Transcriptional repressor TCF25 family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Transcriptional repressor TCF25, putative

Species:

Leishmania braziliensis

UniProt:

A4H423_LEIBR

TriTrypDb:

LbrM.04.1090 , LBRM2903_040018300

Length:

794

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0110165	cellular anatomical entity	1	1
GO:1990112	RQC complex	2	1

Expansion

Sequence features

A4H423

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H423

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.591
CLV_C14_Caspase3-7	182	186	PF00656	0.557
CLV_C14_Caspase3-7	448	452	PF00656	0.454
CLV_C14_Caspase3-7	772	776	PF00656	0.775
CLV_NRD_NRD_1	103	105	PF00675	0.694
CLV_NRD_NRD_1	191	193	PF00675	0.709
CLV_NRD_NRD_1	330	332	PF00675	0.420
CLV_NRD_NRD_1	426	428	PF00675	0.435
CLV_NRD_NRD_1	44	46	PF00675	0.730
CLV_NRD_NRD_1	72	74	PF00675	0.567
CLV_NRD_NRD_1	724	726	PF00675	0.619
CLV_NRD_NRD_1	83	85	PF00675	0.561
CLV_PCSK_FUR_1	401	405	PF00082	0.401
CLV_PCSK_KEX2_1	103	105	PF00082	0.703
CLV_PCSK_KEX2_1	191	193	PF00082	0.709
CLV_PCSK_KEX2_1	330	332	PF00082	0.418
CLV_PCSK_KEX2_1	366	368	PF00082	0.444
CLV_PCSK_KEX2_1	403	405	PF00082	0.372
CLV_PCSK_KEX2_1	426	428	PF00082	0.435
CLV_PCSK_KEX2_1	44	46	PF00082	0.741
CLV_PCSK_KEX2_1	48	50	PF00082	0.698
CLV_PCSK_KEX2_1	71	73	PF00082	0.595
CLV_PCSK_KEX2_1	724	726	PF00082	0.619
CLV_PCSK_KEX2_1	82	84	PF00082	0.565
CLV_PCSK_PC1ET2_1	366	368	PF00082	0.444
CLV_PCSK_PC1ET2_1	403	405	PF00082	0.401
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.674
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.630
CLV_PCSK_PC7_1	187	193	PF00082	0.622
CLV_PCSK_PC7_1	44	50	PF00082	0.557
CLV_PCSK_SKI1_1	331	335	PF00082	0.436
CLV_PCSK_SKI1_1	378	382	PF00082	0.418
CLV_PCSK_SKI1_1	439	443	PF00082	0.485
CLV_PCSK_SKI1_1	45	49	PF00082	0.730
CLV_PCSK_SKI1_1	450	454	PF00082	0.304
CLV_PCSK_SKI1_1	499	503	PF00082	0.344
CLV_PCSK_SKI1_1	646	650	PF00082	0.617
CLV_PCSK_SKI1_1	68	72	PF00082	0.703
CLV_PCSK_SKI1_1	717	721	PF00082	0.654
DEG_APCC_DBOX_1	716	724	PF00400	0.659
DEG_SCF_TRCP1_1	623	628	PF00400	0.786
DEG_SPOP_SBC_1	110	114	PF00917	0.671
DEG_SPOP_SBC_1	551	555	PF00917	0.233
DOC_CKS1_1	220	225	PF01111	0.419
DOC_CYCLIN_RxL_1	375	384	PF00134	0.444
DOC_MAPK_gen_1	196	205	PF00069	0.634
DOC_MAPK_gen_1	376	383	PF00069	0.444
DOC_MAPK_gen_1	401	411	PF00069	0.401
