Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H469_LEIBR

TriTrypDb:

LbrM.05.0240 , LBRM2903_050007400

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4H469

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H469

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.417
CLV_NRD_NRD_1	123	125	PF00675	0.437
CLV_NRD_NRD_1	54	56	PF00675	0.596
CLV_PCSK_FUR_1	121	125	PF00082	0.512
CLV_PCSK_KEX2_1	102	104	PF00082	0.439
CLV_PCSK_KEX2_1	117	119	PF00082	0.397
CLV_PCSK_KEX2_1	123	125	PF00082	0.424
CLV_PCSK_KEX2_1	54	56	PF00082	0.582
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.445
CLV_PCSK_SKI1_1	103	107	PF00082	0.413
CLV_PCSK_SKI1_1	39	43	PF00082	0.609
CLV_PCSK_SKI1_1	71	75	PF00082	0.408
DEG_SCF_FBW7_1	81	87	PF00400	0.536
DOC_CKS1_1	81	86	PF01111	0.533
DOC_CYCLIN_RxL_1	99	109	PF00134	0.614
DOC_USP7_MATH_1	10	14	PF00917	0.374
DOC_USP7_MATH_1	25	29	PF00917	0.337
DOC_USP7_MATH_1	82	86	PF00917	0.681
DOC_WW_Pin1_4	13	18	PF00397	0.374
DOC_WW_Pin1_4	80	85	PF00397	0.699
LIG_14-3-3_CanoR_1	121	127	PF00244	0.716
LIG_14-3-3_CanoR_1	26	34	PF00244	0.358
LIG_BRCT_BRCA1_1	61	65	PF00533	0.480
LIG_FHA_1	85	91	PF00498	0.703
LIG_FHA_2	40	46	PF00498	0.411
LIG_LIR_Apic_2	83	89	PF02991	0.540
LIG_LIR_Gen_1	93	104	PF02991	0.656
LIG_LIR_Nem_3	62	68	PF02991	0.480
LIG_MLH1_MIPbox_1	61	65	PF16413	0.266
LIG_SH2_CRK	78	82	PF00017	0.619
LIG_SH2_NCK_1	44	48	PF00017	0.513
LIG_SH2_NCK_1	78	82	PF00017	0.597
LIG_SH2_SRC	44	47	PF00017	0.423
LIG_SH2_STAP1	44	48	PF00017	0.406
LIG_SH2_STAP1	78	82	PF00017	0.623
LIG_SH2_STAT5	58	61	PF00017	0.319
LIG_SH3_3	14	20	PF00018	0.373
LIG_TRAF2_1	111	114	PF00917	0.618
LIG_TRAF2_1	43	46	PF00917	0.463
LIG_UBA3_1	69	77	PF00899	0.345
LIG_WRPW_2	38	41	PF00400	0.431
MOD_CK1_1	12	18	PF00069	0.373
MOD_CK1_1	28	34	PF00069	0.322
MOD_CK1_1	80	86	PF00069	0.551
MOD_CK2_1	108	114	PF00069	0.635
MOD_CK2_1	39	45	PF00069	0.406
MOD_CK2_1	85	91	PF00069	0.727
MOD_GlcNHglycan	124	127	PF01048	0.550
MOD_GSK3_1	108	115	PF00069	0.658
MOD_GSK3_1	76	83	PF00069	0.549
MOD_GSK3_1	9	16	PF00069	0.490
MOD_NEK2_1	50	55	PF00069	0.446
MOD_NEK2_1	76	81	PF00069	0.575
MOD_PIKK_1	10	16	PF00454	0.376
MOD_PIKK_1	109	115	PF00454	0.651
MOD_PK_1	77	83	PF00069	0.623
MOD_PKA_2	122	128	PF00069	0.694
MOD_PKA_2	25	31	PF00069	0.363
MOD_Plk_4	28	34	PF00069	0.541
MOD_Plk_4	59	65	PF00069	0.480
MOD_ProDKin_1	13	19	PF00069	0.374
MOD_ProDKin_1	80	86	PF00069	0.703
TRG_ENDOCYTIC_2	38	41	PF00928	0.431
TRG_ENDOCYTIC_2	78	81	PF00928	0.608
TRG_ENDOCYTIC_2	96	99	PF00928	0.511
TRG_ER_diArg_1	102	104	PF00400	0.617
TRG_ER_diArg_1	120	123	PF00400	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBL3	Leptomonas seymouri	70%	100%
A0A1X0P0H9	Trypanosomatidae	52%	92%
A0A3S7WP03	Leishmania donovani	89%	100%
A0A422NDL6	Trypanosoma rangeli	47%	100%
A4HSE4	Leishmania infantum	89%	100%
D0A4K0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AKD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QJH8	Leishmania major	85%	100%
V5AVY7	Trypanosoma cruzi	54%	100%