Putative NUDIX hydrolase dihydroneopterin triphosphate pyrophosphohydrolase/hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nudix hydrolase 2, putative

Species:

Leishmania braziliensis

UniProt:

A4H455_LEIBR

TriTrypDb:

LbrM.05.0090 , LBRM2903_050005800

Length:

178

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H455

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H455

Function

Biological processes
Term	Name	Level	Count
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:0110154	RNA decapping	6	1
GO:0110156	methylguanosine-cap decapping	7	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0050072	obsolete m7G(5')pppN diphosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.423
CLV_NRD_NRD_1	88	90	PF00675	0.344
CLV_PCSK_KEX2_1	88	90	PF00082	0.325
CLV_PCSK_SKI1_1	111	115	PF00082	0.419
CLV_PCSK_SKI1_1	161	165	PF00082	0.433
CLV_PCSK_SKI1_1	166	170	PF00082	0.502
CLV_PCSK_SKI1_1	98	102	PF00082	0.322
DEG_Nend_Nbox_1	1	3	PF02207	0.336
DOC_CYCLIN_RxL_1	161	171	PF00134	0.554
DOC_CYCLIN_RxL_1	95	106	PF00134	0.421
DOC_CYCLIN_yCln2_LP_2	114	117	PF00134	0.386
DOC_MAPK_gen_1	127	134	PF00069	0.450
DOC_MAPK_gen_1	96	103	PF00069	0.462
DOC_MAPK_MEF2A_6	3	10	PF00069	0.337
DOC_MAPK_MEF2A_6	96	103	PF00069	0.448
DOC_MAPK_NFAT4_5	96	104	PF00069	0.448
DOC_PP1_RVXF_1	12	18	PF00149	0.394
DOC_PP1_RVXF_1	125	132	PF00149	0.337
DOC_PP1_RVXF_1	96	103	PF00149	0.386
DOC_PP2B_LxvP_1	114	117	PF13499	0.386
DOC_USP7_UBL2_3	173	177	PF12436	0.582
LIG_Actin_WH2_2	43	59	PF00022	0.290
LIG_APCC_ABBA_1	8	13	PF00400	0.386
LIG_FHA_2	102	108	PF00498	0.405
LIG_LIR_Gen_1	25	35	PF02991	0.361
LIG_LIR_Nem_3	125	129	PF02991	0.302
LIG_LIR_Nem_3	130	134	PF02991	0.291
LIG_LIR_Nem_3	25	31	PF02991	0.361
LIG_SH2_NCK_1	79	83	PF00017	0.416
LIG_SH2_STAT3	92	95	PF00017	0.336
LIG_SH2_STAT5	79	82	PF00017	0.346
LIG_SH2_STAT5	92	95	PF00017	0.249
LIG_SH3_3	110	116	PF00018	0.362
LIG_TRAF2_1	122	125	PF00917	0.317
LIG_TRFH_1	79	83	PF08558	0.330
MOD_CK1_1	59	65	PF00069	0.195
MOD_CK2_1	101	107	PF00069	0.442
MOD_N-GLC_2	5	7	PF02516	0.323
MOD_NEK2_1	101	106	PF00069	0.275
MOD_NEK2_1	40	45	PF00069	0.195
MOD_NEK2_1	77	82	PF00069	0.340
MOD_Plk_1	40	46	PF00069	0.337
MOD_Plk_1	59	65	PF00069	0.389
MOD_Plk_4	59	65	PF00069	0.340
MOD_SUMO_rev_2	165	175	PF00179	0.388
TRG_DiLeu_BaEn_2	12	18	PF01217	0.336
TRG_DiLeu_BaEn_4	51	57	PF01217	0.361
TRG_ER_diArg_1	87	89	PF00400	0.346
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P0	Leptomonas seymouri	72%	99%
A0A0N0P9K0	Leptomonas seymouri	30%	76%
A0A0S4J332	Bodo saltans	43%	70%
A0A1X0P2U2	Trypanosomatidae	60%	100%
A0A3S5H5F7	Leishmania donovani	88%	99%
A0A422NYC4	Trypanosoma rangeli	55%	100%
A0A422P4Y4	Trypanosoma rangeli	34%	74%
A1WVE9	Halorhodospira halophila (strain DSM 244 / SL1)	27%	98%
A4HKE1	Leishmania braziliensis	31%	77%
A4HSD8	Leishmania infantum	88%	99%
C9ZPX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AKB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q16BL5	Roseobacter denitrificans (strain ATCC 33942 / OCh 114)	32%	100%
Q4QJJ4	Leishmania major	85%	100%
V5BU70	Trypanosoma cruzi	32%	69%
V5DQQ5	Trypanosoma cruzi	32%	69%