LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4H425_LEIBR
TriTrypDb:
LbrM.04.1110 , LBRM2903_040018600
Length:
108

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H425
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H425

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 29 31 PF00675 0.442
CLV_NRD_NRD_1 64 66 PF00675 0.429
CLV_NRD_NRD_1 90 92 PF00675 0.516
CLV_PCSK_KEX2_1 29 31 PF00082 0.428
CLV_PCSK_KEX2_1 64 66 PF00082 0.471
CLV_PCSK_KEX2_1 90 92 PF00082 0.499
CLV_PCSK_KEX2_1 94 96 PF00082 0.515
CLV_PCSK_PC1ET2_1 94 96 PF00082 0.548
CLV_PCSK_PC7_1 90 96 PF00082 0.362
CLV_PCSK_SKI1_1 30 34 PF00082 0.442
CLV_PCSK_SKI1_1 64 68 PF00082 0.562
DOC_CKS1_1 103 108 PF01111 0.483
DOC_MAPK_gen_1 29 38 PF00069 0.446
DOC_MAPK_gen_1 5 13 PF00069 0.619
DOC_WW_Pin1_4 102 107 PF00397 0.467
LIG_14-3-3_CanoR_1 90 97 PF00244 0.624
LIG_BIR_II_1 1 5 PF00653 0.601
LIG_FHA_1 17 23 PF00498 0.443
LIG_FHA_1 91 97 PF00498 0.364
LIG_Pex14_2 56 60 PF04695 0.430
LIG_REV1ctd_RIR_1 14 22 PF16727 0.588
MOD_GlcNHglycan 42 45 PF01048 0.512
MOD_NEK2_1 38 43 PF00069 0.341
MOD_NEK2_2 9 14 PF00069 0.488
MOD_PKA_1 90 96 PF00069 0.549
MOD_PKA_2 89 95 PF00069 0.580
MOD_Plk_1 9 15 PF00069 0.485
MOD_ProDKin_1 102 108 PF00069 0.476
MOD_SUMO_for_1 17 20 PF00179 0.496
MOD_SUMO_for_1 56 59 PF00179 0.430
MOD_SUMO_rev_2 26 34 PF00179 0.538
TRG_DiLeu_BaLyEn_6 34 39 PF01217 0.351
TRG_ER_diArg_1 35 38 PF00400 0.354
TRG_ER_diArg_1 64 66 PF00400 0.539
TRG_ER_diArg_1 89 91 PF00400 0.623
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.587

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HVA0 Leptomonas seymouri 66% 89%
A0A1X0NLG7 Trypanosomatidae 61% 94%
A0A3R7NSY9 Trypanosoma rangeli 54% 100%
A0A3S7WNW8 Leishmania donovani 77% 99%
A4HSA8 Leishmania infantum 77% 99%
C9ZYA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
E9AK91 Leishmania mexicana (strain MHOM/GT/2001/U1103) 79% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS