ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H470_LEIBR

TriTrypDb:

LbrM.05.0250 , LBRM2903_050007500

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H470

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H470

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	195	199	PF00656	0.506
CLV_C14_Caspase3-7	305	309	PF00656	0.747
CLV_C14_Caspase3-7	313	317	PF00656	0.598
CLV_NRD_NRD_1	257	259	PF00675	0.515
CLV_NRD_NRD_1	264	266	PF00675	0.543
CLV_NRD_NRD_1	272	274	PF00675	0.597
CLV_NRD_NRD_1	282	284	PF00675	0.629
CLV_PCSK_FUR_1	254	258	PF00082	0.451
CLV_PCSK_FUR_1	270	274	PF00082	0.393
CLV_PCSK_KEX2_1	152	154	PF00082	0.492
CLV_PCSK_KEX2_1	231	233	PF00082	0.492
CLV_PCSK_KEX2_1	256	258	PF00082	0.420
CLV_PCSK_KEX2_1	264	266	PF00082	0.514
CLV_PCSK_KEX2_1	272	274	PF00082	0.488
CLV_PCSK_KEX2_1	282	284	PF00082	0.629
CLV_PCSK_KEX2_1	84	86	PF00082	0.536
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.551
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.363
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.604
CLV_PCSK_SKI1_1	188	192	PF00082	0.647
CLV_PCSK_SKI1_1	78	82	PF00082	0.436
CLV_PCSK_SKI1_1	84	88	PF00082	0.432
DEG_Nend_UBRbox_2	1	3	PF02207	0.509
DOC_MAPK_MEF2A_6	107	116	PF00069	0.685
DOC_SPAK_OSR1_1	174	178	PF12202	0.512
DOC_USP7_MATH_1	135	139	PF00917	0.680
DOC_USP7_MATH_1	220	224	PF00917	0.410
DOC_WW_Pin1_4	108	113	PF00397	0.593
DOC_WW_Pin1_4	156	161	PF00397	0.480
DOC_WW_Pin1_4	210	215	PF00397	0.516
LIG_14-3-3_CanoR_1	107	112	PF00244	0.590
LIG_Actin_WH2_2	93	109	PF00022	0.363
LIG_CtBP_PxDLS_1	113	117	PF00389	0.559
LIG_CtBP_PxDLS_1	7	12	PF00389	0.499
LIG_FHA_1	109	115	PF00498	0.584
LIG_FHA_1	182	188	PF00498	0.472
LIG_FHA_1	224	230	PF00498	0.616
LIG_FHA_2	193	199	PF00498	0.576
LIG_FHA_2	238	244	PF00498	0.362
LIG_LIR_Gen_1	245	255	PF02991	0.602
LIG_LIR_Nem_3	117	122	PF02991	0.506
LIG_LIR_Nem_3	244	250	PF02991	0.605
LIG_SH2_CRK	119	123	PF00017	0.506
LIG_SH2_CRK	83	87	PF00017	0.483
LIG_SH2_STAP1	204	208	PF00017	0.461
LIG_SH2_STAT5	262	265	PF00017	0.640
LIG_SUMO_SIM_anti_2	225	231	PF11976	0.512
LIG_TRAF2_1	242	245	PF00917	0.520
LIG_TRAF2_1	277	280	PF00917	0.432
LIG_TRAF2_1	294	297	PF00917	0.438
LIG_TYR_ITIM	81	86	PF00017	0.500
MOD_CDK_SPxK_1	210	216	PF00069	0.624
MOD_CK1_1	138	144	PF00069	0.700
MOD_CK1_1	151	157	PF00069	0.431
MOD_CK1_1	223	229	PF00069	0.460
MOD_CK2_1	121	127	PF00069	0.640
MOD_CK2_1	222	228	PF00069	0.407
MOD_CK2_1	24	30	PF00069	0.543
MOD_CK2_1	274	280	PF00069	0.430
MOD_GlcNHglycan	131	134	PF01048	0.487
MOD_GlcNHglycan	302	305	PF01048	0.803
MOD_GSK3_1	188	195	PF00069	0.479
MOD_N-GLC_1	220	225	PF02516	0.548
MOD_N-GLC_1	300	305	PF02516	0.717
MOD_NEK2_1	106	111	PF00069	0.573
MOD_PKA_2	106	112	PF00069	0.611
MOD_Plk_1	114	120	PF00069	0.627
MOD_Plk_1	138	144	PF00069	0.725
MOD_Plk_2-3	306	312	PF00069	0.551
MOD_Plk_4	114	120	PF00069	0.627
MOD_ProDKin_1	108	114	PF00069	0.590
MOD_ProDKin_1	156	162	PF00069	0.411
MOD_ProDKin_1	210	216	PF00069	0.523
TRG_DiLeu_BaEn_2	243	249	PF01217	0.618
TRG_DiLeu_BaEn_4	8	14	PF01217	0.544
TRG_DiLeu_BaLyEn_6	82	87	PF01217	0.588
TRG_ENDOCYTIC_2	119	122	PF00928	0.498
TRG_ENDOCYTIC_2	83	86	PF00928	0.448
TRG_ER_diArg_1	153	156	PF00400	0.541
TRG_ER_diArg_1	254	257	PF00400	0.538
TRG_ER_diArg_1	263	265	PF00400	0.497
TRG_ER_diArg_1	270	273	PF00400	0.427
TRG_NLS_MonoExtN_4	150	156	PF00514	0.541
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHU8	Leptomonas seymouri	51%	76%
A0A3S7WP15	Leishmania donovani	81%	82%
A4HSE5	Leishmania infantum	81%	82%
E9AKD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	81%
Q4QJH7	Leishmania major	72%	100%