Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania braziliensis

UniProt:

A4H439_LEIBR

TriTrypDb:

LbrM.04.1260 , LBRM2903_000006700 , LBRM2903_040014600

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4H439

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H439

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	207	209	PF00082	0.532
CLV_PCSK_KEX2_1	243	245	PF00082	0.519
CLV_PCSK_PC1ET2_1	207	209	PF00082	0.532
CLV_PCSK_PC1ET2_1	243	245	PF00082	0.519
CLV_PCSK_SKI1_1	7	11	PF00082	0.592
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.366
DOC_MAPK_gen_1	5	12	PF00069	0.545
DOC_PP2B_LxvP_1	141	144	PF13499	0.383
DOC_PP4_FxxP_1	125	128	PF00568	0.375
DOC_USP7_UBL2_3	203	207	PF12436	0.354
DOC_USP7_UBL2_3	239	243	PF12436	0.352
DOC_USP7_UBL2_3	49	53	PF12436	0.368
LIG_EVH1_1	102	106	PF00568	0.390
LIG_FHA_2	160	166	PF00498	0.347
LIG_FHA_2	224	230	PF00498	0.353
LIG_FHA_2	34	40	PF00498	0.444
LIG_FHA_2	73	79	PF00498	0.356
LIG_PDZ_Class_2	310	315	PF00595	0.294
LIG_SH2_STAP1	21	25	PF00017	0.633
LIG_SH2_STAT5	91	94	PF00017	0.432
LIG_SH3_3	59	65	PF00018	0.366
LIG_SH3_3	97	103	PF00018	0.491
LIG_SH3_4	203	210	PF00018	0.351
LIG_SH3_4	239	246	PF00018	0.349
LIG_SH3_4	49	56	PF00018	0.363
LIG_Sin3_3	307	314	PF02671	0.294
LIG_SUMO_SIM_par_1	14	20	PF11976	0.601
MOD_CK2_1	154	160	PF00069	0.360
MOD_CK2_1	223	229	PF00069	0.330
MOD_CK2_1	33	39	PF00069	0.416
MOD_CK2_1	72	78	PF00069	0.350
MOD_GlcNHglycan	297	300	PF01048	0.608
MOD_GlcNHglycan	54	57	PF01048	0.558
MOD_GSK3_1	155	162	PF00069	0.353
MOD_GSK3_1	206	213	PF00069	0.443
MOD_GSK3_1	242	249	PF00069	0.503
MOD_GSK3_1	278	285	PF00069	0.458
MOD_N-GLC_1	168	173	PF02516	0.557
MOD_N-GLC_2	121	123	PF02516	0.529
MOD_N-GLC_2	82	84	PF02516	0.539
MOD_NEK2_1	1	6	PF00069	0.706
MOD_NEK2_1	17	22	PF00069	0.605
MOD_OFUCOSY	214	219	PF10250	0.689
MOD_OFUCOSY	250	255	PF10250	0.731
MOD_PIKK_1	194	200	PF00454	0.342
MOD_PIKK_1	230	236	PF00454	0.339
MOD_PIKK_1	266	272	PF00454	0.333
MOD_PIKK_1	40	46	PF00454	0.349
MOD_Plk_1	159	165	PF00069	0.341
MOD_Plk_1	27	33	PF00069	0.386
MOD_SUMO_rev_2	195	204	PF00179	0.340
MOD_SUMO_rev_2	231	240	PF00179	0.337
MOD_SUMO_rev_2	41	50	PF00179	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZJ5	Leptomonas seymouri	26%	100%
A0A3S5H586	Leishmania donovani	24%	100%
A4H3U2	Leishmania braziliensis	34%	68%
A4HS16	Leishmania infantum	25%	100%
Q9XZY1	Leishmania major	29%	100%