Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H458_LEIBR

TriTrypDb:

LbrM.05.0120 , LBRM2903_050006100

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H458

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H458

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008175	tRNA methyltransferase activity	5	1
GO:0008176	tRNA (guanine-N7-)-methyltransferase activity	7	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016423	tRNA (guanine) methyltransferase activity	6	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140101	catalytic activity, acting on a tRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.608
CLV_NRD_NRD_1	112	114	PF00675	0.449
CLV_NRD_NRD_1	201	203	PF00675	0.410
CLV_NRD_NRD_1	255	257	PF00675	0.555
CLV_NRD_NRD_1	284	286	PF00675	0.602
CLV_NRD_NRD_1	3	5	PF00675	0.595
CLV_NRD_NRD_1	320	322	PF00675	0.397
CLV_PCSK_FUR_1	282	286	PF00082	0.647
CLV_PCSK_KEX2_1	112	114	PF00082	0.474
CLV_PCSK_KEX2_1	196	198	PF00082	0.460
CLV_PCSK_KEX2_1	201	203	PF00082	0.405
CLV_PCSK_KEX2_1	282	284	PF00082	0.659
CLV_PCSK_KEX2_1	3	5	PF00082	0.595
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.326
CLV_PCSK_PC7_1	197	203	PF00082	0.290
CLV_PCSK_SKI1_1	127	131	PF00082	0.447
CLV_PCSK_SKI1_1	161	165	PF00082	0.447
DEG_APCC_DBOX_1	28	36	PF00400	0.591
DEG_Nend_Nbox_1	1	3	PF02207	0.623
DEG_ODPH_VHL_1	103	116	PF01847	0.533
DOC_CYCLIN_RxL_1	124	133	PF00134	0.462
DOC_CYCLIN_yClb1_LxF_4	159	164	PF00134	0.387
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.535
DOC_MAPK_gen_1	289	298	PF00069	0.587
DOC_PP1_RVXF_1	111	118	PF00149	0.488
DOC_PP1_RVXF_1	159	165	PF00149	0.386
DOC_PP1_RVXF_1	200	207	PF00149	0.496
DOC_PP2B_LxvP_1	102	105	PF13499	0.532
DOC_PP2B_LxvP_1	250	253	PF13499	0.497
DOC_USP7_MATH_1	300	304	PF00917	0.463
DOC_USP7_MATH_1	74	78	PF00917	0.526
DOC_USP7_MATH_1	81	85	PF00917	0.550
DOC_WW_Pin1_4	152	157	PF00397	0.544
DOC_WW_Pin1_4	304	309	PF00397	0.538
LIG_14-3-3_CanoR_1	27	33	PF00244	0.541
LIG_14-3-3_CanoR_1	312	318	PF00244	0.599
LIG_14-3-3_CanoR_1	48	54	PF00244	0.575
LIG_14-3-3_CanoR_1	82	86	PF00244	0.454
LIG_APCC_ABBA_1	228	233	PF00400	0.526
LIG_APCC_ABBAyCdc20_2	201	207	PF00400	0.493
LIG_BRCT_BRCA1_1	259	263	PF00533	0.371
LIG_Clathr_ClatBox_1	203	207	PF01394	0.487
LIG_eIF4E_1	124	130	PF01652	0.485
LIG_FHA_1	120	126	PF00498	0.348
LIG_FHA_1	179	185	PF00498	0.419
LIG_FHA_1	309	315	PF00498	0.357
LIG_FHA_1	54	60	PF00498	0.521
LIG_FHA_2	230	236	PF00498	0.396
LIG_FHA_2	304	310	PF00498	0.538
LIG_LIR_Gen_1	136	144	PF02991	0.414
LIG_LIR_Gen_1	168	179	PF02991	0.482
LIG_LIR_Gen_1	235	245	PF02991	0.473
LIG_LIR_LC3C_4	136	140	PF02991	0.438
LIG_LIR_LC3C_4	247	252	PF02991	0.537
LIG_LIR_Nem_3	136	140	PF02991	0.398
LIG_LIR_Nem_3	168	174	PF02991	0.403
LIG_LIR_Nem_3	235	240	PF02991	0.476
LIG_NRBOX	31	37	PF00104	0.565
LIG_PTB_Apo_2	157	164	PF02174	0.270
LIG_REV1ctd_RIR_1	161	170	PF16727	0.464
LIG_SH2_SRC	317	320	PF00017	0.315
LIG_SH2_STAP1	237	241	PF00017	0.489
LIG_SH2_STAP1	269	273	PF00017	0.368
LIG_SH2_STAP1	319	323	PF00017	0.538
LIG_SH2_STAT3	64	67	PF00017	0.526
LIG_SH2_STAT5	124	127	PF00017	0.368
LIG_SH2_STAT5	209	212	PF00017	0.505
LIG_SH2_STAT5	254	257	PF00017	0.655
LIG_SH3_1	219	225	PF00018	0.483
LIG_SH3_3	136	142	PF00018	0.389
LIG_SH3_3	173	179	PF00018	0.441
LIG_SH3_3	184	190	PF00018	0.337
LIG_SH3_3	219	225	PF00018	0.483
LIG_SUMO_SIM_anti_2	183	188	PF11976	0.478
LIG_SUMO_SIM_anti_2	270	278	PF11976	0.517
LIG_SUMO_SIM_par_1	270	278	PF11976	0.395
LIG_TYR_ITIM	267	272	PF00017	0.340
LIG_UBA3_1	241	249	PF00899	0.487
MOD_CK1_1	303	309	PF00069	0.488
MOD_CK2_1	140	146	PF00069	0.494
MOD_CK2_1	229	235	PF00069	0.498
MOD_CK2_1	275	281	PF00069	0.425
MOD_GlcNHglycan	277	280	PF01048	0.590
MOD_GlcNHglycan	302	305	PF01048	0.477
MOD_GlcNHglycan	60	63	PF01048	0.529
MOD_GlcNHglycan	76	79	PF01048	0.334
MOD_GlcNHglycan	91	94	PF01048	0.439
MOD_GSK3_1	119	126	PF00069	0.495
MOD_GSK3_1	192	199	PF00069	0.427
MOD_GSK3_1	300	307	PF00069	0.467
MOD_GSK3_1	308	315	PF00069	0.487
MOD_GSK3_1	49	56	PF00069	0.592
MOD_NEK2_1	130	135	PF00069	0.523
MOD_NEK2_1	2	7	PF00069	0.594
MOD_NEK2_1	89	94	PF00069	0.474
MOD_NEK2_2	49	54	PF00069	0.428
MOD_NEK2_2	81	86	PF00069	0.322
MOD_PIKK_1	257	263	PF00454	0.379
MOD_PKA_1	196	202	PF00069	0.300
MOD_PKA_1	3	9	PF00069	0.610
MOD_PKA_2	119	125	PF00069	0.277
MOD_PKA_2	196	202	PF00069	0.300
MOD_PKA_2	2	8	PF00069	0.591
MOD_PKA_2	28	34	PF00069	0.523
MOD_PKA_2	53	59	PF00069	0.501
MOD_PKA_2	81	87	PF00069	0.402
MOD_Plk_1	308	314	PF00069	0.358
MOD_Plk_4	133	139	PF00069	0.396
MOD_Plk_4	166	172	PF00069	0.457
MOD_ProDKin_1	152	158	PF00069	0.539
MOD_ProDKin_1	304	310	PF00069	0.535
MOD_SUMO_rev_2	243	251	PF00179	0.507
TRG_DiLeu_BaEn_1	246	251	PF01217	0.475
TRG_DiLeu_BaEn_4	293	299	PF01217	0.496
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.568
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.560
TRG_ENDOCYTIC_2	237	240	PF00928	0.493
TRG_ENDOCYTIC_2	269	272	PF00928	0.362
TRG_ENDOCYTIC_2	324	327	PF00928	0.407
TRG_ER_diArg_1	112	114	PF00400	0.474
TRG_ER_diArg_1	2	4	PF00400	0.649
TRG_ER_diArg_1	201	203	PF00400	0.414
TRG_ER_diArg_1	216	219	PF00400	0.446
TRG_ER_diArg_1	282	285	PF00400	0.650
TRG_Pf-PMV_PEXEL_1	127	132	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	265	270	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N8	Leptomonas seymouri	67%	100%
A0A1X0P3K8	Trypanosomatidae	42%	98%
A0A3S5H5F9	Leishmania donovani	88%	100%
A0A3S5ISB0	Trypanosoma rangeli	48%	100%
A4HSE1	Leishmania infantum	88%	100%
C9ZPX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AKB6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QJJ1	Leishmania major	87%	100%
V5AUY0	Trypanosoma cruzi	44%	100%