Putative cytochrome c oxidase assembly factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase assembly factor, putative

Species:

Leishmania braziliensis

UniProt:

A4H427_LEIBR

TriTrypDb:

LbrM.04.1140 , LBRM2903_040019000

Length:

298

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	10
GO:0016020	membrane	2	11
GO:0019866	organelle inner membrane	4	10
GO:0031090	organelle membrane	3	10
GO:0031966	mitochondrial membrane	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4H427

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H427

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	10
GO:0006875	obsolete intracellular metal ion homeostasis	6	10
GO:0006878	intracellular copper ion homeostasis	8	10
GO:0008535	respiratory chain complex IV assembly	7	10
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0017004	cytochrome complex assembly	6	10
GO:0019725	cellular homeostasis	2	10
GO:0022607	cellular component assembly	4	10
GO:0030003	intracellular monoatomic cation homeostasis	5	10
GO:0042592	homeostatic process	3	10
GO:0043933	protein-containing complex organization	4	10
GO:0046916	obsolete intracellular transition metal ion homeostasis	7	10
GO:0048878	chemical homeostasis	4	10
GO:0050801	monoatomic ion homeostasis	5	10
GO:0055065	obsolete metal ion homeostasis	7	10
GO:0055070	copper ion homeostasis	9	10
GO:0055076	obsolete transition metal ion homeostasis	8	10
GO:0055080	monoatomic cation homeostasis	6	10
GO:0055082	intracellular chemical homeostasis	3	10
GO:0065003	protein-containing complex assembly	5	10
GO:0065007	biological regulation	1	10
GO:0065008	regulation of biological quality	2	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0098771	inorganic ion homeostasis	6	10
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	10
GO:0005507	copper ion binding	6	10
GO:0016491	oxidoreductase activity	2	5
GO:0016530	metallochaperone activity	2	10
GO:0016531	copper chaperone activity	3	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0140104	molecular carrier activity	1	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	196	198	PF00675	0.460
CLV_NRD_NRD_1	21	23	PF00675	0.424
CLV_NRD_NRD_1	53	55	PF00675	0.546
CLV_PCSK_KEX2_1	196	198	PF00082	0.483
CLV_PCSK_KEX2_1	21	23	PF00082	0.426
CLV_PCSK_SKI1_1	101	105	PF00082	0.623
CLV_PCSK_SKI1_1	123	127	PF00082	0.555
CLV_PCSK_SKI1_1	276	280	PF00082	0.573
CLV_PCSK_SKI1_1	38	42	PF00082	0.515
CLV_PCSK_SKI1_1	76	80	PF00082	0.271
DEG_APCC_DBOX_1	196	204	PF00400	0.250
DEG_SPOP_SBC_1	40	44	PF00917	0.554
DOC_CKS1_1	218	223	PF01111	0.250
DOC_CYCLIN_yCln2_LP_2	126	132	PF00134	0.250
DOC_MAPK_DCC_7	181	191	PF00069	0.250
DOC_PP1_RVXF_1	262	269	PF00149	0.299
DOC_USP7_MATH_1	110	114	PF00917	0.422
DOC_USP7_MATH_1	227	231	PF00917	0.250
DOC_WW_Pin1_4	217	222	PF00397	0.250
LIG_14-3-3_CanoR_1	115	119	PF00244	0.443
LIG_14-3-3_CanoR_1	14	20	PF00244	0.647
LIG_14-3-3_CanoR_1	169	177	PF00244	0.329
LIG_14-3-3_CanoR_1	21	30	PF00244	0.628
LIG_AP2alpha_1	265	269	PF02296	0.281
LIG_BRCT_BRCA1_1	147	151	PF00533	0.280
LIG_BRCT_BRCA1_1	15	19	PF00533	0.547
LIG_deltaCOP1_diTrp_1	292	298	PF00928	0.321
LIG_eIF4E_1	5	11	PF01652	0.629
LIG_FHA_1	277	283	PF00498	0.310
LIG_FHA_1	41	47	PF00498	0.744
LIG_FHA_2	237	243	PF00498	0.325
LIG_LIR_Gen_1	148	156	PF02991	0.280
LIG_LIR_Gen_1	15	24	PF02991	0.668
LIG_LIR_Gen_1	204	214	PF02991	0.282
LIG_LIR_Nem_3	148	154	PF02991	0.252
LIG_LIR_Nem_3	204	209	PF02991	0.263
LIG_LIR_Nem_3	213	217	PF02991	0.230
LIG_LIR_Nem_3	230	234	PF02991	0.205
LIG_Pex14_1	149	153	PF04695	0.250
LIG_Pex14_2	145	149	PF04695	0.250
LIG_Pex14_2	152	156	PF04695	0.250
LIG_Pex14_2	210	214	PF04695	0.250
LIG_Pex14_2	265	269	PF04695	0.281
LIG_REV1ctd_RIR_1	266	276	PF16727	0.308
LIG_SH2_CRK	235	239	PF00017	0.250
LIG_SH2_CRK	82	86	PF00017	0.345
LIG_SH2_NCK_1	235	239	PF00017	0.250
LIG_SH2_STAT5	107	110	PF00017	0.391
LIG_SH2_STAT5	153	156	PF00017	0.250
LIG_SH2_STAT5	206	209	PF00017	0.250
LIG_SH2_STAT5	248	251	PF00017	0.250
LIG_SH3_3	206	212	PF00018	0.277
LIG_SH3_3	215	221	PF00018	0.218
LIG_TRAF2_1	238	241	PF00917	0.280
LIG_TRAF2_1	243	246	PF00917	0.281
LIG_TRAF2_2	221	226	PF00917	0.250
MOD_CDK_SPK_2	217	222	PF00069	0.250
MOD_CK1_1	117	123	PF00069	0.421
MOD_CK1_1	15	21	PF00069	0.683
MOD_CK1_1	236	242	PF00069	0.242
MOD_CK2_1	138	144	PF00069	0.256
MOD_CK2_1	240	246	PF00069	0.266
MOD_CMANNOS	295	298	PF00535	0.522
MOD_GlcNHglycan	111	115	PF01048	0.627
MOD_GSK3_1	110	117	PF00069	0.438
MOD_GSK3_1	22	29	PF00069	0.687
MOD_GSK3_1	236	243	PF00069	0.266
MOD_GSK3_1	38	45	PF00069	0.612
MOD_N-GLC_1	61	66	PF02516	0.338
MOD_NEK2_1	1	6	PF00069	0.727
MOD_NEK2_1	13	18	PF00069	0.652
MOD_NEK2_1	132	137	PF00069	0.309
MOD_NEK2_1	145	150	PF00069	0.218
MOD_NEK2_1	154	159	PF00069	0.252
MOD_NEK2_1	46	51	PF00069	0.666
MOD_PIKK_1	138	144	PF00454	0.253
MOD_PIKK_1	240	246	PF00454	0.172
MOD_PKA_1	196	202	PF00069	0.250
MOD_PKA_2	114	120	PF00069	0.438
MOD_PKA_2	13	19	PF00069	0.603
MOD_PKA_2	168	174	PF00069	0.247
MOD_PKA_2	196	202	PF00069	0.245
MOD_Plk_1	250	256	PF00069	0.250
MOD_Plk_4	205	211	PF00069	0.289
MOD_Plk_4	92	98	PF00069	0.340
MOD_ProDKin_1	217	223	PF00069	0.250
TRG_ENDOCYTIC_2	153	156	PF00928	0.250
TRG_ENDOCYTIC_2	206	209	PF00928	0.280
TRG_ENDOCYTIC_2	234	237	PF00928	0.250
TRG_ENDOCYTIC_2	82	85	PF00928	0.322
TRG_ER_diArg_1	121	124	PF00400	0.384
TRG_ER_diArg_1	195	197	PF00400	0.262
TRG_ER_diArg_1	20	22	PF00400	0.604
TRG_NES_CRM1_1	198	213	PF08389	0.302
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2G6	Leptomonas seymouri	38%	69%
A0A0N0P3R3	Leptomonas seymouri	79%	96%
A0A0N1I6S1	Leptomonas seymouri	29%	100%
A0A0S4J8R8	Bodo saltans	72%	100%
A0A0S4KH84	Bodo saltans	25%	91%
A0A1X0NLN8	Trypanosomatidae	72%	100%
A0A1X0NWD3	Trypanosomatidae	30%	100%
A0A3Q8ID19	Leishmania donovani	38%	69%
A0A3R7L4G0	Trypanosoma rangeli	30%	100%
A0A3S5H5E9	Leishmania donovani	87%	96%
A0A3S5H786	Leishmania donovani	30%	100%
A4HF41	Leishmania braziliensis	39%	100%
A4HSB1	Leishmania infantum	88%	96%
A4HYS6	Leishmania infantum	29%	100%
A4I2C5	Leishmania infantum	39%	69%
C9ZX87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	77%
C9ZYA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9AID5	Leishmania braziliensis	29%	100%
E9AK94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AUM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AYH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
O97196	Leishmania major	85%	100%
P38072	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	99%
Q4Q8Z5	Leishmania major	39%	100%
Q4QCW2	Leishmania major	29%	100%
Q5RH02	Danio rerio	33%	100%
Q8VYP0	Arabidopsis thaliana	37%	89%
V5BI84	Trypanosoma cruzi	71%	100%
V5BQS4	Trypanosoma cruzi	31%	88%