LeishMANIAdb
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Tudor domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Tudor domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H471_LEIBR
TriTrypDb:
LbrM.05.0260 , LBRM2903_050007600
Length:
322

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H471
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H471

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 2 6 PF00656 0.489
CLV_NRD_NRD_1 266 268 PF00675 0.576
CLV_NRD_NRD_1 319 321 PF00675 0.697
CLV_NRD_NRD_1 81 83 PF00675 0.405
CLV_PCSK_FUR_1 272 276 PF00082 0.579
CLV_PCSK_KEX2_1 266 268 PF00082 0.593
CLV_PCSK_KEX2_1 274 276 PF00082 0.616
CLV_PCSK_KEX2_1 317 319 PF00082 0.653
CLV_PCSK_PC1ET2_1 274 276 PF00082 0.623
CLV_PCSK_PC1ET2_1 317 319 PF00082 0.670
CLV_PCSK_SKI1_1 288 292 PF00082 0.621
DEG_Kelch_Keap1_1 87 92 PF01344 0.649
DEG_SPOP_SBC_1 101 105 PF00917 0.426
DEG_SPOP_SBC_1 107 111 PF00917 0.457
DEG_SPOP_SBC_1 229 233 PF00917 0.734
DOC_ANK_TNKS_1 22 29 PF00023 0.559
DOC_CKS1_1 75 80 PF01111 0.595
DOC_CYCLIN_yCln2_LP_2 115 121 PF00134 0.308
DOC_PP2B_LxvP_1 115 118 PF13499 0.566
DOC_USP7_MATH_1 107 111 PF00917 0.483
DOC_USP7_MATH_1 171 175 PF00917 0.580
DOC_USP7_MATH_1 214 218 PF00917 0.643
DOC_WW_Pin1_4 222 227 PF00397 0.756
DOC_WW_Pin1_4 74 79 PF00397 0.522
DOC_WW_Pin1_4 84 89 PF00397 0.542
LIG_14-3-3_CanoR_1 18 23 PF00244 0.567
LIG_14-3-3_CanoR_1 201 205 PF00244 0.476
LIG_14-3-3_CterR_2 318 322 PF00244 0.550
LIG_BIR_III_4 37 41 PF00653 0.723
LIG_DLG_GKlike_1 18 25 PF00625 0.548
LIG_FHA_1 132 138 PF00498 0.411
LIG_FHA_1 173 179 PF00498 0.634
LIG_FHA_1 205 211 PF00498 0.435
LIG_FHA_1 232 238 PF00498 0.527
LIG_FHA_1 71 77 PF00498 0.489
LIG_FHA_1 88 94 PF00498 0.553
LIG_FHA_2 201 207 PF00498 0.576
LIG_FHA_2 257 263 PF00498 0.570
LIG_GBD_Chelix_1 25 33 PF00786 0.577
LIG_LIR_Gen_1 294 304 PF02991 0.518
LIG_LIR_Nem_3 127 132 PF02991 0.419
LIG_LIR_Nem_3 21 25 PF02991 0.450
LIG_LIR_Nem_3 294 299 PF02991 0.499
LIG_LYPXL_S_1 98 102 PF13949 0.359
LIG_LYPXL_yS_3 129 132 PF13949 0.488
LIG_NRBOX 63 69 PF00104 0.530
LIG_PCNA_yPIPBox_3 291 304 PF02747 0.624
LIG_RPA_C_Plants 277 288 PF08784 0.632
LIG_SH2_CRK 250 254 PF00017 0.551
LIG_SH2_SRC 194 197 PF00017 0.549
LIG_SH2_STAP1 119 123 PF00017 0.451
LIG_SH2_STAP1 162 166 PF00017 0.497
LIG_SH2_STAT5 194 197 PF00017 0.549
LIG_SH3_3 133 139 PF00018 0.467
LIG_SH3_3 165 171 PF00018 0.450
LIG_SH3_3 183 189 PF00018 0.531
LIG_SH3_3 207 213 PF00018 0.536
LIG_SH3_3 234 240 PF00018 0.558
LIG_SH3_3 95 101 PF00018 0.553
LIG_TRAF2_1 14 17 PF00917 0.513
LIG_TRAF2_1 203 206 PF00917 0.628
LIG_TRAF2_1 259 262 PF00917 0.577
MOD_CK1_1 103 109 PF00069 0.627
MOD_CK1_1 217 223 PF00069 0.760
MOD_CK1_1 225 231 PF00069 0.678
MOD_CK1_1 87 93 PF00069 0.562
MOD_CK2_1 11 17 PF00069 0.533
MOD_CK2_1 18 24 PF00069 0.481
MOD_CK2_1 200 206 PF00069 0.595
MOD_CK2_1 256 262 PF00069 0.566
MOD_Cter_Amidation 312 315 PF01082 0.625
MOD_GlcNHglycan 111 114 PF01048 0.424
MOD_GlcNHglycan 307 310 PF01048 0.706
MOD_GSK3_1 102 109 PF00069 0.696
MOD_GSK3_1 169 176 PF00069 0.622
MOD_GSK3_1 200 207 PF00069 0.458
MOD_GSK3_1 214 221 PF00069 0.579
MOD_GSK3_1 224 231 PF00069 0.693
MOD_GSK3_1 235 242 PF00069 0.504
MOD_GSK3_1 70 77 PF00069 0.513
MOD_LATS_1 316 322 PF00433 0.550
MOD_NEK2_1 102 107 PF00069 0.580
MOD_NEK2_1 204 209 PF00069 0.467
MOD_NEK2_2 180 185 PF00069 0.547
MOD_PIKK_1 248 254 PF00454 0.636
MOD_PKA_2 200 206 PF00069 0.469
MOD_PKB_1 254 262 PF00069 0.662
MOD_Plk_1 204 210 PF00069 0.467
MOD_Plk_1 70 76 PF00069 0.598
MOD_Plk_2-3 200 206 PF00069 0.500
MOD_Plk_4 204 210 PF00069 0.459
MOD_ProDKin_1 222 228 PF00069 0.758
MOD_ProDKin_1 74 80 PF00069 0.523
MOD_ProDKin_1 84 90 PF00069 0.542
MOD_SUMO_for_1 257 260 PF00179 0.690
MOD_SUMO_for_1 273 276 PF00179 0.363
TRG_DiLeu_BaEn_1 205 210 PF01217 0.575
TRG_DiLeu_BaEn_1 8 13 PF01217 0.584
TRG_DiLeu_BaEn_1 89 94 PF01217 0.403
TRG_ENDOCYTIC_2 119 122 PF00928 0.399
TRG_ENDOCYTIC_2 129 132 PF00928 0.323
TRG_ENDOCYTIC_2 22 25 PF00928 0.450
TRG_ENDOCYTIC_2 250 253 PF00928 0.483
TRG_ENDOCYTIC_2 99 102 PF00928 0.502
TRG_ER_diArg_1 253 256 PF00400 0.511
TRG_ER_diArg_1 266 268 PF00400 0.556
TRG_ER_diArg_1 318 320 PF00400 0.691
TRG_NLS_MonoCore_2 316 321 PF00514 0.694
TRG_NLS_MonoExtC_3 313 318 PF00514 0.663
TRG_NLS_MonoExtN_4 314 321 PF00514 0.682
TRG_Pf-PMV_PEXEL_1 23 27 PF00026 0.544
TRG_Pf-PMV_PEXEL_1 282 287 PF00026 0.434
TRG_Pf-PMV_PEXEL_1 62 66 PF00026 0.529

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3H6 Leptomonas seymouri 64% 100%
A0A0S4J6H5 Bodo saltans 32% 100%
A0A1X0P0L2 Trypanosomatidae 40% 100%
A0A3R7LUJ2 Trypanosoma rangeli 41% 100%
A0A3S5H5G9 Leishmania donovani 88% 100%
A4HSE6 Leishmania infantum 88% 81%
D0A4J8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AKD2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QJH6 Leishmania major 84% 99%
V5BBA9 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS