LeishMANIAdb
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Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania braziliensis
UniProt:
A4H446_LEIBR
TriTrypDb:
LbrM.04.1340 , LBRM2903_040014600
Length:
197

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 6, no: 0
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4H446
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H446

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 53 55 PF00082 0.385
CLV_PCSK_PC1ET2_1 53 55 PF00082 0.385
CLV_PCSK_SKI1_1 7 11 PF00082 0.460
DEG_SPOP_SBC_1 111 115 PF00917 0.491
DEG_SPOP_SBC_1 147 151 PF00917 0.385
DOC_MAPK_gen_1 5 12 PF00069 0.549
DOC_USP7_MATH_1 110 114 PF00917 0.493
DOC_USP7_MATH_1 146 150 PF00917 0.435
DOC_USP7_UBL2_3 121 125 PF12436 0.413
DOC_USP7_UBL2_3 157 161 PF12436 0.367
DOC_USP7_UBL2_3 49 53 PF12436 0.403
DOC_USP7_UBL2_3 85 89 PF12436 0.414
LIG_FHA_2 34 40 PF00498 0.404
LIG_FHA_2 57 63 PF00498 0.423
LIG_SH2_STAP1 21 25 PF00017 0.499
LIG_SH3_4 121 128 PF00018 0.412
LIG_SH3_4 157 164 PF00018 0.371
LIG_SH3_4 49 56 PF00018 0.403
LIG_SH3_4 85 92 PF00018 0.413
LIG_SUMO_SIM_par_1 14 20 PF11976 0.597
LIG_TRAF2_1 59 62 PF00917 0.357
MOD_CK2_1 127 133 PF00069 0.359
MOD_CK2_1 163 169 PF00069 0.391
MOD_CK2_1 33 39 PF00069 0.383
MOD_CK2_1 56 62 PF00069 0.436
MOD_CK2_1 91 97 PF00069 0.388
MOD_GSK3_1 124 131 PF00069 0.487
MOD_GSK3_1 160 167 PF00069 0.477
MOD_GSK3_1 52 59 PF00069 0.458
MOD_GSK3_1 88 95 PF00069 0.493
MOD_NEK2_1 1 6 PF00069 0.510
MOD_NEK2_1 17 22 PF00069 0.572
MOD_OFUCOSY 132 137 PF10250 0.492
MOD_OFUCOSY 168 173 PF10250 0.563
MOD_OFUCOSY 60 65 PF10250 0.390
MOD_OFUCOSY 96 101 PF10250 0.393
MOD_PIKK_1 112 118 PF00454 0.395
MOD_PIKK_1 148 154 PF00454 0.366
MOD_PIKK_1 76 82 PF00454 0.411
MOD_Plk_1 27 33 PF00069 0.505
MOD_SUMO_rev_2 113 122 PF00179 0.394
MOD_SUMO_rev_2 149 158 PF00179 0.362
MOD_SUMO_rev_2 41 50 PF00179 0.390
MOD_SUMO_rev_2 77 86 PF00179 0.393

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H586 Leishmania donovani 30% 100%
A0A3S7X2Y7 Leishmania donovani 34% 100%
A4H440 Leishmania braziliensis 89% 100%
A4HS16 Leishmania infantum 30% 100%
Q9XZY1 Leishmania major 33% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS