Putative hydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hydrogenase, putative

Species:

Leishmania braziliensis

UniProt:

A4H468_LEIBR

TriTrypDb:

LbrM.05.0220 , LBRM2903_050007200

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H468

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H468

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0051536	iron-sulfur cluster binding	3	1
GO:0051539	4 iron, 4 sulfur cluster binding	4	1
GO:0051540	metal cluster binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	571	575	PF00656	0.561
CLV_NRD_NRD_1	197	199	PF00675	0.260
CLV_NRD_NRD_1	265	267	PF00675	0.212
CLV_NRD_NRD_1	416	418	PF00675	0.233
CLV_PCSK_FUR_1	195	199	PF00082	0.267
CLV_PCSK_KEX2_1	195	197	PF00082	0.255
CLV_PCSK_KEX2_1	2	4	PF00082	0.662
CLV_PCSK_KEX2_1	248	250	PF00082	0.229
CLV_PCSK_KEX2_1	416	418	PF00082	0.212
CLV_PCSK_KEX2_1	452	454	PF00082	0.226
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.635
CLV_PCSK_PC1ET2_1	248	250	PF00082	0.229
CLV_PCSK_PC1ET2_1	452	454	PF00082	0.226
CLV_PCSK_PC7_1	448	454	PF00082	0.315
CLV_PCSK_SKI1_1	111	115	PF00082	0.256
CLV_PCSK_SKI1_1	393	397	PF00082	0.276
CLV_PCSK_SKI1_1	448	452	PF00082	0.223
DEG_APCC_DBOX_1	76	84	PF00400	0.407
DEG_Nend_UBRbox_1	1	4	PF02207	0.479
DEG_SPOP_SBC_1	405	409	PF00917	0.500
DEG_SPOP_SBC_1	62	66	PF00917	0.580
DOC_PP2B_LxvP_1	95	98	PF13499	0.288
DOC_PP2B_PxIxI_1	170	176	PF00149	0.346
DOC_USP7_MATH_1	235	239	PF00917	0.515
DOC_USP7_MATH_1	271	275	PF00917	0.521
DOC_USP7_MATH_1	405	409	PF00917	0.523
DOC_USP7_MATH_1	456	460	PF00917	0.475
DOC_USP7_MATH_1	516	520	PF00917	0.697
DOC_USP7_MATH_1	524	528	PF00917	0.690
DOC_WW_Pin1_4	401	406	PF00397	0.518
DOC_WW_Pin1_4	514	519	PF00397	0.631
DOC_WW_Pin1_4	526	531	PF00397	0.616
DOC_WW_Pin1_4	58	63	PF00397	0.648
LIG_14-3-3_CanoR_1	111	119	PF00244	0.516
LIG_14-3-3_CanoR_1	393	398	PF00244	0.413
LIG_14-3-3_CanoR_1	458	463	PF00244	0.430
LIG_14-3-3_CanoR_1	578	582	PF00244	0.441
LIG_BRCT_BRCA1_1	458	462	PF00533	0.411
LIG_CtBP_PxDLS_1	398	402	PF00389	0.451
LIG_deltaCOP1_diTrp_1	574	581	PF00928	0.401
LIG_eIF4E_1	460	466	PF01652	0.412
LIG_FHA_1	114	120	PF00498	0.557
LIG_FHA_1	277	283	PF00498	0.445
LIG_FHA_1	291	297	PF00498	0.401
LIG_FHA_1	41	47	PF00498	0.390
LIG_FHA_1	410	416	PF00498	0.465
LIG_FHA_1	485	491	PF00498	0.338
LIG_FHA_2	187	193	PF00498	0.434
LIG_FHA_2	25	31	PF00498	0.407
LIG_FHA_2	37	43	PF00498	0.348
LIG_FHA_2	459	465	PF00498	0.412
LIG_FHA_2	578	584	PF00498	0.520
LIG_FHA_2	99	105	PF00498	0.225
LIG_GBD_Chelix_1	446	454	PF00786	0.174
LIG_LIR_Gen_1	101	110	PF02991	0.327
LIG_LIR_Gen_1	459	469	PF02991	0.413
LIG_LIR_Gen_1	585	592	PF02991	0.502
LIG_LIR_Nem_3	101	106	PF02991	0.244
LIG_LIR_Nem_3	459	465	PF02991	0.413
LIG_MYND_1	231	235	PF01753	0.426
LIG_Pex14_1	577	581	PF04695	0.374
LIG_PTAP_UEV_1	358	363	PF05743	0.354
LIG_RPA_C_Fungi	383	395	PF08784	0.241
LIG_SH2_NCK_1	103	107	PF00017	0.391
LIG_SH2_STAP1	103	107	PF00017	0.440
LIG_SH2_STAP1	292	296	PF00017	0.255
LIG_SH2_STAP1	497	501	PF00017	0.479
LIG_SH2_STAT3	339	342	PF00017	0.168
LIG_SH2_STAT3	438	441	PF00017	0.249
LIG_SH2_STAT5	221	224	PF00017	0.249
LIG_SH2_STAT5	292	295	PF00017	0.249
LIG_SH2_STAT5	460	463	PF00017	0.249
LIG_SH2_STAT5	531	534	PF00017	0.454
