Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydrolipoamide branched chain transacylase, putative

Species:

Leishmania braziliensis

UniProt:

A4H464_LEIBR

TriTrypDb:

LbrM.05.0180 , LBRM2903_050006700

Length:

471

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H464

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H464

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0005488	binding	1	1
GO:0005504	fatty acid binding	3	1
GO:0008289	lipid binding	2	1
GO:0016407	acetyltransferase activity	5	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1
GO:0031405	lipoic acid binding	3	1
GO:0031406	carboxylic acid binding	4	1
GO:0033293	monocarboxylic acid binding	5	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0043177	organic acid binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1901681	sulfur compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.467
CLV_C14_Caspase3-7	279	283	PF00656	0.242
CLV_MEL_PAP_1	8	14	PF00089	0.431
CLV_NRD_NRD_1	10	12	PF00675	0.545
CLV_NRD_NRD_1	246	248	PF00675	0.274
CLV_NRD_NRD_1	28	30	PF00675	0.475
CLV_NRD_NRD_1	326	328	PF00675	0.331
CLV_NRD_NRD_1	352	354	PF00675	0.340
CLV_PCSK_KEX2_1	10	12	PF00082	0.564
CLV_PCSK_KEX2_1	246	248	PF00082	0.331
CLV_PCSK_KEX2_1	28	30	PF00082	0.475
CLV_PCSK_SKI1_1	251	255	PF00082	0.208
CLV_PCSK_SKI1_1	354	358	PF00082	0.272
CLV_PCSK_SKI1_1	451	455	PF00082	0.247
CLV_PCSK_SKI1_1	457	461	PF00082	0.365
DEG_APCC_DBOX_1	172	180	PF00400	0.380
DEG_Nend_UBRbox_1	1	4	PF02207	0.607
DOC_CKS1_1	163	168	PF01111	0.437
DOC_CKS1_1	337	342	PF01111	0.272
DOC_CYCLIN_RxL_1	451	464	PF00134	0.331
DOC_CYCLIN_yCln2_LP_2	343	349	PF00134	0.220
DOC_CYCLIN_yCln2_LP_2	402	405	PF00134	0.331
DOC_MAPK_gen_1	190	199	PF00069	0.485
DOC_MAPK_gen_1	287	296	PF00069	0.274
DOC_MAPK_gen_1	327	335	PF00069	0.361
DOC_MAPK_gen_1	353	361	PF00069	0.340
DOC_MAPK_HePTP_8	351	363	PF00069	0.269
DOC_MAPK_MEF2A_6	107	115	PF00069	0.331
DOC_MAPK_MEF2A_6	353	361	PF00069	0.279
DOC_PP1_RVXF_1	291	297	PF00149	0.272
DOC_PP2B_LxvP_1	229	232	PF13499	0.373
DOC_PP2B_LxvP_1	343	346	PF13499	0.317
DOC_PP2B_LxvP_1	402	405	PF13499	0.348
DOC_PP2B_PxIxI_1	240	246	PF00149	0.193
DOC_USP7_MATH_1	127	131	PF00917	0.596
DOC_USP7_MATH_1	139	143	PF00917	0.616
DOC_USP7_MATH_1	145	149	PF00917	0.575
DOC_USP7_MATH_1	202	206	PF00917	0.644
DOC_USP7_MATH_1	218	222	PF00917	0.657
DOC_USP7_MATH_1	276	280	PF00917	0.193
DOC_USP7_MATH_1	320	324	PF00917	0.301
DOC_USP7_MATH_1	65	69	PF00917	0.281
DOC_USP7_UBL2_3	281	285	PF12436	0.331
DOC_USP7_UBL2_3	289	293	PF12436	0.331
DOC_USP7_UBL2_3	92	96	PF12436	0.226
DOC_WW_Pin1_4	132	137	PF00397	0.594
DOC_WW_Pin1_4	162	167	PF00397	0.272
DOC_WW_Pin1_4	208	213	PF00397	0.566
DOC_WW_Pin1_4	336	341	PF00397	0.272
LIG_14-3-3_CanoR_1	147	153	PF00244	0.527
LIG_14-3-3_CanoR_1	451	460	PF00244	0.345
LIG_Actin_WH2_2	266	283	PF00022	0.272
LIG_APCC_ABBA_1	347	352	PF00400	0.193
LIG_BIR_III_4	422	426	PF00653	0.320
LIG_CtBP_PxDLS_1	212	216	PF00389	0.477
LIG_eIF4E_1	268	274	PF01652	0.220
LIG_FHA_1	103	109	PF00498	0.272
LIG_FHA_1	218	224	PF00498	0.589
LIG_FHA_1	32	38	PF00498	0.433
LIG_FHA_1	382	388	PF00498	0.317
LIG_FHA_1	396	402	PF00498	0.317
LIG_FHA_1	82	88	PF00498	0.272
LIG_FHA_2	190	196	PF00498	0.438
LIG_FHA_2	261	267	PF00498	0.332
LIG_FHA_2	363	369	PF00498	0.202
LIG_FHA_2	374	380	PF00498	0.331
LIG_LIR_Nem_3	295	299	PF02991	0.272
LIG_LIR_Nem_3	71	75	PF02991	0.274
LIG_LIR_Nem_3	88	94	PF02991	0.287
LIG_MYND_1	400	404	PF01753	0.331
LIG_Pex14_2	296	300	PF04695	0.272
LIG_PTAP_UEV_1	140	145	PF05743	0.503
LIG_REV1ctd_RIR_1	297	306	PF16727	0.272
LIG_SH2_CRK	91	95	PF00017	0.331
LIG_SH2_STAP1	428	432	PF00017	0.340
LIG_SH2_STAT5	30	33	PF00017	0.512
LIG_SH2_STAT5	99	102	PF00017	0.299
LIG_SH3_3	135	141	PF00018	0.500
LIG_SH3_3	207	213	PF00018	0.649
LIG_SH3_3	229	235	PF00018	0.404
LIG_SH3_3	394	400	PF00018	0.331
LIG_SUMO_SIM_par_1	83	89	PF11976	0.272
LIG_SxIP_EBH_1	35	45	PF03271	0.349
LIG_WRC_WIRS_1	259	264	PF05994	0.272
MOD_CDK_SPxxK_3	162	169	PF00069	0.272
MOD_CK1_1	132	138	PF00069	0.603
MOD_CK1_1	148	154	PF00069	0.714
MOD_CK1_1	155	161	PF00069	0.518
MOD_CK1_1	211	217	PF00069	0.613
MOD_CK1_1	258	264	PF00069	0.331
MOD_CK2_1	260	266	PF00069	0.332
MOD_CK2_1	362	368	PF00069	0.267
MOD_CK2_1	65	71	PF00069	0.340
MOD_GlcNHglycan	131	134	PF01048	0.593
MOD_GlcNHglycan	141	144	PF01048	0.630
MOD_GlcNHglycan	158	161	PF01048	0.550
MOD_GlcNHglycan	220	223	PF01048	0.539
MOD_GlcNHglycan	321	325	PF01048	0.342
MOD_GSK3_1	125	132	PF00069	0.568
MOD_GSK3_1	148	155	PF00069	0.711
MOD_GSK3_1	251	258	PF00069	0.284
MOD_GSK3_1	381	388	PF00069	0.365
MOD_GSK3_1	77	84	PF00069	0.272
MOD_NEK2_1	37	42	PF00069	0.501
MOD_NEK2_1	385	390	PF00069	0.272
MOD_NEK2_1	452	457	PF00069	0.327
MOD_NEK2_2	17	22	PF00069	0.441
MOD_NEK2_2	276	281	PF00069	0.217
MOD_OFUCOSY	35	41	PF10250	0.383
MOD_PIKK_1	125	131	PF00454	0.543
MOD_PIKK_1	23	29	PF00454	0.512
MOD_PIKK_1	251	257	PF00454	0.323
MOD_PIKK_1	374	380	PF00454	0.340
MOD_PK_1	107	113	PF00069	0.331
MOD_PK_1	302	308	PF00069	0.340
MOD_PKA_2	146	152	PF00069	0.533
MOD_PKA_2	189	195	PF00069	0.486
MOD_PKA_2	276	282	PF00069	0.340
MOD_PKA_2	352	358	PF00069	0.340
MOD_Plk_1	268	274	PF00069	0.334
MOD_Plk_1	320	326	PF00069	0.371
MOD_Plk_2-3	352	358	PF00069	0.272
MOD_Plk_2-3	362	368	PF00069	0.272
MOD_Plk_2-3	81	87	PF00069	0.272
MOD_Plk_4	107	113	PF00069	0.272
MOD_Plk_4	235	241	PF00069	0.386
MOD_Plk_4	292	298	PF00069	0.282
MOD_Plk_4	352	358	PF00069	0.272
MOD_Plk_4	362	368	PF00069	0.272
MOD_Plk_4	4	10	PF00069	0.429
MOD_Plk_4	445	451	PF00069	0.286
MOD_ProDKin_1	132	138	PF00069	0.590
MOD_ProDKin_1	162	168	PF00069	0.272
MOD_ProDKin_1	208	214	PF00069	0.567
MOD_ProDKin_1	336	342	PF00069	0.272
MOD_SUMO_rev_2	148	154	PF00179	0.525
TRG_DiLeu_BaEn_1	269	274	PF01217	0.272
TRG_ENDOCYTIC_2	91	94	PF00928	0.331
TRG_ER_diArg_1	245	247	PF00400	0.331
TRG_ER_diArg_1	28	30	PF00400	0.422
TRG_ER_diArg_1	9	11	PF00400	0.492
