259	263	PF00017	0.650
LIG_SH2_STAT5	218	221	PF00017	0.650
LIG_SH3_3	159	165	PF00018	0.688
LIG_SH3_3	225	231	PF00018	0.650
LIG_SH3_3	246	252	PF00018	0.650
LIG_TRAF2_1	242	245	PF00917	0.650
LIG_WRC_WIRS_1	48	53	PF05994	0.711
MOD_CK1_1	170	176	PF00069	0.805
MOD_CK1_1	185	191	PF00069	0.486
MOD_CK1_1	223	229	PF00069	0.650
MOD_CK1_1	8	14	PF00069	0.846
MOD_CK2_1	66	72	PF00069	0.805
MOD_CK2_1	8	14	PF00069	0.846
MOD_GlcNHglycan	176	179	PF01048	0.816
MOD_GlcNHglycan	184	187	PF01048	0.643
MOD_GlcNHglycan	188	191	PF01048	0.518
MOD_GlcNHglycan	225	228	PF01048	0.449
MOD_GlcNHglycan	55	58	PF01048	0.738
MOD_GlcNHglycan	68	71	PF01048	0.576
MOD_GSK3_1	129	136	PF00069	0.639
MOD_GSK3_1	166	173	PF00069	0.783
MOD_GSK3_1	182	189	PF00069	0.499
MOD_GSK3_1	27	34	PF00069	0.779
MOD_GSK3_1	36	43	PF00069	0.585
MOD_GSK3_1	47	54	PF00069	0.366
MOD_GSK3_1	5	12	PF00069	0.840
MOD_GSK3_1	86	93	PF00069	0.818
MOD_N-GLC_1	170	175	PF02516	0.804
MOD_N-GLC_1	66	71	PF02516	0.800
MOD_NEK2_1	118	123	PF00069	0.603
MOD_NEK2_1	129	134	PF00069	0.434
MOD_NEK2_1	156	161	PF00069	0.648
MOD_NEK2_1	27	32	PF00069	0.784
MOD_NEK2_1	47	52	PF00069	0.362
MOD_NEK2_2	40	45	PF00069	0.723
MOD_PK_1	135	141	PF00069	0.630
MOD_PK_1	196	202	PF00069	0.601
MOD_PKA_1	90	96	PF00069	0.808
MOD_PKA_2	90	96	PF00069	0.808
MOD_Plk_1	129	135	PF00069	0.636
MOD_Plk_4	129	135	PF00069	0.636
MOD_Plk_4	190	196	PF00069	0.661
MOD_Plk_4	40	46	PF00069	0.726
MOD_ProDKin_1	107	113	PF00069	0.462
MOD_ProDKin_1	248	254	PF00069	0.650
MOD_ProDKin_1	3	9	PF00069	0.832
MOD_ProDKin_1	36	42	PF00069	0.748
MOD_ProDKin_1	91	97	PF00069	0.804
MOD_SUMO_for_1	77	80	PF00179	0.849
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.712
TRG_ENDOCYTIC_2	218	221	PF00928	0.650
TRG_ER_diArg_1	143	145	PF00400	0.610
TRG_ER_diArg_1	195	198	PF00400	0.617
TRG_NES_CRM1_1	127	141	PF08389	0.629