Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania braziliensis

UniProt:

A4H441_LEIBR

TriTrypDb:

LbrM.04.1280 , LBRM2903_040012400

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H441

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H441

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	218	220	PF00675	0.600
CLV_NRD_NRD_1	226	228	PF00675	0.644
CLV_PCSK_KEX2_1	100	102	PF00082	0.406
CLV_PCSK_KEX2_1	218	220	PF00082	0.581
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.406
CLV_PCSK_SKI1_1	101	105	PF00082	0.501
CLV_PCSK_SKI1_1	115	119	PF00082	0.599
CLV_PCSK_SKI1_1	206	210	PF00082	0.515
CLV_PCSK_SKI1_1	42	46	PF00082	0.562
DEG_SCF_TRCP1_1	25	31	PF00400	0.468
DEG_SPOP_SBC_1	265	269	PF00917	0.572
DOC_PP1_RVXF_1	40	47	PF00149	0.370
DOC_PP2B_LxvP_1	124	127	PF13499	0.665
DOC_PP4_FxxP_1	46	49	PF00568	0.408
DOC_USP7_MATH_1	145	149	PF00917	0.514
DOC_USP7_MATH_1	275	279	PF00917	0.759
DOC_WW_Pin1_4	17	22	PF00397	0.429
DOC_WW_Pin1_4	279	284	PF00397	0.589
DOC_WW_Pin1_4	297	302	PF00397	0.535
DOC_WW_Pin1_4	325	330	PF00397	0.664
DOC_WW_Pin1_4	45	50	PF00397	0.457
DOC_WW_Pin1_4	52	57	PF00397	0.469
LIG_14-3-3_CanoR_1	115	124	PF00244	0.625
LIG_14-3-3_CanoR_1	129	133	PF00244	0.618
LIG_14-3-3_CanoR_1	16	24	PF00244	0.427
LIG_14-3-3_CanoR_1	189	197	PF00244	0.500
LIG_14-3-3_CanoR_1	218	226	PF00244	0.618
LIG_14-3-3_CanoR_1	322	330	PF00244	0.686
LIG_14-3-3_CanoR_1	68	78	PF00244	0.418
LIG_BIR_II_1	1	5	PF00653	0.517
LIG_BIR_III_4	258	262	PF00653	0.536
LIG_CtBP_PxDLS_1	261	266	PF00389	0.538
LIG_deltaCOP1_diTrp_1	164	169	PF00928	0.550
LIG_deltaCOP1_diTrp_1	97	105	PF00928	0.409
LIG_FHA_1	280	286	PF00498	0.579
LIG_FHA_1	29	35	PF00498	0.434
LIG_FHA_1	305	311	PF00498	0.612
LIG_FHA_1	312	318	PF00498	0.619
LIG_FHA_1	80	86	PF00498	0.481
LIG_FHA_2	116	122	PF00498	0.520
LIG_FHA_2	52	58	PF00498	0.484
LIG_FHA_2	70	76	PF00498	0.363
LIG_LIR_Apic_2	45	49	PF02991	0.405
LIG_LIR_Nem_3	31	35	PF02991	0.474
LIG_LIR_Nem_3	97	102	PF02991	0.522
LIG_PCNA_PIPBox_1	188	197	PF02747	0.427
LIG_SH2_STAT3	303	306	PF00017	0.557
LIG_SH2_STAT5	303	306	PF00017	0.620
LIG_SH2_STAT5	32	35	PF00017	0.365
LIG_SH2_STAT5	51	54	PF00017	0.404
LIG_SH3_3	201	207	PF00018	0.663
LIG_SH3_3	254	260	PF00018	0.651
LIG_SH3_3	280	286	PF00018	0.727
LIG_SH3_3	326	332	PF00018	0.671
MOD_CDK_SPK_2	17	22	PF00069	0.427
MOD_CK1_1	131	137	PF00069	0.618
MOD_CK1_1	148	154	PF00069	0.452
MOD_CK1_1	268	274	PF00069	0.616
MOD_CK1_1	278	284	PF00069	0.700
MOD_CK1_1	58	64	PF00069	0.571
MOD_CK2_1	115	121	PF00069	0.521
MOD_CK2_1	237	243	PF00069	0.634
MOD_CK2_1	51	57	PF00069	0.518
MOD_CK2_1	69	75	PF00069	0.370
MOD_Cter_Amidation	216	219	PF01082	0.532
MOD_GlcNHglycan	118	121	PF01048	0.588
MOD_GlcNHglycan	220	223	PF01048	0.630
MOD_GlcNHglycan	243	246	PF01048	0.599
MOD_GlcNHglycan	25	28	PF01048	0.534
MOD_GlcNHglycan	278	281	PF01048	0.731
MOD_GlcNHglycan	317	320	PF01048	0.624
MOD_GlcNHglycan	325	328	PF01048	0.605
MOD_GSK3_1	131	138	PF00069	0.662
MOD_GSK3_1	143	150	PF00069	0.588
MOD_GSK3_1	237	244	PF00069	0.625
MOD_GSK3_1	264	271	PF00069	0.622
MOD_GSK3_1	275	282	PF00069	0.729
MOD_GSK3_1	311	318	PF00069	0.606
MOD_GSK3_1	321	328	PF00069	0.713
MOD_GSK3_1	51	58	PF00069	0.504
MOD_NEK2_1	15	20	PF00069	0.511
MOD_NEK2_1	209	214	PF00069	0.685
MOD_NEK2_1	264	269	PF00069	0.548
MOD_NEK2_1	69	74	PF00069	0.409
MOD_NEK2_2	167	172	PF00069	0.373
MOD_PIKK_1	131	137	PF00454	0.603
MOD_PIKK_1	184	190	PF00454	0.473
MOD_PIKK_1	269	275	PF00454	0.550
MOD_PIKK_1	312	318	PF00454	0.584
MOD_PIKK_1	79	85	PF00454	0.395
MOD_PKA_1	218	224	PF00069	0.579
MOD_PKA_2	128	134	PF00069	0.593
MOD_PKA_2	15	21	PF00069	0.416
MOD_PKA_2	217	223	PF00069	0.599
MOD_PKA_2	232	238	PF00069	0.626
MOD_PKA_2	312	318	PF00069	0.539
MOD_PKA_2	321	327	PF00069	0.716
MOD_Plk_1	167	173	PF00069	0.535
MOD_Plk_4	28	34	PF00069	0.504
MOD_Plk_4	304	310	PF00069	0.521
MOD_ProDKin_1	17	23	PF00069	0.435
MOD_ProDKin_1	279	285	PF00069	0.588
MOD_ProDKin_1	297	303	PF00069	0.536
MOD_ProDKin_1	325	331	PF00069	0.662
MOD_ProDKin_1	45	51	PF00069	0.461
MOD_ProDKin_1	52	58	PF00069	0.469
TRG_PTS1	336	339	PF00515	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P325	Leptomonas seymouri	30%	96%
A0A3S5H5B7	Leishmania donovani	58%	100%
A4HS58	Leishmania infantum	58%	100%
E9ACP8	Leishmania major	54%	100%
E9AK45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	55%	100%