Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein tyrosine phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4H472_LEIBR

TriTrypDb:

LbrM.05.0270 , LBRM2903_050007700

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H472

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H472

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006629	lipid metabolic process	3	11
GO:0006631	fatty acid metabolic process	4	11
GO:0006633	fatty acid biosynthetic process	5	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016053	organic acid biosynthetic process	4	11
GO:0019752	carboxylic acid metabolic process	5	11
GO:0032787	monocarboxylic acid metabolic process	6	11
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046394	carboxylic acid biosynthetic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0072330	monocarboxylic acid biosynthetic process	6	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0000038	very long-chain fatty acid metabolic process	5	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0030148	sphingolipid biosynthetic process	5	1
GO:0030497	fatty acid elongation	6	1
GO:0042761	very long-chain fatty acid biosynthetic process	6	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	5
GO:0016829	lyase activity	2	11
GO:0016835	carbon-oxygen lyase activity	3	11
GO:0016836	hydro-lyase activity	4	11
GO:0102158	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	5	11
GO:0102343	obsolete 3-hydroxy-arachidoyl-CoA dehydratase activity	5	11
GO:0102344	obsolete 3-hydroxy-behenoyl-CoA dehydratase activity	5	11
GO:0102345	obsolete 3-hydroxy-lignoceroyl-CoA dehydratase activity	5	11
GO:0018812	3-hydroxyacyl-CoA dehydratase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.239
CLV_NRD_NRD_1	208	210	PF00675	0.273
CLV_PCSK_KEX2_1	208	210	PF00082	0.273
CLV_PCSK_SKI1_1	209	213	PF00082	0.189
CLV_PCSK_SKI1_1	25	29	PF00082	0.266
DEG_MDM2_SWIB_1	177	185	PF02201	0.311
DOC_CYCLIN_yClb1_LxF_4	172	177	PF00134	0.311
DOC_PP1_RVXF_1	172	178	PF00149	0.311
DOC_PP1_RVXF_1	95	102	PF00149	0.362
DOC_USP7_MATH_1	194	198	PF00917	0.331
DOC_USP7_MATH_1	220	224	PF00917	0.569
DOC_USP7_MATH_1	95	99	PF00917	0.279
DOC_USP7_UBL2_3	210	214	PF12436	0.513
DOC_WW_Pin1_4	65	70	PF00397	0.385
LIG_14-3-3_CanoR_1	115	119	PF00244	0.331
LIG_14-3-3_CanoR_1	135	143	PF00244	0.464
LIG_14-3-3_CterR_2	219	224	PF00244	0.687
LIG_BRCT_BRCA1_1	183	187	PF00533	0.243
LIG_BRCT_BRCA1_1	97	101	PF00533	0.273
LIG_FHA_1	146	152	PF00498	0.355
LIG_FHA_1	50	56	PF00498	0.405
LIG_FHA_1	70	76	PF00498	0.126
LIG_FHA_1	94	100	PF00498	0.292
LIG_LIR_Gen_1	137	147	PF02991	0.312
LIG_LIR_Gen_1	180	190	PF02991	0.315
LIG_LIR_Gen_1	98	107	PF02991	0.273
LIG_LIR_Nem_3	132	136	PF02991	0.476
LIG_LIR_Nem_3	137	142	PF02991	0.295
LIG_LIR_Nem_3	178	182	PF02991	0.260
LIG_LIR_Nem_3	184	190	PF02991	0.306
LIG_LIR_Nem_3	197	201	PF02991	0.253
LIG_LIR_Nem_3	38	43	PF02991	0.313
LIG_LYPXL_S_1	39	43	PF13949	0.528
LIG_LYPXL_yS_3	40	43	PF13949	0.317
LIG_PALB2_WD40_1	182	190	PF16756	0.355
LIG_Pex14_2	177	181	PF04695	0.290
LIG_SH2_CRK	155	159	PF00017	0.355
LIG_SH2_CRK	85	89	PF00017	0.424
LIG_SH2_STAP1	136	140	PF00017	0.536
LIG_SH2_STAP1	201	205	PF00017	0.471
LIG_SH2_STAT5	160	163	PF00017	0.290
LIG_SH2_STAT5	198	201	PF00017	0.326
LIG_SH2_STAT5	7	10	PF00017	0.312
LIG_SH3_3	138	144	PF00018	0.331
LIG_SH3_3	166	172	PF00018	0.273
LIG_SH3_3	63	69	PF00018	0.355
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.313
LIG_TYR_ITIM	83	88	PF00017	0.355
MOD_GlcNHglycan	136	139	PF01048	0.259
MOD_GSK3_1	177	184	PF00069	0.269
MOD_GSK3_1	65	72	PF00069	0.319
MOD_N-GLC_1	11	16	PF02516	0.234
MOD_N-GLC_1	124	129	PF02516	0.182
MOD_N-GLC_1	175	180	PF02516	0.473
MOD_NEK2_1	123	128	PF00069	0.466
MOD_NEK2_1	134	139	PF00069	0.471
MOD_NEK2_1	175	180	PF00069	0.286
MOD_PKA_2	114	120	PF00069	0.331
MOD_PKA_2	134	140	PF00069	0.459
MOD_Plk_1	11	17	PF00069	0.204
MOD_Plk_1	175	181	PF00069	0.273
MOD_Plk_4	114	120	PF00069	0.238
MOD_Plk_4	129	135	PF00069	0.430
MOD_Plk_4	181	187	PF00069	0.307
MOD_Plk_4	194	200	PF00069	0.324
MOD_Plk_4	35	41	PF00069	0.323
MOD_Plk_4	70	76	PF00069	0.330
MOD_ProDKin_1	65	71	PF00069	0.385
TRG_DiLeu_BaEn_1	42	47	PF01217	0.334
TRG_DiLeu_BaLyEn_6	77	82	PF01217	0.355
TRG_ENDOCYTIC_2	136	139	PF00928	0.490
TRG_ENDOCYTIC_2	155	158	PF00928	0.312
TRG_ENDOCYTIC_2	182	185	PF00928	0.327
TRG_ENDOCYTIC_2	201	204	PF00928	0.374
TRG_ENDOCYTIC_2	40	43	PF00928	0.316
TRG_ENDOCYTIC_2	85	88	PF00928	0.355
TRG_ER_diLys_1	221	224	PF00400	0.647
TRG_NLS_MonoExtC_3	161	166	PF00514	0.335
TRG_NLS_MonoExtN_4	159	166	PF00514	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT96	Leptomonas seymouri	75%	100%
A0A0S4J5C4	Bodo saltans	53%	100%
A0A1X0P0I0	Trypanosomatidae	62%	94%
A0A3R7K8T2	Trypanosoma rangeli	61%	93%
A0A3S5H5H0	Leishmania donovani	85%	100%
A2AKM2	Mus musculus	25%	97%
A4HSE7	Leishmania infantum	85%	100%
B0YJ81	Homo sapiens	34%	78%
D0A4J7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	80%
E9AKD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O14346	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
O17040	Caenorhabditis elegans	39%	100%
P40857	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q0P5C7	Bos taurus	23%	97%
Q2KIP8	Bos taurus	39%	88%
Q4QJH5	Leishmania major	84%	100%
Q4W1W1	Canis lupus familiaris	35%	90%
Q5RBK3	Pongo abelii	39%	88%
Q5VWC8	Homo sapiens	23%	97%
Q5ZEJ0	Oryza sativa subsp. japonica	43%	100%
Q6GNB5	Xenopus laevis	25%	100%
Q6Y1H2	Homo sapiens	39%	88%
Q7XSZ4	Oryza sativa subsp. japonica	42%	100%
Q8VZB2	Arabidopsis thaliana	40%	100%
Q9D3B1	Mus musculus	39%	88%
Q9N1R5	Ovis aries	35%	78%
Q9QY80	Mus musculus	35%	80%