Actin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Actin

Gene product:

actin

Species:

Leishmania braziliensis

UniProt:

A4H438_LEIBR

TriTrypDb:

LbrM.04.1250 , LBRM2903_040020500

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4H438

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H438

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	51	55	PF00656	0.617
CLV_NRD_NRD_1	101	103	PF00675	0.333
CLV_NRD_NRD_1	145	147	PF00675	0.333
CLV_PCSK_KEX2_1	101	103	PF00082	0.333
CLV_PCSK_SKI1_1	123	127	PF00082	0.417
CLV_PCSK_SKI1_1	21	25	PF00082	0.384
CLV_Separin_Metazoa	18	22	PF03568	0.617
DEG_Nend_UBRbox_1	1	4	PF02207	0.755
DOC_MAPK_gen_1	146	152	PF00069	0.533
DOC_MAPK_gen_1	64	72	PF00069	0.617
DOC_MAPK_MEF2A_6	64	72	PF00069	0.617
DOC_PP4_FxxP_1	50	53	PF00568	0.617
DOC_PP4_FxxP_1	65	68	PF00568	0.533
LIG_14-3-3_CanoR_1	146	151	PF00244	0.518
LIG_BRCT_BRCA1_1	113	117	PF00533	0.617
LIG_Clathr_ClatBox_1	76	80	PF01394	0.533
LIG_FHA_1	163	169	PF00498	0.533
LIG_FHA_2	11	17	PF00498	0.617
LIG_LIR_Apic_2	47	53	PF02991	0.617
LIG_LIR_Gen_1	161	168	PF02991	0.502
LIG_LIR_Gen_1	87	98	PF02991	0.496
LIG_LIR_Nem_3	103	108	PF02991	0.533
LIG_LIR_Nem_3	114	120	PF02991	0.533
LIG_LIR_Nem_3	87	93	PF02991	0.496
LIG_Pex14_2	163	167	PF04695	0.533
LIG_PTB_Apo_2	59	66	PF02174	0.533
LIG_SH2_CRK	105	109	PF00017	0.450
LIG_SH2_CRK	90	94	PF00017	0.589
LIG_SH2_PTP2	29	32	PF00017	0.617
LIG_SH2_SRC	173	176	PF00017	0.533
LIG_SH2_STAP1	148	152	PF00017	0.533
LIG_SH2_STAT5	29	32	PF00017	0.617
LIG_SH3_3	137	143	PF00018	0.528
LIG_SH3_3	80	86	PF00018	0.617
LIG_TRAF2_1	45	48	PF00917	0.536
LIG_TYR_ITAM	87	108	PF00017	0.617
LIG_TYR_ITIM	27	32	PF00017	0.617
LIG_WRC_WIRS_1	160	165	PF05994	0.533
MOD_CK1_1	111	117	PF00069	0.533
MOD_CK1_1	155	161	PF00069	0.505
MOD_CK1_1	176	182	PF00069	0.617
MOD_CK1_1	41	47	PF00069	0.617
MOD_CK2_1	10	16	PF00069	0.617
MOD_CK2_1	41	47	PF00069	0.617
MOD_GlcNHglycan	110	113	PF01048	0.333
MOD_GlcNHglycan	174	178	PF01048	0.417
MOD_GlcNHglycan	40	43	PF01048	0.417
MOD_GSK3_1	108	115	PF00069	0.533
MOD_GSK3_1	152	159	PF00069	0.498
MOD_GSK3_1	7	14	PF00069	0.617
MOD_N-GLC_2	183	185	PF02516	0.333
MOD_N-GLC_2	94	96	PF02516	0.333
MOD_NEK2_1	38	43	PF00069	0.617
MOD_NEK2_1	4	9	PF00069	0.400
MOD_NEK2_2	112	117	PF00069	0.533
MOD_PK_1	146	152	PF00069	0.533
MOD_PKA_1	146	152	PF00069	0.533
MOD_Plk_1	46	52	PF00069	0.617
MOD_Plk_4	112	118	PF00069	0.533
MOD_Plk_4	146	152	PF00069	0.495
MOD_Plk_4	162	168	PF00069	0.367
MOD_Plk_4	176	182	PF00069	0.533
MOD_Plk_4	72	78	PF00069	0.545
TRG_DiLeu_BaEn_4	47	53	PF01217	0.617
TRG_ENDOCYTIC_2	105	108	PF00928	0.450
TRG_ENDOCYTIC_2	29	32	PF00928	0.617
TRG_ENDOCYTIC_2	90	93	PF00928	0.589
TRG_ER_diArg_1	100	102	PF00400	0.533
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5IRJ8	Trypanosoma rangeli	89%	100%
P10994	Pleurodeles waltl	65%	100%
P24902	Pinus contorta	67%	100%
P86700	Chionoecetes opilio	33%	97%
Q25379	Lytechinus pictus	65%	100%
Q25380	Lytechinus pictus	61%	100%
Q25381	Lytechinus pictus	66%	100%
Q5JWF8	Homo sapiens	33%	76%
Q92192	Calanus finmarchicus	62%	67%
Q92193	Crassostrea virginica	63%	70%