G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania braziliensis

UniProt:

A4H466_LEIBR

TriTrypDb:

LbrM.05.0200 , LBRM2903_050006900

Length:

788

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H466

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H466

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0003924	GTPase activity	7	9
GO:0005488	binding	1	9
GO:0005525	GTP binding	5	9
GO:0016462	pyrophosphatase activity	5	9
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	9
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	9
GO:0019001	guanyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032561	guanyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	23	27	PF00656	0.370
CLV_C14_Caspase3-7	285	289	PF00656	0.559
CLV_C14_Caspase3-7	523	527	PF00656	0.456
CLV_C14_Caspase3-7	66	70	PF00656	0.539
CLV_NRD_NRD_1	21	23	PF00675	0.514
CLV_NRD_NRD_1	233	235	PF00675	0.390
CLV_NRD_NRD_1	456	458	PF00675	0.221
CLV_NRD_NRD_1	501	503	PF00675	0.411
CLV_NRD_NRD_1	539	541	PF00675	0.393
CLV_NRD_NRD_1	707	709	PF00675	0.524
CLV_NRD_NRD_1	765	767	PF00675	0.488
CLV_NRD_NRD_1	781	783	PF00675	0.539
CLV_PCSK_FUR_1	11	15	PF00082	0.554
CLV_PCSK_FUR_1	705	709	PF00082	0.523
CLV_PCSK_KEX2_1	122	124	PF00082	0.353
CLV_PCSK_KEX2_1	13	15	PF00082	0.548
CLV_PCSK_KEX2_1	21	23	PF00082	0.559
CLV_PCSK_KEX2_1	233	235	PF00082	0.390
CLV_PCSK_KEX2_1	314	316	PF00082	0.424
CLV_PCSK_KEX2_1	378	380	PF00082	0.549
CLV_PCSK_KEX2_1	456	458	PF00082	0.248
CLV_PCSK_KEX2_1	501	503	PF00082	0.411
CLV_PCSK_KEX2_1	538	540	PF00082	0.381
CLV_PCSK_KEX2_1	705	707	PF00082	0.534
CLV_PCSK_KEX2_1	709	711	PF00082	0.555
CLV_PCSK_KEX2_1	761	763	PF00082	0.504
CLV_PCSK_KEX2_1	765	767	PF00082	0.488
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.429
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.551
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.424
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.549
CLV_PCSK_PC1ET2_1	709	711	PF00082	0.559
CLV_PCSK_PC1ET2_1	761	763	PF00082	0.504
CLV_PCSK_PC7_1	705	711	PF00082	0.634
CLV_PCSK_SKI1_1	13	17	PF00082	0.609
CLV_PCSK_SKI1_1	140	144	PF00082	0.437
CLV_PCSK_SKI1_1	158	162	PF00082	0.462
CLV_PCSK_SKI1_1	206	210	PF00082	0.499
CLV_PCSK_SKI1_1	216	220	PF00082	0.411
CLV_PCSK_SKI1_1	25	29	PF00082	0.450
CLV_PCSK_SKI1_1	304	308	PF00082	0.557
CLV_PCSK_SKI1_1	309	313	PF00082	0.537
CLV_PCSK_SKI1_1	322	326	PF00082	0.552
CLV_PCSK_SKI1_1	357	361	PF00082	0.568
CLV_PCSK_SKI1_1	457	461	PF00082	0.221
CLV_PCSK_SKI1_1	505	509	PF00082	0.419
CLV_PCSK_SKI1_1	556	560	PF00082	0.325
CLV_PCSK_SKI1_1	698	702	PF00082	0.464
CLV_PCSK_SKI1_1	751	755	PF00082	0.670
CLV_PCSK_SKI1_1	766	770	PF00082	0.489
DEG_APCC_DBOX_1	146	154	PF00400	0.342
DEG_APCC_DBOX_1	683	691	PF00400	0.541
DEG_APCC_DBOX_1	764	772	PF00400	0.583
DEG_SCF_FBW7_1	437	444	PF00400	0.421
DOC_CKS1_1	160	165	PF01111	0.343
DOC_CKS1_1	406	411	PF01111	0.456
DOC_CKS1_1	742	747	PF01111	0.648
DOC_CYCLIN_RxL_1	212	225	PF00134	0.266
DOC_CYCLIN_yCln2_LP_2	325	331	PF00134	0.503
DOC_MAPK_gen_1	216	222	PF00069	0.331
DOC_MAPK_gen_1	321	331	PF00069	0.505
DOC_MAPK_gen_1	443	452	PF00069	0.421
DOC_MAPK_gen_1	553	563	PF00069	0.328
DOC_MAPK_gen_1	765	773	PF00069	0.543
DOC_MAPK_MEF2A_6	180	188	PF00069	0.294
DOC_MAPK_MEF2A_6	556	563	PF00069	0.324
DOC_MAPK_MEF2A_6	725	733	PF00069	0.607
DOC_MAPK_NFAT4_5	556	564	PF00069	0.331
DOC_PP2B_LxvP_1	118	121	PF13499	0.329
DOC_PP2B_LxvP_1	325	328	PF13499	0.537
DOC_PP2B_LxvP_1	450	453	PF13499	0.421
DOC_USP7_MATH_1	208	212	PF00917	0.394
DOC_USP7_MATH_1	268	272	PF00917	0.729
DOC_USP7_MATH_1	365	369	PF00917	0.561
DOC_USP7_MATH_1	598	602	PF00917	0.633
DOC_USP7_MATH_1	677	681	PF00917	0.549
DOC_USP7_UBL2_3	212	216	PF12436	0.490
DOC_USP7_UBL2_3	317	321	PF12436	0.447
DOC_USP7_UBL2_3	49	53	PF12436	0.565
DOC_USP7_UBL2_3	556	560	PF12436	0.419
DOC_USP7_UBL2_3	757	761	PF12436	0.516
DOC_USP7_UBL2_3	96	100	PF12436	0.387
DOC_WW_Pin1_4	159	164	PF00397	0.352
DOC_WW_Pin1_4	405	410	PF00397	0.397
DOC_WW_Pin1_4	437	442	PF00397	0.421
DOC_WW_Pin1_4	593	598	PF00397	0.600
DOC_WW_Pin1_4	741	746	PF00397	0.560
LIG_14-3-3_CanoR_1	147	151	PF00244	0.435
LIG_14-3-3_CanoR_1	21	25	PF00244	0.497
LIG_14-3-3_CanoR_1	47	56	PF00244	0.534
LIG_14-3-3_CanoR_1	646	651	PF00244	0.523
LIG_14-3-3_CanoR_1	679	683	PF00244	0.555
LIG_APCC_ABBA_1	559	564	PF00400	0.332
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_2	665	669	PF00653	0.595
LIG_BIR_III_4	292	296	PF00653	0.465
LIG_BIR_III_4	622	626	PF00653	0.700
LIG_BRCT_BRCA1_1	197	201	PF00533	0.393
LIG_BRCT_BRCA1_2	197	203	PF00533	0.398
LIG_Clathr_ClatBox_1	658	662	PF01394	0.482
LIG_Clathr_ClatBox_1	687	691	PF01394	0.540
LIG_deltaCOP1_diTrp_1	169	175	PF00928	0.296
LIG_FHA_1	447	453	PF00498	0.421
LIG_FHA_1	488	494	PF00498	0.409
LIG_FHA_1	56	62	PF00498	0.441
LIG_FHA_1	608	614	PF00498	0.726
LIG_FHA_2	160	166	PF00498	0.343
LIG_FHA_2	358	364	PF00498	0.482
LIG_FHA_2	381	387	PF00498	0.436
LIG_FHA_2	486	492	PF00498	0.370
LIG_FHA_2	585	591	PF00498	0.518
LIG_FHA_2	681	687	PF00498	0.454
LIG_GBD_Chelix_1	528	536	PF00786	0.429
LIG_IBAR_NPY_1	333	335	PF08397	0.441
LIG_Integrin_RGD_1	243	245	PF01839	0.435
LIG_LIR_Gen_1	110	118	PF02991	0.411
LIG_LIR_Gen_1	380	390	PF02991	0.458
LIG_LIR_Gen_1	444	453	PF02991	0.421
LIG_LIR_Gen_1	564	574	PF02991	0.453
LIG_LIR_Gen_1	62	70	PF02991	0.426
LIG_LIR_Gen_1	633	642	PF02991	0.558
LIG_LIR_Gen_1	683	692	PF02991	0.540
LIG_LIR_Nem_3	110	114	PF02991	0.428
LIG_LIR_Nem_3	169	174	PF02991	0.310
LIG_LIR_Nem_3	198	204	PF02991	0.373
LIG_LIR_Nem_3	245	250	PF02991	0.371
LIG_LIR_Nem_3	380	385	PF02991	0.462
LIG_LIR_Nem_3	444	450	PF02991	0.421
