Leucine-rich repeat protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H461_LEIBR

TriTrypDb:

LbrM.05.0150 , LBRM2903_050006400

Length:

442

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 30
NetGPI	no	yes: 0, no: 30

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	30
GO:0042995	cell projection	2	30
GO:0043226	organelle	2	30
GO:0043227	membrane-bounded organelle	3	30
GO:0110165	cellular anatomical entity	1	31
GO:0120025	plasma membrane bounded cell projection	3	30
GO:0016020	membrane	2	2
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

A4H461

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H461

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	378	380	PF00675	0.404
CLV_NRD_NRD_1	6	8	PF00675	0.648
CLV_PCSK_KEX2_1	29	31	PF00082	0.295
CLV_PCSK_KEX2_1	378	380	PF00082	0.425
CLV_PCSK_KEX2_1	6	8	PF00082	0.648
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.255
CLV_PCSK_SKI1_1	130	134	PF00082	0.380
CLV_PCSK_SKI1_1	158	162	PF00082	0.334
CLV_PCSK_SKI1_1	265	269	PF00082	0.500
CLV_PCSK_SKI1_1	32	36	PF00082	0.345
CLV_PCSK_SKI1_1	361	365	PF00082	0.396
CLV_PCSK_SKI1_1	379	383	PF00082	0.499
CLV_PCSK_SKI1_1	50	54	PF00082	0.307
DEG_SPOP_SBC_1	239	243	PF00917	0.389
DOC_CYCLIN_RxL_1	276	285	PF00134	0.290
DOC_MAPK_gen_1	378	385	PF00069	0.481
DOC_MAPK_MEF2A_6	378	385	PF00069	0.517
DOC_PP1_RVXF_1	404	411	PF00149	0.388
DOC_USP7_MATH_1	110	114	PF00917	0.274
DOC_USP7_MATH_1	240	244	PF00917	0.315
DOC_USP7_MATH_1	402	406	PF00917	0.610
DOC_USP7_UBL2_3	436	440	PF12436	0.518
DOC_WW_Pin1_4	117	122	PF00397	0.457
DOC_WW_Pin1_4	395	400	PF00397	0.335
LIG_14-3-3_CanoR_1	130	136	PF00244	0.416
LIG_14-3-3_CanoR_1	224	230	PF00244	0.519
LIG_14-3-3_CanoR_1	237	245	PF00244	0.365
LIG_14-3-3_CanoR_1	265	273	PF00244	0.424
LIG_14-3-3_CanoR_1	30	35	PF00244	0.244
LIG_14-3-3_CanoR_1	361	367	PF00244	0.435
LIG_14-3-3_CanoR_1	378	382	PF00244	0.385
LIG_14-3-3_CanoR_1	61	65	PF00244	0.337
LIG_14-3-3_CanoR_1	88	96	PF00244	0.407
LIG_APCC_ABBAyCdc20_2	406	412	PF00400	0.388
LIG_BIR_III_4	105	109	PF00653	0.153
LIG_BIR_III_4	401	405	PF00653	0.648
LIG_BRCT_BRCA1_1	21	25	PF00533	0.344
LIG_FHA_1	132	138	PF00498	0.283
LIG_FHA_1	173	179	PF00498	0.246
LIG_FHA_1	217	223	PF00498	0.312
LIG_FHA_1	321	327	PF00498	0.391
LIG_FHA_1	331	337	PF00498	0.413
LIG_FHA_1	358	364	PF00498	0.467
LIG_FHA_1	378	384	PF00498	0.523
LIG_FHA_1	386	392	PF00498	0.561
LIG_FHA_1	413	419	PF00498	0.407
LIG_FHA_2	15	21	PF00498	0.336
LIG_FHA_2	159	165	PF00498	0.408
LIG_FHA_2	167	173	PF00498	0.371
LIG_FHA_2	36	42	PF00498	0.502
LIG_FHA_2	64	70	PF00498	0.367
LIG_GBD_Chelix_1	296	304	PF00786	0.404
LIG_LIR_Gen_1	131	138	PF02991	0.384
LIG_LIR_Gen_1	164	172	PF02991	0.301
LIG_LIR_Gen_1	63	70	PF02991	0.362
LIG_LIR_Nem_3	131	136	PF02991	0.387
LIG_LIR_Nem_3	164	170	PF02991	0.334
LIG_LIR_Nem_3	254	260	PF02991	0.422
LIG_LIR_Nem_3	63	67	PF02991	0.308
LIG_MYND_3	304	308	PF01753	0.217
LIG_PCNA_yPIPBox_3	129	141	PF02747	0.254
LIG_SH2_GRB2like	95	98	PF00017	0.246
LIG_SH2_NCK_1	190	194	PF00017	0.182
LIG_SH2_STAP1	190	194	PF00017	0.182
LIG_SH2_STAT5	204	207	PF00017	0.371
LIG_SH2_STAT5	26	29	PF00017	0.431
LIG_SH2_STAT5	64	67	PF00017	0.382
LIG_SH2_STAT5	95	98	PF00017	0.305
LIG_SH3_3	9	15	PF00018	0.576
LIG_SUMO_SIM_anti_2	134	139	PF11976	0.422
LIG_SUMO_SIM_anti_2	333	339	PF11976	0.443
LIG_SUMO_SIM_par_1	380	389	PF11976	0.527
LIG_TRAF2_1	422	425	PF00917	0.421
LIG_TYR_ITIM	93	98	PF00017	0.304
LIG_UBA3_1	408	413	PF00899	0.637
LIG_WRC_WIRS_1	64	69	PF05994	0.153
MOD_CK1_1	166	172	PF00069	0.160
MOD_CK1_1	82	88	PF00069	0.421
MOD_CK2_1	14	20	PF00069	0.497
MOD_CK2_1	166	172	PF00069	0.407
MOD_CK2_1	68	74	PF00069	0.228
MOD_GlcNHglycan	112	115	PF01048	0.386
MOD_GlcNHglycan	121	124	PF01048	0.499
MOD_GlcNHglycan	3	6	PF01048	0.690
MOD_GlcNHglycan	373	376	PF01048	0.509
MOD_GSK3_1	20	27	PF00069	0.421
MOD_GSK3_1	277	284	PF00069	0.285
MOD_GSK3_1	320	327	PF00069	0.368
MOD_LATS_1	377	383	PF00433	0.504
MOD_N-GLC_1	117	122	PF02516	0.457
MOD_N-GLC_1	128	133	PF02516	0.356
MOD_N-GLC_1	172	177	PF02516	0.331
MOD_N-GLC_1	281	286	PF02516	0.340
MOD_N-GLC_1	96	101	PF02516	0.290
MOD_NEK2_1	238	243	PF00069	0.393
MOD_NEK2_1	330	335	PF00069	0.312
MOD_NEK2_1	35	40	PF00069	0.481
MOD_NEK2_1	60	65	PF00069	0.331
MOD_NEK2_1	68	73	PF00069	0.326
MOD_NEK2_1	96	101	PF00069	0.309
MOD_NEK2_2	128	133	PF00069	0.366
MOD_NEK2_2	274	279	PF00069	0.421
MOD_PIKK_1	213	219	PF00454	0.536
MOD_PK_1	30	36	PF00069	0.532
MOD_PKA_2	223	229	PF00069	0.526
MOD_PKA_2	377	383	PF00069	0.407
MOD_PKA_2	60	66	PF00069	0.158
MOD_Plk_1	128	134	PF00069	0.359
MOD_Plk_1	143	149	PF00069	0.322
MOD_Plk_1	158	164	PF00069	0.288
MOD_Plk_1	246	252	PF00069	0.316
MOD_Plk_2-3	303	309	PF00069	0.304
MOD_Plk_4	143	149	PF00069	0.326
MOD_Plk_4	240	246	PF00069	0.471
MOD_Plk_4	60	66	PF00069	0.369
MOD_Plk_4	82	88	PF00069	0.458
MOD_ProDKin_1	117	123	PF00069	0.458
MOD_ProDKin_1	395	401	PF00069	0.342
MOD_SUMO_rev_2	308	318	PF00179	0.371
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.261
TRG_ENDOCYTIC_2	64	67	PF00928	0.302
TRG_ENDOCYTIC_2	95	98	PF00928	0.304
TRG_ER_diLys_1	437	442	PF00400	0.582
TRG_NES_CRM1_1	303	314	PF08389	0.344
TRG_NLS_MonoExtC_3	27	32	PF00514	0.527
TRG_NLS_MonoExtC_3	435	440	PF00514	0.508
TRG_NLS_MonoExtN_4	28	33	PF00514	0.397
TRG_Pf-PMV_PEXEL_1	265	269	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N0	Leptomonas seymouri	25%	100%
A0A0N1HUH0	Leptomonas seymouri	29%	94%
A0A0N1I317	Leptomonas seymouri	26%	100%
A0A0N1PD72	Leptomonas seymouri	70%	99%
A0A0S4IT30	Bodo saltans	25%	66%
A0A0S4JGH2	Bodo saltans	26%	100%
A0A0S4JL85	Bodo saltans	46%	100%
A0A0S4JPV3	Bodo saltans	29%	92%
A0A1X0NTY3	Trypanosomatidae	28%	98%
A0A1X0P364	Trypanosomatidae	50%	100%
A0A3Q8IDE6	Leishmania donovani	28%	100%
A0A3R7L7Y9	Trypanosoma rangeli	28%	99%
A0A3R7P015	Trypanosoma rangeli	51%	93%
A0A3S5H5G2	Leishmania donovani	87%	100%
A0A3S7WZL6	Leishmania donovani	28%	100%
A4HEQ6	Leishmania braziliensis	29%	100%
A4HFQ6	Leishmania braziliensis	27%	100%
A4HHW0	Leishmania braziliensis	26%	100%
A4HSD0	Leishmania infantum	87%	100%
A4I1Y5	Leishmania infantum	28%	100%
A4I2T1	Leishmania infantum	28%	100%
C9ZPX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	99%
E9ADA9	Leishmania major	28%	100%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	93%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
P10775	Sus scrofa	26%	97%
Q0VAA2	Homo sapiens	24%	91%
Q4Q9E1	Leishmania major	28%	100%
Q4QBG0	Leishmania major	24%	100%
Q4QJI8	Leishmania major	88%	100%
Q8IZ02	Homo sapiens	22%	95%
Q9LE82	Arabidopsis thaliana	26%	83%
Q9M651	Arabidopsis thaliana	26%	81%
V5BC66	Trypanosoma cruzi	29%	67%
V5BJF0	Trypanosoma cruzi	52%	89%
V5BPZ7	Trypanosoma cruzi	29%	98%
V5DHF2	Trypanosoma cruzi	24%	100%