Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

basal body component, putative

Species:

Leishmania braziliensis

UniProt:

A4H463_LEIBR

TriTrypDb:

LbrM.05.0170 , LBRM2903_050006600

Length:

748

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H463

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H463

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	702	706	PF00656	0.727
CLV_NRD_NRD_1	139	141	PF00675	0.518
CLV_NRD_NRD_1	15	17	PF00675	0.564
CLV_NRD_NRD_1	212	214	PF00675	0.723
CLV_NRD_NRD_1	284	286	PF00675	0.515
CLV_NRD_NRD_1	405	407	PF00675	0.736
CLV_PCSK_KEX2_1	139	141	PF00082	0.546
CLV_PCSK_KEX2_1	212	214	PF00082	0.723
CLV_PCSK_KEX2_1	284	286	PF00082	0.515
CLV_PCSK_KEX2_1	405	407	PF00082	0.736
CLV_PCSK_KEX2_1	598	600	PF00082	0.598
CLV_PCSK_PC1ET2_1	598	600	PF00082	0.598
CLV_PCSK_SKI1_1	310	314	PF00082	0.453
CLV_PCSK_SKI1_1	331	335	PF00082	0.585
CLV_PCSK_SKI1_1	386	390	PF00082	0.726
CLV_PCSK_SKI1_1	431	435	PF00082	0.573
CLV_PCSK_SKI1_1	634	638	PF00082	0.839
CLV_PCSK_SKI1_1	733	737	PF00082	0.536
CLV_Separin_Metazoa	402	406	PF03568	0.735
CLV_Separin_Metazoa	411	415	PF03568	0.659
DEG_APCC_DBOX_1	307	315	PF00400	0.705
DEG_APCC_DBOX_1	405	413	PF00400	0.791
DEG_SIAH_1	200	208	PF03145	0.554
DEG_SPOP_SBC_1	648	652	PF00917	0.570
DOC_CKS1_1	435	440	PF01111	0.713
DOC_CKS1_1	577	582	PF01111	0.804
DOC_CYCLIN_RxL_1	477	488	PF00134	0.801
DOC_CYCLIN_yCln2_LP_2	412	418	PF00134	0.678
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.567
DOC_MAPK_DCC_7	502	511	PF00069	0.574
DOC_MAPK_gen_1	139	145	PF00069	0.672
DOC_MAPK_gen_1	740	748	PF00069	0.434
DOC_PP2B_LxvP_1	519	522	PF13499	0.768
DOC_USP7_MATH_1	181	185	PF00917	0.780
DOC_USP7_MATH_1	188	192	PF00917	0.738
DOC_USP7_MATH_1	537	541	PF00917	0.812
DOC_USP7_MATH_1	583	587	PF00917	0.571
DOC_USP7_MATH_1	597	601	PF00917	0.594
DOC_USP7_MATH_1	648	652	PF00917	0.758
DOC_USP7_UBL2_3	296	300	PF12436	0.444
DOC_WW_Pin1_4	203	208	PF00397	0.685
DOC_WW_Pin1_4	434	439	PF00397	0.711
DOC_WW_Pin1_4	449	454	PF00397	0.788
DOC_WW_Pin1_4	486	491	PF00397	0.585
DOC_WW_Pin1_4	504	509	PF00397	0.753
DOC_WW_Pin1_4	514	519	PF00397	0.679
DOC_WW_Pin1_4	533	538	PF00397	0.623
DOC_WW_Pin1_4	541	546	PF00397	0.774
DOC_WW_Pin1_4	559	564	PF00397	0.761
DOC_WW_Pin1_4	573	578	PF00397	0.600
DOC_WW_Pin1_4	589	594	PF00397	0.732
DOC_WW_Pin1_4	640	645	PF00397	0.788
DOC_WW_Pin1_4	654	659	PF00397	0.616
DOC_WW_Pin1_4	665	670	PF00397	0.768
DOC_WW_Pin1_4	689	694	PF00397	0.749
DOC_WW_Pin1_4	705	710	PF00397	0.504
LIG_14-3-3_CanoR_1	144	152	PF00244	0.599
LIG_14-3-3_CanoR_1	192	196	PF00244	0.692
LIG_14-3-3_CanoR_1	213	221	PF00244	0.719
LIG_14-3-3_CanoR_1	284	290	PF00244	0.681
LIG_14-3-3_CanoR_1	310	315	PF00244	0.509
LIG_14-3-3_CanoR_1	373	379	PF00244	0.607
LIG_14-3-3_CanoR_1	406	416	PF00244	0.712
LIG_14-3-3_CanoR_1	431	436	PF00244	0.682
LIG_14-3-3_CanoR_1	634	644	PF00244	0.697
LIG_14-3-3_CanoR_1	742	747	PF00244	0.430
LIG_BIR_III_2	251	255	PF00653	0.728
LIG_BIR_III_2	527	531	PF00653	0.581
LIG_BRCT_BRCA1_1	451	455	PF00533	0.795
LIG_FHA_1	200	206	PF00498	0.646
LIG_FHA_1	230	236	PF00498	0.756
LIG_FHA_1	338	344	PF00498	0.606
LIG_FHA_1	567	573	PF00498	0.583
LIG_FHA_1	641	647	PF00498	0.676
LIG_FHA_2	120	126	PF00498	0.459
LIG_FHA_2	204	210	PF00498	0.610
LIG_FHA_2	257	263	PF00498	0.600
LIG_FHA_2	332	338	PF00498	0.619
LIG_FHA_2	677	683	PF00498	0.840
LIG_GBD_Chelix_1	395	403	PF00786	0.548
LIG_LIR_Apic_2	719	725	PF02991	0.549
LIG_MYND_1	644	648	PF01753	0.565
LIG_PDZ_Class_2	743	748	PF00595	0.450
LIG_Pex14_2	385	389	PF04695	0.623
LIG_PTAP_UEV_1	474	479	PF05743	0.578
LIG_SH2_STAT3	38	41	PF00017	0.549
LIG_SH2_STAT3	623	626	PF00017	0.829
LIG_SH2_STAT5	121	124	PF00017	0.555
LIG_SH2_STAT5	378	381	PF00017	0.710
LIG_SH3_1	472	478	PF00018	0.706
LIG_SH3_2	475	480	PF14604	0.699
LIG_SH3_2	593	598	PF14604	0.644
LIG_SH3_3	182	188	PF00018	0.706
LIG_SH3_3	205	211	PF00018	0.656
LIG_SH3_3	361	367	PF00018	0.774
LIG_SH3_3	387	393	PF00018	0.646
LIG_SH3_3	447	453	PF00018	0.789
LIG_SH3_3	472	478	PF00018	0.706
LIG_SH3_3	519	525	PF00018	0.751
LIG_SH3_3	574	580	PF00018	0.718
LIG_SH3_3	590	596	PF00018	0.724
LIG_SH3_3	641	647	PF00018	0.686
LIG_SH3_CIN85_PxpxPR_1	518	523	PF14604	0.824
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.348
LIG_SUMO_SIM_par_1	507	513	PF11976	0.571
LIG_SUMO_SIM_par_1	569	576	PF11976	0.824
LIG_TRAF2_1	237	240	PF00917	0.833
LIG_TRAF2_1	321	324	PF00917	0.695
LIG_TRAF2_1	97	100	PF00917	0.651
LIG_UBA3_1	736	744	PF00899	0.429
MOD_CDC14_SPxK_1	544	547	PF00782	0.799
MOD_CDC14_SPxK_1	562	565	PF00782	0.804
MOD_CDC14_SPxK_1	595	598	PF00782	0.643
MOD_CDK_SPxK_1	541	547	PF00069	0.805
MOD_CDK_SPxK_1	559	565	PF00069	0.804
MOD_CDK_SPxK_1	592	598	PF00069	0.633
MOD_CDK_SPxK_1	654	660	PF00069	0.591
MOD_CDK_SPxxK_3	592	599	PF00069	0.570
MOD_CK1_1	163	169	PF00069	0.638
MOD_CK1_1	172	178	PF00069	0.607
MOD_CK1_1	191	197	PF00069	0.701
MOD_CK1_1	229	235	PF00069	0.655
MOD_CK1_1	256	262	PF00069	0.605
MOD_CK1_1	325	331	PF00069	0.569
MOD_CK1_1	351	357	PF00069	0.739
MOD_CK1_1	576	582	PF00069	0.809
MOD_CK1_1	592	598	PF00069	0.503
MOD_CK1_1	617	623	PF00069	0.791
MOD_CK1_1	651	657	PF00069	0.737
MOD_CK1_1	671	677	PF00069	0.779
MOD_CK1_1	688	694	PF00069	0.619
MOD_CK1_1	695	701	PF00069	0.702
MOD_CK1_1	707	713	PF00069	0.778
MOD_CK1_1	716	722	PF00069	0.819
MOD_CK2_1	119	125	PF00069	0.424
MOD_CK2_1	256	262	PF00069	0.605
MOD_CK2_1	331	337	PF00069	0.616
MOD_CK2_1	507	513	PF00069	0.668
MOD_CK2_1	649	655	PF00069	0.737
MOD_CK2_1	676	682	PF00069	0.839
MOD_DYRK1A_RPxSP_1	640	644	PF00069	0.576
MOD_GlcNHglycan	171	174	PF01048	0.572
MOD_GlcNHglycan	228	231	PF01048	0.605
MOD_GlcNHglycan	242	246	PF01048	0.737
MOD_GlcNHglycan	255	258	PF01048	0.662
MOD_GlcNHglycan	327	330	PF01048	0.826
MOD_GlcNHglycan	467	470	PF01048	0.742
MOD_GlcNHglycan	475	478	PF01048	0.628
MOD_GlcNHglycan	496	499	PF01048	0.778
MOD_GlcNHglycan	513	517	PF01048	0.596
MOD_GlcNHglycan	585	588	PF01048	0.579
MOD_GlcNHglycan	599	602	PF01048	0.597
MOD_GlcNHglycan	637	640	PF01048	0.813
MOD_GlcNHglycan	676	679	PF01048	0.780
MOD_GlcNHglycan	687	690	PF01048	0.733
MOD_GlcNHglycan	697	700	PF01048	0.736
MOD_GlcNHglycan	701	704	PF01048	0.732
MOD_GlcNHglycan	715	718	PF01048	0.824
MOD_GSK3_1	190	197	PF00069	0.643
MOD_GSK3_1	199	206	PF00069	0.535
MOD_GSK3_1	337	344	PF00069	0.705
MOD_GSK3_1	347	354	PF00069	0.700
MOD_GSK3_1	461	468	PF00069	0.757
MOD_GSK3_1	529	536	PF00069	0.776
MOD_GSK3_1	537	544	PF00069	0.784
MOD_GSK3_1	610	617	PF00069	0.608
MOD_GSK3_1	635	642	PF00069	0.725
MOD_GSK3_1	647	654	PF00069	0.727
MOD_GSK3_1	665	672	PF00069	0.826
MOD_GSK3_1	673	680	PF00069	0.789
MOD_GSK3_1	685	692	PF00069	0.768
MOD_GSK3_1	695	702	PF00069	0.719
MOD_GSK3_1	707	714	PF00069	0.653
MOD_GSK3_1	738	745	PF00069	0.558
MOD_LATS_1	320	326	PF00433	0.543
MOD_N-GLC_1	351	356	PF02516	0.846
MOD_N-GLC_1	431	436	PF02516	0.575
MOD_N-GLC_1	665	670	PF02516	0.561
MOD_N-GLC_1	710	715	PF02516	0.579
MOD_NEK2_1	162	167	PF00069	0.605
MOD_NEK2_1	421	426	PF00069	0.638
MOD_NEK2_1	433	438	PF00069	0.720
MOD_NEK2_1	621	626	PF00069	0.622
MOD_NEK2_1	673	678	PF00069	0.731
MOD_NEK2_1	704	709	PF00069	0.584
MOD_NEK2_2	223	228	PF00069	0.605
MOD_PIKK_1	621	627	PF00454	0.604
MOD_PK_1	285	291	PF00069	0.442
MOD_PK_1	322	328	PF00069	0.554
MOD_PK_1	742	748	PF00069	0.445
MOD_PKA_2	143	149	PF00069	0.614
MOD_PKA_2	191	197	PF00069	0.691
MOD_PKA_2	214	220	PF00069	0.712
MOD_PKA_2	280	286	PF00069	0.449
MOD_PKA_2	369	375	PF00069	0.597
MOD_PKA_2	639	645	PF00069	0.739
MOD_PKA_2	73	79	PF00069	0.549
MOD_PKB_1	308	316	PF00069	0.455
MOD_PKB_1	740	748	PF00069	0.585
MOD_Plk_1	241	247	PF00069	0.718
MOD_Plk_1	322	328	PF00069	0.554
MOD_Plk_1	431	437	PF00069	0.575
MOD_Plk_1	617	623	PF00069	0.791
MOD_Plk_4	163	169	PF00069	0.643
MOD_Plk_4	285	291	PF00069	0.695
MOD_ProDKin_1	203	209	PF00069	0.686
MOD_ProDKin_1	434	440	PF00069	0.703
MOD_ProDKin_1	449	455	PF00069	0.792
MOD_ProDKin_1	486	492	PF00069	0.588
MOD_ProDKin_1	504	510	PF00069	0.751
MOD_ProDKin_1	514	520	PF00069	0.679
MOD_ProDKin_1	533	539	PF00069	0.620
MOD_ProDKin_1	541	547	PF00069	0.775
MOD_ProDKin_1	559	565	PF00069	0.763
MOD_ProDKin_1	573	579	PF00069	0.596
MOD_ProDKin_1	589	595	PF00069	0.733
MOD_ProDKin_1	640	646	PF00069	0.789
MOD_ProDKin_1	654	660	PF00069	0.618
MOD_ProDKin_1	665	671	PF00069	0.769
MOD_ProDKin_1	689	695	PF00069	0.748
MOD_ProDKin_1	705	711	PF00069	0.506
MOD_SUMO_for_1	379	382	PF00179	0.702
MOD_SUMO_for_1	93	96	PF00179	0.381
TRG_DiLeu_BaEn_4	570	576	PF01217	0.836
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.423
TRG_ER_diArg_1	114	117	PF00400	0.510
TRG_ER_diArg_1	211	213	PF00400	0.808
TRG_ER_diArg_1	404	406	PF00400	0.742
TRG_ER_diArg_1	659	662	PF00400	0.780
TRG_ER_diArg_1	737	740	PF00400	0.546
TRG_Pf-PMV_PEXEL_1	480	485	PF00026	0.799
TRG_Pf-PMV_PEXEL_1	54	59	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWW2	Leptomonas seymouri	43%	99%
A0A3S7WNZ4	Leishmania donovani	67%	99%
A4HSD2	Leishmania infantum	68%	99%
E9AKC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	65%	98%
Q4QJI6	Leishmania major	66%	99%