Putative paraflagellar rod component par4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component par4, putative

Species:

Leishmania braziliensis

UniProt:

A4H450_LEIBR

TriTrypDb:

LbrM.05.0040 , LBRM2903_050005300

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A4H450

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H450

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	438	442	PF00656	0.540
CLV_C14_Caspase3-7	539	543	PF00656	0.520
CLV_NRD_NRD_1	220	222	PF00675	0.480
CLV_NRD_NRD_1	239	241	PF00675	0.415
CLV_NRD_NRD_1	280	282	PF00675	0.475
CLV_NRD_NRD_1	359	361	PF00675	0.359
CLV_NRD_NRD_1	43	45	PF00675	0.416
CLV_NRD_NRD_1	567	569	PF00675	0.515
CLV_NRD_NRD_1	69	71	PF00675	0.529
CLV_PCSK_KEX2_1	171	173	PF00082	0.622
CLV_PCSK_KEX2_1	238	240	PF00082	0.433
CLV_PCSK_KEX2_1	43	45	PF00082	0.431
CLV_PCSK_KEX2_1	549	551	PF00082	0.441
CLV_PCSK_KEX2_1	567	569	PF00082	0.349
CLV_PCSK_KEX2_1	69	71	PF00082	0.523
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.616
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.454
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.451
CLV_PCSK_SKI1_1	103	107	PF00082	0.508
CLV_PCSK_SKI1_1	201	205	PF00082	0.599
CLV_PCSK_SKI1_1	222	226	PF00082	0.464
CLV_PCSK_SKI1_1	295	299	PF00082	0.523
CLV_PCSK_SKI1_1	435	439	PF00082	0.467
CLV_PCSK_SKI1_1	465	469	PF00082	0.631
CLV_PCSK_SKI1_1	476	480	PF00082	0.539
CLV_PCSK_SKI1_1	510	514	PF00082	0.626
CLV_PCSK_SKI1_1	52	56	PF00082	0.331
CLV_PCSK_SKI1_1	62	66	PF00082	0.306
CLV_PCSK_SKI1_1	9	13	PF00082	0.507
DOC_CYCLIN_RxL_1	169	180	PF00134	0.359
DOC_MAPK_gen_1	221	229	PF00069	0.508
DOC_MAPK_gen_1	510	518	PF00069	0.489
DOC_MAPK_gen_1	531	540	PF00069	0.417
DOC_MAPK_gen_1	567	575	PF00069	0.424
DOC_MAPK_MEF2A_6	57	65	PF00069	0.301
DOC_PP1_RVXF_1	366	372	PF00149	0.407
DOC_PP1_RVXF_1	50	56	PF00149	0.352
DOC_USP7_MATH_1	163	167	PF00917	0.347
DOC_USP7_MATH_1	283	287	PF00917	0.500
DOC_USP7_MATH_1	323	327	PF00917	0.464
DOC_USP7_UBL2_3	5	9	PF12436	0.523
LIG_14-3-3_CanoR_1	221	227	PF00244	0.468
LIG_14-3-3_CanoR_1	284	291	PF00244	0.502
LIG_14-3-3_CanoR_1	435	443	PF00244	0.491
LIG_14-3-3_CanoR_1	494	502	PF00244	0.425
LIG_14-3-3_CanoR_1	568	574	PF00244	0.429
LIG_Actin_WH2_2	460	478	PF00022	0.507
LIG_Actin_WH2_2	505	521	PF00022	0.488
LIG_Actin_WH2_2	534	551	PF00022	0.524
LIG_CaM_IQ_9	421	437	PF13499	0.347
LIG_CaM_IQ_9	541	557	PF13499	0.530
LIG_Clathr_ClatBox_1	112	116	PF01394	0.417
LIG_FHA_1	296	302	PF00498	0.537
LIG_FHA_1	570	576	PF00498	0.420
