RNI-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNI-like protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H435_LEIBR

TriTrypDb:

LbrM.04.1220 , LBRM2903_040019900

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	13
GO:0042995	cell projection	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0110165	cellular anatomical entity	1	13
GO:0120025	plasma membrane bounded cell projection	3	13
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H435

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H435

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.359
CLV_NRD_NRD_1	15	17	PF00675	0.738
CLV_PCSK_KEX2_1	17	19	PF00082	0.529
CLV_PCSK_KEX2_1	172	174	PF00082	0.574
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.529
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.574
CLV_PCSK_SKI1_1	172	176	PF00082	0.396
CLV_PCSK_SKI1_1	5	9	PF00082	0.605
DOC_PP1_RVXF_1	90	97	PF00149	0.369
DOC_USP7_MATH_1	180	184	PF00917	0.460
DOC_USP7_MATH_1	48	52	PF00917	0.471
DOC_USP7_UBL2_3	13	17	PF12436	0.565
DOC_WW_Pin1_4	24	29	PF00397	0.397
LIG_14-3-3_CanoR_1	176	184	PF00244	0.540
LIG_14-3-3_CanoR_1	44	53	PF00244	0.536
LIG_APCC_ABBAyCdc20_2	92	98	PF00400	0.287
LIG_BRCT_BRCA1_1	124	128	PF00533	0.495
LIG_FHA_1	10	16	PF00498	0.626
LIG_FHA_1	48	54	PF00498	0.448
LIG_FHA_1	63	69	PF00498	0.424
LIG_LIR_Gen_1	120	129	PF02991	0.469
LIG_LIR_Gen_1	47	54	PF02991	0.548
LIG_LIR_Nem_3	120	124	PF02991	0.469
LIG_LIR_Nem_3	47	52	PF02991	0.575
LIG_MYND_3	116	120	PF01753	0.502
LIG_SH2_STAT5	34	37	PF00017	0.413
LIG_SH2_STAT5	72	75	PF00017	0.333
LIG_SH3_2	3	8	PF14604	0.683
LIG_SH3_3	3	9	PF00018	0.667
LIG_SH3_3	56	62	PF00018	0.356
LIG_SUMO_SIM_par_1	148	153	PF11976	0.283
LIG_SUMO_SIM_par_1	63	69	PF11976	0.427
LIG_TRAF2_1	29	32	PF00917	0.530
LIG_UBA3_1	165	172	PF00899	0.549
LIG_UBA3_1	81	87	PF00899	0.544
MOD_CK1_1	47	53	PF00069	0.477
MOD_CK2_1	26	32	PF00069	0.486
MOD_CK2_1	34	40	PF00069	0.441
MOD_GlcNHglycan	111	114	PF01048	0.438
MOD_GlcNHglycan	46	49	PF01048	0.428
MOD_GSK3_1	180	187	PF00069	0.550
MOD_GSK3_1	20	27	PF00069	0.642
MOD_GSK3_1	44	51	PF00069	0.503
MOD_GSK3_1	62	69	PF00069	0.366
MOD_N-GLC_1	20	25	PF02516	0.744
MOD_NEK2_1	152	157	PF00069	0.516
MOD_NEK2_1	66	71	PF00069	0.264
MOD_NEK2_2	11	16	PF00069	0.728
MOD_PIKK_1	175	181	PF00454	0.538
MOD_PKA_1	172	178	PF00069	0.591
MOD_PKA_2	172	178	PF00069	0.589
MOD_Plk_1	62	68	PF00069	0.472
MOD_Plk_4	180	186	PF00069	0.646
MOD_Plk_4	48	54	PF00069	0.536
MOD_ProDKin_1	24	30	PF00069	0.381
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.434
TRG_ER_diArg_1	101	104	PF00400	0.538
TRG_ER_diArg_1	15	18	PF00400	0.650
TRG_NLS_MonoExtN_4	13	20	PF00514	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I143	Leptomonas seymouri	69%	92%
A0A0S4IYV0	Bodo saltans	42%	97%
A0A0S4JTE7	Bodo saltans	42%	97%
A0A1X0NKZ2	Trypanosomatidae	45%	100%
A0A3S5H5F3	Leishmania donovani	81%	100%
A0A422NNV2	Trypanosoma rangeli	46%	100%
A4HSB9	Leishmania infantum	81%	100%
C9ZYB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AKA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
O97000	Leishmania major	82%	100%
V5DEE3	Trypanosoma cruzi	46%	75%