Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4H462_LEIBR

TriTrypDb:

LbrM.05.0160 , LBRM2903_050006500

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H462

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H462

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	105	107	PF00675	0.700
CLV_NRD_NRD_1	222	224	PF00675	0.620
CLV_NRD_NRD_1	266	268	PF00675	0.664
CLV_NRD_NRD_1	432	434	PF00675	0.683
CLV_PCSK_KEX2_1	105	107	PF00082	0.700
CLV_PCSK_KEX2_1	222	224	PF00082	0.620
CLV_PCSK_KEX2_1	266	268	PF00082	0.563
CLV_PCSK_KEX2_1	432	434	PF00082	0.683
CLV_PCSK_SKI1_1	17	21	PF00082	0.576
CLV_PCSK_SKI1_1	433	437	PF00082	0.695
CLV_PCSK_SKI1_1	67	71	PF00082	0.568
DEG_SCF_FBW7_1	225	232	PF00400	0.550
DOC_CKS1_1	226	231	PF01111	0.555
DOC_PP1_RVXF_1	279	286	PF00149	0.512
DOC_USP7_MATH_1	154	158	PF00917	0.659
DOC_USP7_MATH_1	210	214	PF00917	0.394
DOC_USP7_MATH_1	250	254	PF00917	0.615
DOC_USP7_MATH_1	329	333	PF00917	0.617
DOC_USP7_MATH_1	423	427	PF00917	0.595
DOC_USP7_MATH_1	460	464	PF00917	0.506
DOC_USP7_MATH_1	487	491	PF00917	0.660
DOC_USP7_MATH_1	497	501	PF00917	0.740
DOC_USP7_UBL2_3	172	176	PF12436	0.583
DOC_WW_Pin1_4	177	182	PF00397	0.782
DOC_WW_Pin1_4	186	191	PF00397	0.642
DOC_WW_Pin1_4	225	230	PF00397	0.708
DOC_WW_Pin1_4	488	493	PF00397	0.777
DOC_WW_Pin1_4	514	519	PF00397	0.680
DOC_WW_Pin1_4	522	527	PF00397	0.710
LIG_14-3-3_CanoR_1	139	146	PF00244	0.580
LIG_14-3-3_CanoR_1	153	163	PF00244	0.653
LIG_14-3-3_CanoR_1	266	276	PF00244	0.424
LIG_14-3-3_CanoR_1	281	286	PF00244	0.397
LIG_14-3-3_CanoR_1	291	300	PF00244	0.460
LIG_14-3-3_CanoR_1	303	311	PF00244	0.355
LIG_14-3-3_CanoR_1	324	334	PF00244	0.399
LIG_14-3-3_CanoR_1	67	74	PF00244	0.458
LIG_APCC_ABBA_1	528	533	PF00400	0.511
LIG_APCC_ABBAyCdc20_2	5	11	PF00400	0.720
LIG_CaM_IQ_9	53	69	PF13499	0.527
LIG_DLG_GKlike_1	281	288	PF00625	0.402
LIG_eIF4E_1	198	204	PF01652	0.534
LIG_EVH1_1	225	229	PF00568	0.537
LIG_FHA_1	25	31	PF00498	0.406
LIG_FHA_1	387	393	PF00498	0.452
LIG_FHA_2	140	146	PF00498	0.636
LIG_FHA_2	268	274	PF00498	0.606
LIG_FHA_2	297	303	PF00498	0.663
LIG_FHA_2	308	314	PF00498	0.422
LIG_FHA_2	380	386	PF00498	0.575
LIG_FHA_2	58	64	PF00498	0.537
LIG_FHA_2	94	100	PF00498	0.576
LIG_LIR_Gen_1	147	154	PF02991	0.562
LIG_LIR_Gen_1	213	221	PF02991	0.528
LIG_LIR_Gen_1	270	280	PF02991	0.415
LIG_LIR_Gen_1	284	290	PF02991	0.510
LIG_LIR_Nem_3	147	152	PF02991	0.566
LIG_LIR_Nem_3	213	217	PF02991	0.613
LIG_LIR_Nem_3	270	275	PF02991	0.426
LIG_LIR_Nem_3	284	288	PF02991	0.514
LIG_PTB_Apo_2	110	117	PF02174	0.508
LIG_PTB_Phospho_1	110	116	PF10480	0.506
LIG_SH2_CRK	116	120	PF00017	0.528
LIG_SH2_NCK_1	513	517	PF00017	0.523
LIG_SH2_STAP1	405	409	PF00017	0.551
LIG_SH3_1	223	229	PF00018	0.672
LIG_SH3_3	171	177	PF00018	0.685
LIG_SH3_3	178	184	PF00018	0.565
LIG_SH3_3	223	229	PF00018	0.721
LIG_SH3_3	486	492	PF00018	0.696
LIG_SH3_3	523	529	PF00018	0.534
LIG_SUMO_SIM_anti_2	284	290	PF11976	0.612
LIG_SUMO_SIM_par_1	459	471	PF11976	0.495
LIG_TRAF2_1	142	145	PF00917	0.594
LIG_TRAF2_1	299	302	PF00917	0.662
LIG_TRAF2_1	328	331	PF00917	0.401
LIG_TRAF2_1	382	385	PF00917	0.609
LIG_TRAF2_1	78	81	PF00917	0.642
LIG_WRC_WIRS_1	211	216	PF05994	0.404
LIG_WRC_WIRS_1	282	287	PF05994	0.510
LIG_WW_3	180	184	PF00397	0.574
MOD_CDC14_SPxK_1	180	183	PF00782	0.573
MOD_CDK_SPxK_1	177	183	PF00069	0.581
MOD_CK1_1	104	110	PF00069	0.698
MOD_CK1_1	463	469	PF00069	0.659
MOD_CK1_1	488	494	PF00069	0.776
MOD_CK1_1	502	508	PF00069	0.677
MOD_CK1_1	514	520	PF00069	0.662
MOD_CK2_1	104	110	PF00069	0.658
MOD_CK2_1	139	145	PF00069	0.635
MOD_CK2_1	210	216	PF00069	0.403
MOD_CK2_1	296	302	PF00069	0.656
MOD_CK2_1	307	313	PF00069	0.618
MOD_CK2_1	325	331	PF00069	0.380
MOD_CK2_1	379	385	PF00069	0.576
MOD_CK2_1	487	493	PF00069	0.592
MOD_CK2_1	57	63	PF00069	0.630
MOD_GlcNHglycan	125	128	PF01048	0.661
MOD_GlcNHglycan	327	330	PF01048	0.534
MOD_GlcNHglycan	331	334	PF01048	0.537
MOD_GlcNHglycan	452	455	PF01048	0.485
MOD_GlcNHglycan	458	461	PF01048	0.569
MOD_GlcNHglycan	475	478	PF01048	0.682
MOD_GlcNHglycan	501	504	PF01048	0.667
MOD_GlcNHglycan	507	510	PF01048	0.633
MOD_GSK3_1	182	189	PF00069	0.714
MOD_GSK3_1	225	232	PF00069	0.686
MOD_GSK3_1	3	10	PF00069	0.481
MOD_GSK3_1	325	332	PF00069	0.601
MOD_GSK3_1	340	347	PF00069	0.572
MOD_GSK3_1	375	382	PF00069	0.612
MOD_GSK3_1	386	393	PF00069	0.539
MOD_GSK3_1	419	426	PF00069	0.559
MOD_GSK3_1	456	463	PF00069	0.594
MOD_GSK3_1	464	471	PF00069	0.653
MOD_GSK3_1	488	495	PF00069	0.703
MOD_GSK3_1	498	505	PF00069	0.667
MOD_GSK3_1	507	514	PF00069	0.763
MOD_GSK3_1	520	527	PF00069	0.744
MOD_N-GLC_1	123	128	PF02516	0.787
MOD_N-GLC_1	204	209	PF02516	0.558
MOD_N-GLC_1	354	359	PF02516	0.649
MOD_N-GLC_1	450	455	PF02516	0.550
MOD_N-GLC_1	47	52	PF02516	0.401
MOD_NEK2_1	204	209	PF00069	0.554
MOD_NEK2_1	325	330	PF00069	0.506
MOD_NEK2_1	387	392	PF00069	0.560
MOD_NEK2_1	419	424	PF00069	0.593
MOD_NEK2_1	450	455	PF00069	0.535
MOD_NEK2_1	464	469	PF00069	0.707
MOD_NEK2_1	473	478	PF00069	0.707
MOD_NEK2_1	531	536	PF00069	0.701
MOD_NEK2_1	69	74	PF00069	0.420
MOD_NEK2_2	307	312	PF00069	0.649
MOD_PIKK_1	139	145	PF00454	0.803
MOD_PIKK_1	204	210	PF00454	0.542
MOD_PIKK_1	291	297	PF00454	0.414
MOD_PIKK_1	380	386	PF00454	0.397
MOD_PIKK_1	390	396	PF00454	0.544
MOD_PIKK_1	69	75	PF00454	0.527
MOD_PK_1	485	491	PF00069	0.564
MOD_PKA_2	104	110	PF00069	0.675
MOD_PKA_2	155	161	PF00069	0.591
MOD_PKA_2	168	174	PF00069	0.602
MOD_PKA_2	24	30	PF00069	0.501
MOD_PKA_2	302	308	PF00069	0.405
MOD_PKA_2	323	329	PF00069	0.658
MOD_PKA_2	390	396	PF00069	0.544
MOD_Plk_1	144	150	PF00069	0.608
MOD_Plk_1	47	53	PF00069	0.402
MOD_Plk_1	531	537	PF00069	0.536
MOD_Plk_2-3	313	319	PF00069	0.416
MOD_Plk_4	313	319	PF00069	0.416
MOD_Plk_4	468	474	PF00069	0.521
MOD_Plk_4	507	513	PF00069	0.515
MOD_Plk_4	531	537	PF00069	0.700
MOD_ProDKin_1	177	183	PF00069	0.782
MOD_ProDKin_1	186	192	PF00069	0.635
MOD_ProDKin_1	225	231	PF00069	0.714
MOD_ProDKin_1	488	494	PF00069	0.776
MOD_ProDKin_1	514	520	PF00069	0.681
MOD_ProDKin_1	522	528	PF00069	0.709
TRG_DiLeu_BaEn_1	64	69	PF01217	0.414
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.508
TRG_DiLeu_BaLyEn_6	278	283	PF01217	0.439
TRG_DiLeu_LyEn_5	64	69	PF01217	0.414
TRG_ENDOCYTIC_2	116	119	PF00928	0.529
TRG_ER_diArg_1	221	223	PF00400	0.623
TRG_ER_diArg_1	265	267	PF00400	0.681
TRG_ER_diArg_1	30	33	PF00400	0.414
TRG_Pf-PMV_PEXEL_1	298	302	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.667

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKE8	Leptomonas seymouri	40%	100%
A0A3S7WNZ9	Leishmania donovani	67%	100%
A4HSD1	Leishmania infantum	66%	100%
E9AKC0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4QJI7	Leishmania major	65%	95%