Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H444_LEIBR

TriTrypDb:

LbrM.04.1320 , LBRM2903_040007300

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4H444

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H444

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.641
CLV_NRD_NRD_1	107	109	PF00675	0.562
CLV_NRD_NRD_1	250	252	PF00675	0.587
CLV_NRD_NRD_1	77	79	PF00675	0.518
CLV_PCSK_KEX2_1	107	109	PF00082	0.555
CLV_PCSK_KEX2_1	249	251	PF00082	0.587
CLV_PCSK_PC7_1	103	109	PF00082	0.365
CLV_PCSK_SKI1_1	79	83	PF00082	0.483
DEG_Nend_UBRbox_2	1	3	PF02207	0.430
DEG_SIAH_1	165	173	PF03145	0.782
DEG_SPOP_SBC_1	113	117	PF00917	0.662
DOC_CKS1_1	172	177	PF01111	0.665
DOC_CYCLIN_yClb3_PxF_3	165	171	PF00134	0.731
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.658
DOC_MAPK_gen_1	249	257	PF00069	0.785
DOC_PP1_RVXF_1	252	258	PF00149	0.785
DOC_PP2B_LxvP_1	211	214	PF13499	0.641
DOC_PP2B_LxvP_1	217	220	PF13499	0.639
DOC_PP2B_PxIxI_1	36	42	PF00149	0.530
DOC_PP4_FxxP_1	234	237	PF00568	0.660
DOC_USP7_MATH_1	113	117	PF00917	0.599
DOC_USP7_MATH_1	25	29	PF00917	0.498
DOC_WW_Pin1_4	135	140	PF00397	0.714
DOC_WW_Pin1_4	171	176	PF00397	0.668
DOC_WW_Pin1_4	190	195	PF00397	0.716
DOC_WW_Pin1_4	219	224	PF00397	0.800
DOC_WW_Pin1_4	240	245	PF00397	0.768
DOC_WW_Pin1_4	33	38	PF00397	0.567
LIG_14-3-3_CanoR_1	146	155	PF00244	0.755
LIG_deltaCOP1_diTrp_1	84	94	PF00928	0.540
LIG_FHA_1	226	232	PF00498	0.662
LIG_FHA_1	59	65	PF00498	0.260
LIG_FHA_2	91	97	PF00498	0.556
LIG_LIR_Gen_1	93	102	PF02991	0.596
LIG_LIR_Nem_3	84	90	PF02991	0.682
LIG_LIR_Nem_3	93	97	PF02991	0.597
LIG_MYND_1	185	189	PF01753	0.658
LIG_PDZ_Class_2	255	260	PF00595	0.782
LIG_Pex14_2	51	55	PF04695	0.384
LIG_PTB_Apo_2	180	187	PF02174	0.787
LIG_PTB_Apo_2	196	203	PF02174	0.642
LIG_PTB_Apo_2	3	10	PF02174	0.508
LIG_PTB_Phospho_1	180	186	PF10480	0.786
LIG_PTB_Phospho_1	196	202	PF10480	0.643
LIG_SH2_NCK_1	15	19	PF00017	0.370
LIG_SH2_STAT5	186	189	PF00017	0.793
LIG_SH3_2	244	249	PF14604	0.791
LIG_SH3_3	163	169	PF00018	0.771
LIG_SH3_3	179	185	PF00018	0.606
LIG_SH3_3	217	223	PF00018	0.745
LIG_SH3_3	241	247	PF00018	0.723
LIG_SUMO_SIM_anti_2	36	42	PF11976	0.530
LIG_SUMO_SIM_par_1	36	42	PF11976	0.389
MOD_CK1_1	106	112	PF00069	0.722
MOD_CK1_1	116	122	PF00069	0.667
MOD_CK1_1	148	154	PF00069	0.681
MOD_CK1_1	193	199	PF00069	0.794
MOD_CK1_1	253	259	PF00069	0.683
MOD_CK1_1	28	34	PF00069	0.522
MOD_GlcNHglycan	109	112	PF01048	0.409
MOD_GlcNHglycan	116	119	PF01048	0.407
MOD_GlcNHglycan	15	18	PF01048	0.582
MOD_GlcNHglycan	30	34	PF01048	0.592
MOD_GSK3_1	103	110	PF00069	0.652
MOD_GSK3_1	112	119	PF00069	0.674
MOD_GSK3_1	123	130	PF00069	0.689
MOD_GSK3_1	133	140	PF00069	0.736
MOD_GSK3_1	146	153	PF00069	0.742
MOD_GSK3_1	221	228	PF00069	0.738
MOD_GSK3_1	236	243	PF00069	0.701
MOD_GSK3_1	25	32	PF00069	0.382
MOD_N-GLC_1	190	195	PF02516	0.454
MOD_N-GLC_1	198	203	PF02516	0.429
MOD_N-GLC_1	97	102	PF02516	0.431
MOD_NEK2_1	83	88	PF00069	0.577
MOD_NEK2_1	90	95	PF00069	0.578
MOD_PIKK_1	127	133	PF00454	0.715
MOD_PIKK_1	221	227	PF00454	0.715
MOD_PKA_1	107	113	PF00069	0.654
MOD_PKA_1	250	256	PF00069	0.786
MOD_PKA_2	106	112	PF00069	0.700
MOD_PKA_2	122	128	PF00069	0.625
MOD_PKA_2	145	151	PF00069	0.755
MOD_PKA_2	250	256	PF00069	0.786
MOD_Plk_1	198	204	PF00069	0.646
MOD_Plk_1	83	89	PF00069	0.568
MOD_Plk_1	97	103	PF00069	0.603
MOD_Plk_4	253	259	PF00069	0.782
MOD_Plk_4	58	64	PF00069	0.315
MOD_Plk_4	83	89	PF00069	0.568
MOD_Plk_4	97	103	PF00069	0.603
MOD_ProDKin_1	135	141	PF00069	0.711
MOD_ProDKin_1	171	177	PF00069	0.667
MOD_ProDKin_1	190	196	PF00069	0.716
MOD_ProDKin_1	219	225	PF00069	0.800
MOD_ProDKin_1	240	246	PF00069	0.768
MOD_ProDKin_1	33	39	PF00069	0.566
MOD_SUMO_for_1	81	84	PF00179	0.682
TRG_ENDOCYTIC_2	87	90	PF00928	0.683
TRG_ER_diArg_1	248	251	PF00400	0.788

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H588	Leishmania donovani	57%	100%
A4HS18	Leishmania infantum	57%	100%
E9AK05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
Q9U191	Leishmania major	57%	98%