31-O-demethyl-FK506 methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

31-O-demethyl-FK506 methyltransferase

Species:

Leishmania braziliensis

UniProt:

A4H431_LEIBR

TriTrypDb:

LbrM.04.1180 , LBRM2903_040019400

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4H431

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H431

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	4
GO:0032259	methylation	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0008168	methyltransferase activity	4	4
GO:0016740	transferase activity	2	4
GO:0016741	transferase activity, transferring one-carbon groups	3	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	236	238	PF00675	0.283
CLV_NRD_NRD_1	264	266	PF00675	0.206
CLV_NRD_NRD_1	295	297	PF00675	0.212
CLV_NRD_NRD_1	312	314	PF00675	0.229
CLV_NRD_NRD_1	347	349	PF00675	0.325
CLV_PCSK_FUR_1	310	314	PF00082	0.200
CLV_PCSK_KEX2_1	235	237	PF00082	0.292
CLV_PCSK_KEX2_1	263	265	PF00082	0.216
CLV_PCSK_KEX2_1	295	297	PF00082	0.212
CLV_PCSK_KEX2_1	312	314	PF00082	0.229
CLV_PCSK_KEX2_1	32	34	PF00082	0.476
CLV_PCSK_KEX2_1	347	349	PF00082	0.372
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.280
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.476
CLV_PCSK_SKI1_1	207	211	PF00082	0.407
CLV_PCSK_SKI1_1	264	268	PF00082	0.367
CLV_PCSK_SKI1_1	63	67	PF00082	0.427
DEG_APCC_KENBOX_2	122	126	PF00400	0.243
DOC_CYCLIN_yCln2_LP_2	217	223	PF00134	0.237
DOC_MAPK_gen_1	235	246	PF00069	0.520
DOC_MAPK_gen_1	295	302	PF00069	0.412
DOC_MAPK_gen_1	319	328	PF00069	0.412
DOC_MAPK_MEF2A_6	295	304	PF00069	0.402
DOC_MAPK_MEF2A_6	73	80	PF00069	0.248
DOC_PP2B_LxvP_1	217	220	PF13499	0.242
DOC_PP2B_LxvP_1	255	258	PF13499	0.426
DOC_USP7_MATH_1	158	162	PF00917	0.243
DOC_WW_Pin1_4	229	234	PF00397	0.355
DOC_WW_Pin1_4	80	85	PF00397	0.271
LIG_14-3-3_CanoR_1	178	183	PF00244	0.320
LIG_14-3-3_CanoR_1	252	256	PF00244	0.412
LIG_14-3-3_CanoR_1	263	273	PF00244	0.378
LIG_14-3-3_CanoR_1	340	345	PF00244	0.525
LIG_Actin_WH2_2	11	28	PF00022	0.338
LIG_BIR_II_1	1	5	PF00653	0.400
LIG_BIR_III_4	39	43	PF00653	0.318
LIG_Clathr_ClatBox_1	273	277	PF01394	0.391
LIG_FHA_1	196	202	PF00498	0.411
LIG_FHA_1	213	219	PF00498	0.164
LIG_FHA_1	25	31	PF00498	0.373
LIG_FHA_1	5	11	PF00498	0.349
LIG_FHA_1	56	62	PF00498	0.263
LIG_FHA_2	347	353	PF00498	0.532
LIG_GBD_Chelix_1	61	69	PF00786	0.436
LIG_LIR_Gen_1	282	290	PF02991	0.410
LIG_LIR_Nem_3	282	286	PF02991	0.470
LIG_LIR_Nem_3	291	297	PF02991	0.439
LIG_LIR_Nem_3	46	52	PF02991	0.261
LIG_NRBOX	200	206	PF00104	0.252
LIG_NRBOX	212	218	PF00104	0.178
LIG_SH2_CRK	49	53	PF00017	0.235
LIG_SH2_PTP2	13	16	PF00017	0.219
LIG_SH2_STAP1	163	167	PF00017	0.432
LIG_SH2_STAT3	129	132	PF00017	0.258
LIG_SH2_STAT5	13	16	PF00017	0.290
LIG_SH2_STAT5	71	74	PF00017	0.236
LIG_SH3_3	191	197	PF00018	0.305
LIG_SH3_4	207	214	PF00018	0.200
LIG_SUMO_SIM_anti_2	215	220	PF11976	0.219
LIG_SUMO_SIM_par_1	197	203	PF11976	0.255
LIG_SUMO_SIM_par_1	300	306	PF11976	0.421
LIG_SUMO_SIM_par_1	83	88	PF11976	0.209
LIG_TRAF2_1	329	332	PF00917	0.501
LIG_TYR_ITIM	47	52	PF00017	0.317
LIG_UBA3_1	200	207	PF00899	0.255
LIG_UBA3_1	227	235	PF00899	0.434
MOD_CDC14_SPxK_1	232	235	PF00782	0.479
MOD_CDK_SPxK_1	229	235	PF00069	0.340
MOD_CDK_SPxxK_3	229	236	PF00069	0.355
MOD_CK1_1	141	147	PF00069	0.290
MOD_CK2_1	143	149	PF00069	0.358
MOD_CK2_1	158	164	PF00069	0.228
MOD_CK2_1	200	206	PF00069	0.252
MOD_CK2_1	346	352	PF00069	0.532
MOD_GlcNHglycan	140	143	PF01048	0.444
MOD_GlcNHglycan	145	148	PF01048	0.449
MOD_GlcNHglycan	39	43	PF01048	0.516
MOD_GSK3_1	158	165	PF00069	0.263
MOD_GSK3_1	31	38	PF00069	0.268
MOD_N-GLC_1	186	191	PF02516	0.472
MOD_NEK2_1	200	205	PF00069	0.260
MOD_NEK2_1	250	255	PF00069	0.433
MOD_NEK2_1	4	9	PF00069	0.336
MOD_NEK2_1	69	74	PF00069	0.243
MOD_NEK2_2	158	163	PF00069	0.246
MOD_NEK2_2	94	99	PF00069	0.227
MOD_PIKK_1	31	37	PF00454	0.266
MOD_PK_1	178	184	PF00069	0.304
MOD_PK_1	340	346	PF00069	0.439
MOD_PKA_1	264	270	PF00069	0.412
MOD_PKA_2	251	257	PF00069	0.412
MOD_PKA_2	264	270	PF00069	0.371
MOD_PKA_2	346	352	PF00069	0.501
MOD_Plk_1	250	256	PF00069	0.400
MOD_Plk_4	158	164	PF00069	0.316
MOD_Plk_4	178	184	PF00069	0.355
MOD_Plk_4	195	201	PF00069	0.231
MOD_Plk_4	212	218	PF00069	0.160
MOD_Plk_4	340	346	PF00069	0.431
MOD_ProDKin_1	229	235	PF00069	0.358
MOD_ProDKin_1	80	86	PF00069	0.265
MOD_SUMO_rev_2	46	52	PF00179	0.240
TRG_DiLeu_BaEn_1	282	287	PF01217	0.431
TRG_ENDOCYTIC_2	13	16	PF00928	0.219
TRG_ENDOCYTIC_2	49	52	PF00928	0.316
TRG_ER_diArg_1	262	265	PF00400	0.494
TRG_ER_diArg_1	294	296	PF00400	0.412
TRG_ER_diArg_1	310	313	PF00400	0.433
TRG_NLS_MonoExtN_4	233	239	PF00514	0.472
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.200
TRG_Pf-PMV_PEXEL_1	295	299	PF00026	0.263

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBS3	Leptomonas seymouri	58%	99%
A0A0S4JIM3	Bodo saltans	35%	95%
A0A3S7WNZ2	Leishmania donovani	56%	100%