LIG_LIR_Nem_3	564	570	PF02991	0.443
LIG_LIR_Nem_3	62	67	PF02991	0.422
LIG_LIR_Nem_3	633	639	PF02991	0.553
LIG_LIR_Nem_3	680	685	PF02991	0.563
LIG_LYPXL_yS_3	417	420	PF13949	0.421
LIG_Pex14_1	236	240	PF04695	0.316
LIG_REV1ctd_RIR_1	247	253	PF16727	0.420
LIG_RPA_C_Fungi	364	376	PF08784	0.386
LIG_RPA_C_Fungi	691	703	PF08784	0.544
LIG_SH2_CRK	672	676	PF00017	0.526
LIG_SH2_NCK_1	272	276	PF00017	0.487
LIG_SH2_NCK_1	335	339	PF00017	0.368
LIG_SH2_PTP2	569	572	PF00017	0.387
LIG_SH2_SRC	272	275	PF00017	0.486
LIG_SH2_SRC	562	565	PF00017	0.339
LIG_SH2_SRC	569	572	PF00017	0.353
LIG_SH2_STAP1	164	168	PF00017	0.320
LIG_SH2_STAP1	335	339	PF00017	0.521
LIG_SH2_STAT3	239	242	PF00017	0.346
LIG_SH2_STAT3	588	591	PF00017	0.587
LIG_SH2_STAT3	90	93	PF00017	0.394
LIG_SH2_STAT5	204	207	PF00017	0.395
LIG_SH2_STAT5	239	242	PF00017	0.331
LIG_SH2_STAT5	562	565	PF00017	0.433
LIG_SH2_STAT5	566	569	PF00017	0.346
LIG_SH2_STAT5	588	591	PF00017	0.599
LIG_SH2_STAT5	657	660	PF00017	0.486
LIG_SH2_STAT5	75	78	PF00017	0.558
LIG_SH2_STAT5	90	93	PF00017	0.569
LIG_SH3_3	118	124	PF00018	0.339
LIG_SH3_3	251	257	PF00018	0.500
LIG_SH3_3	328	334	PF00018	0.470
LIG_SH3_3	381	387	PF00018	0.434
LIG_SH3_3	403	409	PF00018	0.439
LIG_SH3_3	412	418	PF00018	0.266
LIG_SH3_3	567	573	PF00018	0.379
LIG_SH3_3	746	752	PF00018	0.658
LIG_SH3_4	757	764	PF00018	0.584
LIG_SUMO_SIM_anti_2	182	189	PF11976	0.288
LIG_SUMO_SIM_anti_2	392	400	PF11976	0.286
LIG_SUMO_SIM_par_1	734	744	PF11976	0.633
LIG_TRAF2_1	300	303	PF00917	0.637
LIG_TRAF2_1	360	363	PF00917	0.537
LIG_TRAF2_1	609	612	PF00917	0.648
LIG_TRAF2_1	630	633	PF00917	0.577
LIG_TRAF2_1	70	73	PF00917	0.526
LIG_TRAF2_2	387	392	PF00917	0.352
LIG_TYR_ITIM	415	420	PF00017	0.258
LIG_UBA3_1	219	224	PF00899	0.292
LIG_WRC_WIRS_1	468	473	PF05994	0.348
LIG_WW_1	573	576	PF00397	0.402
MOD_CDK_SPxK_1	437	443	PF00069	0.258
MOD_CDK_SPxxK_3	159	166	PF00069	0.344
MOD_CK1_1	470	476	PF00069	0.361
MOD_CK1_1	584	590	PF00069	0.407
MOD_CK1_1	680	686	PF00069	0.517
MOD_CK2_1	159	165	PF00069	0.362
MOD_CK2_1	208	214	PF00069	0.479
MOD_CK2_1	274	280	PF00069	0.486
MOD_CK2_1	357	363	PF00069	0.489
MOD_CK2_1	51	57	PF00069	0.434
MOD_CK2_1	524	530	PF00069	0.388
MOD_CK2_1	584	590	PF00069	0.517
MOD_CK2_1	627	633	PF00069	0.597
MOD_CK2_1	680	686	PF00069	0.463
MOD_Cter_Amidation	19	22	PF01082	0.540
MOD_GlcNHglycan	130	133	PF01048	0.403
MOD_GlcNHglycan	197	200	PF01048	0.383
MOD_GlcNHglycan	206	209	PF01048	0.337
MOD_GlcNHglycan	250	253	PF01048	0.343
MOD_GlcNHglycan	437	440	PF01048	0.278
MOD_GlcNHglycan	593	596	PF01048	0.589
MOD_GlcNHglycan	600	603	PF01048	0.629
MOD_GlcNHglycan	640	643	PF01048	0.598
MOD_GSK3_1	112	119	PF00069	0.432
MOD_GSK3_1	204	211	PF00069	0.416
MOD_GSK3_1	222	229	PF00069	0.223
MOD_GSK3_1	264	271	PF00069	0.576
MOD_GSK3_1	401	408	PF00069	0.453
MOD_GSK3_1	437	444	PF00069	0.262
MOD_GSK3_1	467	474	PF00069	0.342
MOD_GSK3_1	47	54	PF00069	0.486
MOD_GSK3_1	485	492	PF00069	0.367
MOD_GSK3_1	9	16	PF00069	0.471
MOD_LATS_1	313	319	PF00433	0.563
MOD_N-GLC_1	222	227	PF02516	0.322
MOD_N-GLC_1	512	517	PF02516	0.382
MOD_NEK2_1	1	6	PF00069	0.497
MOD_NEK2_1	114	119	PF00069	0.437
MOD_NEK2_1	248	253	PF00069	0.425
MOD_NEK2_1	471	476	PF00069	0.397
MOD_NEK2_1	493	498	PF00069	0.543
MOD_NEK2_1	512	517	PF00069	0.263
MOD_NEK2_1	678	683	PF00069	0.534
MOD_NEK2_1	9	14	PF00069	0.450
MOD_PIKK_1	256	262	PF00454	0.431
MOD_PIKK_1	47	53	PF00454	0.554
MOD_PKA_1	13	19	PF00069	0.491
MOD_PKA_1	708	714	PF00069	0.545
MOD_PKA_2	13	19	PF00069	0.495
MOD_PKA_2	146	152	PF00069	0.436
MOD_PKA_2	20	26	PF00069	0.475
MOD_PKA_2	365	371	PF00069	0.470
MOD_PKA_2	678	684	PF00069	0.569
MOD_PKB_1	706	714	PF00069	0.512
MOD_Plk_1	287	293	PF00069	0.549
MOD_Plk_1	512	518	PF00069	0.390
MOD_Plk_1	71	77	PF00069	0.385
MOD_Plk_2-3	380	386	PF00069	0.446
MOD_Plk_2-3	524	530	PF00069	0.423
MOD_Plk_2-3	607	613	PF00069	0.506
MOD_Plk_2-3	627	633	PF00069	0.598
MOD_Plk_4	51	57	PF00069	0.434
MOD_Plk_4	512	518	PF00069	0.341
MOD_Plk_4	584	590	PF00069	0.407
MOD_Plk_4	653	659	PF00069	0.478
MOD_Plk_4	71	77	PF00069	0.337
MOD_Plk_4	718	724	PF00069	0.569
MOD_ProDKin_1	159	165	PF00069	0.345
MOD_ProDKin_1	405	411	PF00069	0.388
MOD_ProDKin_1	437	443	PF00069	0.258
MOD_ProDKin_1	593	599	PF00069	0.602
MOD_ProDKin_1	741	747	PF00069	0.562
MOD_SUMO_for_1	353	356	PF00179	0.640
MOD_SUMO_for_1	377	380	PF00179	0.537
MOD_SUMO_rev_2	133	143	PF00179	0.550
MOD_SUMO_rev_2	154	160	PF00179	0.492
MOD_SUMO_rev_2	211	218	PF00179	0.483
MOD_SUMO_rev_2	350	359	PF00179	0.454
TRG_DiLeu_BaEn_1	156	161	PF01217	0.475
TRG_DiLeu_BaEn_2	138	144	PF01217	0.344
TRG_DiLeu_BaLyEn_6	528	533	PF01217	0.375
TRG_ENDOCYTIC_2	417	420	PF00928	0.258
TRG_ENDOCYTIC_2	685	688	PF00928	0.547
TRG_ER_diArg_1	456	458	PF00400	0.258
TRG_ER_diArg_1	501	503	PF00400	0.411
TRG_ER_diArg_1	538	540	PF00400	0.381
TRG_ER_diArg_1	705	708	PF00400	0.510
TRG_NES_CRM1_1	386	400	PF08389	0.281
TRG_NLS_MonoExtN_4	319	325	PF00514	0.439
TRG_NLS_MonoExtN_4	705	712	PF00514	0.564
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.568
TRG_Pf-PMV_PEXEL_1	646	650	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	766	770	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S3	Leptomonas seymouri	74%	100%
A0A3S5H5G5	Leishmania donovani	86%	100%
A0A422NYH3	Trypanosoma rangeli	51%	100%
A4HSD4	Leishmania infantum	86%	100%
C9ZPW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
E9AKC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q2YDM7	Bos taurus	34%	100%
Q4QJI3	Leishmania major	85%	100%
Q4R8L2	Macaca fascicularis	33%	100%
Q6NY89	Danio rerio	37%	100%
Q9SJF1	Arabidopsis thaliana	34%	100%