LIG_FHA_2	267	273	PF00498	0.580
LIG_FHA_2	409	415	PF00498	0.395
LIG_FHA_2	436	442	PF00498	0.626
LIG_FHA_2	444	450	PF00498	0.404
LIG_FHA_2	559	565	PF00498	0.556
LIG_FHA_2	88	94	PF00498	0.463
LIG_Integrin_isoDGR_2	378	380	PF01839	0.574
LIG_LIR_Gen_1	34	42	PF02991	0.340
LIG_LIR_Gen_1	364	374	PF02991	0.390
LIG_LIR_Gen_1	458	467	PF02991	0.502
LIG_LIR_Nem_3	293	297	PF02991	0.320
LIG_LIR_Nem_3	34	39	PF02991	0.337
LIG_LIR_Nem_3	364	369	PF02991	0.386
LIG_LIR_Nem_3	458	464	PF02991	0.588
LIG_NRBOX	225	231	PF00104	0.495
LIG_PCNA_yPIPBox_3	216	230	PF02747	0.524
LIG_PCNA_yPIPBox_3	349	358	PF02747	0.550
LIG_PTB_Apo_2	128	135	PF02174	0.320
LIG_PTB_Phospho_1	128	134	PF10480	0.321
LIG_SH2_CRK	294	298	PF00017	0.317
LIG_SH2_STAP1	241	245	PF00017	0.462
LIG_SH2_STAP1	432	436	PF00017	0.521
LIG_SH2_STAP1	92	96	PF00017	0.548
LIG_SH2_STAT3	134	137	PF00017	0.456
LIG_SH2_STAT3	92	95	PF00017	0.548
LIG_SH2_STAT5	134	137	PF00017	0.389
LIG_SH2_STAT5	307	310	PF00017	0.405
LIG_SUMO_SIM_anti_2	272	279	PF11976	0.438
LIG_SUMO_SIM_anti_2	536	543	PF11976	0.412
LIG_SUMO_SIM_par_1	571	577	PF11976	0.356
LIG_TRAF2_1	411	414	PF00917	0.602
LIG_UBA3_1	436	444	PF00899	0.444
MOD_CK1_1	130	136	PF00069	0.317
MOD_CK1_1	144	150	PF00069	0.316
MOD_CK1_1	177	183	PF00069	0.355
MOD_CK1_1	493	499	PF00069	0.571
MOD_CK1_1	558	564	PF00069	0.309
MOD_CK2_1	257	263	PF00069	0.544
MOD_CK2_1	266	272	PF00069	0.461
MOD_CK2_1	408	414	PF00069	0.487
MOD_CK2_1	416	422	PF00069	0.477
MOD_CK2_1	443	449	PF00069	0.510
MOD_CK2_1	467	473	PF00069	0.469
MOD_CK2_1	87	93	PF00069	0.461
MOD_Cter_Amidation	2	5	PF01082	0.549
MOD_Cter_Amidation	7	10	PF01082	0.532
MOD_GSK3_1	163	170	PF00069	0.420
MOD_GSK3_1	349	356	PF00069	0.329
MOD_GSK3_1	404	411	PF00069	0.468
MOD_GSK3_1	416	423	PF00069	0.437
MOD_GSK3_1	490	497	PF00069	0.575
MOD_GSK3_1	574	581	PF00069	0.401
MOD_GSK3_1	87	94	PF00069	0.582
MOD_N-GLC_1	130	135	PF02516	0.524
MOD_N-GLC_1	222	227	PF02516	0.519
MOD_N-GLC_1	404	409	PF02516	0.448
MOD_N-GLC_1	555	560	PF02516	0.423
MOD_NEK2_1	167	172	PF00069	0.533
MOD_NEK2_1	266	271	PF00069	0.473
MOD_NEK2_1	344	349	PF00069	0.455
MOD_NEK2_1	443	448	PF00069	0.433
MOD_NEK2_1	518	523	PF00069	0.549
MOD_PIKK_1	155	161	PF00454	0.606
MOD_PIKK_1	266	272	PF00454	0.609
MOD_PIKK_1	344	350	PF00454	0.565
MOD_PIKK_1	91	97	PF00454	0.479
MOD_PK_1	555	561	PF00069	0.315
MOD_PKA_1	349	355	PF00069	0.328
MOD_PKA_1	9	15	PF00069	0.590
MOD_PKA_2	127	133	PF00069	0.540
MOD_PKA_2	138	144	PF00069	0.549
MOD_PKA_2	250	256	PF00069	0.537
