Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H447_LEIBR

TriTrypDb:

LbrM.05.0010 , LBRM2903_050005000

Length:

915

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	1
GO:0000922	spindle pole	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H447

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H447

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.590
CLV_C14_Caspase3-7	620	624	PF00656	0.394
CLV_C14_Caspase3-7	664	668	PF00656	0.370
CLV_C14_Caspase3-7	73	77	PF00656	0.559
CLV_C14_Caspase3-7	795	799	PF00656	0.362
CLV_NRD_NRD_1	322	324	PF00675	0.482
CLV_NRD_NRD_1	45	47	PF00675	0.483
CLV_NRD_NRD_1	470	472	PF00675	0.423
CLV_NRD_NRD_1	620	622	PF00675	0.614
CLV_NRD_NRD_1	741	743	PF00675	0.618
CLV_NRD_NRD_1	756	758	PF00675	0.429
CLV_NRD_NRD_1	768	770	PF00675	0.569
CLV_NRD_NRD_1	802	804	PF00675	0.346
CLV_NRD_NRD_1	825	827	PF00675	0.538
CLV_NRD_NRD_1	836	838	PF00675	0.576
CLV_NRD_NRD_1	861	863	PF00675	0.455
CLV_NRD_NRD_1	97	99	PF00675	0.498
CLV_PCSK_KEX2_1	283	285	PF00082	0.454
CLV_PCSK_KEX2_1	322	324	PF00082	0.551
CLV_PCSK_KEX2_1	45	47	PF00082	0.483
CLV_PCSK_KEX2_1	470	472	PF00082	0.423
CLV_PCSK_KEX2_1	741	743	PF00082	0.650
CLV_PCSK_KEX2_1	756	758	PF00082	0.429
CLV_PCSK_KEX2_1	802	804	PF00082	0.588
CLV_PCSK_KEX2_1	825	827	PF00082	0.524
CLV_PCSK_KEX2_1	861	863	PF00082	0.545
CLV_PCSK_KEX2_1	904	906	PF00082	0.604
CLV_PCSK_KEX2_1	97	99	PF00082	0.577
CLV_PCSK_PC1ET2_1	283	285	PF00082	0.547
CLV_PCSK_PC1ET2_1	802	804	PF00082	0.632
CLV_PCSK_PC1ET2_1	904	906	PF00082	0.604
CLV_PCSK_SKI1_1	360	364	PF00082	0.516
CLV_PCSK_SKI1_1	602	606	PF00082	0.532
CLV_PCSK_SKI1_1	684	688	PF00082	0.589
CLV_PCSK_SKI1_1	706	710	PF00082	0.630
CLV_PCSK_SKI1_1	729	733	PF00082	0.576
CLV_PCSK_SKI1_1	808	812	PF00082	0.456
CLV_Separin_Metazoa	530	534	PF03568	0.374
DEG_APCC_DBOX_1	461	469	PF00400	0.518
DEG_Nend_UBRbox_2	1	3	PF02207	0.609
DOC_CDC14_PxL_1	897	905	PF14671	0.683
DOC_CYCLIN_RxL_1	243	253	PF00134	0.517
DOC_CYCLIN_RxL_1	357	367	PF00134	0.381
DOC_MAPK_DCC_7	862	872	PF00069	0.442
DOC_MAPK_gen_1	204	211	PF00069	0.574
DOC_MAPK_gen_1	269	277	PF00069	0.486
DOC_MAPK_gen_1	283	291	PF00069	0.480
DOC_MAPK_gen_1	322	328	PF00069	0.476
DOC_MAPK_gen_1	45	51	PF00069	0.522
DOC_MAPK_MEF2A_6	270	279	PF00069	0.538
DOC_MAPK_MEF2A_6	863	872	PF00069	0.605
DOC_PP1_RVXF_1	5	12	PF00149	0.519
DOC_USP7_MATH_1	100	104	PF00917	0.455
DOC_USP7_MATH_1	502	506	PF00917	0.567
DOC_USP7_MATH_1	708	712	PF00917	0.517
DOC_USP7_MATH_1	787	791	PF00917	0.358
DOC_USP7_UBL2_3	17	21	PF12436	0.478
DOC_USP7_UBL2_3	183	187	PF12436	0.562
DOC_USP7_UBL2_3	3	7	PF12436	0.542
DOC_USP7_UBL2_3	360	364	PF12436	0.451
DOC_USP7_UBL2_3	56	60	PF12436	0.483
DOC_USP7_UBL2_3	788	792	PF12436	0.380
DOC_USP7_UBL2_3	804	808	PF12436	0.378
LIG_14-3-3_CanoR_1	127	135	PF00244	0.487
LIG_14-3-3_CanoR_1	162	170	PF00244	0.641
LIG_14-3-3_CanoR_1	462	472	PF00244	0.483
LIG_14-3-3_CanoR_1	490	496	PF00244	0.455
LIG_14-3-3_CanoR_1	569	573	PF00244	0.586
LIG_14-3-3_CanoR_1	649	658	PF00244	0.568
LIG_Actin_WH2_2	349	366	PF00022	0.513
LIG_Actin_WH2_2	601	617	PF00022	0.399
LIG_Actin_WH2_2	810	827	PF00022	0.598
LIG_Actin_WH2_2	889	906	PF00022	0.701
LIG_deltaCOP1_diTrp_1	344	347	PF00928	0.621
LIG_DLG_GKlike_1	284	291	PF00625	0.397
LIG_FHA_1	148	154	PF00498	0.600
LIG_FHA_1	357	363	PF00498	0.444
LIG_FHA_1	526	532	PF00498	0.495
LIG_FHA_2	106	112	PF00498	0.588
LIG_FHA_2	153	159	PF00498	0.606
LIG_FHA_2	391	397	PF00498	0.588
LIG_FHA_2	615	621	PF00498	0.584
LIG_FHA_2	640	646	PF00498	0.380
LIG_LIR_Gen_1	158	166	PF02991	0.514
LIG_LIR_Gen_1	346	356	PF02991	0.598
LIG_LIR_Gen_1	489	500	PF02991	0.595
LIG_LIR_Gen_1	505	511	PF02991	0.457
LIG_LIR_Gen_1	603	613	PF02991	0.379
LIG_LIR_Gen_1	656	661	PF02991	0.512
LIG_LIR_Gen_1	670	681	PF02991	0.525
LIG_LIR_Gen_1	764	772	PF02991	0.596
LIG_LIR_Nem_3	158	163	PF02991	0.518
LIG_LIR_Nem_3	285	291	PF02991	0.398
LIG_LIR_Nem_3	346	352	PF02991	0.604
LIG_LIR_Nem_3	489	495	PF02991	0.591
LIG_LIR_Nem_3	505	510	PF02991	0.459
LIG_LIR_Nem_3	603	608	PF02991	0.386
LIG_LIR_Nem_3	656	660	PF02991	0.421
LIG_LIR_Nem_3	670	676	PF02991	0.479
LIG_LIR_Nem_3	764	768	PF02991	0.589
LIG_NRBOX	464	470	PF00104	0.421
LIG_NRBOX	750	756	PF00104	0.550
LIG_PCNA_yPIPBox_3	406	414	PF02747	0.395
LIG_Pex14_1	345	349	PF04695	0.617
LIG_Pex14_1	846	850	PF04695	0.458
LIG_Pex14_2	629	633	PF04695	0.381
LIG_RPA_C_Fungi	85	97	PF08784	0.389
LIG_SH2_CRK	507	511	PF00017	0.381
LIG_SH2_PTP2	657	660	PF00017	0.373
LIG_SH2_STAP1	507	511	PF00017	0.381
LIG_SH2_STAT3	128	131	PF00017	0.456
LIG_SH2_STAT5	657	660	PF00017	0.521
LIG_Sin3_3	674	681	PF02671	0.378
LIG_SUMO_SIM_anti_2	568	574	PF11976	0.492
LIG_SUMO_SIM_par_1	395	403	PF11976	0.674
LIG_TRAF2_1	109	112	PF00917	0.588
LIG_TRAF2_1	393	396	PF00917	0.627
LIG_TRAF2_1	474	477	PF00917	0.439
LIG_TRAF2_1	558	561	PF00917	0.461
LIG_TRAF2_1	642	645	PF00917	0.384
LIG_TRAF2_1	731	734	PF00917	0.365
LIG_TRAF2_1	85	88	PF00917	0.382
LIG_TYR_ITIM	655	660	PF00017	0.376
LIG_UBA3_1	249	255	PF00899	0.563
LIG_UBA3_1	676	684	PF00899	0.523
LIG_UBA3_1	896	904	PF00899	0.498
LIG_WRC_WIRS_1	409	414	PF05994	0.394
LIG_WRC_WIRS_1	492	497	PF05994	0.572
LIG_WRC_WIRS_1	765	770	PF05994	0.562
MOD_CK1_1	161	167	PF00069	0.573
MOD_CK1_1	287	293	PF00069	0.516
MOD_CK1_1	351	357	PF00069	0.422
MOD_CK1_1	366	372	PF00069	0.562
MOD_CK1_1	764	770	PF00069	0.611
MOD_CK2_1	105	111	PF00069	0.588
MOD_CK2_1	127	133	PF00069	0.537
MOD_CK2_1	176	182	PF00069	0.552
MOD_CK2_1	347	353	PF00069	0.492
MOD_CK2_1	390	396	PF00069	0.553
MOD_CK2_1	414	420	PF00069	0.555
MOD_CK2_1	436	442	PF00069	0.635
MOD_CK2_1	47	53	PF00069	0.508
MOD_CK2_1	471	477	PF00069	0.461
MOD_CK2_1	483	489	PF00069	0.451
MOD_CK2_1	491	497	PF00069	0.348
MOD_CK2_1	614	620	PF00069	0.473
MOD_CK2_1	638	644	PF00069	0.592
MOD_CK2_1	686	692	PF00069	0.575
MOD_CK2_1	816	822	PF00069	0.629
MOD_GlcNHglycan	30	33	PF01048	0.583
MOD_GlcNHglycan	366	369	PF01048	0.575
MOD_GlcNHglycan	438	441	PF01048	0.642
MOD_GlcNHglycan	576	580	PF01048	0.506
MOD_GlcNHglycan	602	605	PF01048	0.662
MOD_GlcNHglycan	700	704	PF01048	0.630
MOD_GSK3_1	127	134	PF00069	0.578
MOD_GSK3_1	211	218	PF00069	0.578
MOD_GSK3_1	283	290	PF00069	0.537
MOD_GSK3_1	343	350	PF00069	0.580
MOD_GSK3_1	362	369	PF00069	0.345
MOD_GSK3_1	634	641	PF00069	0.470
MOD_GSK3_1	687	694	PF00069	0.418
MOD_GSK3_1	708	715	PF00069	0.660
MOD_GSK3_1	746	753	PF00069	0.371
MOD_GSK3_1	880	887	PF00069	0.484
MOD_GSK3_1	892	899	PF00069	0.491
MOD_N-GLC_1	100	105	PF02516	0.536
MOD_N-GLC_1	500	505	PF02516	0.375
MOD_NEK2_1	191	196	PF00069	0.531
MOD_NEK2_1	219	224	PF00069	0.564
MOD_NEK2_1	233	238	PF00069	0.456
MOD_NEK2_1	289	294	PF00069	0.615
MOD_NEK2_1	326	331	PF00069	0.483
MOD_NEK2_1	347	352	PF00069	0.552
MOD_NEK2_1	362	367	PF00069	0.430
MOD_NEK2_1	491	496	PF00069	0.419
MOD_NEK2_1	500	505	PF00069	0.398
MOD_NEK2_1	661	666	PF00069	0.516
MOD_NEK2_1	896	901	PF00069	0.489
MOD_NEK2_2	502	507	PF00069	0.380
MOD_NEK2_2	787	792	PF00069	0.359
MOD_PIKK_1	127	133	PF00454	0.512
MOD_PIKK_1	176	182	PF00454	0.495
MOD_PIKK_1	293	299	PF00454	0.528
MOD_PIKK_1	326	332	PF00454	0.483
MOD_PIKK_1	400	406	PF00454	0.582
MOD_PIKK_1	463	469	PF00454	0.519
MOD_PIKK_1	746	752	PF00454	0.432
MOD_PKA_1	283	289	PF00069	0.609
MOD_PKA_1	56	62	PF00069	0.574
MOD_PKA_2	158	164	PF00069	0.587
MOD_PKA_2	283	289	PF00069	0.661
MOD_PKA_2	568	574	PF00069	0.588
MOD_PKA_2	648	654	PF00069	0.541
MOD_Plk_1	100	106	PF00069	0.539
MOD_Plk_1	191	197	PF00069	0.457
MOD_Plk_1	219	225	PF00069	0.652
MOD_Plk_1	233	239	PF00069	0.526
MOD_Plk_1	284	290	PF00069	0.394
MOD_Plk_1	324	330	PF00069	0.491
MOD_Plk_1	343	349	PF00069	0.490
MOD_Plk_1	500	506	PF00069	0.458
MOD_Plk_1	518	524	PF00069	0.510
MOD_Plk_1	560	566	PF00069	0.436
MOD_Plk_1	699	705	PF00069	0.593
MOD_Plk_2-3	215	221	PF00069	0.489
MOD_Plk_2-3	47	53	PF00069	0.457
MOD_Plk_2-3	483	489	PF00069	0.391
MOD_Plk_2-3	761	767	PF00069	0.589
MOD_Plk_4	191	197	PF00069	0.457
MOD_Plk_4	284	290	PF00069	0.394
MOD_Plk_4	408	414	PF00069	0.396
MOD_Plk_4	519	525	PF00069	0.527
MOD_Plk_4	672	678	PF00069	0.630
MOD_Plk_4	750	756	PF00069	0.513
MOD_Plk_4	892	898	PF00069	0.485
MOD_SUMO_for_1	268	271	PF00179	0.578
MOD_SUMO_rev_2	168	177	PF00179	0.536
MOD_SUMO_rev_2	213	219	PF00179	0.577
MOD_SUMO_rev_2	329	338	PF00179	0.586
MOD_SUMO_rev_2	382	390	PF00179	0.607
MOD_SUMO_rev_2	50	58	PF00179	0.519
MOD_SUMO_rev_2	596	604	PF00179	0.505
MOD_SUMO_rev_2	616	624	PF00179	0.391
MOD_SUMO_rev_2	702	711	PF00179	0.586
MOD_SUMO_rev_2	759	764	PF00179	0.506
MOD_SUMO_rev_2	800	810	PF00179	0.452
TRG_AP2beta_CARGO_1	158	167	PF09066	0.403
TRG_DiLeu_BaEn_1	376	381	PF01217	0.559
TRG_DiLeu_BaEn_1	386	391	PF01217	0.495
TRG_DiLeu_BaEn_2	475	481	PF01217	0.490
TRG_DiLeu_BaEn_4	396	402	PF01217	0.594
TRG_DiLeu_BaEn_4	476	482	PF01217	0.393
TRG_DiLeu_BaEn_4	734	740	PF01217	0.371
TRG_ENDOCYTIC_2	349	352	PF00928	0.592
TRG_ENDOCYTIC_2	507	510	PF00928	0.384
TRG_ENDOCYTIC_2	657	660	PF00928	0.437
TRG_ENDOCYTIC_2	845	848	PF00928	0.514
TRG_ER_diArg_1	321	323	PF00400	0.574
TRG_ER_diArg_1	44	46	PF00400	0.481
TRG_ER_diArg_1	469	471	PF00400	0.424
TRG_ER_diArg_1	755	757	PF00400	0.561
TRG_ER_diArg_1	824	826	PF00400	0.617
TRG_ER_diArg_1	96	98	PF00400	0.504
TRG_NES_CRM1_1	131	144	PF08389	0.484
TRG_NES_CRM1_1	190	203	PF08389	0.549
TRG_NLS_Bipartite_1	802	819	PF00514	0.587
TRG_NLS_MonoExtC_3	814	820	PF00514	0.600
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.605
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.666
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.612
TRG_PTS2	1	34	PF00400	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P634	Leptomonas seymouri	51%	100%
A0A3R7LAM9	Trypanosoma rangeli	32%	99%
A0A3S5H5F4	Leishmania donovani	75%	100%
A4HSC4	Leishmania infantum	75%	100%
C9ZPY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	99%
E9AKA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4QJK2	Leishmania major	74%	100%