LeishMANIAdb
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Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania braziliensis
UniProt:
A4H445_LEIBR
TriTrypDb:
LbrM.04.1330 , LBRM2903_040014600
Length:
125

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 5, no: 0
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H445
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H445

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 53 55 PF00082 0.505
CLV_PCSK_PC1ET2_1 53 55 PF00082 0.505
CLV_PCSK_SKI1_1 7 11 PF00082 0.578
DOC_MAPK_gen_1 5 12 PF00069 0.377
DOC_USP7_UBL2_3 49 53 PF12436 0.320
LIG_FHA_2 34 40 PF00498 0.312
LIG_PDZ_Class_2 120 125 PF00595 0.605
LIG_SH2_STAP1 21 25 PF00017 0.423
LIG_SH3_4 49 56 PF00018 0.319
LIG_Sin3_3 117 124 PF02671 0.263
LIG_SUMO_SIM_par_1 14 20 PF11976 0.441
MOD_CK2_1 33 39 PF00069 0.302
MOD_GlcNHglycan 107 110 PF01048 0.263
MOD_GSK3_1 88 95 PF00069 0.347
MOD_NEK2_1 1 6 PF00069 0.537
MOD_NEK2_1 17 22 PF00069 0.417
MOD_OFUCOSY 60 65 PF10250 0.580
MOD_PIKK_1 76 82 PF00454 0.347
MOD_Plk_1 27 33 PF00069 0.321
MOD_SUMO_rev_2 41 50 PF00179 0.308

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0Z4 Leptomonas seymouri 38% 98%
A0A3S5H6E3 Leishmania donovani 53% 100%
A4HS15 Leishmania infantum 36% 69%
Q9XZY0 Leishmania major 36% 69%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS