RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA helicase

Gene product:

nucleolar RNA helicase II, putative

Species:

Leishmania braziliensis

UniProt:

A4H460_LEIBR

TriTrypDb:

LbrM.05.0140 , LBRM2903_050006300

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H460

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H460

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003724	RNA helicase activity	3	12
GO:0003743	translation initiation factor activity	4	11
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	11
GO:0008186	ATP-dependent activity, acting on RNA	2	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.410
CLV_C14_Caspase3-7	384	388	PF00656	0.424
CLV_C14_Caspase3-7	418	422	PF00656	0.424
CLV_C14_Caspase3-7	70	74	PF00656	0.475
CLV_NRD_NRD_1	3	5	PF00675	0.600
CLV_NRD_NRD_1	318	320	PF00675	0.308
CLV_NRD_NRD_1	434	436	PF00675	0.398
CLV_NRD_NRD_1	490	492	PF00675	0.466
CLV_NRD_NRD_1	687	689	PF00675	0.557
CLV_PCSK_KEX2_1	3	5	PF00082	0.600
CLV_PCSK_KEX2_1	318	320	PF00082	0.308
CLV_PCSK_KEX2_1	490	492	PF00082	0.466
CLV_PCSK_KEX2_1	50	52	PF00082	0.579
CLV_PCSK_KEX2_1	687	689	PF00082	0.557
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.579
CLV_PCSK_SKI1_1	147	151	PF00082	0.288
CLV_PCSK_SKI1_1	220	224	PF00082	0.208
CLV_PCSK_SKI1_1	456	460	PF00082	0.364
CLV_PCSK_SKI1_1	490	494	PF00082	0.372
CLV_PCSK_SKI1_1	572	576	PF00082	0.223
CLV_PCSK_SKI1_1	601	605	PF00082	0.235
DOC_CKS1_1	213	218	PF01111	0.400
DOC_CKS1_1	596	601	PF01111	0.463
DOC_CYCLIN_RxL_1	144	153	PF00134	0.503
DOC_CYCLIN_RxL_1	340	350	PF00134	0.400
DOC_CYCLIN_RxL_1	398	409	PF00134	0.400
DOC_MAPK_DCC_7	401	410	PF00069	0.400
DOC_MAPK_gen_1	157	166	PF00069	0.400
DOC_MAPK_gen_1	203	213	PF00069	0.503
DOC_MAPK_gen_1	351	359	PF00069	0.426
DOC_MAPK_gen_1	386	394	PF00069	0.400
DOC_MAPK_gen_1	432	442	PF00069	0.469
DOC_MAPK_gen_1	453	462	PF00069	0.350
DOC_MAPK_HePTP_8	398	410	PF00069	0.400
DOC_MAPK_MEF2A_6	206	213	PF00069	0.503
DOC_MAPK_MEF2A_6	250	257	PF00069	0.410
DOC_MAPK_MEF2A_6	401	410	PF00069	0.400
DOC_MAPK_MEF2A_6	435	442	PF00069	0.312
DOC_MAPK_NFAT4_5	250	258	PF00069	0.410
DOC_PP1_RVXF_1	134	141	PF00149	0.410
DOC_PP1_RVXF_1	341	348	PF00149	0.400
DOC_PP1_RVXF_1	599	606	PF00149	0.503
DOC_PP1_SILK_1	556	561	PF00149	0.400
DOC_PP2B_LxvP_1	403	406	PF13499	0.400
DOC_PP2B_LxvP_1	465	468	PF13499	0.354
DOC_PP2B_LxvP_1	550	553	PF13499	0.410
DOC_PP4_FxxP_1	140	143	PF00568	0.400
DOC_USP7_MATH_1	100	104	PF00917	0.396
DOC_USP7_MATH_1	518	522	PF00917	0.352
DOC_USP7_UBL2_3	34	38	PF12436	0.768
DOC_WW_Pin1_4	212	217	PF00397	0.400
DOC_WW_Pin1_4	533	538	PF00397	0.444
DOC_WW_Pin1_4	595	600	PF00397	0.468
LIG_14-3-3_CanoR_1	309	317	PF00244	0.518
LIG_14-3-3_CanoR_1	51	60	PF00244	0.598
LIG_14-3-3_CanoR_1	601	606	PF00244	0.478
LIG_14-3-3_CanoR_1	86	95	PF00244	0.353
LIG_APCC_ABBAyCdc20_2	225	231	PF00400	0.466
LIG_BIR_III_2	506	510	PF00653	0.412
LIG_deltaCOP1_diTrp_1	285	292	PF00928	0.492
LIG_FHA_1	167	173	PF00498	0.402
LIG_FHA_1	522	528	PF00498	0.437
LIG_FHA_2	265	271	PF00498	0.460
LIG_FHA_2	280	286	PF00498	0.400
LIG_FHA_2	348	354	PF00498	0.400
LIG_FHA_2	360	366	PF00498	0.424
LIG_FHA_2	467	473	PF00498	0.362
LIG_FHA_2	65	71	PF00498	0.629
LIG_LIR_Apic_2	137	143	PF02991	0.400
LIG_LIR_Gen_1	116	124	PF02991	0.410
LIG_LIR_Gen_1	227	238	PF02991	0.418
LIG_LIR_Gen_1	296	307	PF02991	0.381
LIG_LIR_Gen_1	387	398	PF02991	0.410
LIG_LIR_Gen_1	536	544	PF02991	0.495
LIG_LIR_Gen_1	604	613	PF02991	0.503
LIG_LIR_Nem_3	116	120	PF02991	0.400
LIG_LIR_Nem_3	190	196	PF02991	0.441
LIG_LIR_Nem_3	227	233	PF02991	0.418
LIG_LIR_Nem_3	387	393	PF02991	0.435
LIG_LIR_Nem_3	536	542	PF02991	0.495
LIG_LIR_Nem_3	604	608	PF02991	0.503
LIG_SH2_CRK	193	197	PF00017	0.400
LIG_SH2_CRK	555	559	PF00017	0.466
LIG_SH2_GRB2like	198	201	PF00017	0.503
LIG_SH2_PTP2	539	542	PF00017	0.503
LIG_SH2_STAP1	523	527	PF00017	0.400
LIG_SH2_STAT3	198	201	PF00017	0.400
LIG_SH2_STAT5	449	452	PF00017	0.326
LIG_SH2_STAT5	523	526	PF00017	0.400
LIG_SH2_STAT5	539	542	PF00017	0.400
LIG_SH2_STAT5	555	558	PF00017	0.400
LIG_SH3_3	210	216	PF00018	0.400
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.424
LIG_SUMO_SIM_anti_2	251	258	PF11976	0.459
LIG_SUMO_SIM_anti_2	508	515	PF11976	0.362
LIG_SUMO_SIM_anti_2	573	580	PF11976	0.400
LIG_TRAF2_1	199	202	PF00917	0.400
LIG_TRAF2_1	445	448	PF00917	0.422
LIG_TRAF2_1	469	472	PF00917	0.469
LIG_TRAF2_1	5	8	PF00917	0.626
LIG_UBA3_1	244	250	PF00899	0.400
LIG_UBA3_1	329	335	PF00899	0.352
LIG_WRC_WIRS_1	382	387	PF05994	0.400
MOD_CDK_SPxK_1	212	218	PF00069	0.400
MOD_CDK_SPxK_1	595	601	PF00069	0.466
MOD_CK1_1	134	140	PF00069	0.400
MOD_CK1_1	14	20	PF00069	0.597
MOD_CK1_1	153	159	PF00069	0.427
MOD_CK1_1	324	330	PF00069	0.324
MOD_CK1_1	521	527	PF00069	0.234
MOD_CK2_1	264	270	PF00069	0.367
MOD_CK2_1	279	285	PF00069	0.441
MOD_CK2_1	466	472	PF00069	0.387
MOD_CK2_1	64	70	PF00069	0.579
MOD_CK2_1	86	92	PF00069	0.514
MOD_Cter_Amidation	433	436	PF01082	0.317
MOD_GlcNHglycan	133	136	PF01048	0.200
MOD_GlcNHglycan	206	209	PF01048	0.238
MOD_GlcNHglycan	267	270	PF01048	0.218
MOD_GlcNHglycan	279	282	PF01048	0.191
MOD_GlcNHglycan	337	340	PF01048	0.234
MOD_GlcNHglycan	514	517	PF01048	0.335
MOD_GlcNHglycan	520	523	PF01048	0.356
MOD_GSK3_1	11	18	PF00069	0.752
MOD_GSK3_1	265	272	PF00069	0.347
MOD_GSK3_1	273	280	PF00069	0.400
MOD_GSK3_1	30	37	PF00069	0.707
MOD_GSK3_1	321	328	PF00069	0.378
MOD_GSK3_1	341	348	PF00069	0.400
MOD_GSK3_1	355	362	PF00069	0.410
MOD_GSK3_1	377	384	PF00069	0.400
MOD_GSK3_1	51	58	PF00069	0.549
MOD_GSK3_1	518	525	PF00069	0.386
MOD_GSK3_1	538	545	PF00069	0.315
MOD_GSK3_1	591	598	PF00069	0.437
MOD_N-GLC_1	21	26	PF02516	0.559
MOD_N-GLC_1	263	268	PF02516	0.200
MOD_N-GLC_1	321	326	PF02516	0.413
MOD_N-GLC_1	359	364	PF02516	0.210
MOD_N-GLC_1	525	530	PF02516	0.303
MOD_N-GLC_1	619	624	PF02516	0.667
MOD_N-GLC_2	79	81	PF02516	0.665
MOD_NEK2_1	187	192	PF00069	0.467
MOD_NEK2_1	255	260	PF00069	0.503
MOD_NEK2_1	277	282	PF00069	0.416
MOD_NEK2_1	345	350	PF00069	0.400
MOD_NEK2_1	591	596	PF00069	0.413
MOD_NEK2_1	619	624	PF00069	0.719
MOD_NEK2_2	105	110	PF00069	0.347
MOD_NEK2_2	269	274	PF00069	0.347
MOD_PIKK_1	255	261	PF00454	0.503
MOD_PIKK_1	363	369	PF00454	0.400
MOD_PKA_1	490	496	PF00069	0.458
MOD_PKA_2	377	383	PF00069	0.400
MOD_PKA_2	490	496	PF00069	0.458
MOD_PKB_1	4	12	PF00069	0.687
MOD_PKB_1	570	578	PF00069	0.410
MOD_Plk_1	269	275	PF00069	0.347
MOD_Plk_1	324	330	PF00069	0.306
MOD_Plk_1	355	361	PF00069	0.400
MOD_Plk_1	378	384	PF00069	0.400
MOD_Plk_1	564	570	PF00069	0.427
MOD_Plk_1	572	578	PF00069	0.377
MOD_Plk_4	105	111	PF00069	0.338
MOD_Plk_4	273	279	PF00069	0.400
MOD_Plk_4	288	294	PF00069	0.346
MOD_Plk_4	325	331	PF00069	0.347
MOD_Plk_4	554	560	PF00069	0.420
MOD_Plk_4	564	570	PF00069	0.458
MOD_Plk_4	591	597	PF00069	0.410
MOD_ProDKin_1	212	218	PF00069	0.400
MOD_ProDKin_1	533	539	PF00069	0.444
MOD_ProDKin_1	595	601	PF00069	0.468
MOD_SUMO_rev_2	384	391	PF00179	0.421
MOD_SUMO_rev_2	7	14	PF00179	0.662
TRG_DiLeu_BaLyEn_6	144	149	PF01217	0.503
TRG_ENDOCYTIC_2	193	196	PF00928	0.400
TRG_ENDOCYTIC_2	539	542	PF00928	0.495
TRG_ENDOCYTIC_2	555	558	PF00928	0.400
TRG_ER_diArg_1	2	4	PF00400	0.615
TRG_ER_diArg_1	317	319	PF00400	0.292
TRG_ER_diArg_1	569	572	PF00400	0.466
TRG_ER_diArg_1	687	689	PF00400	0.557
TRG_Pf-PMV_PEXEL_1	147	152	PF00026	0.224
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.200

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J1	Leptomonas seymouri	29%	77%
A0A0N1IKV7	Leptomonas seymouri	87%	100%
A0A0S4IWD0	Bodo saltans	31%	100%
A0A0S4JPY9	Bodo saltans	72%	100%
A0A1D6GDY8	Zea mays	37%	92%
A0A1D6LAB7	Zea mays	37%	93%
A0A1X0P2M8	Trypanosomatidae	79%	100%
A0A3Q8ID91	Leishmania donovani	32%	100%
A0A3S5H5G1	Leishmania donovani	92%	100%
A0A3S7XAT8	Leishmania donovani	31%	100%
A0A422NYD5	Trypanosoma rangeli	75%	100%
A0R8U6	Bacillus thuringiensis (strain Al Hakam)	34%	100%
A2QFL3	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	30%	100%
A4HGR1	Leishmania braziliensis	32%	100%
A4HP48	Leishmania braziliensis	30%	100%
A4HP49	Leishmania braziliensis	32%	100%
A4HSE3	Leishmania infantum	93%	100%
A4HT33	Leishmania infantum	34%	100%
A4HZF8	Leishmania infantum	27%	100%
A4I3T6	Leishmania infantum	32%	100%
A4IDF6	Leishmania infantum	31%	100%
C9ZPX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	81%	100%
D0A6Z3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9AJG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AKB8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9ASV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9B028	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
P0A4D7	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	31%	100%
P0A4D8	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	31%	100%
P33906	Klebsiella pneumoniae	33%	100%
P96614	Bacillus subtilis (strain 168)	34%	100%
Q0DM51	Oryza sativa subsp. japonica	37%	91%
Q2FF45	Staphylococcus aureus (strain USA300)	30%	100%
Q2FWH5	Staphylococcus aureus (strain NCTC 8325 / PS 47)	30%	100%
Q2YUH3	Staphylococcus aureus (strain bovine RF122 / ET3-1)	30%	100%
Q39189	Arabidopsis thaliana	42%	100%
Q3B8Q1	Rattus norvegicus	40%	88%
Q41382	Spinacia oleracea	39%	100%
Q49Z29	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	32%	100%
Q4L7W0	Staphylococcus haemolyticus (strain JCSC1435)	32%	100%
Q4Q1N9	Leishmania major	30%	100%
Q4Q858	Leishmania major	31%	100%
Q4QJI9	Leishmania major	93%	100%
Q5HEB9	Staphylococcus aureus (strain COL)	30%	100%
Q5HME0	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	31%	100%
Q5L3G9	Geobacillus kaustophilus (strain HTA426)	35%	100%
Q63GX5	Bacillus cereus (strain ZK / E33L)	34%	100%
Q650T9	Oryza sativa subsp. japonica	38%	99%
Q6G7M9	Staphylococcus aureus (strain MSSA476)	30%	100%
Q6GEZ3	Staphylococcus aureus (strain MRSA252)	31%	100%
Q6HPE6	Bacillus thuringiensis subsp. konkukian (strain 97-27)	34%	100%
Q6K7R9	Oryza sativa subsp. japonica	33%	85%
Q6NZQ2	Mus musculus	31%	100%
Q73EU1	Bacillus cereus (strain ATCC 10987 / NRS 248)	34%	100%
Q7A0D2	Staphylococcus aureus (strain MW2)	30%	100%
Q7A4G0	Staphylococcus aureus (strain N315)	30%	100%
Q81IT9	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	34%	100%
Q81VG0	Bacillus anthracis	34%	100%
Q8CRP6	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	32%	100%
Q8K9H6	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	34%	100%
Q8L7S8	Arabidopsis thaliana	36%	92%
Q8Y8N0	Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)	35%	100%
Q99MJ9	Mus musculus	40%	94%
Q99SH6	Staphylococcus aureus (strain Mu50 / ATCC 700699)	30%	100%
Q9BQ39	Homo sapiens	39%	93%
Q9DF35	Xenopus laevis	36%	91%
Q9DF36	Xenopus laevis	39%	86%
Q9JIK5	Mus musculus	40%	81%
Q9NR30	Homo sapiens	39%	88%
Q9Z6C9	Limosilactobacillus reuteri	33%	100%
V5BEY7	Trypanosoma cruzi	76%	100%