C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Fip1 motif/Zinc finger C-x8-C-x5-C-x3-H type (and similar), putative

Species:

Leishmania braziliensis

UniProt:

A4H465_LEIBR

TriTrypDb:

LbrM.05.0190 , LBRM2903_050006800

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	8
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4H465

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H465

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006378	mRNA polyadenylation	7	1
GO:0006379	mRNA cleavage	7	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	1
GO:0090501	RNA phosphodiester bond hydrolysis	6	1
GO:0098787	mRNA cleavage involved in mRNA processing	8	1
GO:0098789	pre-mRNA cleavage required for polyadenylation	9	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.654
CLV_PCSK_KEX2_1	335	337	PF00082	0.669
CLV_PCSK_KEX2_1	72	74	PF00082	0.338
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.669
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.300
CLV_PCSK_PC7_1	331	337	PF00082	0.665
DEG_Nend_UBRbox_2	1	3	PF02207	0.555
DOC_CKS1_1	275	280	PF01111	0.718
DOC_CYCLIN_yCln2_LP_2	299	302	PF00134	0.612
DOC_PP2B_LxvP_1	299	302	PF13499	0.612
DOC_PP4_FxxP_1	197	200	PF00568	0.553
DOC_PP4_FxxP_1	330	333	PF00568	0.669
DOC_USP7_MATH_1	25	29	PF00917	0.508
DOC_USP7_MATH_1	315	319	PF00917	0.616
DOC_WW_Pin1_4	274	279	PF00397	0.723
LIG_ActinCP_TwfCPI_2	197	206	PF01115	0.429
LIG_BIR_III_2	24	28	PF00653	0.658
LIG_BRCT_BRCA1_1	59	63	PF00533	0.588
LIG_FHA_1	112	118	PF00498	0.539
LIG_FHA_1	37	43	PF00498	0.623
LIG_FHA_2	32	38	PF00498	0.671
LIG_Integrin_RGD_1	220	222	PF01839	0.329
LIG_LIR_Apic_2	196	200	PF02991	0.493
LIG_LIR_Apic_2	328	333	PF02991	0.687
LIG_LIR_Nem_3	7	11	PF02991	0.600
LIG_LIR_Nem_3	84	88	PF02991	0.299
LIG_LIR_Nem_3	92	98	PF02991	0.300
LIG_MYND_1	244	248	PF01753	0.513
LIG_Pex14_2	86	90	PF04695	0.300
LIG_PTB_Apo_2	84	91	PF02174	0.300
LIG_SH2_CRK	180	184	PF00017	0.673
LIG_SH2_CRK	276	280	PF00017	0.691
LIG_SH2_GRB2like	85	88	PF00017	0.300
LIG_SH2_NCK_1	276	280	PF00017	0.685
LIG_SH2_SRC	65	68	PF00017	0.300
LIG_SH2_STAP1	65	69	PF00017	0.376
LIG_SH2_STAT3	168	171	PF00017	0.646
LIG_SH2_STAT3	345	348	PF00017	0.654
LIG_SH2_STAT5	276	279	PF00017	0.644
LIG_SH2_STAT5	298	301	PF00017	0.649
LIG_SH2_STAT5	85	88	PF00017	0.300
LIG_SH2_STAT5	98	101	PF00017	0.300
LIG_SH3_1	180	186	PF00018	0.666
LIG_SH3_1	275	281	PF00018	0.650
LIG_SH3_1	331	337	PF00018	0.681
LIG_SH3_2	290	295	PF14604	0.671
LIG_SH3_3	180	186	PF00018	0.666
LIG_SH3_3	238	244	PF00018	0.733
LIG_SH3_3	275	281	PF00018	0.739
LIG_SH3_3	287	293	PF00018	0.615
LIG_SH3_3	309	315	PF00018	0.574
LIG_SH3_3	331	337	PF00018	0.723
LIG_SH3_3	341	347	PF00018	0.630
LIG_SH3_3	50	56	PF00018	0.568
LIG_SUMO_SIM_anti_2	66	71	PF11976	0.376
LIG_TRAF2_1	100	103	PF00917	0.376
LIG_TRAF2_1	139	142	PF00917	0.563
LIG_TRAF2_1	337	340	PF00917	0.552
MOD_CK1_1	59	65	PF00069	0.612
MOD_CK2_1	31	37	PF00069	0.629
MOD_GlcNHglycan	2	5	PF01048	0.476
MOD_GlcNHglycan	255	258	PF01048	0.671
MOD_GlcNHglycan	321	324	PF01048	0.686
MOD_GlcNHglycan	327	330	PF01048	0.686
MOD_GlcNHglycan	59	62	PF01048	0.590
MOD_GSK3_1	31	38	PF00069	0.536
MOD_GSK3_1	315	322	PF00069	0.677
MOD_PKA_2	25	31	PF00069	0.584
MOD_Plk_1	105	111	PF00069	0.495
MOD_Plk_1	91	97	PF00069	0.309
MOD_Plk_4	105	111	PF00069	0.522
MOD_ProDKin_1	274	280	PF00069	0.721
MOD_SUMO_rev_2	35	45	PF00179	0.503
TRG_DiLeu_BaEn_3	141	147	PF01217	0.485
TRG_ENDOCYTIC_2	98	101	PF00928	0.300
TRG_NLS_MonoCore_2	334	339	PF00514	0.684
TRG_NLS_MonoExtC_3	334	340	PF00514	0.667
TRG_NLS_MonoExtN_4	333	339	PF00514	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N7	Leptomonas seymouri	53%	100%
A0A3S5H5G4	Leishmania donovani	79%	97%
A4HSD3	Leishmania infantum	79%	97%
C9ZPW6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AKC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	94%
Q4QJI4	Leishmania major	80%	100%