LIG_SH3_2	311	316	PF14604	0.325
LIG_SH3_3	308	314	PF00018	0.404
LIG_SH3_3	356	362	PF00018	0.168
LIG_SH3_3	9	15	PF00018	0.657
LIG_SUMO_SIM_anti_2	461	467	PF11976	0.249
LIG_SUMO_SIM_anti_2	487	495	PF11976	0.285
LIG_SUMO_SIM_par_1	174	179	PF11976	0.375
LIG_SUMO_SIM_par_1	208	213	PF11976	0.392
LIG_SUMO_SIM_par_1	79	85	PF11976	0.312
LIG_TRAF2_1	118	121	PF00917	0.319
LIG_TRAF2_1	189	192	PF00917	0.254
LIG_TYR_ITSM	99	106	PF00017	0.222
LIG_UBA3_1	302	307	PF00899	0.385
MOD_CK1_1	400	406	PF00069	0.425
MOD_CK1_1	61	67	PF00069	0.678
MOD_CK1_1	82	88	PF00069	0.297
MOD_CK2_1	186	192	PF00069	0.249
MOD_CK2_1	295	301	PF00069	0.264
MOD_CK2_1	36	42	PF00069	0.364
MOD_CK2_1	458	464	PF00069	0.249
MOD_CK2_1	47	53	PF00069	0.349
MOD_CK2_1	98	104	PF00069	0.358
MOD_GlcNHglycan	125	128	PF01048	0.563
MOD_GlcNHglycan	146	149	PF01048	0.711
MOD_GlcNHglycan	150	153	PF01048	0.388
MOD_GlcNHglycan	184	187	PF01048	0.404
MOD_GlcNHglycan	212	215	PF01048	0.200
MOD_GlcNHglycan	226	229	PF01048	0.329
MOD_GlcNHglycan	237	240	PF01048	0.367
MOD_GlcNHglycan	34	37	PF01048	0.442
MOD_GlcNHglycan	349	355	PF01048	0.316
MOD_GlcNHglycan	359	362	PF01048	0.297
MOD_GlcNHglycan	376	379	PF01048	0.259
MOD_GlcNHglycan	518	521	PF01048	0.689
MOD_GlcNHglycan	526	529	PF01048	0.725
MOD_GlcNHglycan	55	58	PF01048	0.458
MOD_GlcNHglycan	67	70	PF01048	0.657
MOD_GlcNHglycan	73	76	PF01048	0.432
MOD_GSK3_1	109	116	PF00069	0.284
MOD_GSK3_1	144	151	PF00069	0.733
MOD_GSK3_1	182	189	PF00069	0.298
MOD_GSK3_1	276	283	PF00069	0.391
MOD_GSK3_1	318	325	PF00069	0.331
MOD_GSK3_1	32	39	PF00069	0.377
MOD_GSK3_1	393	400	PF00069	0.360
MOD_GSK3_1	401	408	PF00069	0.350
MOD_GSK3_1	501	508	PF00069	0.556
MOD_GSK3_1	514	521	PF00069	0.616
MOD_GSK3_1	53	60	PF00069	0.528
MOD_GSK3_1	561	568	PF00069	0.591
MOD_GSK3_1	61	68	PF00069	0.637
MOD_N-GLC_1	334	339	PF02516	0.451
MOD_N-GLC_1	405	410	PF02516	0.293
MOD_N-GLC_1	561	566	PF02516	0.368
MOD_NEK2_1	109	114	PF00069	0.311
MOD_NEK2_1	210	215	PF00069	0.249
MOD_NEK2_1	32	37	PF00069	0.396
MOD_NEK2_1	352	357	PF00069	0.168
MOD_NEK2_1	374	379	PF00069	0.249
MOD_NEK2_2	577	582	PF00069	0.437
MOD_NEK2_2	98	103	PF00069	0.228
MOD_PIKK_1	285	291	PF00454	0.230
MOD_PIKK_1	342	348	PF00454	0.265
MOD_PIKK_1	479	485	PF00454	0.491
MOD_PIKK_1	82	88	PF00454	0.412
MOD_PK_1	79	85	PF00069	0.440
MOD_PKA_2	123	129	PF00069	0.597
MOD_PKA_2	271	277	PF00069	0.333
MOD_PKA_2	479	485	PF00069	0.456
MOD_PKA_2	577	583	PF00069	0.456
MOD_PKB_1	77	85	PF00069	0.461
MOD_Plk_1	369	375	PF00069	0.278
MOD_Plk_1	561	567	PF00069	0.525
MOD_Plk_4	380	386	PF00069	0.192
MOD_Plk_4	40	46	PF00069	0.398
MOD_Plk_4	458	464	PF00069	0.249
MOD_Plk_4	98	104	PF00069	0.233
MOD_ProDKin_1	401	407	PF00069	0.397
MOD_ProDKin_1	514	520	PF00069	0.630
MOD_ProDKin_1	526	532	PF00069	0.615
MOD_ProDKin_1	58	64	PF00069	0.658
MOD_SUMO_rev_2	259	268	PF00179	0.249
TRG_DiLeu_BaEn_2	169	175	PF01217	0.168
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.325
TRG_ENDOCYTIC_2	103	106	PF00928	0.410
TRG_ENDOCYTIC_2	460	463	PF00928	0.249
TRG_ER_diArg_1	195	198	PF00400	0.309
TRG_ER_diArg_1	415	417	PF00400	0.278
TRG_ER_diArg_1	550	553	PF00400	0.649
TRG_ER_diArg_1	76	79	PF00400	0.542
TRG_NLS_MonoExtC_3	450	455	PF00514	0.385
TRG_NLS_MonoExtN_4	448	455	PF00514	0.249

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2B2	Leptomonas seymouri	55%	94%
A0A0S4J2N1	Bodo saltans	38%	100%
A0A1X0P0T4	Trypanosomatidae	42%	100%
A0A3S7WP18	Leishmania donovani	76%	95%
A0A422NE31	Trypanosoma rangeli	42%	100%
A2Q9A9	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	28%	100%
A3LYR2	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	25%	100%
A4HSF5	Leishmania infantum	76%	95%
A5DSI2	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	26%	100%
A6RR15	Botryotinia fuckeliana (strain B05.10)	27%	100%
A7E7C4	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	27%	100%
A7SDA8	Nematostella vectensis	27%	100%
A8WH18	Xenopus tropicalis	26%	100%
B0Y4F9	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	28%	100%
B3N018	Drosophila ananassae	28%	100%
B3NKH7	Drosophila erecta	27%	100%
B4GXC8	Drosophila persimilis	28%	100%
B4IMH3	Drosophila sechellia	27%	100%
B4ISL0	Drosophila yakuba	27%	100%
B4JBE6	Drosophila grimshawi	28%	100%
B4KFU7	Drosophila mojavensis	27%	100%
B4LQR5	Drosophila virilis	29%	100%
B4MUM8	Drosophila willistoni	26%	100%
B5DK31	Drosophila pseudoobscura pseudoobscura	28%	100%
B6K2N0	Schizosaccharomyces japonicus (strain yFS275 / FY16936)	27%	100%
B6QQH9	Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)	27%	100%
D0A4K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AKC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	95%
Q0CR17	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	26%	100%
Q0UM75	Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)	28%	95%
Q16ML2	Aedes aegypti	26%	100%
Q1E736	Coccidioides immitis (strain RS)	26%	97%
Q2HEF1	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	27%	100%
Q4QJI0	Leishmania major	74%	100%
Q4WQ87	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	28%	100%
Q5B748	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q6DHP6	Danio rerio	26%	100%
Q7PWB8	Anopheles gambiae	25%	100%
Q7SGW5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	27%	100%
Q9CYQ7	Mus musculus	27%	100%
Q9UHQ1	Homo sapiens	26%	100%
Q9Y7N7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
V5DC01	Trypanosoma cruzi	42%	100%