Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Double RNA binding domain protein 3

Species:

Leishmania braziliensis

UniProt:

A4H432_LEIBR

TriTrypDb:

LbrM.04.1190 , LBRM2903_040019500

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H432

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H432

Function

Biological processes
Term	Name	Level	Count
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003729	mRNA binding	5	1
GO:0003730	mRNA 3'-UTR binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	155	161	PF00089	0.577
CLV_NRD_NRD_1	153	155	PF00675	0.457
CLV_PCSK_KEX2_1	153	155	PF00082	0.457
CLV_PCSK_SKI1_1	173	177	PF00082	0.427
CLV_PCSK_SKI1_1	242	246	PF00082	0.335
CLV_PCSK_SKI1_1	92	96	PF00082	0.312
DEG_APCC_DBOX_1	172	180	PF00400	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.633
DEG_SCF_FBW7_1	94	99	PF00400	0.510
DEG_SPOP_SBC_1	302	306	PF00917	0.706
DOC_CYCLIN_RxL_1	170	178	PF00134	0.445
DOC_MAPK_gen_1	153	159	PF00069	0.578
DOC_PP4_FxxP_1	142	145	PF00568	0.572
DOC_PP4_MxPP_1	308	311	PF00568	0.742
DOC_USP7_MATH_1	234	238	PF00917	0.607
DOC_USP7_MATH_1	27	31	PF00917	0.616
DOC_USP7_MATH_1	275	279	PF00917	0.628
DOC_WW_Pin1_4	128	133	PF00397	0.607
DOC_WW_Pin1_4	190	195	PF00397	0.356
DOC_WW_Pin1_4	23	28	PF00397	0.704
DOC_WW_Pin1_4	92	97	PF00397	0.516
LIG_14-3-3_CanoR_1	158	165	PF00244	0.610
LIG_Clathr_ClatBox_1	229	233	PF01394	0.510
LIG_FHA_1	170	176	PF00498	0.464
LIG_FHA_1	191	197	PF00498	0.476
LIG_FHA_1	255	261	PF00498	0.464
LIG_FHA_1	274	280	PF00498	0.536
LIG_FHA_1	83	89	PF00498	0.561
LIG_FHA_1	93	99	PF00498	0.474
LIG_FHA_2	180	186	PF00498	0.511
LIG_FHA_2	249	255	PF00498	0.531
LIG_LIR_Apic_2	140	145	PF02991	0.575
LIG_LIR_Gen_1	144	155	PF02991	0.463
LIG_LIR_Gen_1	195	204	PF02991	0.574
LIG_LIR_Gen_1	261	270	PF02991	0.475
LIG_LIR_LC3C_4	276	281	PF02991	0.622
LIG_LIR_Nem_3	144	150	PF02991	0.456
LIG_LIR_Nem_3	195	201	PF02991	0.560
LIG_LIR_Nem_3	203	207	PF02991	0.540
LIG_LYPXL_S_1	308	312	PF13949	0.674
LIG_LYPXL_yS_3	309	312	PF13949	0.650
LIG_PTB_Apo_2	178	185	PF02174	0.485
LIG_PTB_Phospho_1	178	184	PF10480	0.477
LIG_REV1ctd_RIR_1	139	144	PF16727	0.475
LIG_SH2_CRK	12	16	PF00017	0.667
LIG_SH2_CRK	39	43	PF00017	0.749
LIG_SH2_GRB2like	43	46	PF00017	0.796
LIG_SH2_NCK_1	147	151	PF00017	0.454
LIG_SH2_NCK_1	39	43	PF00017	0.749
LIG_SH2_SRC	147	150	PF00017	0.445
LIG_SH2_SRC	20	23	PF00017	0.779
LIG_SH2_SRC	39	42	PF00017	0.772
LIG_SH2_SRC	43	46	PF00017	0.706
LIG_SH2_STAT3	2	5	PF00017	0.641
LIG_SH2_STAT5	156	159	PF00017	0.438
LIG_SH3_3	16	22	PF00018	0.696
LIG_SH3_3	208	214	PF00018	0.510
LIG_SUMO_SIM_anti_2	208	214	PF11976	0.574
LIG_SUMO_SIM_anti_2	30	37	PF11976	0.785
LIG_SUMO_SIM_par_1	172	178	PF11976	0.432
LIG_SUMO_SIM_par_1	248	255	PF11976	0.627
LIG_UBA3_1	126	133	PF00899	0.604
MOD_CDK_SPK_2	128	133	PF00069	0.607
MOD_CK1_1	131	137	PF00069	0.521
MOD_CK1_1	203	209	PF00069	0.569
MOD_CK1_1	28	34	PF00069	0.630
MOD_CK2_1	248	254	PF00069	0.686
MOD_Cter_Amidation	151	154	PF01082	0.482
MOD_GlcNHglycan	133	136	PF01048	0.310
MOD_GlcNHglycan	236	239	PF01048	0.404
MOD_GSK3_1	165	172	PF00069	0.524
MOD_GSK3_1	175	182	PF00069	0.469
MOD_GSK3_1	23	30	PF00069	0.731
MOD_GSK3_1	248	255	PF00069	0.626
MOD_GSK3_1	269	276	PF00069	0.634
MOD_GSK3_1	66	73	PF00069	0.711
MOD_GSK3_1	92	99	PF00069	0.510
MOD_N-GLC_1	163	168	PF02516	0.653
MOD_N-GLC_1	215	220	PF02516	0.310
MOD_N-GLC_1	83	88	PF02516	0.578
MOD_N-GLC_1	92	97	PF02516	0.274
MOD_NEK2_1	165	170	PF00069	0.532
MOD_NEK2_1	175	180	PF00069	0.427
MOD_NEK2_1	252	257	PF00069	0.604
MOD_NEK2_1	303	308	PF00069	0.744
MOD_PIKK_1	165	171	PF00454	0.522
MOD_PIKK_1	179	185	PF00454	0.494
MOD_PIKK_1	216	222	PF00454	0.535
MOD_PIKK_1	70	76	PF00454	0.809
MOD_PIKK_1	96	102	PF00454	0.511
MOD_PKA_2	157	163	PF00069	0.504
MOD_PKA_2	234	240	PF00069	0.604
MOD_Plk_1	216	222	PF00069	0.604
MOD_Plk_1	83	89	PF00069	0.524
MOD_Plk_1	96	102	PF00069	0.493
MOD_Plk_4	175	181	PF00069	0.446
MOD_Plk_4	275	281	PF00069	0.622
MOD_Plk_4	304	310	PF00069	0.639
MOD_Plk_4	31	37	PF00069	0.775
MOD_Plk_4	84	90	PF00069	0.676
MOD_ProDKin_1	128	134	PF00069	0.607
MOD_ProDKin_1	190	196	PF00069	0.356
MOD_ProDKin_1	23	29	PF00069	0.707
MOD_ProDKin_1	92	98	PF00069	0.516
MOD_SUMO_for_1	214	217	PF00179	0.521
MOD_SUMO_rev_2	265	273	PF00179	0.534
TRG_ENDOCYTIC_2	147	150	PF00928	0.435
TRG_ENDOCYTIC_2	156	159	PF00928	0.426
TRG_ENDOCYTIC_2	198	201	PF00928	0.510
TRG_ENDOCYTIC_2	204	207	PF00928	0.510
TRG_ENDOCYTIC_2	309	312	PF00928	0.650
TRG_ER_diArg_1	153	155	PF00400	0.457
TRG_ER_diArg_1	75	78	PF00400	0.694

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I013	Leptomonas seymouri	76%	97%
A0A0S4JUP2	Bodo saltans	67%	78%
A0A1X0NMJ6	Trypanosomatidae	67%	99%
A0A3R7NIY6	Trypanosoma rangeli	65%	98%
A0A3S7WNY0	Leishmania donovani	95%	100%
A4HSB6	Leishmania infantum	95%	100%
C9ZYA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	96%
E9AK98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O97003	Leishmania major	94%	99%
V5BDL5	Trypanosoma cruzi	64%	100%