DOC_MAPK_gen_1	525	533	PF00069	0.233
DOC_MAPK_RevD_3	315	331	PF00069	0.452
DOC_MAPK_RevD_3	391	404	PF00069	0.401
DOC_PP2B_LxvP_1	459	462	PF13499	0.485
DOC_USP7_MATH_1	10	14	PF00917	0.763
DOC_USP7_MATH_1	133	137	PF00917	0.773
DOC_USP7_MATH_1	19	23	PF00917	0.717
DOC_USP7_MATH_1	230	234	PF00917	0.565
DOC_USP7_MATH_1	266	270	PF00917	0.485
DOC_USP7_MATH_1	43	47	PF00917	0.719
DOC_USP7_MATH_1	430	434	PF00917	0.501
DOC_USP7_MATH_1	511	515	PF00917	0.491
DOC_USP7_MATH_1	551	555	PF00917	0.396
DOC_USP7_MATH_1	578	582	PF00917	0.401
DOC_USP7_MATH_1	59	63	PF00917	0.588
DOC_USP7_MATH_1	621	625	PF00917	0.434
DOC_USP7_UBL2_3	71	75	PF12436	0.499
DOC_WW_Pin1_4	116	121	PF00397	0.804
DOC_WW_Pin1_4	185	190	PF00397	0.674
DOC_WW_Pin1_4	219	224	PF00397	0.405
DOC_WW_Pin1_4	509	514	PF00397	0.416
DOC_WW_Pin1_4	547	552	PF00397	0.233
DOC_WW_Pin1_4	778	783	PF00397	0.562
LIG_14-3-3_CanoR_1	265	271	PF00244	0.485
LIG_14-3-3_CanoR_1	378	384	PF00244	0.444
LIG_14-3-3_CanoR_1	44	51	PF00244	0.712
LIG_14-3-3_CanoR_1	506	510	PF00244	0.485
LIG_Actin_WH2_2	350	368	PF00022	0.344
LIG_Actin_WH2_2	435	452	PF00022	0.485
LIG_BIR_III_4	245	249	PF00653	0.364
LIG_BIR_III_4	535	539	PF00653	0.452
LIG_BRCT_BRCA1_1	201	205	PF00533	0.506
LIG_BRCT_BRCA1_1	259	263	PF00533	0.516
LIG_Clathr_ClatBox_1	380	384	PF01394	0.394
LIG_Clathr_ClatBox_1	392	396	PF01394	0.280
LIG_deltaCOP1_diTrp_1	245	251	PF00928	0.601
LIG_EH1_1	605	613	PF00400	0.485
LIG_eIF4E_1	293	299	PF01652	0.344
LIG_FAT_LD_1	696	704	PF03623	0.501
LIG_FHA_1	149	155	PF00498	0.542
LIG_FHA_1	198	204	PF00498	0.594
LIG_FHA_1	375	381	PF00498	0.342
LIG_FHA_1	587	593	PF00498	0.358
LIG_FHA_1	614	620	PF00498	0.323
LIG_FHA_2	165	171	PF00498	0.470
LIG_FHA_2	237	243	PF00498	0.556
LIG_FHA_2	370	376	PF00498	0.344
LIG_FHA_2	446	452	PF00498	0.501
LIG_FHA_2	779	785	PF00498	0.566
LIG_LIR_Gen_1	150	159	PF02991	0.585
LIG_LIR_Gen_1	25	35	PF02991	0.775
LIG_LIR_Gen_1	252	262	PF02991	0.289
LIG_LIR_Gen_1	396	402	PF02991	0.378
LIG_LIR_Gen_1	558	567	PF02991	0.372
LIG_LIR_Nem_3	150	156	PF02991	0.603
LIG_LIR_Nem_3	25	31	PF02991	0.779
LIG_LIR_Nem_3	252	257	PF02991	0.390
LIG_LIR_Nem_3	396	400	PF02991	0.368
LIG_LIR_Nem_3	558	563	PF02991	0.372
LIG_LIR_Nem_3	643	648	PF02991	0.550
LIG_LIR_Nem_3	750	754	PF02991	0.781
LIG_LIR_Nem_3	764	768	PF02991	0.640
LIG_OCRL_FandH_1	586	598	PF00620	0.444
LIG_PCNA_PIPBox_1	580	589	PF02747	0.233
LIG_PCNA_yPIPBox_3	347	357	PF02747	0.378
LIG_PCNA_yPIPBox_3	580	590	PF02747	0.233
LIG_PTB_Apo_2	460	467	PF02174	0.444
LIG_SH2_CRK	231	235	PF00017	0.420
LIG_SH2_CRK	293	297	PF00017	0.344
LIG_SH2_CRK	397	401	PF00017	0.444
LIG_SH2_CRK	645	649	PF00017	0.641
LIG_SH2_NCK_1	766	770	PF00017	0.774
LIG_SH2_STAP1	303	307	PF00017	0.444
LIG_SH2_STAP1	464	468	PF00017	0.401
LIG_SH2_STAT5	254	257	PF00017	0.386
LIG_SH2_STAT5	397	400	PF00017	0.344
LIG_SH2_STAT5	715	718	PF00017	0.686
LIG_SH3_3	114	120	PF00018	0.811
LIG_SH3_3	15	21	PF00018	0.715
LIG_SH3_3	382	388	PF00018	0.444
LIG_SH3_3	488	494	PF00018	0.233
LIG_SH3_3	609	615	PF00018	0.339
LIG_SH3_3	656	662	PF00018	0.484
LIG_SUMO_SIM_anti_2	598	605	PF11976	0.446
LIG_SUMO_SIM_par_1	379	384	PF11976	0.423
LIG_SUMO_SIM_par_1	390	396	PF11976	0.363
LIG_TRAF2_1	239	242	PF00917	0.576
LIG_TRAF2_1	51	54	PF00917	0.535
LIG_TRAF2_1	735	738	PF00917	0.824
LIG_TRAF2_1	91	94	PF00917	0.646
LIG_TYR_ITIM	229	234	PF00017	0.522
LIG_TYR_ITIM	395	400	PF00017	0.344
MOD_CDK_SPxK_1	185	191	PF00069	0.674
MOD_CDK_SPxK_1	219	225	PF00069	0.417
MOD_CDK_SPxxK_3	185	192	PF00069	0.673
MOD_CK1_1	136	142	PF00069	0.811
MOD_CK1_1	22	28	PF00069	0.822
MOD_CK1_1	39	45	PF00069	0.538
MOD_CK1_1	549	555	PF00069	0.408
MOD_CK1_1	613	619	PF00069	0.446
MOD_CK1_1	640	646	PF00069	0.557
MOD_CK1_1	767	773	PF00069	0.777
MOD_CK2_1	164	170	PF00069	0.406
MOD_CK2_1	236	242	PF00069	0.560
MOD_CK2_1	369	375	PF00069	0.344
MOD_CK2_1	450	456	PF00069	0.354
MOD_CK2_1	731	737	PF00069	0.664
MOD_GlcNHglycan	12	15	PF01048	0.831
MOD_GlcNHglycan	143	146	PF01048	0.558
MOD_GlcNHglycan	21	24	PF01048	0.665
MOD_GlcNHglycan	217	220	PF01048	0.511
MOD_GlcNHglycan	310	313	PF01048	0.444
MOD_GlcNHglycan	334	337	PF01048	0.432
MOD_GlcNHglycan	347	350	PF01048	0.463
MOD_GlcNHglycan	45	48	PF01048	0.722
MOD_GlcNHglycan	514	517	PF01048	0.387
MOD_GlcNHglycan	519	522	PF01048	0.372
MOD_GlcNHglycan	567	570	PF01048	0.425
MOD_GlcNHglycan	60	64	PF01048	0.680
MOD_GlcNHglycan	623	626	PF01048	0.481
MOD_GlcNHglycan	639	642	PF01048	0.672
MOD_GlcNHglycan	733	736	PF01048	0.817
MOD_GlcNHglycan	737	741	PF01048	0.804
MOD_GlcNHglycan	769	772	PF01048	0.777
MOD_GSK3_1	197	204	PF00069	0.568
MOD_GSK3_1	215	222	PF00069	0.289
MOD_GSK3_1	35	42	PF00069	0.769
MOD_GSK3_1	505	512	PF00069	0.474
MOD_GSK3_1	546	553	PF00069	0.392
MOD_GSK3_1	621	628	PF00069	0.347
MOD_GSK3_1	633	640	PF00069	0.672
