Putative tRNA nucleotidyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tRNA nucleotidyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4H434_LEIBR

TriTrypDb:

LbrM.04.1210 , LBRM2903_040019800

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H434

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H434

Function

Biological processes
Term	Name	Level	Count
GO:0001680	tRNA 3'-terminal CCA addition	9	11
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0031123	RNA 3'-end processing	7	12
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	11
GO:0042780	tRNA 3'-end processing	8	11
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071076	RNA 3' uridylation	8	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016779	nucleotidyltransferase activity	4	12
GO:0050265	RNA uridylyltransferase activity	4	12
GO:0070569	uridylyltransferase activity	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	3
GO:0004810	CCA tRNA nucleotidyltransferase activity	8	3
GO:0052929	ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity	9	3
GO:0070566	adenylyltransferase activity	5	3
GO:0140101	catalytic activity, acting on a tRNA	4	3
GO:1990817	poly(A) RNA polymerase activity	7	3
GO:0052927	CTP:tRNA cytidylyltransferase activity	5	2
GO:0070567	cytidylyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.271
CLV_NRD_NRD_1	369	371	PF00675	0.390
CLV_NRD_NRD_1	398	400	PF00675	0.491
CLV_PCSK_KEX2_1	141	143	PF00082	0.271
CLV_PCSK_KEX2_1	296	298	PF00082	0.543
CLV_PCSK_KEX2_1	369	371	PF00082	0.389
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.543
CLV_PCSK_SKI1_1	142	146	PF00082	0.307
CLV_PCSK_SKI1_1	238	242	PF00082	0.313
CLV_PCSK_SKI1_1	340	344	PF00082	0.536
CLV_PCSK_SKI1_1	39	43	PF00082	0.291
CLV_PCSK_SKI1_1	399	403	PF00082	0.458
CLV_PCSK_SKI1_1	419	423	PF00082	0.368
CLV_PCSK_SKI1_1	496	500	PF00082	0.483
DEG_APCC_DBOX_1	38	46	PF00400	0.504
DEG_MDM2_SWIB_1	447	455	PF02201	0.522
DEG_Nend_UBRbox_1	1	4	PF02207	0.346
DOC_CKS1_1	502	507	PF01111	0.367
DOC_MAPK_gen_1	296	304	PF00069	0.520
DOC_MAPK_gen_1	492	499	PF00069	0.500
DOC_MAPK_MEF2A_6	105	113	PF00069	0.562
DOC_MAPK_MEF2A_6	13	21	PF00069	0.363
DOC_MAPK_MEF2A_6	326	333	PF00069	0.487
DOC_MAPK_MEF2A_6	492	499	PF00069	0.502
DOC_MAPK_NFAT4_5	492	500	PF00069	0.490
DOC_PP1_RVXF_1	190	197	PF00149	0.348
DOC_PP2B_LxvP_1	334	337	PF13499	0.346
DOC_PP2B_LxvP_1	358	361	PF13499	0.404
DOC_PP2B_LxvP_1	466	469	PF13499	0.567
DOC_USP7_MATH_1	115	119	PF00917	0.397
DOC_USP7_MATH_1	22	26	PF00917	0.489
DOC_USP7_MATH_1	292	296	PF00917	0.576
DOC_USP7_MATH_1	342	346	PF00917	0.496
DOC_USP7_MATH_1	361	365	PF00917	0.320
DOC_USP7_UBL2_3	234	238	PF12436	0.516
DOC_USP7_UBL2_3	492	496	PF12436	0.482
DOC_WW_Pin1_4	436	441	PF00397	0.390
DOC_WW_Pin1_4	5	10	PF00397	0.362
DOC_WW_Pin1_4	501	506	PF00397	0.564
LIG_14-3-3_CanoR_1	180	190	PF00244	0.513
LIG_14-3-3_CanoR_1	303	308	PF00244	0.466
LIG_14-3-3_CanoR_1	412	421	PF00244	0.382
LIG_Actin_WH2_2	212	228	PF00022	0.360
LIG_Actin_WH2_2	483	498	PF00022	0.542
LIG_APCC_ABBA_1	288	293	PF00400	0.555
LIG_APCC_ABBAyCdc20_2	117	123	PF00400	0.501
LIG_FHA_1	153	159	PF00498	0.478
LIG_FHA_1	160	166	PF00498	0.470
LIG_FHA_1	210	216	PF00498	0.452
LIG_FHA_1	28	34	PF00498	0.352
LIG_FHA_1	341	347	PF00498	0.498
LIG_FHA_1	99	105	PF00498	0.518
LIG_FHA_2	161	167	PF00498	0.490
LIG_FHA_2	180	186	PF00498	0.266
LIG_FHA_2	382	388	PF00498	0.310
LIG_FHA_2	405	411	PF00498	0.471
LIG_FHA_2	502	508	PF00498	0.551
LIG_LIR_Apic_2	477	482	PF02991	0.563
LIG_LIR_Gen_1	112	121	PF02991	0.459
LIG_LIR_Gen_1	235	243	PF02991	0.520
LIG_LIR_Gen_1	364	372	PF02991	0.373
LIG_LIR_Gen_1	373	383	PF02991	0.445
LIG_LIR_Gen_1	444	455	PF02991	0.472
LIG_LIR_Gen_1	73	81	PF02991	0.397
LIG_LIR_Nem_3	112	116	PF02991	0.459
LIG_LIR_Nem_3	364	368	PF02991	0.369
LIG_LIR_Nem_3	373	378	PF02991	0.426
LIG_LIR_Nem_3	444	450	PF02991	0.481
LIG_LIR_Nem_3	73	78	PF02991	0.566
LIG_NRBOX	330	336	PF00104	0.345
LIG_OCRL_FandH_1	149	161	PF00620	0.539
LIG_Pex14_2	447	451	PF04695	0.523
LIG_REV1ctd_RIR_1	336	344	PF16727	0.534
LIG_SH2_CRK	365	369	PF00017	0.268
LIG_SH2_CRK	375	379	PF00017	0.258
LIG_SH2_CRK	479	483	PF00017	0.582
LIG_SH2_STAP1	379	383	PF00017	0.292
LIG_SH2_STAT5	121	124	PF00017	0.480
LIG_SH2_STAT5	161	164	PF00017	0.491
LIG_SH3_3	129	135	PF00018	0.483
LIG_SH3_3	173	179	PF00018	0.513
LIG_SH3_3	304	310	PF00018	0.476
LIG_SH3_3	452	458	PF00018	0.462
LIG_SH3_3	495	501	PF00018	0.497
LIG_SUMO_SIM_anti_2	216	224	PF11976	0.492
LIG_TRAF2_1	474	477	PF00917	0.313
LIG_TRFH_1	333	337	PF08558	0.228
LIG_TYR_ITIM	423	428	PF00017	0.473
LIG_UBA3_1	219	226	PF00899	0.413
LIG_UBA3_1	490	496	PF00899	0.503
MOD_CK1_1	436	442	PF00069	0.515
MOD_CK2_1	160	166	PF00069	0.492
MOD_CK2_1	203	209	PF00069	0.502
MOD_CK2_1	22	28	PF00069	0.304
MOD_CK2_1	342	348	PF00069	0.460
MOD_CK2_1	381	387	PF00069	0.476
MOD_CK2_1	471	477	PF00069	0.312
MOD_Cter_Amidation	272	275	PF01082	0.659
MOD_GlcNHglycan	429	433	PF01048	0.555
MOD_GlcNHglycan	435	438	PF01048	0.531
MOD_GlcNHglycan	447	450	PF01048	0.502
MOD_GSK3_1	115	122	PF00069	0.502
MOD_GSK3_1	342	349	PF00069	0.523
MOD_GSK3_1	404	411	PF00069	0.489
MOD_GSK3_1	441	448	PF00069	0.528
MOD_GSK3_1	80	87	PF00069	0.497
MOD_N-GLC_1	203	208	PF02516	0.440
MOD_N-GLC_1	408	413	PF02516	0.304
MOD_N-GLC_1	445	450	PF02516	0.349
MOD_N-GLC_2	352	354	PF02516	0.483
MOD_NEK2_1	262	267	PF00069	0.417
MOD_NEK2_1	27	32	PF00069	0.509
MOD_NEK2_1	302	307	PF00069	0.417
MOD_NEK2_1	408	413	PF00069	0.422
MOD_NEK2_1	464	469	PF00069	0.417
MOD_NEK2_2	389	394	PF00069	0.586
MOD_PK_1	303	309	PF00069	0.266
MOD_PKA_2	179	185	PF00069	0.440
MOD_PKA_2	302	308	PF00069	0.518
MOD_Plk_1	122	128	PF00069	0.558
MOD_Plk_1	142	148	PF00069	0.480
MOD_Plk_1	203	209	PF00069	0.438
MOD_Plk_1	215	221	PF00069	0.434
MOD_Plk_1	27	33	PF00069	0.419
MOD_Plk_1	346	352	PF00069	0.540
MOD_Plk_1	379	385	PF00069	0.410
MOD_Plk_1	408	414	PF00069	0.446
MOD_Plk_1	445	451	PF00069	0.305
MOD_Plk_2-3	119	125	PF00069	0.397
MOD_Plk_4	215	221	PF00069	0.389
MOD_Plk_4	262	268	PF00069	0.461
MOD_Plk_4	297	303	PF00069	0.502
MOD_Plk_4	486	492	PF00069	0.525
MOD_Plk_4	84	90	PF00069	0.490
MOD_ProDKin_1	436	442	PF00069	0.383
MOD_ProDKin_1	5	11	PF00069	0.351
MOD_ProDKin_1	501	507	PF00069	0.563
MOD_SUMO_rev_2	20	27	PF00179	0.523
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.394
TRG_DiLeu_BaLyEn_6	367	372	PF01217	0.496
TRG_ENDOCYTIC_2	365	368	PF00928	0.344
TRG_ENDOCYTIC_2	375	378	PF00928	0.412
TRG_ENDOCYTIC_2	425	428	PF00928	0.396
TRG_ENDOCYTIC_2	75	78	PF00928	0.397
TRG_ER_diArg_1	168	171	PF00400	0.543
TRG_ER_diArg_1	368	370	PF00400	0.407
TRG_NES_CRM1_1	217	230	PF08389	0.438
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.317
TRG_PTS1	515	518	PF00515	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUG7	Leptomonas seymouri	64%	98%
A0A0S4JS32	Bodo saltans	31%	100%
A0A0S4JSB5	Bodo saltans	45%	100%
A0A1X0NL45	Trypanosomatidae	47%	98%
A0A3S7WNX9	Leishmania donovani	82%	99%
A0A422NNU3	Trypanosoma rangeli	46%	99%
A4HSB8	Leishmania infantum	82%	99%
C9ZYB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	98%
E9AKA0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
O97001	Leishmania major	82%	100%
V5BI79	Trypanosoma cruzi	46%	98%