MOD_PKA_2	266	272	PF00069	0.495
MOD_PKA_2	283	289	PF00069	0.469
MOD_PKA_2	416	422	PF00069	0.392
MOD_PKA_2	493	499	PF00069	0.593
MOD_PKA_2	569	575	PF00069	0.595
MOD_PKA_2	79	85	PF00069	0.551
MOD_Plk_1	108	114	PF00069	0.321
MOD_Plk_1	130	136	PF00069	0.421
MOD_Plk_1	144	150	PF00069	0.450
MOD_Plk_1	222	228	PF00069	0.518
MOD_Plk_1	257	263	PF00069	0.365
MOD_Plk_1	404	410	PF00069	0.578
MOD_Plk_1	555	561	PF00069	0.337
MOD_Plk_1	97	103	PF00069	0.451
MOD_Plk_4	108	114	PF00069	0.327
MOD_Plk_4	130	136	PF00069	0.317
MOD_Plk_4	180	186	PF00069	0.494
MOD_Plk_4	222	228	PF00069	0.462
MOD_Plk_4	353	359	PF00069	0.467
MOD_Plk_4	367	373	PF00069	0.474
MOD_Plk_4	97	103	PF00069	0.350
MOD_SUMO_for_1	113	116	PF00179	0.444
MOD_SUMO_for_1	16	19	PF00179	0.364
MOD_SUMO_for_1	512	515	PF00179	0.492
MOD_SUMO_for_1	562	565	PF00179	0.444
MOD_SUMO_rev_2	147	156	PF00179	0.524
MOD_SUMO_rev_2	182	190	PF00179	0.495
MOD_SUMO_rev_2	214	224	PF00179	0.527
MOD_SUMO_rev_2	258	266	PF00179	0.517
MOD_SUMO_rev_2	288	297	PF00179	0.425
MOD_SUMO_rev_2	462	470	PF00179	0.447
MOD_SUMO_rev_2	542	551	PF00179	0.569
TRG_AP2beta_CARGO_1	34	43	PF09066	0.340
TRG_DiLeu_BaEn_1	19	24	PF01217	0.476
TRG_DiLeu_BaEn_1	353	358	PF01217	0.421
TRG_DiLeu_BaEn_3	118	124	PF01217	0.456
TRG_DiLeu_BaEn_3	50	56	PF01217	0.477
TRG_DiLeu_BaEn_4	151	157	PF01217	0.483
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.348
TRG_DiLeu_LyEn_5	19	24	PF01217	0.356
TRG_ENDOCYTIC_2	294	297	PF00928	0.319
TRG_ENDOCYTIC_2	461	464	PF00928	0.591
TRG_ER_diArg_1	239	241	PF00400	0.453
TRG_ER_diArg_1	450	453	PF00400	0.595
TRG_ER_diArg_1	530	533	PF00400	0.535
TRG_ER_diArg_1	566	568	PF00400	0.506
TRG_ER_diArg_1	69	71	PF00400	0.535
TRG_NES_CRM1_1	507	520	PF08389	0.542
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.575
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.598
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	27	32	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	435	439	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.606
TRG_Pf-PMV_PEXEL_1	476	480	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWW9	Leptomonas seymouri	49%	100%
A0A0S4JPX7	Bodo saltans	35%	99%
A0A1X0P3Y1	Trypanosomatidae	38%	100%
A0A3R7MZM3	Trypanosoma rangeli	39%	100%
A0A3S5H5F5	Leishmania donovani	80%	100%
A4HSC7	Leishmania infantum	80%	100%
C9ZPY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AKA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QJJ9	Leishmania major	79%	100%
V5BJE7	Trypanosoma cruzi	40%	100%