LeishMANIAdb
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Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania braziliensis
UniProt:
A4H440_LEIBR
TriTrypDb:
LbrM.04.1270 , LBRM2903_040014600
Length:
197

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 3, no: 0
NetGPI no yes: 0, no: 3
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4H440
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H440

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 53 55 PF00082 0.570
CLV_PCSK_PC1ET2_1 53 55 PF00082 0.570
CLV_PCSK_SKI1_1 7 11 PF00082 0.603
DEG_SPOP_SBC_1 111 115 PF00917 0.455
DOC_MAPK_gen_1 5 12 PF00069 0.682
DOC_USP7_MATH_1 110 114 PF00917 0.458
DOC_USP7_UBL2_3 121 125 PF12436 0.380
DOC_USP7_UBL2_3 49 53 PF12436 0.387
DOC_USP7_UBL2_3 85 89 PF12436 0.390
LIG_FHA_2 34 40 PF00498 0.383
LIG_FHA_2 70 76 PF00498 0.351
LIG_FHA_2 93 99 PF00498 0.337
LIG_PDZ_Class_2 192 197 PF00595 0.296
LIG_SH2_STAP1 21 25 PF00017 0.511
LIG_SH3_4 121 128 PF00018 0.381
LIG_SH3_4 49 56 PF00018 0.385
LIG_SH3_4 85 92 PF00018 0.389
LIG_Sin3_3 189 196 PF02671 0.296
LIG_SUMO_SIM_par_1 14 20 PF11976 0.639
LIG_TRAF2_1 95 98 PF00917 0.339
MOD_CK2_1 127 133 PF00069 0.371
MOD_CK2_1 33 39 PF00069 0.365
MOD_CK2_1 69 75 PF00069 0.342
MOD_CK2_1 92 98 PF00069 0.376
MOD_GlcNHglycan 179 182 PF01048 0.574
MOD_GSK3_1 124 131 PF00069 0.466
MOD_GSK3_1 160 167 PF00069 0.414
MOD_GSK3_1 88 95 PF00069 0.468
MOD_NEK2_1 1 6 PF00069 0.527
MOD_NEK2_1 17 22 PF00069 0.577
MOD_OFUCOSY 132 137 PF10250 0.736
MOD_OFUCOSY 60 65 PF10250 0.573
MOD_OFUCOSY 96 101 PF10250 0.575
MOD_PIKK_1 112 118 PF00454 0.375
MOD_PIKK_1 76 82 PF00454 0.375
MOD_Plk_1 27 33 PF00069 0.467
MOD_SUMO_rev_2 113 122 PF00179 0.373
MOD_SUMO_rev_2 41 50 PF00179 0.370
MOD_SUMO_rev_2 77 86 PF00179 0.374

Homologs

Protein Taxonomy Sequence identity Coverage
A4H446 Leishmania braziliensis 89% 100%
Q9XZY1 Leishmania major 27% 71%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS