BHLH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H443_LEIBR

TriTrypDb:

LbrM.04.1300 , LBRM2903_040012200

Length:

164

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H443

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H443

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.638
CLV_NRD_NRD_1	115	117	PF00675	0.672
CLV_NRD_NRD_1	94	96	PF00675	0.671
CLV_PCSK_FUR_1	113	117	PF00082	0.676
CLV_PCSK_KEX2_1	112	114	PF00082	0.676
CLV_PCSK_KEX2_1	115	117	PF00082	0.638
CLV_PCSK_KEX2_1	93	95	PF00082	0.669
CLV_PCSK_PC1ET2_1	112	114	PF00082	0.676
CLV_PCSK_SKI1_1	116	120	PF00082	0.663
DEG_SPOP_SBC_1	2	6	PF00917	0.551
DOC_CDC14_PxL_1	46	54	PF14671	0.679
DOC_CKS1_1	19	24	PF01111	0.719
DOC_USP7_MATH_1	152	156	PF00917	0.695
DOC_USP7_MATH_1	2	6	PF00917	0.642
DOC_USP7_UBL2_3	119	123	PF12436	0.667
DOC_WW_Pin1_4	13	18	PF00397	0.535
LIG_14-3-3_CanoR_1	41	47	PF00244	0.671
LIG_Actin_WH2_2	39	55	PF00022	0.672
LIG_FHA_1	61	67	PF00498	0.511
LIG_FHA_2	19	25	PF00498	0.719
LIG_MYND_1	18	22	PF01753	0.712
LIG_SH2_STAT5	39	42	PF00017	0.660
LIG_SH3_3	16	22	PF00018	0.594
LIG_TRAF2_1	21	24	PF00917	0.717
LIG_TRAF2_1	97	100	PF00917	0.474
MOD_CDK_SPxxK_3	18	25	PF00069	0.717
MOD_CK1_1	137	143	PF00069	0.682
MOD_CK1_1	145	151	PF00069	0.637
MOD_CK1_1	154	160	PF00069	0.538
MOD_CK1_1	3	9	PF00069	0.810
MOD_CK2_1	156	162	PF00069	0.532
MOD_CK2_1	18	24	PF00069	0.775
MOD_GlcNHglycan	13	16	PF01048	0.668
MOD_GlcNHglycan	138	142	PF01048	0.676
MOD_GlcNHglycan	6	9	PF01048	0.766
MOD_GSK3_1	139	146	PF00069	0.643
MOD_GSK3_1	147	154	PF00069	0.549
MOD_GSK3_1	60	67	PF00069	0.732
MOD_NEK2_1	105	110	PF00069	0.476
MOD_NEK2_1	144	149	PF00069	0.629
MOD_NEK2_1	52	57	PF00069	0.726
MOD_NEK2_2	42	47	PF00069	0.589
MOD_PIKK_1	105	111	PF00454	0.476
MOD_PKA_2	52	58	PF00069	0.702
MOD_PKB_1	132	140	PF00069	0.621
MOD_Plk_2-3	156	162	PF00069	0.517
MOD_Plk_4	35	41	PF00069	0.662
MOD_ProDKin_1	13	19	PF00069	0.535
TRG_ER_diArg_1	113	116	PF00400	0.747
TRG_ER_diArg_1	131	134	PF00400	0.497
TRG_ER_diArg_1	50	53	PF00400	0.727
TRG_ER_diArg_1	92	95	PF00400	0.495
TRG_NLS_Bipartite_1	93	115	PF00514	0.650
TRG_NLS_MonoExtC_3	110	115	PF00514	0.678
TRG_NLS_MonoExtC_3	118	123	PF00514	0.573
TRG_NLS_MonoExtN_4	111	116	PF00514	0.659
TRG_NLS_MonoExtN_4	119	126	PF00514	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WNR8	Leishmania donovani	84%	98%
A4HS56	Leishmania infantum	84%	98%
E9AK43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
Q9NEE1	Leishmania major	85%	100%