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHV8	Leptomonas seymouri	25%	100%
A0A0N1PBB0	Leptomonas seymouri	69%	83%
A0A0S4JC61	Bodo saltans	28%	100%
A0A0S4JS90	Bodo saltans	49%	100%
A0A1X0NKN9	Trypanosomatidae	24%	100%
A0A1X0P2L7	Trypanosomatidae	40%	94%
A0A3Q8IJE7	Leishmania donovani	25%	100%
A0A3S5H5G3	Leishmania donovani	82%	99%
A0A3S5ISA9	Trypanosoma rangeli	43%	100%
A4HPD2	Leishmania braziliensis	26%	100%
A4ICH2	Leishmania infantum	25%	100%
C9ZPW7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A3J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AG63	Leishmania infantum	82%	99%
E9AKC2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
E9AT43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
G0S4X6	Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)	26%	100%
O00330	Homo sapiens	25%	94%
O06159	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	30%	100%
O31550	Bacillus subtilis (strain 168)	25%	100%
O59816	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	98%
O66119	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)	25%	100%
O94681	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P06959	Escherichia coli (strain K12)	32%	75%
P08461	Rattus norvegicus	27%	75%
P09062	Pseudomonas putida	31%	100%
P0AFG6	Escherichia coli (strain K12)	27%	100%
P0AFG7	Escherichia coli O157:H7	27%	100%
P10515	Homo sapiens	27%	73%
P10802	Azotobacter vinelandii	32%	74%
P11181	Bos taurus	42%	98%
P11182	Homo sapiens	42%	98%
P11961	Geobacillus stearothermophilus	34%	100%
P12695	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	98%
P16263	Bacillus subtilis (strain 168)	29%	100%
P19262	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P20285	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	26%	100%
P20708	Azotobacter vinelandii	27%	100%
P21883	Bacillus subtilis (strain 168)	31%	100%
P22439	Bos taurus	26%	94%
P35489	Acholeplasma laidlawii	30%	87%
P36413	Dictyostelium discoideum	27%	74%
P37942	Bacillus subtilis (strain 168)	32%	100%
P45118	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	28%	83%
P45302	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	26%	100%
P47514	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	26%	100%
P52993	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	28%	100%
P53395	Mus musculus	43%	98%
P57302	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	25%	100%
P65634	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	33%	85%
P65635	Staphylococcus aureus (strain Mu50 / ATCC 700699)	36%	100%
P65636	Staphylococcus aureus (strain N315)	36%	100%
P9WIS6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	33%	85%
P9WIS7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	33%	85%
Q0WQF7	Arabidopsis thaliana	25%	74%
Q19749	Caenorhabditis elegans	31%	93%
Q1RHI5	Rickettsia bellii (strain RML369-C)	30%	100%
Q1RJT3	Rickettsia bellii (strain RML369-C)	27%	100%
Q23571	Caenorhabditis elegans	44%	100%
Q2FH26	Staphylococcus aureus (strain USA300)	28%	100%
Q2FYM2	Staphylococcus aureus (strain NCTC 8325 / PS 47)	28%	100%
Q2YY06	Staphylococcus aureus (strain bovine RF122 / ET3-1)	28%	100%
Q49110	Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)	31%	100%
Q49XM4	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	28%	100%
Q4L6C3	Staphylococcus haemolyticus (strain JCSC1435)	29%	100%
Q4Q1F5	Leishmania major	26%	100%
Q4QJI5	Leishmania major	80%	100%
Q4UKI7	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	27%	100%
Q4ULG1	Rickettsia felis (strain ATCC VR-1525 / URRWXCal2)	27%	100%
Q59098	Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337)	33%	85%
Q59638	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	31%	86%
Q59821	Staphylococcus aureus	36%	100%
Q5HG07	Staphylococcus aureus (strain COL)	28%	100%
Q5HGY9	Staphylococcus aureus (strain COL)	36%	100%
Q5HPC7	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	29%	100%
Q5HQ74	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	33%	100%
Q5M729	Arabidopsis thaliana	30%	87%
Q68WK6	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	25%	100%
Q68XI8	Rickettsia typhi (strain ATCC VR-144 / Wilmington)	27%	100%
Q6ABX9	Leifsonia xyli subsp. xyli (strain CTCB07)	28%	100%
Q6FYD4	Bartonella quintana (strain Toulouse)	29%	100%
Q6G9E9	Staphylococcus aureus (strain MSSA476)	28%	100%
Q6GAB9	Staphylococcus aureus (strain MSSA476)	36%	100%
Q6GGZ6	Staphylococcus aureus (strain MRSA252)	27%	100%
Q6GHZ0	Staphylococcus aureus (strain MRSA252)	36%	100%
Q7A5N4	Staphylococcus aureus (strain N315)	28%	100%
Q89AJ6	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	23%	100%
Q89AQ9	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	27%	100%
Q8BKZ9	Mus musculus	26%	94%
Q8BMF4	Mus musculus	27%	73%
Q8CSL9	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	28%	100%
Q8CT13	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	33%	100%
Q8GCY1	Bartonella vinsonii subsp. berkhoffii	28%	100%
Q8K9T8	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	26%	100%
Q8NNJ2	Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025)	31%	70%
Q8NWR7	Staphylococcus aureus (strain MW2)	28%	100%
Q8NX76	Staphylococcus aureus (strain MW2)	36%	100%
Q8RWN9	Arabidopsis thaliana	30%	87%
Q92HK7	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	27%	100%
Q92J43	Rickettsia conorii (strain ATCC VR-613 / Malish 7)	27%	100%
Q99U75	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
Q9C8P0	Arabidopsis thaliana	27%	100%
Q9I1M0	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	30%	100%
Q9I3D2	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	28%	100%
Q9M7Z1	Arabidopsis thaliana	36%	98%
Q9R9N3	Rhizobium meliloti (strain 1021)	30%	100%
Q9SQI8	Arabidopsis thaliana	30%	98%
Q9ZD20	Rickettsia prowazekii (strain Madrid E)	27%	100%
Q9ZDY4	Rickettsia prowazekii (strain Madrid E)	27%	100%
V5BFP9	Trypanosoma cruzi	28%	100%
V5BJF4	Trypanosoma cruzi	44%	100%