MOD_GSK3_1	688	695	PF00069	0.653
MOD_N-GLC_1	632	637	PF02516	0.734
MOD_N-GLC_1	646	651	PF02516	0.599
MOD_NEK2_1	215	220	PF00069	0.418
MOD_NEK2_1	256	261	PF00069	0.435
MOD_NEK2_1	332	337	PF00069	0.375
MOD_NEK2_1	395	400	PF00069	0.444
MOD_NEK2_1	586	591	PF00069	0.437
MOD_NEK2_1	632	637	PF00069	0.729
MOD_NEK2_1	654	659	PF00069	0.580
MOD_NEK2_2	201	206	PF00069	0.587
MOD_NEK2_2	445	450	PF00069	0.485
MOD_PIKK_1	552	558	PF00454	0.491
MOD_PIKK_1	688	694	PF00454	0.530
MOD_PK_1	276	282	PF00069	0.233
MOD_PKA_2	197	203	PF00069	0.582
MOD_PKA_2	43	49	PF00069	0.789
MOD_PKA_2	492	498	PF00069	0.422
MOD_PKA_2	505	511	PF00069	0.453
MOD_PKA_2	649	655	PF00069	0.641
MOD_PKB_1	644	652	PF00069	0.648
MOD_Plk_1	149	155	PF00069	0.632
MOD_Plk_1	35	41	PF00069	0.703
MOD_Plk_1	395	401	PF00069	0.444
MOD_Plk_1	450	456	PF00069	0.358
MOD_Plk_1	632	638	PF00069	0.633
MOD_Plk_1	677	683	PF00069	0.642
MOD_Plk_4	149	155	PF00069	0.592
MOD_Plk_4	201	207	PF00069	0.512
MOD_Plk_4	294	300	PF00069	0.344
MOD_Plk_4	555	561	PF00069	0.415
MOD_Plk_4	649	655	PF00069	0.597
MOD_ProDKin_1	116	122	PF00069	0.803
MOD_ProDKin_1	185	191	PF00069	0.674
MOD_ProDKin_1	219	225	PF00069	0.417
MOD_ProDKin_1	509	515	PF00069	0.416
MOD_ProDKin_1	547	553	PF00069	0.233
MOD_ProDKin_1	778	784	PF00069	0.565
MOD_SUMO_rev_2	432	441	PF00179	0.484
MOD_SUMO_rev_2	6	10	PF00179	0.566
TRG_DiLeu_BaEn_1	599	604	PF01217	0.444
TRG_DiLeu_BaEn_1	92	97	PF01217	0.538
TRG_DiLeu_BaEn_4	92	98	PF01217	0.559
TRG_ENDOCYTIC_2	226	229	PF00928	0.449
TRG_ENDOCYTIC_2	231	234	PF00928	0.392
TRG_ENDOCYTIC_2	254	257	PF00928	0.485
TRG_ENDOCYTIC_2	397	400	PF00928	0.344
TRG_ENDOCYTIC_2	645	648	PF00928	0.575
TRG_ER_diArg_1	171	174	PF00400	0.460
TRG_ER_diArg_1	329	331	PF00400	0.397
TRG_ER_diArg_1	411	414	PF00400	0.423
TRG_ER_diArg_1	425	427	PF00400	0.444
TRG_ER_diArg_1	723	725	PF00400	0.646
TRG_ER_diArg_1	82	84	PF00400	0.620
TRG_NLS_MonoCore_2	70	75	PF00514	0.614
TRG_NLS_MonoExtC_3	70	75	PF00514	0.636
TRG_NLS_MonoExtN_4	68	75	PF00514	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q4	Leptomonas seymouri	52%	92%
A0A1X0NMM7	Trypanosomatidae	35%	94%
A0A3R7KGE4	Trypanosoma rangeli	35%	96%
A0A3S5H5E5	Leishmania donovani	78%	91%
A4HSA5	Leishmania infantum	78%	91%
C9ZY97	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	96%
E9AK89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	90%
Q9NF87	Leishmania major	77%	100%