LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H457_LEIBR
TriTrypDb:
LbrM.05.0110 , LBRM2903_050006000
Length:
123

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H457
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H457

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 91 95 PF00082 0.508
DEG_APCC_DBOX_1 109 117 PF00400 0.475
DEG_Nend_UBRbox_3 1 3 PF02207 0.518
DEG_SCF_FBW7_1 37 42 PF00400 0.343
DOC_CKS1_1 13 18 PF01111 0.473
DOC_CYCLIN_yCln2_LP_2 13 19 PF00134 0.524
DOC_MAPK_gen_1 81 90 PF00069 0.346
DOC_MAPK_MEF2A_6 46 54 PF00069 0.453
DOC_SPAK_OSR1_1 31 35 PF12202 0.322
DOC_USP7_MATH_1 97 101 PF00917 0.463
DOC_WW_Pin1_4 12 17 PF00397 0.443
DOC_WW_Pin1_4 35 40 PF00397 0.529
LIG_AP2alpha_2 118 120 PF02296 0.569
LIG_BRCT_BRCA1_1 116 120 PF00533 0.505
LIG_FHA_1 1 7 PF00498 0.544
LIG_FHA_2 13 19 PF00498 0.553
LIG_FHA_2 57 63 PF00498 0.304
LIG_NRBOX 8 14 PF00104 0.485
LIG_PTB_Apo_2 11 18 PF02174 0.473
LIG_SH2_STAP1 73 77 PF00017 0.450
LIG_SH3_3 22 28 PF00018 0.483
LIG_UBA3_1 33 41 PF00899 0.327
MOD_CDK_SPxK_1 35 41 PF00069 0.335
MOD_CK1_1 42 48 PF00069 0.544
MOD_CK2_1 98 104 PF00069 0.388
MOD_GlcNHglycan 100 103 PF01048 0.390
MOD_GSK3_1 35 42 PF00069 0.518
MOD_PIKK_1 83 89 PF00454 0.461
MOD_PKA_2 83 89 PF00069 0.456
MOD_Plk_1 42 48 PF00069 0.500
MOD_ProDKin_1 12 18 PF00069 0.449
MOD_ProDKin_1 35 41 PF00069 0.540
MOD_SUMO_for_1 40 43 PF00179 0.436
MOD_SUMO_rev_2 62 67 PF00179 0.344
TRG_DiLeu_BaEn_1 49 54 PF01217 0.439
TRG_DiLeu_BaLyEn_6 2 7 PF01217 0.362
TRG_ER_diArg_1 110 113 PF00400 0.532
TRG_ER_diArg_1 78 81 PF00400 0.408
TRG_Pf-PMV_PEXEL_1 31 35 PF00026 0.420
TRG_Pf-PMV_PEXEL_1 5 10 PF00026 0.360

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P630 Leptomonas seymouri 67% 100%
A0A1X0P3X1 Trypanosomatidae 32% 85%
A0A3R7LAM0 Trypanosoma rangeli 38% 75%
A0A3S7WNZ5 Leishmania donovani 85% 100%
A4HSE0 Leishmania infantum 85% 100%
C9ZPX2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9AKB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4QJJ2 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS